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P13601

- AL1A7_RAT

UniProt

P13601 - AL1A7_RAT

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Protein

Aldehyde dehydrogenase, cytosolic 1

Gene

Aldh1a7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Can oxidize benzaldehyde, propionaldehyde and acetaldehyde. No detectable activity with retinal.1 Publication

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Kineticsi

The highest catalytic efficiency is observed with benzaldehyde as substrate. No activity with retinal.

  1. KM=2.4 mM for acetaldehyde1 Publication
  2. KM=1.6 mM for propionaldehyde1 Publication
  3. KM=4.7 µM for benzaldehyde1 Publication

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei170 – 1701Transition state stabilizerBy similarity
Active sitei269 – 2691Proton acceptorPROSITE-ProRule annotation
Active sitei303 – 3031NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi246 – 2516NADBy similarity

GO - Molecular functioni

  1. 3-chloroallyl aldehyde dehydrogenase activity Source: RGD
  2. aldehyde dehydrogenase (NAD) activity Source: RGD
  3. benzaldehyde dehydrogenase (NAD+) activity Source: RGD
  4. identical protein binding Source: RGD

GO - Biological processi

  1. ethanol catabolic process Source: UniProtKB-UniPathway
  2. operant conditioning Source: RGD
  3. protein homotetramerization Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

SABIO-RKP13601.
UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase, cytosolic 1 (EC:1.2.1.3)
Alternative name(s):
ALDH class 1
ALDH-E1
ALHDII
Aldehyde dehydrogenase family 1 member A7
Aldehyde dehydrogenase phenobarbital-inducible
Gene namesi
Name:Aldh1a7
Synonyms:Aldh-pb, Aldh1, Aldh1a4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620252. Aldh1a7.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Aldehyde dehydrogenase, cytosolic 1PRO_0000056426Add
BLAST

Proteomic databases

PRIDEiP13601.

Expressioni

Tissue specificityi

Very low levels in lung and liver.1 Publication

Inductioni

By phenobarbital.

Gene expression databases

GenevestigatoriP13601.

Interactioni

Subunit structurei

Homotetramer.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP13601.
SMRiP13601. Positions 9-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

HOVERGENiHBG000097.
InParanoidiP13601.
PhylomeDBiP13601.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13601-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSPAQPAVP APLANLKIQH TKIFINNEWH NSLNGKKFPV INPATEEVIC
60 70 80 90 100
HVEEGDKADV DKAVKAARQA FQIGSPWRTM DASERGCLLN KLADLMERDR
110 120 130 140 150
VLLATMESMN AGKIFTHAYL LDTEVSIKAL KYFAGWADKI HGQTIPSDGD
160 170 180 190 200
VFTYTRREPI GVCGQIIPWN GPLILFIWKI GAALSCGNTV IVKPAEQTPL
210 220 230 240 250
TALYMASLIK EAGFPPGVVN VVPGYGSTAG AAISSHMDID KVSFTGSTEV
260 270 280 290 300
GKLIKEAAGK SNLKRVTLEL GGKSPCIVFA DADLDSAVEF AHQGVFFHQG
310 320 330 340 350
QICVAASRLF VEESIYDEFV RRSVERAKKY VLGNPLDSGI SQGPQIDKEQ
360 370 380 390 400
HAKILDLIES GKKEGAKLEC GGGRWGNKGF FVQPTVFSNV TDEMRIAKEE
410 420 430 440 450
IFGPVQQIMK FKSIDEVIKR ANNTPYGLAA GVFTKDLDRA ITVSSALQAG
460 470 480 490 500
TVWVNCYLTL SVQCPFGGFK MSGNGREMGE QGVYEYTELK TVAMKISQKN

S
Length:501
Mass (Da):54,560
Last modified:January 23, 2007 - v2
Checksum:iE6806A1AF736AF1F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M23995 mRNA. Translation: AAA40718.1.
PIRiA32616.
RefSeqiNP_058968.14. NM_017272.15.
UniGeneiRn.74044.

Genome annotation databases

UCSCiRGD:620252. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M23995 mRNA. Translation: AAA40718.1 .
PIRi A32616.
RefSeqi NP_058968.14. NM_017272.15.
UniGenei Rn.74044.

3D structure databases

ProteinModelPortali P13601.
SMRi P13601. Positions 9-501.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P13601.
ChEMBLi CHEMBL5354.

Proteomic databases

PRIDEi P13601.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:620252. rat.

Organism-specific databases

RGDi 620252. Aldh1a7.

Phylogenomic databases

HOVERGENi HBG000097.
InParanoidi P13601.
PhylomeDBi P13601.

Enzyme and pathway databases

UniPathwayi UPA00780 ; UER00768 .
SABIO-RK P13601.

Gene expression databases

Genevestigatori P13601.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Phenobarbital-inducible aldehyde dehydrogenase in the rat. cDNA sequence and regulation of the mRNA by phenobarbital in responsive rats."
    Dunn T.J., Koleske A.J., Lindahl R., Pitot H.C.
    J. Biol. Chem. 264:13057-13065(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Rat liver constitutive and phenobarbital-inducible cytosolic aldehyde dehydrogenases are highly homologous proteins that function as distinct isozymes."
    Kathmann E.C., Naylor S., Lipsky J.J.
    Biochemistry 39:11170-11176(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBUNIT, TISSUE SPECIFICITY.

Entry informationi

Entry nameiAL1A7_RAT
AccessioniPrimary (citable) accession number: P13601
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3