Reviewed, UniProtKB/Swiss-Prot P13603 (ADH1_TRIRP)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase 1
    EC=1.1.1.1

Gene names

Name:

ADH1

Organism

Trifolium repens (Creeping white clover)

Taxonomic identifier

3899 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids I › Fabales › Fabaceae › Papilionoideae › Trifolieae › Trifolium

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Cofactor	Binds 2 zinc ions per subunit.
Subunit structure	Homodimer.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alcohol dehydrogenase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 380	380	Alcohol dehydrogenase 1		PRO_0000160715
Sites
	Metal binding	48	1	Zinc 1; catalytic By similarity
	Metal binding	70	1	Zinc 1; catalytic By similarity
	Metal binding	100	1	Zinc 2 By similarity
	Metal binding	103	1	Zinc 2 By similarity
	Metal binding	106	1	Zinc 2 By similarity
	Metal binding	114	1	Zinc 2 By similarity
	Metal binding	178	1	Zinc 1; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	P13603-1 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: 6C6E805FC3ABA663	FASTA	380	41,172
	10 20 30 40 50 60 MSNTAGQVIK CRAAVAWEAG KPLVIEEVEV APPQAGEVRL KILFTSLCHT DVYFWEAKGQ 70 80 90 100 110 120 TPLFPRIFGH EAGGIVESVG EGVTHLKPGD HALPVFTGEC GECPHCKSEE SNMCNLLRIN 130 140 150 160 170 180 TDRGVMINDN KSRFSIKGQP VHHFVGTSTF SEYTVVHAGC VAKINPDAPL DKVCILSCGI 190 200 210 220 230 240 CTGLGATVNV AKPKPGSSVA IFGLGAVGLA AAEGARMSGA SRIIGVDLVS SRFELAKKFG 250 260 270 280 290 300 VNEFVNPKDH DKPVQQVIAE MTDGGVDRAV ECTGSIQAMI SAFECVHDGW GVAVLVGVPK 310 320 330 340 350 360 KDDAFKTHPM NFLNERTLKG TFYGNYKPRT DLPNVVEQYM KGELELEKFI THSIPFSEIN 370 380 KAFDYMLKGE SIRCIIRMEE

References

[1]	"Nucleotide sequence of a white clover alcohol dehydrogenase cDNA." Ellison N.W., Yu P.L., White D.W.R. Nucleic Acids Res. 18:4913-4913(1990) [PubMed: 2395651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Huia.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X14826 mRNA. Translation: CAA32934.1.
PIR	DEJYAW. S14680.
3D structure databases
HSSP	HSSP built from PDB template 1M6H based on UniProtKB P11766.
ModBase	Search...
Family and domain databases
InterPro	IPR013154. AlcDHase_GroES-like. IPR002085. AlcDHase_SF_Zn. IPR013149. AlcDHase_Zn-bd. IPR002328. AlcDHase_Zn_CS. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH1_TRIRP

Accession

Primary (citable) accession number: P13603

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	November 25, 2008
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)