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P13598

- ICAM2_HUMAN

UniProt

P13598 - ICAM2_HUMAN

Protein

Intercellular adhesion molecule 2

Gene

ICAM2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 158 (01 Oct 2014)
      Sequence version 2 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

    GO - Molecular functioni

    1. integrin binding Source: BHF-UCL

    GO - Biological processi

    1. extracellular matrix organization Source: Reactome
    2. regulation of immune response Source: Reactome
    3. single organismal cell-cell adhesion Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_13552. Integrin cell surface interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Intercellular adhesion molecule 2
    Short name:
    ICAM-2
    Alternative name(s):
    CD_antigen: CD102
    Gene namesi
    Name:ICAM2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:5345. ICAM2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of plasma membrane Source: ProtInc
    3. membrane Source: UniProtKB
    4. plasma membrane Source: Reactome
    5. uropod Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29593.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 24241 PublicationAdd
    BLAST
    Chaini25 – 275251Intercellular adhesion molecule 2PRO_0000014790Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi47 – 471N-linked (GlcNAc...)
    Disulfide bondi48 ↔ 91
    Disulfide bondi52 ↔ 95
    Glycosylationi82 – 821N-linked (GlcNAc...)1 Publication
    Glycosylationi105 – 1051N-linked (GlcNAc...)2 Publications
    Disulfide bondi134 ↔ 190
    Glycosylationi153 – 1531N-linked (GlcNAc...)1 Publication
    Glycosylationi176 – 1761N-linked (GlcNAc...)2 Publications
    Glycosylationi187 – 1871N-linked (GlcNAc...)

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP13598.
    PaxDbiP13598.
    PRIDEiP13598.

    PTM databases

    PhosphoSiteiP13598.

    Expressioni

    Gene expression databases

    ArrayExpressiP13598.
    BgeeiP13598.
    CleanExiHS_ICAM2.
    GenevestigatoriP13598.

    Organism-specific databases

    HPAiHPA002020.

    Interactioni

    Protein-protein interaction databases

    BioGridi109611. 5 interactions.
    DIPiDIP-629N.
    IntActiP13598. 6 interactions.
    STRINGi9606.ENSP00000225760.

    Structurei

    Secondary structure

    1
    275
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi29 – 3810
    Beta strandi42 – 5110
    Beta strandi56 – 616
    Beta strandi63 – 7210
    Beta strandi75 – 839
    Beta strandi87 – 959
    Beta strandi98 – 10811
    Beta strandi116 – 12510
    Beta strandi128 – 1369
    Helixi142 – 1443
    Beta strandi145 – 1517
    Beta strandi154 – 1607
    Beta strandi171 – 1788
    Helixi181 – 1855
    Beta strandi188 – 1958
    Helixi197 – 1993
    Beta strandi203 – 2075
    Beta strandi214 – 2163

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ZXQX-ray2.20A25-216[»]
    ProteinModelPortaliP13598.
    SMRiP13598. Positions 25-216.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP13598.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 223199ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini249 – 27527CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei224 – 24825HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 9858Ig-like C2-type 1Add
    BLAST
    Domaini127 – 19771Ig-like C2-type 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily. ICAM family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41332.
    HOVERGENiHBG052075.
    InParanoidiP13598.
    KOiK06523.
    OMAiFTIECRV.
    PhylomeDBiP13598.
    TreeFamiTF333745.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR003988. ICAM.
    IPR015653. ICAM2.
    IPR013768. ICAM_N.
    IPR003987. ICAM_VCAM_N.
    IPR013783. Ig-like_fold.
    [Graphical view]
    PANTHERiPTHR13771:SF3. PTHR13771:SF3. 1 hit.
    PfamiPF03921. ICAM_N. 1 hit.
    [Graphical view]
    PRINTSiPR01473. ICAM.
    PR01472. ICAMVCAM1.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P13598-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSFGYRTLT VALFTLICCP GSDEKVFEVH VRPKKLAVEP KGSLEVNCST    50
    TCNQPEVGGL ETSLDKILLD EQAQWKHYLV SNISHDTVLQ CHFTCSGKQE 100
    SMNSNVSVYQ PPRQVILTLQ PTLVAVGKSF TIECRVPTVE PLDSLTLFLF 150
    RGNETLHYET FGKAAPAPQE ATATFNSTAD REDGHRNFSC LAVLDLMSRG 200
    GNIFHKHSAP KMLEIYEPVS DSQMVIIVTV VSVLLSLFVT SVLLCFIFGQ 250
    HLRQQRMGTY GVRAAWRRLP QAFRP 275
    Length:275
    Mass (Da):30,654
    Last modified:October 3, 2006 - v2
    Checksum:iC54FB34D92A6FC38
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti65 – 651D → N(PubMed:2497351)Curated
    Sequence conflicti65 – 651D → N(PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti37 – 371A → T.
    Corresponds to variant rs5503 [ dbSNP | Ensembl ].
    VAR_014655
    Natural varianti199 – 1991R → H.
    Corresponds to variant rs5504 [ dbSNP | Ensembl ].
    VAR_014656
    Natural varianti256 – 2561R → Q.
    Corresponds to variant rs3764867 [ dbSNP | Ensembl ].
    VAR_021920

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15606 mRNA. Translation: CAA33630.1.
    M32334
    , M32331, M32332, M32333 Genomic DNA. Translation: AAA36035.1.
    BC003097 mRNA. Translation: AAH03097.1.
    CCDSiCCDS11657.1.
    PIRiS03967.
    RefSeqiNP_000864.2. NM_000873.3.
    NP_001093256.1. NM_001099786.1.
    NP_001093257.1. NM_001099787.1.
    NP_001093258.1. NM_001099788.1.
    NP_001093259.1. NM_001099789.1.
    UniGeneiHs.431460.

    Genome annotation databases

    EnsembliENST00000412356; ENSP00000415283; ENSG00000108622.
    ENST00000418105; ENSP00000388666; ENSG00000108622.
    ENST00000449662; ENSP00000392634; ENSG00000108622.
    ENST00000579687; ENSP00000462579; ENSG00000108622.
    ENST00000579788; ENSP00000464665; ENSG00000108622.
    GeneIDi3384.
    KEGGihsa:3384.
    UCSCiuc002jdu.4. human.

    Polymorphism databases

    DMDMi115502404.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    ICAM-2

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15606 mRNA. Translation: CAA33630.1 .
    M32334
    , M32331 , M32332 , M32333 Genomic DNA. Translation: AAA36035.1 .
    BC003097 mRNA. Translation: AAH03097.1 .
    CCDSi CCDS11657.1.
    PIRi S03967.
    RefSeqi NP_000864.2. NM_000873.3.
    NP_001093256.1. NM_001099786.1.
    NP_001093257.1. NM_001099787.1.
    NP_001093258.1. NM_001099788.1.
    NP_001093259.1. NM_001099789.1.
    UniGenei Hs.431460.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ZXQ X-ray 2.20 A 25-216 [» ]
    ProteinModelPortali P13598.
    SMRi P13598. Positions 25-216.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109611. 5 interactions.
    DIPi DIP-629N.
    IntActi P13598. 6 interactions.
    STRINGi 9606.ENSP00000225760.

    PTM databases

    PhosphoSitei P13598.

    Polymorphism databases

    DMDMi 115502404.

    Proteomic databases

    MaxQBi P13598.
    PaxDbi P13598.
    PRIDEi P13598.

    Protocols and materials databases

    DNASUi 3384.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000412356 ; ENSP00000415283 ; ENSG00000108622 .
    ENST00000418105 ; ENSP00000388666 ; ENSG00000108622 .
    ENST00000449662 ; ENSP00000392634 ; ENSG00000108622 .
    ENST00000579687 ; ENSP00000462579 ; ENSG00000108622 .
    ENST00000579788 ; ENSP00000464665 ; ENSG00000108622 .
    GeneIDi 3384.
    KEGGi hsa:3384.
    UCSCi uc002jdu.4. human.

    Organism-specific databases

    CTDi 3384.
    GeneCardsi GC17M062079.
    H-InvDB HIX0014082.
    HGNCi HGNC:5345. ICAM2.
    HPAi HPA002020.
    MIMi 146630. gene.
    neXtProti NX_P13598.
    PharmGKBi PA29593.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41332.
    HOVERGENi HBG052075.
    InParanoidi P13598.
    KOi K06523.
    OMAi FTIECRV.
    PhylomeDBi P13598.
    TreeFami TF333745.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_13552. Integrin cell surface interactions.

    Miscellaneous databases

    ChiTaRSi ICAM2. human.
    EvolutionaryTracei P13598.
    GeneWikii ICAM2.
    GenomeRNAii 3384.
    NextBioi 13380.
    PROi P13598.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P13598.
    Bgeei P13598.
    CleanExi HS_ICAM2.
    Genevestigatori P13598.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR003988. ICAM.
    IPR015653. ICAM2.
    IPR013768. ICAM_N.
    IPR003987. ICAM_VCAM_N.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    PANTHERi PTHR13771:SF3. PTHR13771:SF3. 1 hit.
    Pfami PF03921. ICAM_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01473. ICAM.
    PR01472. ICAMVCAM1.
    ProtoNeti Search...

    Publicationsi

    1. "Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1."
      Staunton D.E., Dustin M.L., Springer T.A.
      Nature 339:61-64(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Endothelial cell.
    2. "Structure of the gene for the human intercellular adhesion molecule 2 (ICAM-2)."
      Garcia-Aguilar J., Staunton D., Springer T.A.
      Submitted (FEB-1990) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."
      Xu G., Shin S.B., Jaffrey S.R.
      Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 25-33.
      Tissue: Leukemic T-cell.
    5. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-105 AND ASN-176.
      Tissue: Plasma.
    6. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-82; ASN-105; ASN-153 AND ASN-176.
      Tissue: Leukemic T-cell.
    7. "Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface."
      Casasnovas J.M., Springer T.A., Liu J.-H., Harrison S.C., Wang J.-H.
      Nature 387:312-315(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 25-216.

    Entry informationi

    Entry nameiICAM2_HUMAN
    AccessioniPrimary (citable) accession number: P13598
    Secondary accession number(s): Q14600
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 158 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3