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Protein

Intercellular adhesion molecule 2

Gene

ICAM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

GO - Molecular functioni

  • integrin binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-216083 Integrin cell surface interactions
R-HSA-5621575 CD209 (DC-SIGN) signaling
SIGNORiP13598

Names & Taxonomyi

Protein namesi
Recommended name:
Intercellular adhesion molecule 2
Short name:
ICAM-2
Alternative name(s):
CD_antigen: CD102
Gene namesi
Name:ICAM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108622.10
HGNCiHGNC:5345 ICAM2
MIMi146630 gene
neXtProtiNX_P13598

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 223ExtracellularSequence analysisAdd BLAST199
Transmembranei224 – 248HelicalSequence analysisAdd BLAST25
Topological domaini249 – 275CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3384
OpenTargetsiENSG00000108622
PharmGKBiPA29593

Polymorphism and mutation databases

BioMutaiICAM2
DMDMi115502404

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000001479025 – 275Intercellular adhesion molecule 2Add BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi48 ↔ 91Combined sources1 Publication
Disulfide bondi52 ↔ 95Combined sources1 Publication
Glycosylationi82N-linked (GlcNAc...) asparagineCombined sources2 Publications1
Glycosylationi105N-linked (GlcNAc...) asparagineCombined sources3 Publications1
Disulfide bondi134 ↔ 190Combined sources1 Publication
Glycosylationi153N-linked (GlcNAc...) asparagineCombined sources2 Publications1
Glycosylationi176N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi187N-linked (GlcNAc...) asparagineCombined sources1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP13598
PaxDbiP13598
PeptideAtlasiP13598
PRIDEiP13598

PTM databases

GlyConnecti682
iPTMnetiP13598
PhosphoSitePlusiP13598
SwissPalmiP13598
UniCarbKBiP13598

Expressioni

Gene expression databases

BgeeiENSG00000108622
CleanExiHS_ICAM2
ExpressionAtlasiP13598 baseline and differential
GenevisibleiP13598 HS

Organism-specific databases

HPAiHPA071155

Interactioni

Subunit structurei

Interacts with RDX, EZR and MSN.By similarity

GO - Molecular functioni

  • integrin binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi109611, 18 interactors
IntActiP13598, 6 interactors
STRINGi9606.ENSP00000388666

Structurei

Secondary structure

1275
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 38Combined sources10
Beta strandi42 – 51Combined sources10
Beta strandi56 – 61Combined sources6
Beta strandi63 – 72Combined sources10
Beta strandi75 – 83Combined sources9
Beta strandi87 – 95Combined sources9
Beta strandi98 – 108Combined sources11
Beta strandi116 – 125Combined sources10
Beta strandi128 – 136Combined sources9
Helixi142 – 144Combined sources3
Beta strandi145 – 151Combined sources7
Beta strandi154 – 160Combined sources7
Beta strandi171 – 178Combined sources8
Helixi181 – 185Combined sources5
Beta strandi188 – 195Combined sources8
Helixi197 – 199Combined sources3
Beta strandi203 – 207Combined sources5
Beta strandi214 – 216Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZXQX-ray2.20A25-216[»]
ProteinModelPortaliP13598
SMRiP13598
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13598

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 98Ig-like C2-type 1Add BLAST58
Domaini127 – 197Ig-like C2-type 2Add BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni251 – 275Required for interaction with EZR, MSN and RDX and co-localization to microvilliBy similarityAdd BLAST25

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH57 Eukaryota
ENOG410Z9H1 LUCA
GeneTreeiENSGT00530000063246
HOVERGENiHBG052075
InParanoidiP13598
KOiK06523
OMAiNFSCLAV
OrthoDBiEOG091G022Y
PhylomeDBiP13598
TreeFamiTF333745

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003988 ICAM
IPR015653 ICAM2
IPR013768 ICAM_N
IPR003987 ICAM_VCAM_N
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
PANTHERiPTHR13771:SF3 PTHR13771:SF3, 1 hit
PfamiView protein in Pfam
PF03921 ICAM_N, 1 hit
PRINTSiPR01473 ICAM
PR01472 ICAMVCAM1
SUPFAMiSSF48726 SSF48726, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13598-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSFGYRTLT VALFTLICCP GSDEKVFEVH VRPKKLAVEP KGSLEVNCST
60 70 80 90 100
TCNQPEVGGL ETSLDKILLD EQAQWKHYLV SNISHDTVLQ CHFTCSGKQE
110 120 130 140 150
SMNSNVSVYQ PPRQVILTLQ PTLVAVGKSF TIECRVPTVE PLDSLTLFLF
160 170 180 190 200
RGNETLHYET FGKAAPAPQE ATATFNSTAD REDGHRNFSC LAVLDLMSRG
210 220 230 240 250
GNIFHKHSAP KMLEIYEPVS DSQMVIIVTV VSVLLSLFVT SVLLCFIFGQ
260 270
HLRQQRMGTY GVRAAWRRLP QAFRP
Length:275
Mass (Da):30,654
Last modified:October 3, 2006 - v2
Checksum:iC54FB34D92A6FC38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65D → N (PubMed:2497351).Curated1
Sequence conflicti65D → N (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01465537A → T. Corresponds to variant dbSNP:rs5503Ensembl.1
Natural variantiVAR_014656199R → H. Corresponds to variant dbSNP:rs5504Ensembl.1
Natural variantiVAR_021920256R → Q. Corresponds to variant dbSNP:rs3764867Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15606 mRNA Translation: CAA33630.1
M32334
, M32331, M32332, M32333 Genomic DNA Translation: AAA36035.1
BC003097 mRNA Translation: AAH03097.1
CCDSiCCDS11657.1
PIRiS03967
RefSeqiNP_000864.2, NM_000873.3
NP_001093256.1, NM_001099786.1
NP_001093257.1, NM_001099787.1
NP_001093258.1, NM_001099788.1
NP_001093259.1, NM_001099789.1
UniGeneiHs.431460

Genome annotation databases

EnsembliENST00000412356; ENSP00000415283; ENSG00000108622
ENST00000418105; ENSP00000388666; ENSG00000108622
ENST00000449662; ENSP00000392634; ENSG00000108622
ENST00000579687; ENSP00000462579; ENSG00000108622
ENST00000579788; ENSP00000464665; ENSG00000108622
GeneIDi3384
KEGGihsa:3384

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiICAM2_HUMAN
AccessioniPrimary (citable) accession number: P13598
Secondary accession number(s): Q14600
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 3, 2006
Last modified: May 23, 2018
This is version 187 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

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