Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

IgG receptor FcRn large subunit p51

Gene

Fcgrt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (By similarity).By similarity

GO - Molecular functioni

  • antigen binding Source: GO_Central
  • beta-2-microglobulin binding Source: RGD
  • IgG receptor activity Source: RGD

GO - Biological processi

  • antigen processing and presentation Source: GO_Central
  • humoral immune response Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

IgG-binding protein

Names & Taxonomyi

Protein namesi
Recommended name:
IgG receptor FcRn large subunit p51
Short name:
FcRn
Alternative name(s):
IgG Fc fragment receptor transporter alpha chain
Neonatal Fc receptor
Gene namesi
Name:Fcgrt
Synonyms:Fcrn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi61811. Fcgrt.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 298276ExtracellularSequence analysisAdd
BLAST
Transmembranei299 – 32224HelicalSequence analysisAdd
BLAST
Topological domaini323 – 36644CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Add
BLAST
Chaini23 – 366344IgG receptor FcRn large subunit p51PRO_0000015160Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence analysis
Disulfide bondi120 ↔ 183PROSITE-ProRule annotation
Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence analysis
Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence analysis
Disulfide bondi222 ↔ 276PROSITE-ProRule annotation
Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence analysis
Modified residuei335 – 3351PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP13599.
PRIDEiP13599.

PTM databases

iPTMnetiP13599.
PhosphoSiteiP13599.

Expressioni

Tissue specificityi

Intestinal epithelium.

Gene expression databases

GenevisibleiP13599. RN.

Interactioni

Subunit structurei

FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MCH class I-like heterodimer.

GO - Molecular functioni

  • beta-2-microglobulin binding Source: RGD

Protein-protein interaction databases

IntActiP13599. 1 interaction.
STRINGi10116.ENSRNOP00000027944.

Structurei

Secondary structure

1
366
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 379Combined sources
Beta strandi45 – 528Combined sources
Beta strandi55 – 617Combined sources
Turni62 – 643Combined sources
Helixi71 – 755Combined sources
Helixi82 – 10726Combined sources
Beta strandi108 – 1103Combined sources
Beta strandi113 – 12210Combined sources
Beta strandi128 – 1369Combined sources
Beta strandi139 – 1446Combined sources
Turni146 – 1483Combined sources
Beta strandi150 – 1523Combined sources
Helixi156 – 16510Combined sources
Helixi169 – 18012Combined sources
Helixi182 – 19312Combined sources
Helixi195 – 1984Combined sources
Beta strandi205 – 2128Combined sources
Beta strandi217 – 23014Combined sources
Beta strandi233 – 2386Combined sources
Beta strandi247 – 2526Combined sources
Beta strandi254 – 2563Combined sources
Beta strandi258 – 26710Combined sources
Helixi271 – 2733Combined sources
Beta strandi274 – 2796Combined sources
Beta strandi283 – 2853Combined sources
Beta strandi287 – 2893Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FRTX-ray4.50A23-291[»]
1I1AX-ray2.80A23-291[»]
2FRTmodel-A/C23-291[»]
3FRUX-ray2.20A/C/E23-291[»]
ProteinModelPortaliP13599.
SMRiP13599. Positions 23-291.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13599.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini203 – 29088Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 11189Alpha-1Add
BLAST
Regioni112 – 20190Alpha-2Add
BLAST
Regioni202 – 29190Alpha-3Add
BLAST
Regioni293 – 2986Connecting peptide

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPRY. Eukaryota.
ENOG4111C4R. LUCA.
GeneTreeiENSGT00740000114936.
HOGENOMiHOG000112560.
HOVERGENiHBG100415.
InParanoidiP13599.
OMAiPWISLRG.
OrthoDBiEOG7TBC29.
PhylomeDBiP13599.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13599-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMSQPGVLL SLLLVLLPQT WGAEPRLPLM YHLAAVSDLS TGLPSFWATG
60 70 80 90 100
WLGAQQYLTY NNLRQEADPC GAWIWENQVS WYWEKETTDL KSKEQLFLEA
110 120 130 140 150
IRTLENQING TFTLQGLLGC ELAPDNSSLP TAVFALNGEE FMRFNPRTGN
160 170 180 190 200
WSGEWPETDI VGNLWMKQPE AARKESEFLL TSCPERLLGH LERGRQNLEW
210 220 230 240 250
KEPPSMRLKA RPGNSGSSVL TCAAFSFYPP ELKFRFLRNG LASGSGNCST
260 270 280 290 300
GPNGDGSFHA WSLLEVKRGD EHHYQCQVEH EGLAQPLTVD LDSPARSSVP
310 320 330 340 350
VVGIILGLLL VVVAIAGGVL LWNRMRSGLP APWLSLSGDD SGDLLPGGNL
360
PPEAEPQGVN AFPATS
Length:366
Mass (Da):40,169
Last modified:January 1, 1990 - v1
Checksum:i8A8BF2873A698BB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14323 mRNA. Translation: CAA32503.1.
M35495 mRNA. Translation: AAA41611.1.
BC061975 mRNA. Translation: AAH61975.1.
PIRiA37374.
RefSeqiNP_203502.1. NM_033351.2.
XP_006229105.1. XM_006229043.1.
XP_008757565.1. XM_008759343.1.
UniGeneiRn.15845.

Genome annotation databases

EnsembliENSRNOT00000027944; ENSRNOP00000027944; ENSRNOG00000020583.
GeneIDi29558.
KEGGirno:29558.
UCSCiRGD:61811. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14323 mRNA. Translation: CAA32503.1.
M35495 mRNA. Translation: AAA41611.1.
BC061975 mRNA. Translation: AAH61975.1.
PIRiA37374.
RefSeqiNP_203502.1. NM_033351.2.
XP_006229105.1. XM_006229043.1.
XP_008757565.1. XM_008759343.1.
UniGeneiRn.15845.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FRTX-ray4.50A23-291[»]
1I1AX-ray2.80A23-291[»]
2FRTmodel-A/C23-291[»]
3FRUX-ray2.20A/C/E23-291[»]
ProteinModelPortaliP13599.
SMRiP13599. Positions 23-291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP13599. 1 interaction.
STRINGi10116.ENSRNOP00000027944.

PTM databases

iPTMnetiP13599.
PhosphoSiteiP13599.

Proteomic databases

PaxDbiP13599.
PRIDEiP13599.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027944; ENSRNOP00000027944; ENSRNOG00000020583.
GeneIDi29558.
KEGGirno:29558.
UCSCiRGD:61811. rat.

Organism-specific databases

CTDi2217.
RGDi61811. Fcgrt.

Phylogenomic databases

eggNOGiENOG410IPRY. Eukaryota.
ENOG4111C4R. LUCA.
GeneTreeiENSGT00740000114936.
HOGENOMiHOG000112560.
HOVERGENiHBG100415.
InParanoidiP13599.
OMAiPWISLRG.
OrthoDBiEOG7TBC29.
PhylomeDBiP13599.

Miscellaneous databases

EvolutionaryTraceiP13599.
PROiP13599.

Gene expression databases

GenevisibleiP13599. RN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An Fc receptor structurally related to MHC class I antigens."
    Simister N.E., Mostov K.E.
    Nature 337:184-187(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: Wistar.
  2. "Cloning and expression of the neonatal rat intestinal Fc receptor, a major histocompatibility complex class I antigen homolog."
    Simister N.E., Mostov K.E.
    Cold Spring Harb. Symp. Quant. Biol. 54:571-580(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Epithelium.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  4. "Crystal structure of the complex of rat neonatal Fc receptor with Fc."
    Burmeister W.P., Huber A.H., Bjorkman P.J.
    Nature 372:379-383(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
  5. "Structural basis of pH-dependent antibody binding by the neonatal Fc receptor."
    Vaughn D.E., Bjorkman P.J.
    Structure 6:63-73(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).

Entry informationi

Entry nameiFCGRN_RAT
AccessioniPrimary (citable) accession number: P13599
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: July 6, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.