P13611 (CSPG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Versican core protein

Alternative name(s):
Chondroitin sulfate proteoglycan core protein 2
Short name=Chondroitin sulfate proteoglycan 2
Glial hyaluronate-binding protein
Short name=GHAP
Large fibroblast proteoglycan
PG-M

Gene names

Name:	VCAN
Synonyms:	CSPG2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	3396 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
Subunit structure	Interacts with FBLN1 By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix.
Tissue specificity	Cerebral white matter and plasma. Isoform V0 and isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas. Isoform V2 is restricted to normal brain and gliomas. Isoform V3 is found in all these tissues except medulloblastomas. Ref.12
Developmental stage	Disappears after the cartilage development.
Post-translational modification	Phosphorylation sites are present in the extracellular medium.
Involvement in disease	Wagner syndrome 1 (WGN1) [MIM:143200]: Dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. Systemic manifestations are absent in WGN. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13
Sequence similarities	Belongs to the aggrecan/versican proteoglycan family. Contains 1 C-type lectin domain. Contains 2 EGF-like domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Contains 2 Link domains. Contains 1 Sushi (CCP/SCR) domain.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Cataract
Domain	EGF-like domain Immunoglobulin domain Repeat Signal Sushi
Ligand	Calcium Hyaluronic acid Lectin
PTM	Disulfide bond Glycoprotein Phosphoprotein Proteoglycan
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Traceable author statement. Source: Reactome cell adhesion Traceable author statement Ref.1. Source: ProtInc cell recognition Traceable author statement Ref.1. Source: ProtInc chondroitin sulfate biosynthetic process Traceable author statement. Source: Reactome chondroitin sulfate catabolic process Traceable author statement. Source: Reactome dermatan sulfate biosynthetic process Traceable author statement. Source: Reactome glial cell migration Inferred from direct assay PubMed 18431253PubMed 18431253. Source: BHF-UCL heart development Inferred from electronic annotation. Source: Compara multicellular organismal development Traceable author statement Ref.1. Source: ProtInc
Cellular_component	Golgi lumen Traceable author statement. Source: Reactome extracellular space Inferred from direct assay PubMed 20551380. Source: BHF-UCL lysosomal lumen Traceable author statement. Source: Reactome proteinaceous extracellular matrix Traceable author statement Ref.1. Source: ProtInc
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro carbohydrate binding Inferred from electronic annotation. Source: InterPro hyaluronic acid binding Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform V0 (identifier: P13611-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform V1 (identifier: P13611-2)

The sequence of this isoform differs from the canonical sequence as follows:
     348-348: P → R
     349-1335: Missing.

Isoform V2 (identifier: P13611-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1336-3089: Missing.

Isoform V3 (identifier: P13611-4)

The sequence of this isoform differs from the canonical sequence as follows:
     348-348: P → R
     349-3089: Missing.

Isoform Vint (identifier: P13611-5)

The sequence of this isoform differs from the canonical sequence as follows:
     3355-3396: PSAYQRTYSMKYFKNSSSAKDNSINTSKHDHRWSRRWQESRR → RKWSFRKNGLPCYNNY

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Ref.9
	Chain	21 – 3396	3376	Versican core protein		PRO_0000017522
Regions
	Domain	21 – 146	126	Ig-like V-type
	Domain	150 – 245	96	Link 1
	Domain	251 – 347	97	Link 2
	Domain	3089 – 3125	37	EGF-like 1
	Domain	3127 – 3163	37	EGF-like 2; calcium-binding Potential
	Domain	3176 – 3290	115	C-type lectin
	Domain	3294 – 3354	61	Sushi
	Region	348 – 1335	988	GAG-alpha (glucosaminoglycan attachment domain)
	Region	1336 – 3089	1754	GAG-beta
Amino acid modifications
	Glycosylation	57	1	N-linked (GlcNAc...) Potential
	Glycosylation	330	1	N-linked (GlcNAc...)
	Glycosylation	615	1	N-linked (GlcNAc...) Potential
	Glycosylation	782	1	N-linked (GlcNAc...) Potential
	Glycosylation	809	1	N-linked (GlcNAc...) Potential
	Glycosylation	1332	1	N-linked (GlcNAc...) Potential
	Glycosylation	1398	1	N-linked (GlcNAc...) Potential
	Glycosylation	1442	1	N-linked (GlcNAc...) Potential
	Glycosylation	1468	1	N-linked (GlcNAc...) Potential
	Glycosylation	1663	1	N-linked (GlcNAc...) Potential
	Glycosylation	1898	1	N-linked (GlcNAc...) Potential
	Glycosylation	2179	1	N-linked (GlcNAc...) Potential
	Glycosylation	2272	1	N-linked (GlcNAc...) Potential
	Glycosylation	2280	1	N-linked (GlcNAc...) Potential
	Glycosylation	2360	1	N-linked (GlcNAc...) Potential
	Glycosylation	2385	1	N-linked (GlcNAc...) Potential
	Glycosylation	2392	1	N-linked (GlcNAc...) Potential
	Glycosylation	2496	1	N-linked (GlcNAc...) Potential
	Glycosylation	2628	1	N-linked (GlcNAc...) Potential
	Glycosylation	2934	1	N-linked (GlcNAc...) Potential
	Glycosylation	3067	1	N-linked (GlcNAc...) Potential
	Glycosylation	3369	1	N-linked (GlcNAc...) Potential
	Glycosylation	3379	1	N-linked (GlcNAc...) Potential
	Disulfide bond	44 ↔ 130		By similarity
	Disulfide bond	172 ↔ 243		By similarity
	Disulfide bond	196 ↔ 217		By similarity
	Disulfide bond	270 ↔ 345		By similarity
	Disulfide bond	294 ↔ 315		By similarity
	Disulfide bond	3093 ↔ 3104		By similarity
	Disulfide bond	3098 ↔ 3113		By similarity
	Disulfide bond	3115 ↔ 3124		By similarity
	Disulfide bond	3131 ↔ 3142		By similarity
	Disulfide bond	3136 ↔ 3151		By similarity
	Disulfide bond	3153 ↔ 3162		By similarity
	Disulfide bond	3169 ↔ 3180		By similarity
	Disulfide bond	3197 ↔ 3289		By similarity
	Disulfide bond	3265 ↔ 3281		By similarity
	Disulfide bond	3296 ↔ 3339		By similarity
	Disulfide bond	3325 ↔ 3352		By similarity
Natural variations
	Alternative sequence	348	1	P → R in isoform V1 and isoform V3.		VSP_003082
	Alternative sequence	349 – 3089	2741	Missing in isoform V3.		VSP_003085
	Alternative sequence	349 – 1335	987	Missing in isoform V1.		VSP_003083
	Alternative sequence	1336 – 3089	1754	Missing in isoform V2.		VSP_003084
	Alternative sequence	3355 – 3396	42	PSAYQ…QESRR → RKWSFRKNGLPCYNNY in isoform Vint.		VSP_003086
	Natural variant	300	1	S → L. Corresponds to variant rs2652098 [ dbSNP | Ensembl ].		VAR_021958
	Natural variant	428	1	G → D. Corresponds to variant rs2287926 [ dbSNP | Ensembl ].		VAR_020214
	Natural variant	1516	1	K → R. Corresponds to variant rs309559 [ dbSNP | Ensembl ].		VAR_021959
	Natural variant	1826	1	R → H. Corresponds to variant rs188703 [ dbSNP | Ensembl ].		VAR_031632
	Natural variant	2301	1	F → Y. Corresponds to variant rs160278 [ dbSNP | Ensembl ].		VAR_020215
	Natural variant	2315	1	V → L. Corresponds to variant rs3734094 [ dbSNP | Ensembl ].		VAR_020216
	Natural variant	2937	1	D → Y. Corresponds to variant rs160277 [ dbSNP | Ensembl ].		VAR_021960
	Natural variant	3011	1	N → K. Corresponds to variant rs16900532 [ dbSNP | Ensembl ].		VAR_031633
Experimental info
	Sequence conflict	88	1	N → D AA sequence Ref.10
	Sequence conflict	260	1	K → I AA sequence Ref.10
	Sequence conflict	274	1	D → A in BAA06801. Ref.4
	Sequence conflict	284	1	Q → G AA sequence Ref.10
	Sequence conflict	2709 – 2713	5	IKAEA → EFREV in AAA36437. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform V0 [UniParc]. Last modified November 1, 1997. Version 3. Checksum: D174A1BBB8304FEC	FASTA	3,396	372,820
	10 20 30 40 50 60 MFINIKSILW MCSTLIVTHA LHKVKVGKSP PVRGSLSGKV SLPCHFSTMP TLPPSYNTSE 70 80 90 100 110 120 FLRIKWSKIE VDKNGKDLKE TTVLVAQNGN IKIGQDYKGR VSVPTHPEAV GDASLTVVKL 130 140 150 160 170 180 LASDAGLYRC DVMYGIEDTQ DTVSLTVDGV VFHYRAATSR YTLNFEAAQK ACLDVGAVIA 190 200 210 220 230 240 TPEQLFAAYE DGFEQCDAGW LADQTVRYPI RAPRVGCYGD KMGKAGVRTY GFRSPQETYD 250 260 270 280 290 300 VYCYVDHLDG DVFHLTVPSK FTFEEAAKEC ENQDARLATV GELQAAWRNG FDQCDYGWLS 310 320 330 340 350 360 DASVRHPVTV ARAQCGGGLL GVRTLYRFEN QTGFPPPDSR FDAYCFKPKE ATTIDLSILA 370 380 390 400 410 420 ETASPSLSKE PQMVSDRTTP IIPLVDELPV IPTEFPPVGN IVSFEQKATV QPQAITDSLA 430 440 450 460 470 480 TKLPTPTGST KKPWDMDDYS PSASGPLGKL DISEIKEEVL QSTTGVSHYA TDSWDGVVED 490 500 510 520 530 540 KQTQESVTQI EQIEVGPLVT SMEILKHIPS KEFPVTETPL VTARMILESK TEKKMVSTVS 550 560 570 580 590 600 ELVTTGHYGF TLGEEDDEDR TLTVGSDEST LIFDQIPEVI TVSKTSEDTI HTHLEDLESV 610 620 630 640 650 660 SASTTVSPLI MPDNNGSSMD DWEERQTSGR ITEEFLGKYL STTPFPSQHR TEIELFPYSG 670 680 690 700 710 720 DKILVEGIST VIYPSLQTEM THRRERTETL IPEMRTDTYT DEIQEEITKS PFMGKTEEEV 730 740 750 760 770 780 FSGMKLSTSL SEPIHVTESS VEMTKSFDFP TLITKLSAEP TEVRDMEEDF TATPGTTKYD 790 800 810 820 830 840 ENITTVLLAH GTLSVEAATV SKWSWDEDNT TSKPLESTEP SASSKLPPAL LTTVGMNGKD 850 860 870 880 890 900 KDIPSFTEDG ADEFTLIPDS TQKQLEEVTD EDIAAHGKFT IRFQPTTSTG IAEKSTLRDS 910 920 930 940 950 960 TTEEKVPPIT STEGQVYATM EGSALGEVED VDLSKPVSTV PQFAHTSEVE GLAFVSYSST 970 980 990 1000 1010 1020 QEPTTYVDSS HTIPLSVIPK TDWGVLVPSV PSEDEVLGEP SQDILVIDQT RLEATISPET 1030 1040 1050 1060 1070 1080 MRTTKITEGT TQEEFPWKEQ TAEKPVPALS STAWTPKEAV TPLDEQEGDG SAYTVSEDEL 1090 1100 1110 1120 1130 1140 LTGSERVPVL ETTPVGKIDH SVSYPPGAVT EHKVKTDEVV TLTPRIGPKV SLSPGPEQKY 1150 1160 1170 1180 1190 1200 ETEGSSTTGF TSSLSPFSTH ITQLMEETTT EKTSLEDIDL GSGLFEKPKA TELIEFSTIK 1210 1220 1230 1240 1250 1260 VTVPSDITTA FSSVDRLHTT SAFKPSSAIT KKPPLIDREP GEETTSDMVI IGESTSHVPP 1270 1280 1290 1300 1310 1320 TTLEDIVAKE TETDIDREYF TTSSPPATQP TRPPTVEDKE AFGPQALSTP QPPASTKFHP 1330 1340 1350 1360 1370 1380 DINVYIIEVR ENKTGRMSDL SVIGHPIDSE SKEDEPCSEE TDPVHDLMAE ILPEFPDIIE 1390 1400 1410 1420 1430 1440 IDLYHSEENE EEEEECANAT DVTTTPSVQY INGKHLVTTV PKDPEAAEAR RGQFESVAPS 1450 1460 1470 1480 1490 1500 QNFSDSSESD THPFVIAKTE LSTAVQPNES TETTESLEVT WKPETYPETS EHFSGGEPDV 1510 1520 1530 1540 1550 1560 FPTVPFHEEF ESGTAKKGAE SVTERDTEVG HQAHEHTEPV SLFPEESSGE IAIDQESQKI 1570 1580 1590 1600 1610 1620 AFARATEVTF GEEVEKSTSV TYTPTIVPSS ASAYVSEEEA VTLIGNPWPD DLLSTKESWV 1630 1640 1650 1660 1670 1680 EATPRQVVEL SGSSSIPITE GSGEAEEDED TMFTMVTDLS QRNTTDTLIT LDTSRIITES 1690 1700 1710 1720 1730 1740 FFEVPATTIY PVSEQPSAKV VPTKFVSETD TSEWISSTTV EEKKRKEEEG TTGTASTFEV 1750 1760 1770 1780 1790 1800 YSSTQRSDQL ILPFELESPN VATSSDSGTR KSFMSLTTPT QSEREMTDST PVFTETNTLE 1810 1820 1830 1840 1850 1860 NLGAQTTEHS SIHQPGVQEG LTTLPRSPAS VFMEQGSGEA AADPETTTVS SFSLNVEYAI 1870 1880 1890 1900 1910 1920 QAEKEVAGTL SPHVETTFST EPTGLVLSTV MDRVVAENIT QTSREIVISE RLGEPNYGAE 1930 1940 1950 1960 1970 1980 IRGFSTGFPL EEDFSGDFRE YSTVSHPIAK EETVMMEGSG DAAFRDTQTS PSTVPTSVHI 1990 2000 2010 2020 2030 2040 SHISDSEGPS STMVSTSAFP WEEFTSSAEG SGEQLVTVSS SVVPVLPSAV QKFSGTASSI 2050 2060 2070 2080 2090 2100 IDEGLGEVGT VNEIDRRSTI LPTAEVEGTK APVEKEEVKV SGTVSTNFPQ TIEPAKLWSR 2110 2120 2130 2140 2150 2160 QEVNPVRQEI ESETTSEEQI QEEKSFESPQ NSPATEQTIF DSQTFTETEL KTTDYSVLTT 2170 2180 2190 2200 2210 2220 KKTYSDDKEM KEEDTSLVNM STPDPDANGL ESYTTLPEAT EKSHFFLATA LVTESIPAEH 2230 2240 2250 2260 2270 2280 VVTDSPIKKE ESTKHFPKGM RPTIQESDTE LLFSGLGSGE EVLPTLPTES VNFTEVEQIN 2290 2300 2310 2320 2330 2340 NTLYPHTSQV ESTSSDKIED FNRMENVAKE VGPLVSQTDI FEGSGSVTST TLIEILSDTG 2350 2360 2370 2380 2390 2400 AEGPTVAPLP FSTDIGHPQN QTVRWAEEIQ TSRPQTITEQ DSNKNSSTAE INETTTSSTD 2410 2420 2430 2440 2450 2460 FLARAYGFEM AKEFVTSAPK PSDLYYEPSG EGSGEVDIVD SFHTSATTQA TRQESSTTFV 2470 2480 2490 2500 2510 2520 SDGSLEKHPE VPSAKAVTAD GFPTVSVMLP LHSEQNKSSP DPTSTLSNTV SYERSTDGSF 2530 2540 2550 2560 2570 2580 QDRFREFEDS TLKPNRKKPT ENIIIDLDKE DKDLILTITE STILEILPEL TSDKNTIIDI 2590 2600 2610 2620 2630 2640 DHTKPVYEDI LGMQTDIDTE VPSEPHDSND ESNDDSTQVQ EIYEAAVNLS LTEETFEGSA 2650 2660 2670 2680 2690 2700 DVLASYTQAT HDESMTYEDR SQLDHMGFHF TTGIPAPSTE TELDVLLPTA TSLPIPRKSA 2710 2720 2730 2740 2750 2760 TVIPEIEGIK AEAKALDDMF ESSTLSDGQA IADQSEIIPT LGQFERTQEE YEDKKHAGPS 2770 2780 2790 2800 2810 2820 FQPEFSSGAE EALVDHTPYL SIATTHLMDQ SVTEVPDVME GSNPPYYTDT TLAVSTFAKL 2830 2840 2850 2860 2870 2880 SSQTPSSPLT IYSGSEASGH TEIPQPSALP GIDVGSSVMS PQDSFKEIHV NIEATFKPSS 2890 2900 2910 2920 2930 2940 EEYLHITEPP SLSPDTKLEP SEDDGKPELL EEMEASPTEL IAVEGTEILQ DFQNKTDGQV 2950 2960 2970 2980 2990 3000 SGEAIKMFPT IKTPEAGTVI TTADEIELEG ATQWPHSTSA SATYGVEAGV VPWLSPQTSE 3010 3020 3030 3040 3050 3060 RPTLSSSPEI NPETQAALIR GQDSTIAASE QQVAARILDS NDQATVNPVE FNTEVATPPF 3070 3080 3090 3100 3110 3120 SLLETSNETD FLIGINEESV EGTAIYLPGP DRCKMNPCLN GGTCYPTETS YVCTCVPGYS 3130 3140 3150 3160 3170 3180 GDQCELDFDE CHSNPCRNGA TCVDGFNTFR CLCLPSYVGA LCEQDTETCD YGWHKFQGQC 3190 3200 3210 3220 3230 3240 YKYFAHRRTW DAAERECRLQ GAHLTSILSH EEQMFVNRVG HDYQWIGLND KMFEHDFRWT 3250 3260 3270 3280 3290 3300 DGSTLQYENW RPNQPDSFFS AGEDCVVIIW HENGQWNDVP CNYHLTYTCK KGTVACGQPP 3310 3320 3330 3340 3350 3360 VVENAKTFGK MKPRYEINSL IRYHCKDGFI QRHLPTIRCL GNGRWAIPKI TCMNPSAYQR 3370 3380 3390 TYSMKYFKNS SSAKDNSINT SKHDHRWSRR WQESRR
	Isoform V1 [UniParc]. Checksum: 4D290F9BF5A3F704	FASTA	2,409	265,050
	10 20 30 40 50 60 MFINIKSILW MCSTLIVTHA LHKVKVGKSP PVRGSLSGKV SLPCHFSTMP TLPPSYNTSE 70 80 90 100 110 120 FLRIKWSKIE VDKNGKDLKE TTVLVAQNGN IKIGQDYKGR VSVPTHPEAV GDASLTVVKL 130 140 150 160 170 180 LASDAGLYRC DVMYGIEDTQ DTVSLTVDGV VFHYRAATSR YTLNFEAAQK ACLDVGAVIA 190 200 210 220 230 240 TPEQLFAAYE DGFEQCDAGW LADQTVRYPI RAPRVGCYGD KMGKAGVRTY GFRSPQETYD 250 260 270 280 290 300 VYCYVDHLDG DVFHLTVPSK FTFEEAAKEC ENQDARLATV GELQAAWRNG FDQCDYGWLS 310 320 330 340 350 360 DASVRHPVTV ARAQCGGGLL GVRTLYRFEN QTGFPPPDSR FDAYCFKRRM SDLSVIGHPI 370 380 390 400 410 420 DSESKEDEPC SEETDPVHDL MAEILPEFPD IIEIDLYHSE ENEEEEEECA NATDVTTTPS 430 440 450 460 470 480 VQYINGKHLV TTVPKDPEAA EARRGQFESV APSQNFSDSS ESDTHPFVIA KTELSTAVQP 490 500 510 520 530 540 NESTETTESL EVTWKPETYP ETSEHFSGGE PDVFPTVPFH EEFESGTAKK GAESVTERDT 550 560 570 580 590 600 EVGHQAHEHT EPVSLFPEES SGEIAIDQES QKIAFARATE VTFGEEVEKS TSVTYTPTIV 610 620 630 640 650 660 PSSASAYVSE EEAVTLIGNP WPDDLLSTKE SWVEATPRQV VELSGSSSIP ITEGSGEAEE 670 680 690 700 710 720 DEDTMFTMVT DLSQRNTTDT LITLDTSRII TESFFEVPAT TIYPVSEQPS AKVVPTKFVS 730 740 750 760 770 780 ETDTSEWISS TTVEEKKRKE EEGTTGTAST FEVYSSTQRS DQLILPFELE SPNVATSSDS 790 800 810 820 830 840 GTRKSFMSLT TPTQSEREMT DSTPVFTETN TLENLGAQTT EHSSIHQPGV QEGLTTLPRS 850 860 870 880 890 900 PASVFMEQGS GEAAADPETT TVSSFSLNVE YAIQAEKEVA GTLSPHVETT FSTEPTGLVL 910 920 930 940 950 960 STVMDRVVAE NITQTSREIV ISERLGEPNY GAEIRGFSTG FPLEEDFSGD FREYSTVSHP 970 980 990 1000 1010 1020 IAKEETVMME GSGDAAFRDT QTSPSTVPTS VHISHISDSE GPSSTMVSTS AFPWEEFTSS 1030 1040 1050 1060 1070 1080 AEGSGEQLVT VSSSVVPVLP SAVQKFSGTA SSIIDEGLGE VGTVNEIDRR STILPTAEVE 1090 1100 1110 1120 1130 1140 GTKAPVEKEE VKVSGTVSTN FPQTIEPAKL WSRQEVNPVR QEIESETTSE EQIQEEKSFE 1150 1160 1170 1180 1190 1200 SPQNSPATEQ TIFDSQTFTE TELKTTDYSV LTTKKTYSDD KEMKEEDTSL VNMSTPDPDA 1210 1220 1230 1240 1250 1260 NGLESYTTLP EATEKSHFFL ATALVTESIP AEHVVTDSPI KKEESTKHFP KGMRPTIQES 1270 1280 1290 1300 1310 1320 DTELLFSGLG SGEEVLPTLP TESVNFTEVE QINNTLYPHT SQVESTSSDK IEDFNRMENV 1330 1340 1350 1360 1370 1380 AKEVGPLVSQ TDIFEGSGSV TSTTLIEILS DTGAEGPTVA PLPFSTDIGH PQNQTVRWAE 1390 1400 1410 1420 1430 1440 EIQTSRPQTI TEQDSNKNSS TAEINETTTS STDFLARAYG FEMAKEFVTS APKPSDLYYE 1450 1460 1470 1480 1490 1500 PSGEGSGEVD IVDSFHTSAT TQATRQESST TFVSDGSLEK HPEVPSAKAV TADGFPTVSV 1510 1520 1530 1540 1550 1560 MLPLHSEQNK SSPDPTSTLS NTVSYERSTD GSFQDRFREF EDSTLKPNRK KPTENIIIDL 1570 1580 1590 1600 1610 1620 DKEDKDLILT ITESTILEIL PELTSDKNTI IDIDHTKPVY EDILGMQTDI DTEVPSEPHD 1630 1640 1650 1660 1670 1680 SNDESNDDST QVQEIYEAAV NLSLTEETFE GSADVLASYT QATHDESMTY EDRSQLDHMG 1690 1700 1710 1720 1730 1740 FHFTTGIPAP STETELDVLL PTATSLPIPR KSATVIPEIE GIKAEAKALD DMFESSTLSD 1750 1760 1770 1780 1790 1800 GQAIADQSEI IPTLGQFERT QEEYEDKKHA GPSFQPEFSS GAEEALVDHT PYLSIATTHL 1810 1820 1830 1840 1850 1860 MDQSVTEVPD VMEGSNPPYY TDTTLAVSTF AKLSSQTPSS PLTIYSGSEA SGHTEIPQPS 1870 1880 1890 1900 1910 1920 ALPGIDVGSS VMSPQDSFKE IHVNIEATFK PSSEEYLHIT EPPSLSPDTK LEPSEDDGKP 1930 1940 1950 1960 1970 1980 ELLEEMEASP TELIAVEGTE ILQDFQNKTD GQVSGEAIKM FPTIKTPEAG TVITTADEIE 1990 2000 2010 2020 2030 2040 LEGATQWPHS TSASATYGVE AGVVPWLSPQ TSERPTLSSS PEINPETQAA LIRGQDSTIA 2050 2060 2070 2080 2090 2100 ASEQQVAARI LDSNDQATVN PVEFNTEVAT PPFSLLETSN ETDFLIGINE ESVEGTAIYL 2110 2120 2130 2140 2150 2160 PGPDRCKMNP CLNGGTCYPT ETSYVCTCVP GYSGDQCELD FDECHSNPCR NGATCVDGFN 2170 2180 2190 2200 2210 2220 TFRCLCLPSY VGALCEQDTE TCDYGWHKFQ GQCYKYFAHR RTWDAAEREC RLQGAHLTSI 2230 2240 2250 2260 2270 2280 LSHEEQMFVN RVGHDYQWIG LNDKMFEHDF RWTDGSTLQY ENWRPNQPDS FFSAGEDCVV 2290 2300 2310 2320 2330 2340 IIWHENGQWN DVPCNYHLTY TCKKGTVACG QPPVVENAKT FGKMKPRYEI NSLIRYHCKD 2350 2360 2370 2380 2390 2400 GFIQRHLPTI RCLGNGRWAI PKITCMNPSA YQRTYSMKYF KNSSSAKDNS INTSKHDHRW SRRWQESRR
	Isoform V2 [UniParc]. Checksum: 25C238F0C5E94DBE	FASTA	1,642	182,062
	10 20 30 40 50 60 MFINIKSILW MCSTLIVTHA LHKVKVGKSP PVRGSLSGKV SLPCHFSTMP TLPPSYNTSE 70 80 90 100 110 120 FLRIKWSKIE VDKNGKDLKE TTVLVAQNGN IKIGQDYKGR VSVPTHPEAV GDASLTVVKL 130 140 150 160 170 180 LASDAGLYRC DVMYGIEDTQ DTVSLTVDGV VFHYRAATSR YTLNFEAAQK ACLDVGAVIA 190 200 210 220 230 240 TPEQLFAAYE DGFEQCDAGW LADQTVRYPI RAPRVGCYGD KMGKAGVRTY GFRSPQETYD 250 260 270 280 290 300 VYCYVDHLDG DVFHLTVPSK FTFEEAAKEC ENQDARLATV GELQAAWRNG FDQCDYGWLS 310 320 330 340 350 360 DASVRHPVTV ARAQCGGGLL GVRTLYRFEN QTGFPPPDSR FDAYCFKPKE ATTIDLSILA 370 380 390 400 410 420 ETASPSLSKE PQMVSDRTTP IIPLVDELPV IPTEFPPVGN IVSFEQKATV QPQAITDSLA 430 440 450 460 470 480 TKLPTPTGST KKPWDMDDYS PSASGPLGKL DISEIKEEVL QSTTGVSHYA TDSWDGVVED 490 500 510 520 530 540 KQTQESVTQI EQIEVGPLVT SMEILKHIPS KEFPVTETPL VTARMILESK TEKKMVSTVS 550 560 570 580 590 600 ELVTTGHYGF TLGEEDDEDR TLTVGSDEST LIFDQIPEVI TVSKTSEDTI HTHLEDLESV 610 620 630 640 650 660 SASTTVSPLI MPDNNGSSMD DWEERQTSGR ITEEFLGKYL STTPFPSQHR TEIELFPYSG 670 680 690 700 710 720 DKILVEGIST VIYPSLQTEM THRRERTETL IPEMRTDTYT DEIQEEITKS PFMGKTEEEV 730 740 750 760 770 780 FSGMKLSTSL SEPIHVTESS VEMTKSFDFP TLITKLSAEP TEVRDMEEDF TATPGTTKYD 790 800 810 820 830 840 ENITTVLLAH GTLSVEAATV SKWSWDEDNT TSKPLESTEP SASSKLPPAL LTTVGMNGKD 850 860 870 880 890 900 KDIPSFTEDG ADEFTLIPDS TQKQLEEVTD EDIAAHGKFT IRFQPTTSTG IAEKSTLRDS 910 920 930 940 950 960 TTEEKVPPIT STEGQVYATM EGSALGEVED VDLSKPVSTV PQFAHTSEVE GLAFVSYSST 970 980 990 1000 1010 1020 QEPTTYVDSS HTIPLSVIPK TDWGVLVPSV PSEDEVLGEP SQDILVIDQT RLEATISPET 1030 1040 1050 1060 1070 1080 MRTTKITEGT TQEEFPWKEQ TAEKPVPALS STAWTPKEAV TPLDEQEGDG SAYTVSEDEL 1090 1100 1110 1120 1130 1140 LTGSERVPVL ETTPVGKIDH SVSYPPGAVT EHKVKTDEVV TLTPRIGPKV SLSPGPEQKY 1150 1160 1170 1180 1190 1200 ETEGSSTTGF TSSLSPFSTH ITQLMEETTT EKTSLEDIDL GSGLFEKPKA TELIEFSTIK 1210 1220 1230 1240 1250 1260 VTVPSDITTA FSSVDRLHTT SAFKPSSAIT KKPPLIDREP GEETTSDMVI IGESTSHVPP 1270 1280 1290 1300 1310 1320 TTLEDIVAKE TETDIDREYF TTSSPPATQP TRPPTVEDKE AFGPQALSTP QPPASTKFHP 1330 1340 1350 1360 1370 1380 DINVYIIEVR ENKTGPDRCK MNPCLNGGTC YPTETSYVCT CVPGYSGDQC ELDFDECHSN 1390 1400 1410 1420 1430 1440 PCRNGATCVD GFNTFRCLCL PSYVGALCEQ DTETCDYGWH KFQGQCYKYF AHRRTWDAAE 1450 1460 1470 1480 1490 1500 RECRLQGAHL TSILSHEEQM FVNRVGHDYQ WIGLNDKMFE HDFRWTDGST LQYENWRPNQ 1510 1520 1530 1540 1550 1560 PDSFFSAGED CVVIIWHENG QWNDVPCNYH LTYTCKKGTV ACGQPPVVEN AKTFGKMKPR 1570 1580 1590 1600 1610 1620 YEINSLIRYH CKDGFIQRHL PTIRCLGNGR WAIPKITCMN PSAYQRTYSM KYFKNSSSAK 1630 1640 DNSINTSKHD HRWSRRWQES RR
	Isoform V3 [UniParc]. Checksum: 4933DFA2E0D7A0AD	FASTA	655	74,293
	10 20 30 40 50 60 MFINIKSILW MCSTLIVTHA LHKVKVGKSP PVRGSLSGKV SLPCHFSTMP TLPPSYNTSE 70 80 90 100 110 120 FLRIKWSKIE VDKNGKDLKE TTVLVAQNGN IKIGQDYKGR VSVPTHPEAV GDASLTVVKL 130 140 150 160 170 180 LASDAGLYRC DVMYGIEDTQ DTVSLTVDGV VFHYRAATSR YTLNFEAAQK ACLDVGAVIA 190 200 210 220 230 240 TPEQLFAAYE DGFEQCDAGW LADQTVRYPI RAPRVGCYGD KMGKAGVRTY GFRSPQETYD 250 260 270 280 290 300 VYCYVDHLDG DVFHLTVPSK FTFEEAAKEC ENQDARLATV GELQAAWRNG FDQCDYGWLS 310 320 330 340 350 360 DASVRHPVTV ARAQCGGGLL GVRTLYRFEN QTGFPPPDSR FDAYCFKRPD RCKMNPCLNG 370 380 390 400 410 420 GTCYPTETSY VCTCVPGYSG DQCELDFDEC HSNPCRNGAT CVDGFNTFRC LCLPSYVGAL 430 440 450 460 470 480 CEQDTETCDY GWHKFQGQCY KYFAHRRTWD AAERECRLQG AHLTSILSHE EQMFVNRVGH 490 500 510 520 530 540 DYQWIGLNDK MFEHDFRWTD GSTLQYENWR PNQPDSFFSA GEDCVVIIWH ENGQWNDVPC 550 560 570 580 590 600 NYHLTYTCKK GTVACGQPPV VENAKTFGKM KPRYEINSLI RYHCKDGFIQ RHLPTIRCLG 610 620 630 640 650 NGRWAIPKIT CMNPSAYQRT YSMKYFKNSS SAKDNSINTS KHDHRWSRRW QESRR
	Isoform Vint [UniParc]. Checksum: E76563A26BDA34C6	FASTA	3,370	369,688
	10 20 30 40 50 60 MFINIKSILW MCSTLIVTHA LHKVKVGKSP PVRGSLSGKV SLPCHFSTMP TLPPSYNTSE 70 80 90 100 110 120 FLRIKWSKIE VDKNGKDLKE TTVLVAQNGN IKIGQDYKGR VSVPTHPEAV GDASLTVVKL 130 140 150 160 170 180 LASDAGLYRC DVMYGIEDTQ DTVSLTVDGV VFHYRAATSR YTLNFEAAQK ACLDVGAVIA 190 200 210 220 230 240 TPEQLFAAYE DGFEQCDAGW LADQTVRYPI RAPRVGCYGD KMGKAGVRTY GFRSPQETYD 250 260 270 280 290 300 VYCYVDHLDG DVFHLTVPSK FTFEEAAKEC ENQDARLATV GELQAAWRNG FDQCDYGWLS 310 320 330 340 350 360 DASVRHPVTV ARAQCGGGLL GVRTLYRFEN QTGFPPPDSR FDAYCFKPKE ATTIDLSILA 370 380 390 400 410 420 ETASPSLSKE PQMVSDRTTP IIPLVDELPV IPTEFPPVGN IVSFEQKATV QPQAITDSLA 430 440 450 460 470 480 TKLPTPTGST KKPWDMDDYS PSASGPLGKL DISEIKEEVL QSTTGVSHYA TDSWDGVVED 490 500 510 520 530 540 KQTQESVTQI EQIEVGPLVT SMEILKHIPS KEFPVTETPL VTARMILESK TEKKMVSTVS 550 560 570 580 590 600 ELVTTGHYGF TLGEEDDEDR TLTVGSDEST LIFDQIPEVI TVSKTSEDTI HTHLEDLESV 610 620 630 640 650 660 SASTTVSPLI MPDNNGSSMD DWEERQTSGR ITEEFLGKYL STTPFPSQHR TEIELFPYSG 670 680 690 700 710 720 DKILVEGIST VIYPSLQTEM THRRERTETL IPEMRTDTYT DEIQEEITKS PFMGKTEEEV 730 740 750 760 770 780 FSGMKLSTSL SEPIHVTESS VEMTKSFDFP TLITKLSAEP TEVRDMEEDF TATPGTTKYD 790 800 810 820 830 840 ENITTVLLAH GTLSVEAATV SKWSWDEDNT TSKPLESTEP SASSKLPPAL LTTVGMNGKD 850 860 870 880 890 900 KDIPSFTEDG ADEFTLIPDS TQKQLEEVTD EDIAAHGKFT IRFQPTTSTG IAEKSTLRDS 910 920 930 940 950 960 TTEEKVPPIT STEGQVYATM EGSALGEVED VDLSKPVSTV PQFAHTSEVE GLAFVSYSST 970 980 990 1000 1010 1020 QEPTTYVDSS HTIPLSVIPK TDWGVLVPSV PSEDEVLGEP SQDILVIDQT RLEATISPET 1030 1040 1050 1060 1070 1080 MRTTKITEGT TQEEFPWKEQ TAEKPVPALS STAWTPKEAV TPLDEQEGDG SAYTVSEDEL 1090 1100 1110 1120 1130 1140 LTGSERVPVL ETTPVGKIDH SVSYPPGAVT EHKVKTDEVV TLTPRIGPKV SLSPGPEQKY 1150 1160 1170 1180 1190 1200 ETEGSSTTGF TSSLSPFSTH ITQLMEETTT EKTSLEDIDL GSGLFEKPKA TELIEFSTIK 1210 1220 1230 1240 1250 1260 VTVPSDITTA FSSVDRLHTT SAFKPSSAIT KKPPLIDREP GEETTSDMVI IGESTSHVPP 1270 1280 1290 1300 1310 1320 TTLEDIVAKE TETDIDREYF TTSSPPATQP TRPPTVEDKE AFGPQALSTP QPPASTKFHP 1330 1340 1350 1360 1370 1380 DINVYIIEVR ENKTGRMSDL SVIGHPIDSE SKEDEPCSEE TDPVHDLMAE ILPEFPDIIE 1390 1400 1410 1420 1430 1440 IDLYHSEENE EEEEECANAT DVTTTPSVQY INGKHLVTTV PKDPEAAEAR RGQFESVAPS 1450 1460 1470 1480 1490 1500 QNFSDSSESD THPFVIAKTE LSTAVQPNES TETTESLEVT WKPETYPETS EHFSGGEPDV 1510 1520 1530 1540 1550 1560 FPTVPFHEEF ESGTAKKGAE SVTERDTEVG HQAHEHTEPV SLFPEESSGE IAIDQESQKI 1570 1580 1590 1600 1610 1620 AFARATEVTF GEEVEKSTSV TYTPTIVPSS ASAYVSEEEA VTLIGNPWPD DLLSTKESWV 1630 1640 1650 1660 1670 1680 EATPRQVVEL SGSSSIPITE GSGEAEEDED TMFTMVTDLS QRNTTDTLIT LDTSRIITES 1690 1700 1710 1720 1730 1740 FFEVPATTIY PVSEQPSAKV VPTKFVSETD TSEWISSTTV EEKKRKEEEG TTGTASTFEV 1750 1760 1770 1780 1790 1800 YSSTQRSDQL ILPFELESPN VATSSDSGTR KSFMSLTTPT QSEREMTDST PVFTETNTLE 1810 1820 1830 1840 1850 1860 NLGAQTTEHS SIHQPGVQEG LTTLPRSPAS VFMEQGSGEA AADPETTTVS SFSLNVEYAI 1870 1880 1890 1900 1910 1920 QAEKEVAGTL SPHVETTFST EPTGLVLSTV MDRVVAENIT QTSREIVISE RLGEPNYGAE 1930 1940 1950 1960 1970 1980 IRGFSTGFPL EEDFSGDFRE YSTVSHPIAK EETVMMEGSG DAAFRDTQTS PSTVPTSVHI 1990 2000 2010 2020 2030 2040 SHISDSEGPS STMVSTSAFP WEEFTSSAEG SGEQLVTVSS SVVPVLPSAV QKFSGTASSI 2050 2060 2070 2080 2090 2100 IDEGLGEVGT VNEIDRRSTI LPTAEVEGTK APVEKEEVKV SGTVSTNFPQ TIEPAKLWSR 2110 2120 2130 2140 2150 2160 QEVNPVRQEI ESETTSEEQI QEEKSFESPQ NSPATEQTIF DSQTFTETEL KTTDYSVLTT 2170 2180 2190 2200 2210 2220 KKTYSDDKEM KEEDTSLVNM STPDPDANGL ESYTTLPEAT EKSHFFLATA LVTESIPAEH 2230 2240 2250 2260 2270 2280 VVTDSPIKKE ESTKHFPKGM RPTIQESDTE LLFSGLGSGE EVLPTLPTES VNFTEVEQIN 2290 2300 2310 2320 2330 2340 NTLYPHTSQV ESTSSDKIED FNRMENVAKE VGPLVSQTDI FEGSGSVTST TLIEILSDTG 2350 2360 2370 2380 2390 2400 AEGPTVAPLP FSTDIGHPQN QTVRWAEEIQ TSRPQTITEQ DSNKNSSTAE INETTTSSTD 2410 2420 2430 2440 2450 2460 FLARAYGFEM AKEFVTSAPK PSDLYYEPSG EGSGEVDIVD SFHTSATTQA TRQESSTTFV 2470 2480 2490 2500 2510 2520 SDGSLEKHPE VPSAKAVTAD GFPTVSVMLP LHSEQNKSSP DPTSTLSNTV SYERSTDGSF 2530 2540 2550 2560 2570 2580 QDRFREFEDS TLKPNRKKPT ENIIIDLDKE DKDLILTITE STILEILPEL TSDKNTIIDI 2590 2600 2610 2620 2630 2640 DHTKPVYEDI LGMQTDIDTE VPSEPHDSND ESNDDSTQVQ EIYEAAVNLS LTEETFEGSA 2650 2660 2670 2680 2690 2700 DVLASYTQAT HDESMTYEDR SQLDHMGFHF TTGIPAPSTE TELDVLLPTA TSLPIPRKSA 2710 2720 2730 2740 2750 2760 TVIPEIEGIK AEAKALDDMF ESSTLSDGQA IADQSEIIPT LGQFERTQEE YEDKKHAGPS 2770 2780 2790 2800 2810 2820 FQPEFSSGAE EALVDHTPYL SIATTHLMDQ SVTEVPDVME GSNPPYYTDT TLAVSTFAKL 2830 2840 2850 2860 2870 2880 SSQTPSSPLT IYSGSEASGH TEIPQPSALP GIDVGSSVMS PQDSFKEIHV NIEATFKPSS 2890 2900 2910 2920 2930 2940 EEYLHITEPP SLSPDTKLEP SEDDGKPELL EEMEASPTEL IAVEGTEILQ DFQNKTDGQV 2950 2960 2970 2980 2990 3000 SGEAIKMFPT IKTPEAGTVI TTADEIELEG ATQWPHSTSA SATYGVEAGV VPWLSPQTSE 3010 3020 3030 3040 3050 3060 RPTLSSSPEI NPETQAALIR GQDSTIAASE QQVAARILDS NDQATVNPVE FNTEVATPPF 3070 3080 3090 3100 3110 3120 SLLETSNETD FLIGINEESV EGTAIYLPGP DRCKMNPCLN GGTCYPTETS YVCTCVPGYS 3130 3140 3150 3160 3170 3180 GDQCELDFDE CHSNPCRNGA TCVDGFNTFR CLCLPSYVGA LCEQDTETCD YGWHKFQGQC 3190 3200 3210 3220 3230 3240 YKYFAHRRTW DAAERECRLQ GAHLTSILSH EEQMFVNRVG HDYQWIGLND KMFEHDFRWT 3250 3260 3270 3280 3290 3300 DGSTLQYENW RPNQPDSFFS AGEDCVVIIW HENGQWNDVP CNYHLTYTCK KGTVACGQPP 3310 3320 3330 3340 3350 3360 VVENAKTFGK MKPRYEINSL IRYHCKDGFI QRHLPTIRCL GNGRWAIPKI TCMNRKWSFR 3370 KNGLPCYNNY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Multiple domains of the large fibroblast proteoglycan, versican." Zimmermann D.R., Ruoslahti E. EMBO J. 8:2975-2981(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM V1). Tissue: Placenta.
[2]	"A novel glycosaminoglycan attachment domain identified in two alternative splice variants of human versican." Dours-Zimmermann M.T., Zimmermann D.R. J. Biol. Chem. 269:32992-32998(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM V2). Tissue: Glial tumor.
[3]	"Characterization of the complete genomic structure of the human versican gene and functional analysis of its promoter." Naso M.F., Zimmermann D.R., Iozzo R.V. J. Biol. Chem. 269:32999-33008(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM V0).
[4]	"Expression of PG-M(V3), an alternatively spliced form of PG-M without a chondroitin sulfate attachment in region in mouse and human tissues." Zako M., Shinomura T., Ujita M., Ito K., Kimata K. J. Biol. Chem. 270:3914-3918(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM V3). Tissue: Brain.
[5]	"Identification of the proteoglycan versican in aorta and smooth muscle cells by DNA sequence analysis, in situ hybridization and immunohistochemistry." Yao L.Y., Moody C., Schoenherr E., Wight T.N., Sandell L.J. Matrix Biol. 14:213-225(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 208-1427; 2081-2372 AND 2897-3233 (ISOFORM V1).
[6]	"Mapping of the versican proteoglycan gene (CSPG2) to the long arm of human chromosome 5 (5q12-5q14)." Iozzo R.V., Naso M.F., Cannizzaro L.A., Wasmuth J.J., McPherson J.D. Genomics 14:845-851(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 251-347.
[7]	"A fibroblast chondroitin sulfate proteoglycan core protein contains lectin-like and growth factor-like sequences." Krusius T., Gehlsen K.R., Ruoslahti E. J. Biol. Chem. 262:13120-13125(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2709-3396. Tissue: Lung fibroblast.
[8]	"Versican/PG-M isoforms in vascular smooth muscle cells." Lemire J.M., Braun K.R., Maurel P., Kaplan E.D., Schwartz S.M., Wight T.N. Arterioscler. Thromb. Vasc. Biol. 19:1630-1639(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3333-3396 (ISOFORM VINT). Tissue: Aortic smooth muscle.
[9]	"Isolation of a large aggregating proteoglycan from human brain." Perides G., Rahemtulla F., Lane W.S., Asher R.A., Bignami A. J. Biol. Chem. 267:23883-23887(1992) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 21-37.
[10]	"Isolation and partial characterization of a glial hyaluronate-binding protein." Perides G., Lane W.S., Andrews D., Dahl D., Bignami A. J. Biol. Chem. 264:5981-5987(1989) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-50; 80-119; 128-155; 167-218; 229-268 AND 277-290. Tissue: Brain.
[11]	"Structural similarity of hyaluronate binding proteins in brain and cartilage." Bignami A., Lane W.S., Andrews D., Dahl D. Brain Res. Bull. 22:67-70(1989) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 171-210 AND 289-303.
[12]	"Differential expression of versican isoforms in brain tumors." Paulus W., Baur I., Dours-Zimmermann M.T., Zimmermann D.R. J. Neuropathol. Exp. Neurol. 55:528-533(1996) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY (ISOFORMS V0; V1; V2 AND V3).
[13]	"Identification of a novel splice site mutation of the CSPG2 gene in a Japanese family with Wagner syndrome." Miyamoto T., Inoue H., Sakamoto Y., Kudo E., Naito T., Mikawa T., Mikawa Y., Isashiki Y., Osabe D., Shinohara S., Shiota H., Itakura M. Invest. Ophthalmol. Vis. Sci. 46:2726-2735(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN WGN1.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Web resources

Functional Glycomics Gateway - Glycan Binding

Versican

Cross-references

Sequence databases
EMBL GenBank DDBJ	X15998 mRNA. Translation: CAA34128.1. U16306 mRNA. Translation: AAA65018.1. U26555 mRNA. Translation: AAA67565.1. D32039 mRNA. Translation: BAA06801.1. S52488 Genomic DNA. Translation: AAB24878.1. J02814 mRNA. Translation: AAA36437.1. AF084545 mRNA. Translation: AAD48545.1.
IPI	IPI00009802. IPI00215628. IPI00215629. IPI00215630. IPI00215631.
PIR	A60979. S06014.
RefSeq	NP_001119808.1. NM_001126336.2. NP_001157569.1. NM_001164097.1. NP_001157570.1. NM_001164098.1. NP_004376.2. NM_004385.4.
UniGene	Hs.643801.
3D structure databases
ProteinModelPortal	P13611.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4529155.
STRING	9606.ENSP00000265077.
PTM databases
PhosphoSite	P13611.
Polymorphism databases
DMDM	2506816.
Proteomic databases
PaxDb	P13611.
PRIDE	P13611.
Protocols and materials databases
DNASU	1462.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000265077; ENSP00000265077; ENSG00000038427. ENST00000342785; ENSP00000342768; ENSG00000038427. ENST00000343200; ENSP00000340062; ENSG00000038427. ENST00000502527; ENSP00000421362; ENSG00000038427.
GeneID	1462.
KEGG	hsa:1462.
UCSC	uc003kii.3. human. uc003kij.3. human. uc003kik.3. human. uc010jau.2. human.
Organism-specific databases
CTD	1462.
GeneCards	GC05P082804.
HGNC	HGNC:2464. VCAN.
HPA	CAB008979. HPA004726.
MIM	118661. gene. 143200. phenotype.
neXtProt	NX_P13611.
Orphanet	898. Wagner disease.
PharmGKB	PA162408788.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOVERGEN	HBG051140.
InParanoid	P13611.
KO	K06793.
OMA	INTSKHD.
OrthoDB	EOG4G4GPG.
PhylomeDB	P13611.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism. REACT_116125. Disease.
Gene expression databases
ArrayExpress	P13611.
Bgee	P13611.
CleanEx	HS_VCAN.
Genevestigator	P13611.
GermOnline	ENSG00000038427. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 1 hit. 3.10.100.10. 3 hits.
InterPro	IPR001304. C-type_lectin. IPR016186. C-type_lectin-like. IPR018378. C-type_lectin_CS. IPR016187. C-type_lectin_fold. IPR000742. EG-like_dom. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR018097. EGF_Ca-bd_CS. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set. IPR000538. Link. IPR000436. Sushi_SCR_CCP. [Graphical view]
Pfam	PF00008. EGF. 2 hits. PF00059. Lectin_C. 1 hit. PF00084. Sushi. 1 hit. PF07686. V-set. 1 hit. PF00193. Xlink. 2 hits. [Graphical view]
PRINTS	PR01265. LINKMODULE.
SMART	SM00032. CCP. 1 hit. SM00034. CLECT. 1 hit. SM00181. EGF. 1 hit. SM00179. EGF_CA. 1 hit. SM00409. IG. 1 hit. SM00445. LINK. 2 hits. [Graphical view]
SUPFAM	SSF56436. C-type_lectin_fold. 3 hits. SSF57535. Complement_control_module. 1 hit.
PROSITE	PS00010. ASX_HYDROXYL. 1 hit. PS00615. C_TYPE_LECTIN_1. 1 hit. PS50041. C_TYPE_LECTIN_2. 1 hit. PS00022. EGF_1. 2 hits. PS01186. EGF_2. 1 hit. PS50026. EGF_3. 2 hits. PS01187. EGF_CA. 1 hit. PS50835. IG_LIKE. 1 hit. PS01241. LINK_1. 2 hits. PS50963. LINK_2. 2 hits. PS50923. SUSHI. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	VCAN. human.
GenomeRNAi	1462.
NextBio	6005.
PMAP-CutDB	P13611.
SOURCE	Search...

Entry information

Entry name

CSPG2_HUMAN

Accession

Primary (citable) accession number: P13611
Secondary accession number(s): P20754 , Q13010, Q13189, Q15123, Q9UCL9, Q9UNW5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 163 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.