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Protein

Serglycin

Gene

Srgn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.7 Publications

GO - Biological processi

  • biomineral tissue development Source: UniProtKB-KW
  • granzyme-mediated apoptotic signaling pathway Source: UniProtKB
  • maintenance of granzyme B location in T cell secretory granule Source: UniProtKB
  • maintenance of protease location in mast cell secretory granule Source: UniProtKB
  • mast cell secretory granule organization Source: UniProtKB
  • negative regulation of bone mineralization Source: UniProtKB
  • negative regulation of cytokine secretion Source: UniProtKB
  • protein processing Source: UniProtKB
  • T cell secretory granule organization Source: UniProtKB

Keywordsi

Biological processApoptosis, Biomineralization

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Serglycin
Alternative name(s):
Mastocytoma proteoglycan core protein
Secretory granule proteoglycan core protein
gp600
Gene namesi
Name:Srgn
Synonyms:Prg, Prg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:97756 Srgn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice develop normally and are fertile but display mast cell granule and T-lymphocyte secretory granule defects. Granules are more amorphous than in the wild-type and show a less defined dense core formation. There is a lack of mast cell-specific protease activity although mRNAs for a variety of proteases are detected and storage of granzyme B is affected in T-lymphocytes. Neutrophil granules display a lack of neutrophil elastase and processing of MMP2 is abrogated. Macrophages show no major morphological defects.5 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000029003626 – 74Activation peptideBy similarityAdd BLAST49
ChainiPRO_000002668075 – 152SerglycinAdd BLAST78

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 47Sequence analysis
Glycosylationi92O-linked (Xyl...) (glycosaminoglycan) serineBy similarity1
Glycosylationi94O-linked (Xyl...) (glycosaminoglycan) serineBy similarity1
Glycosylationi98O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi100O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi102O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi104O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi106O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi108O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1

Post-translational modificationi

O-glycosylated; contains chondroitin sulfate and heparan sulfate.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

EPDiP13609
MaxQBiP13609
PaxDbiP13609
PRIDEiP13609

Expressioni

Inductioni

By phorbol myristate acetate in T-lymphocytes. This induction is not inhibited by cyclosporine.1 Publication

Gene expression databases

BgeeiENSMUSG00000020077
CleanExiMM_SRGN
ExpressionAtlasiP13609 baseline and differential
GenevisibleiP13609 MM

Interactioni

Subunit structurei

Binds to activated CD44 and to GZMB.

Protein-protein interaction databases

BioGridi202359, 1 interactor
IntActiP13609, 1 interactor
STRINGi10090.ENSMUSP00000020271

Structurei

3D structure databases

ProteinModelPortaliP13609
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati89 – 9012
Repeati91 – 9222
Repeati93 – 9432
Repeati95 – 9642
Repeati97 – 9852
Repeati99 – 10062
Repeati101 – 10272
Repeati103 – 10482
Repeati105 – 10692
Repeati107 – 108102

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni89 – 10810 X 2 AA tandem repeats of G-SAdd BLAST20

Sequence similaritiesi

Belongs to the serglycin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J42T Eukaryota
ENOG4111DTK LUCA
GeneTreeiENSGT00390000000885
HOGENOMiHOG000154415
HOVERGENiHBG008180
InParanoidiP13609
KOiK06849
OMAiQWVRCNP
OrthoDBiEOG091G19FW
PhylomeDBiP13609
TreeFamiTF336310

Family and domain databases

InterProiView protein in InterPro
IPR007455 Serglycin
PfamiView protein in Pfam
PF04360 Serglycin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13609-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVPVGSRLV LALAFVLVWG SSVQGYPARR ARYQWVRCKP NGFFANCIEE
60 70 80 90 100
KGPQFDLIDE SNNIGPPMNN PVLMEGPSKD FISNYDDYGS GSGSGSGSGS
110 120 130 140 150
GSGSGSGSGF LGDMEWEYQP TDESNIVYFN YKPFDRILTE QNQDQPEDDF

II
Length:152
Mass (Da):16,711
Last modified:January 1, 1990 - v1
Checksum:iDCEC9829BA31036F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16133 mRNA Translation: CAA34259.1
M27393, M27391, M27392 Genomic DNA Translation: AAA39965.1
J04549 mRNA Translation: AAA40111.1
M33499 Genomic DNA Translation: AAA39900.1
M34603 mRNA Translation: AAA39991.1
AK087960 mRNA Translation: BAC40059.1
AK151357 mRNA Translation: BAE30332.1
AK157945 mRNA Translation: BAE34275.1
BC037076 mRNA Translation: AAH37076.1
CCDSiCCDS23889.1
PIRiJQ0791
RefSeqiNP_035287.1, NM_011157.2
XP_006513438.1, XM_006513375.2
XP_006513439.1, XM_006513376.3
XP_006513440.1, XM_006513377.3
UniGeneiMm.338790
Mm.486627
Mm.488040

Genome annotation databases

EnsembliENSMUST00000020271; ENSMUSP00000020271; ENSMUSG00000020077
ENSMUST00000160987; ENSMUSP00000125622; ENSMUSG00000020077
ENSMUST00000162161; ENSMUSP00000125533; ENSMUSG00000020077
GeneIDi19073
KEGGimmu:19073
UCSCiuc007fhi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSRGN_MOUSE
AccessioniPrimary (citable) accession number: P13609
Secondary accession number(s): Q3TZD4, Q8C2U2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: April 25, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health