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Protein

Serglycin

Gene

Srgn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.7 Publications

GO - Biological processi

  • biomineral tissue development Source: UniProtKB-KW
  • granzyme-mediated apoptotic signaling pathway Source: UniProtKB
  • maintenance of granzyme B location in T cell secretory granule Source: UniProtKB
  • maintenance of protease location in mast cell secretory granule Source: UniProtKB
  • mast cell secretory granule organization Source: UniProtKB
  • negative regulation of bone mineralization Source: UniProtKB
  • negative regulation of cytokine secretion Source: UniProtKB
  • protein processing Source: UniProtKB
  • T cell secretory granule organization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Biomineralization

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Serglycin
Alternative name(s):
Mastocytoma proteoglycan core protein
Secretory granule proteoglycan core protein
gp600
Gene namesi
Name:Srgn
Synonyms:Prg, Prg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:97756. Srgn.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: Ensembl
  • mast cell granule Source: UniProtKB
  • zymogen granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice develop normally and are fertile but display mast cell granule and T-lymphocyte secretory granule defects. Granules are more amorphous than in the wild-type and show a less defined dense core formation. There is a lack of mast cell-specific protease activity although mRNAs for a variety of proteases are detected and storage of granzyme B is affected in T-lymphocytes. Neutrophil granules display a lack of neutrophil elastase and processing of MMP2 is abrogated. Macrophages show no major morphological defects.5 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000029003626 – 74Activation peptideBy similarityAdd BLAST49
ChainiPRO_000002668075 – 152SerglycinAdd BLAST78

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 47Sequence analysis
Glycosylationi92O-linked (Xyl...) (glycosaminoglycan)By similarity1
Glycosylationi94O-linked (Xyl...) (glycosaminoglycan)By similarity1
Glycosylationi98O-linked (Xyl...) (glycosaminoglycan)Sequence analysis1
Glycosylationi100O-linked (Xyl...) (glycosaminoglycan)Sequence analysis1
Glycosylationi102O-linked (Xyl...) (glycosaminoglycan)Sequence analysis1
Glycosylationi104O-linked (Xyl...) (glycosaminoglycan)Sequence analysis1
Glycosylationi106O-linked (Xyl...) (glycosaminoglycan)Sequence analysis1
Glycosylationi108O-linked (Xyl...) (glycosaminoglycan)Sequence analysis1

Post-translational modificationi

O-glycosylated; contains chondroitin sulfate and heparan sulfate.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

EPDiP13609.
MaxQBiP13609.
PaxDbiP13609.
PRIDEiP13609.

Expressioni

Inductioni

By phorbol myristate acetate in T-lymphocytes. This induction is not inhibited by cyclosporine.1 Publication

Gene expression databases

BgeeiENSMUSG00000020077.
CleanExiMM_SRGN.
ExpressionAtlasiP13609. baseline and differential.
GenevisibleiP13609. MM.

Interactioni

Subunit structurei

Binds to activated CD44 and to GZMB.

Protein-protein interaction databases

BioGridi202359. 1 interactor.
IntActiP13609. 1 interactor.
STRINGi10090.ENSMUSP00000020271.

Structurei

3D structure databases

ProteinModelPortaliP13609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati89 – 9012
Repeati91 – 9222
Repeati93 – 9432
Repeati95 – 9642
Repeati97 – 9852
Repeati99 – 10062
Repeati101 – 10272
Repeati103 – 10482
Repeati105 – 10692
Repeati107 – 108102

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni89 – 10810 X 2 AA tandem repeats of G-SAdd BLAST20

Sequence similaritiesi

Belongs to the serglycin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J42T. Eukaryota.
ENOG4111DTK. LUCA.
GeneTreeiENSGT00390000000885.
HOGENOMiHOG000154415.
HOVERGENiHBG008180.
InParanoidiP13609.
KOiK06849.
OMAiSNSANCI.
OrthoDBiEOG091G19FW.
PhylomeDBiP13609.
TreeFamiTF336310.

Family and domain databases

InterProiIPR007455. Serglycin.
[Graphical view]
PfamiPF04360. Serglycin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13609-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVPVGSRLV LALAFVLVWG SSVQGYPARR ARYQWVRCKP NGFFANCIEE
60 70 80 90 100
KGPQFDLIDE SNNIGPPMNN PVLMEGPSKD FISNYDDYGS GSGSGSGSGS
110 120 130 140 150
GSGSGSGSGF LGDMEWEYQP TDESNIVYFN YKPFDRILTE QNQDQPEDDF

II
Length:152
Mass (Da):16,711
Last modified:January 1, 1990 - v1
Checksum:iDCEC9829BA31036F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16133 mRNA. Translation: CAA34259.1.
M27393, M27391, M27392 Genomic DNA. Translation: AAA39965.1.
J04549 mRNA. Translation: AAA40111.1.
M33499 Genomic DNA. Translation: AAA39900.1.
M34603 mRNA. Translation: AAA39991.1.
AK087960 mRNA. Translation: BAC40059.1.
AK151357 mRNA. Translation: BAE30332.1.
AK157945 mRNA. Translation: BAE34275.1.
BC037076 mRNA. Translation: AAH37076.1.
CCDSiCCDS23889.1.
PIRiJQ0791.
RefSeqiNP_035287.1. NM_011157.2.
XP_006513438.1. XM_006513375.2.
XP_006513439.1. XM_006513376.3.
XP_006513440.1. XM_006513377.3.
UniGeneiMm.338790.

Genome annotation databases

EnsembliENSMUST00000020271; ENSMUSP00000020271; ENSMUSG00000020077.
ENSMUST00000160987; ENSMUSP00000125622; ENSMUSG00000020077.
ENSMUST00000162161; ENSMUSP00000125533; ENSMUSG00000020077.
GeneIDi19073.
KEGGimmu:19073.
UCSCiuc007fhi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16133 mRNA. Translation: CAA34259.1.
M27393, M27391, M27392 Genomic DNA. Translation: AAA39965.1.
J04549 mRNA. Translation: AAA40111.1.
M33499 Genomic DNA. Translation: AAA39900.1.
M34603 mRNA. Translation: AAA39991.1.
AK087960 mRNA. Translation: BAC40059.1.
AK151357 mRNA. Translation: BAE30332.1.
AK157945 mRNA. Translation: BAE34275.1.
BC037076 mRNA. Translation: AAH37076.1.
CCDSiCCDS23889.1.
PIRiJQ0791.
RefSeqiNP_035287.1. NM_011157.2.
XP_006513438.1. XM_006513375.2.
XP_006513439.1. XM_006513376.3.
XP_006513440.1. XM_006513377.3.
UniGeneiMm.338790.

3D structure databases

ProteinModelPortaliP13609.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202359. 1 interactor.
IntActiP13609. 1 interactor.
STRINGi10090.ENSMUSP00000020271.

Proteomic databases

EPDiP13609.
MaxQBiP13609.
PaxDbiP13609.
PRIDEiP13609.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020271; ENSMUSP00000020271; ENSMUSG00000020077.
ENSMUST00000160987; ENSMUSP00000125622; ENSMUSG00000020077.
ENSMUST00000162161; ENSMUSP00000125533; ENSMUSG00000020077.
GeneIDi19073.
KEGGimmu:19073.
UCSCiuc007fhi.1. mouse.

Organism-specific databases

CTDi5552.
MGIiMGI:97756. Srgn.

Phylogenomic databases

eggNOGiENOG410J42T. Eukaryota.
ENOG4111DTK. LUCA.
GeneTreeiENSGT00390000000885.
HOGENOMiHOG000154415.
HOVERGENiHBG008180.
InParanoidiP13609.
KOiK06849.
OMAiSNSANCI.
OrthoDBiEOG091G19FW.
PhylomeDBiP13609.
TreeFamiTF336310.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Miscellaneous databases

PROiP13609.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020077.
CleanExiMM_SRGN.
ExpressionAtlasiP13609. baseline and differential.
GenevisibleiP13609. MM.

Family and domain databases

InterProiIPR007455. Serglycin.
[Graphical view]
PfamiPF04360. Serglycin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRGN_MOUSE
AccessioniPrimary (citable) accession number: P13609
Secondary accession number(s): Q3TZD4, Q8C2U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.