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Protein

IgG receptor FcRn large subunit p51

Gene

Fcgrt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the Fc region of monomeric immunoglobulins gamma (PubMed:18818657, PubMed:7969498). Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (PubMed:7298722, PubMed:18818657). Possible role in transfer of immunoglobulin G from mother to fetus (By similarity).By similarity3 Publications

GO - Molecular functioni

  • antigen binding Source: GO_Central
  • beta-2-microglobulin binding Source: RGD
  • IgG receptor activity Source: RGD

GO - Biological processi

  • antigen processing and presentation Source: GO_Central
  • humoral immune response Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

IgG-binding protein

Names & Taxonomyi

Protein namesi
Recommended name:
IgG receptor FcRn large subunit p51
Short name:
FcRn
Alternative name(s):
IgG Fc fragment receptor transporter alpha chain
Neonatal Fc receptor
Gene namesi
Name:Fcgrt
Synonyms:Fcrn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi61811. Fcgrt.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 298ExtracellularSequence analysisAdd BLAST276
Transmembranei299 – 322HelicalSequence analysisAdd BLAST24
Topological domaini323 – 366CytoplasmicSequence analysisAdd BLAST44

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000001516023 – 366IgG receptor FcRn large subunit p511 PublicationAdd BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi109N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi120 ↔ 183PROSITE-ProRule annotation
Glycosylationi126N-linked (GlcNAc...)Sequence analysis1
Glycosylationi150N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi222 ↔ 276PROSITE-ProRule annotation
Glycosylationi247N-linked (GlcNAc...)Sequence analysis1
Modified residuei335PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP13599.
PRIDEiP13599.

PTM databases

iPTMnetiP13599.
PhosphoSitePlusiP13599.

Expressioni

Tissue specificityi

Intestinal epithelium.1 Publication

Gene expression databases

BgeeiENSRNOG00000020583.
GenevisibleiP13599. RN.

Interactioni

Subunit structurei

FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MCH class I-like heterodimer.3 Publications

GO - Molecular functioni

  • beta-2-microglobulin binding Source: RGD

Protein-protein interaction databases

IntActiP13599. 1 interactor.
STRINGi10116.ENSRNOP00000027944.

Structurei

Secondary structure

1366
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 37Combined sources9
Beta strandi45 – 52Combined sources8
Beta strandi55 – 61Combined sources7
Turni62 – 64Combined sources3
Helixi71 – 75Combined sources5
Helixi82 – 107Combined sources26
Beta strandi108 – 110Combined sources3
Beta strandi113 – 122Combined sources10
Beta strandi128 – 136Combined sources9
Beta strandi139 – 144Combined sources6
Turni146 – 148Combined sources3
Beta strandi150 – 152Combined sources3
Helixi156 – 165Combined sources10
Helixi169 – 180Combined sources12
Helixi182 – 193Combined sources12
Helixi195 – 198Combined sources4
Beta strandi205 – 212Combined sources8
Beta strandi217 – 230Combined sources14
Beta strandi233 – 238Combined sources6
Beta strandi247 – 252Combined sources6
Beta strandi254 – 256Combined sources3
Beta strandi258 – 267Combined sources10
Helixi271 – 273Combined sources3
Beta strandi274 – 279Combined sources6
Beta strandi283 – 285Combined sources3
Beta strandi287 – 289Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FRTX-ray4.50A23-291[»]
1I1AX-ray2.80A23-291[»]
2FRTmodel-A/C23-291[»]
3FRUX-ray2.20A/C/E23-291[»]
ProteinModelPortaliP13599.
SMRiP13599.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13599.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini203 – 290Ig-like C1-typePROSITE-ProRule annotationAdd BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 111Alpha-1Combined sources2 PublicationsAdd BLAST89
Regioni112 – 201Alpha-2Combined sources2 PublicationsAdd BLAST90
Regioni202 – 291Alpha-3Combined sources2 PublicationsAdd BLAST90
Regioni293 – 298Connecting peptide6

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPRY. Eukaryota.
ENOG4111C4R. LUCA.
GeneTreeiENSGT00740000114936.
HOGENOMiHOG000112560.
HOVERGENiHBG100415.
InParanoidiP13599.
OMAiPWISLRG.
OrthoDBiEOG091G0KJB.
PhylomeDBiP13599.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13599-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMSQPGVLL SLLLVLLPQT WGAEPRLPLM YHLAAVSDLS TGLPSFWATG
60 70 80 90 100
WLGAQQYLTY NNLRQEADPC GAWIWENQVS WYWEKETTDL KSKEQLFLEA
110 120 130 140 150
IRTLENQING TFTLQGLLGC ELAPDNSSLP TAVFALNGEE FMRFNPRTGN
160 170 180 190 200
WSGEWPETDI VGNLWMKQPE AARKESEFLL TSCPERLLGH LERGRQNLEW
210 220 230 240 250
KEPPSMRLKA RPGNSGSSVL TCAAFSFYPP ELKFRFLRNG LASGSGNCST
260 270 280 290 300
GPNGDGSFHA WSLLEVKRGD EHHYQCQVEH EGLAQPLTVD LDSPARSSVP
310 320 330 340 350
VVGIILGLLL VVVAIAGGVL LWNRMRSGLP APWLSLSGDD SGDLLPGGNL
360
PPEAEPQGVN AFPATS
Length:366
Mass (Da):40,169
Last modified:January 1, 1990 - v1
Checksum:i8A8BF2873A698BB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14323 mRNA. Translation: CAA32503.1.
M35495 mRNA. Translation: AAA41611.1.
BC061975 mRNA. Translation: AAH61975.1.
PIRiA37374.
RefSeqiNP_203502.1. NM_033351.2.
XP_006229105.1. XM_006229043.2.
XP_008757565.1. XM_008759343.2.
UniGeneiRn.15845.

Genome annotation databases

EnsembliENSRNOT00000027944; ENSRNOP00000027944; ENSRNOG00000020583.
GeneIDi29558.
KEGGirno:29558.
UCSCiRGD:61811. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14323 mRNA. Translation: CAA32503.1.
M35495 mRNA. Translation: AAA41611.1.
BC061975 mRNA. Translation: AAH61975.1.
PIRiA37374.
RefSeqiNP_203502.1. NM_033351.2.
XP_006229105.1. XM_006229043.2.
XP_008757565.1. XM_008759343.2.
UniGeneiRn.15845.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FRTX-ray4.50A23-291[»]
1I1AX-ray2.80A23-291[»]
2FRTmodel-A/C23-291[»]
3FRUX-ray2.20A/C/E23-291[»]
ProteinModelPortaliP13599.
SMRiP13599.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP13599. 1 interactor.
STRINGi10116.ENSRNOP00000027944.

PTM databases

iPTMnetiP13599.
PhosphoSitePlusiP13599.

Proteomic databases

PaxDbiP13599.
PRIDEiP13599.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027944; ENSRNOP00000027944; ENSRNOG00000020583.
GeneIDi29558.
KEGGirno:29558.
UCSCiRGD:61811. rat.

Organism-specific databases

CTDi2217.
RGDi61811. Fcgrt.

Phylogenomic databases

eggNOGiENOG410IPRY. Eukaryota.
ENOG4111C4R. LUCA.
GeneTreeiENSGT00740000114936.
HOGENOMiHOG000112560.
HOVERGENiHBG100415.
InParanoidiP13599.
OMAiPWISLRG.
OrthoDBiEOG091G0KJB.
PhylomeDBiP13599.

Miscellaneous databases

EvolutionaryTraceiP13599.
PROiP13599.

Gene expression databases

BgeeiENSRNOG00000020583.
GenevisibleiP13599. RN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFCGRN_RAT
AccessioniPrimary (citable) accession number: P13599
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 30, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.