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Protein

Beta-nerve growth factor

Gene

NGF

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

Enzyme and pathway databases

ReactomeiR-BTA-167060. NGF processing.
R-BTA-170968. Frs2-mediated activation.
R-BTA-170984. ARMS-mediated activation.
R-BTA-177504. Retrograde neurotrophin signalling.
R-BTA-187042. TRKA activation by NGF.
R-BTA-198203. PI3K/AKT activation.
R-BTA-205017. NFG and proNGF binds to p75NTR.
R-BTA-205025. NADE modulates death signalling.
R-BTA-205043. NRIF signals cell death from the nucleus.
R-BTA-209543. p75NTR recruits signalling complexes.
R-BTA-209560. NF-kB is activated and signals survival.
R-BTA-209563. Axonal growth stimulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-nerve growth factor
Short name:
Beta-NGF
Gene namesi
Name:NGF
Synonyms:NGFB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000001959519 – 121By similarityAdd BLAST103
ChainiPRO_0000019596122 – 241Beta-nerve growth factorAdd BLAST120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi136 ↔ 201By similarity
Glycosylationi166N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi179 ↔ 229By similarity
Disulfide bondi189 ↔ 231By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP13600.
PRIDEiP13600.

Expressioni

Gene expression databases

BgeeiENSBTAG00000007446.

Interactioni

Subunit structurei

Homodimer. Interacts with ADAM10 in a divalent cation-dependent manner.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009796.

Structurei

3D structure databases

ProteinModelPortaliP13600.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIPQ. Eukaryota.
ENOG4111F87. LUCA.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP13600.
KOiK02582.
OMAiNNVFKQY.
OrthoDBiEOG091G0GHL.
TreeFamiTF106463.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR020425. Nerve_growth_factor_bsu.
IPR020437. Nerve_growth_factor_bsu_mml.
IPR019846. Nerve_growth_factor_CS.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01925. MAMLNGFBETA.
PR00268. NGF.
PR01913. NGFBETA.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13600-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMLFYTLIT ALLIGIQAAP HTESNVPAGH AIPQAHWIKL QHSLDTVLRR
60 70 80 90 100
AHSAPAGPIA ARVAGQTHNI TVDPKLFKKR RLRSPRVLFS TQPPPVAADT
110 120 130 140 150
QDLDFEAGGA SSFNRTHRSK RSSSHPVFHR GEFSVCDSIS VWVGDKTTAT
160 170 180 190 200
DIKGKEVMVL GEVNINNSVF KQYFFETKCR DPNPVDSGCR GIDAKHWNSY
210 220 230 240
CTTTHTFVKA LTMDGKQAAW RFIRIDTACV CVLSRKTGQR A
Length:241
Mass (Da):26,669
Last modified:February 20, 2007 - v3
Checksum:i40C77C7727916188
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12L → F in CAA70759 (PubMed:9284944).Curated1
Sequence conflicti128F → L in CAA70759 (PubMed:9284944).Curated1
Sequence conflicti171K → R in CAA70759 (PubMed:9284944).Curated1
Sequence conflicti240 – 241RA → AP in CAA70759 (PubMed:9284944).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146037 mRNA. Translation: AAI46038.1.
Y09566 Genomic DNA. Translation: CAA70759.1.
M26809 mRNA. Translation: AAA30666.1.
PIRiA26312.
RefSeqiNP_001092832.1. NM_001099362.1.
XP_010801404.1. XM_010803102.2.
UniGeneiBt.12757.

Genome annotation databases

EnsembliENSBTAT00000009796; ENSBTAP00000009796; ENSBTAG00000007446.
GeneIDi281350.
KEGGibta:281350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146037 mRNA. Translation: AAI46038.1.
Y09566 Genomic DNA. Translation: CAA70759.1.
M26809 mRNA. Translation: AAA30666.1.
PIRiA26312.
RefSeqiNP_001092832.1. NM_001099362.1.
XP_010801404.1. XM_010803102.2.
UniGeneiBt.12757.

3D structure databases

ProteinModelPortaliP13600.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009796.

Proteomic databases

PaxDbiP13600.
PRIDEiP13600.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000009796; ENSBTAP00000009796; ENSBTAG00000007446.
GeneIDi281350.
KEGGibta:281350.

Organism-specific databases

CTDi4803.

Phylogenomic databases

eggNOGiENOG410IIPQ. Eukaryota.
ENOG4111F87. LUCA.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP13600.
KOiK02582.
OMAiNNVFKQY.
OrthoDBiEOG091G0GHL.
TreeFamiTF106463.

Enzyme and pathway databases

ReactomeiR-BTA-167060. NGF processing.
R-BTA-170968. Frs2-mediated activation.
R-BTA-170984. ARMS-mediated activation.
R-BTA-177504. Retrograde neurotrophin signalling.
R-BTA-187042. TRKA activation by NGF.
R-BTA-198203. PI3K/AKT activation.
R-BTA-205017. NFG and proNGF binds to p75NTR.
R-BTA-205025. NADE modulates death signalling.
R-BTA-205043. NRIF signals cell death from the nucleus.
R-BTA-209543. p75NTR recruits signalling complexes.
R-BTA-209560. NF-kB is activated and signals survival.
R-BTA-209563. Axonal growth stimulation.

Gene expression databases

BgeeiENSBTAG00000007446.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR020425. Nerve_growth_factor_bsu.
IPR020437. Nerve_growth_factor_bsu_mml.
IPR019846. Nerve_growth_factor_CS.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01925. MAMLNGFBETA.
PR00268. NGF.
PR01913. NGFBETA.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNGF_BOVIN
AccessioniPrimary (citable) accession number: P13600
Secondary accession number(s): A6H6X9, O18969
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 20, 2007
Last modified: October 5, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.