Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P13601

- AL1A7_RAT

UniProt

P13601 - AL1A7_RAT

Protein

Aldehyde dehydrogenase, cytosolic 1

Gene

Aldh1a7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Can oxidize benzaldehyde, propionaldehyde and acetaldehyde. No detectable activity with retinal.1 Publication

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Kineticsi

    The highest catalytic efficiency is observed with benzaldehyde as substrate. No activity with retinal.

    1. KM=2.4 mM for acetaldehyde1 Publication
    2. KM=1.6 mM for propionaldehyde1 Publication
    3. KM=4.7 µM for benzaldehyde1 Publication

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei170 – 1701Transition state stabilizerBy similarity
    Active sitei269 – 2691Proton acceptorPROSITE-ProRule annotation
    Active sitei303 – 3031NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi246 – 2516NADBy similarity

    GO - Molecular functioni

    1. 3-chloroallyl aldehyde dehydrogenase activity Source: RGD
    2. aldehyde dehydrogenase (NAD) activity Source: RGD
    3. benzaldehyde dehydrogenase (NAD+) activity Source: RGD
    4. identical protein binding Source: RGD

    GO - Biological processi

    1. ethanol catabolic process Source: UniProtKB-UniPathway
    2. operant conditioning Source: RGD
    3. protein homotetramerization Source: RGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    SABIO-RKP13601.
    UniPathwayiUPA00780; UER00768.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase, cytosolic 1 (EC:1.2.1.3)
    Alternative name(s):
    ALDH class 1
    ALDH-E1
    ALHDII
    Aldehyde dehydrogenase family 1 member A7
    Aldehyde dehydrogenase phenobarbital-inducible
    Gene namesi
    Name:Aldh1a7
    Synonyms:Aldh-pb, Aldh1, Aldh1a4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620252. Aldh1a7.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 501501Aldehyde dehydrogenase, cytosolic 1PRO_0000056426Add
    BLAST

    Proteomic databases

    PRIDEiP13601.

    Expressioni

    Tissue specificityi

    Very low levels in lung and liver.1 Publication

    Inductioni

    By phenobarbital.

    Gene expression databases

    GenevestigatoriP13601.

    Interactioni

    Subunit structurei

    Homotetramer.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliP13601.
    SMRiP13601. Positions 9-501.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    HOVERGENiHBG000097.
    PhylomeDBiP13601.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P13601-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSPAQPAVP APLANLKIQH TKIFINNEWH NSLNGKKFPV INPATEEVIC    50
    HVEEGDKADV DKAVKAARQA FQIGSPWRTM DASERGCLLN KLADLMERDR 100
    VLLATMESMN AGKIFTHAYL LDTEVSIKAL KYFAGWADKI HGQTIPSDGD 150
    VFTYTRREPI GVCGQIIPWN GPLILFIWKI GAALSCGNTV IVKPAEQTPL 200
    TALYMASLIK EAGFPPGVVN VVPGYGSTAG AAISSHMDID KVSFTGSTEV 250
    GKLIKEAAGK SNLKRVTLEL GGKSPCIVFA DADLDSAVEF AHQGVFFHQG 300
    QICVAASRLF VEESIYDEFV RRSVERAKKY VLGNPLDSGI SQGPQIDKEQ 350
    HAKILDLIES GKKEGAKLEC GGGRWGNKGF FVQPTVFSNV TDEMRIAKEE 400
    IFGPVQQIMK FKSIDEVIKR ANNTPYGLAA GVFTKDLDRA ITVSSALQAG 450
    TVWVNCYLTL SVQCPFGGFK MSGNGREMGE QGVYEYTELK TVAMKISQKN 500
    S 501
    Length:501
    Mass (Da):54,560
    Last modified:January 23, 2007 - v2
    Checksum:iE6806A1AF736AF1F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M23995 mRNA. Translation: AAA40718.1.
    PIRiA32616.
    RefSeqiNP_058968.14. NM_017272.15.
    UniGeneiRn.74044.

    Genome annotation databases

    UCSCiRGD:620252. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M23995 mRNA. Translation: AAA40718.1 .
    PIRi A32616.
    RefSeqi NP_058968.14. NM_017272.15.
    UniGenei Rn.74044.

    3D structure databases

    ProteinModelPortali P13601.
    SMRi P13601. Positions 9-501.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P13601.
    ChEMBLi CHEMBL5354.

    Proteomic databases

    PRIDEi P13601.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:620252. rat.

    Organism-specific databases

    RGDi 620252. Aldh1a7.

    Phylogenomic databases

    HOVERGENi HBG000097.
    PhylomeDBi P13601.

    Enzyme and pathway databases

    UniPathwayi UPA00780 ; UER00768 .
    SABIO-RK P13601.

    Gene expression databases

    Genevestigatori P13601.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Phenobarbital-inducible aldehyde dehydrogenase in the rat. cDNA sequence and regulation of the mRNA by phenobarbital in responsive rats."
      Dunn T.J., Koleske A.J., Lindahl R., Pitot H.C.
      J. Biol. Chem. 264:13057-13065(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Rat liver constitutive and phenobarbital-inducible cytosolic aldehyde dehydrogenases are highly homologous proteins that function as distinct isozymes."
      Kathmann E.C., Naylor S., Lipsky J.J.
      Biochemistry 39:11170-11176(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBUNIT, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiAL1A7_RAT
    AccessioniPrimary (citable) accession number: P13601
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3