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Protein

Intercellular adhesion molecule 2

Gene

ICAM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

GO - Molecular functioni

  • integrin binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108622-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-216083. Integrin cell surface interactions.
R-HSA-5621575. CD209 (DC-SIGN) signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Intercellular adhesion molecule 2
Short name:
ICAM-2
Alternative name(s):
CD_antigen: CD102
Gene namesi
Name:ICAM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:5345. ICAM2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 223ExtracellularSequence analysisAdd BLAST199
Transmembranei224 – 248HelicalSequence analysisAdd BLAST25
Topological domaini249 – 275CytoplasmicSequence analysisAdd BLAST27

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
  • uropod Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3384.
OpenTargetsiENSG00000108622.
PharmGKBiPA29593.

Polymorphism and mutation databases

BioMutaiICAM2.
DMDMi115502404.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000001479025 – 275Intercellular adhesion molecule 2Add BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...)Combined sources1 Publication1
Disulfide bondi48 ↔ 91Combined sources1 Publication
Disulfide bondi52 ↔ 95Combined sources1 Publication
Glycosylationi82N-linked (GlcNAc...)Combined sources2 Publications1
Glycosylationi105N-linked (GlcNAc...)Combined sources3 Publications1
Disulfide bondi134 ↔ 190Combined sources1 Publication
Glycosylationi153N-linked (GlcNAc...)Combined sources2 Publications1
Glycosylationi176N-linked (GlcNAc...)2 Publications1
Glycosylationi187N-linked (GlcNAc...)Combined sources1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP13598.
PaxDbiP13598.
PeptideAtlasiP13598.
PRIDEiP13598.

PTM databases

iPTMnetiP13598.
PhosphoSitePlusiP13598.
SwissPalmiP13598.
UniCarbKBiP13598.

Expressioni

Gene expression databases

BgeeiENSG00000108622.
CleanExiHS_ICAM2.
ExpressionAtlasiP13598. baseline and differential.
GenevisibleiP13598. HS.

Organism-specific databases

HPAiHPA002020.

Interactioni

GO - Molecular functioni

  • integrin binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi109611. 18 interactors.
IntActiP13598. 6 interactors.
STRINGi9606.ENSP00000388666.

Structurei

Secondary structure

1275
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 38Combined sources10
Beta strandi42 – 51Combined sources10
Beta strandi56 – 61Combined sources6
Beta strandi63 – 72Combined sources10
Beta strandi75 – 83Combined sources9
Beta strandi87 – 95Combined sources9
Beta strandi98 – 108Combined sources11
Beta strandi116 – 125Combined sources10
Beta strandi128 – 136Combined sources9
Helixi142 – 144Combined sources3
Beta strandi145 – 151Combined sources7
Beta strandi154 – 160Combined sources7
Beta strandi171 – 178Combined sources8
Helixi181 – 185Combined sources5
Beta strandi188 – 195Combined sources8
Helixi197 – 199Combined sources3
Beta strandi203 – 207Combined sources5
Beta strandi214 – 216Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZXQX-ray2.20A25-216[»]
ProteinModelPortaliP13598.
SMRiP13598.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13598.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 98Ig-like C2-type 1Add BLAST58
Domaini127 – 197Ig-like C2-type 2Add BLAST71

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH57. Eukaryota.
ENOG410Z9H1. LUCA.
GeneTreeiENSGT00530000063246.
HOVERGENiHBG052075.
InParanoidiP13598.
KOiK06523.
OMAiNFSCLAV.
OrthoDBiEOG091G022Y.
PhylomeDBiP13598.
TreeFamiTF333745.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003988. ICAM.
IPR015653. ICAM2.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PANTHERiPTHR13771:SF3. PTHR13771:SF3. 1 hit.
PfamiPF03921. ICAM_N. 1 hit.
[Graphical view]
PRINTSiPR01473. ICAM.
PR01472. ICAMVCAM1.
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13598-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSFGYRTLT VALFTLICCP GSDEKVFEVH VRPKKLAVEP KGSLEVNCST
60 70 80 90 100
TCNQPEVGGL ETSLDKILLD EQAQWKHYLV SNISHDTVLQ CHFTCSGKQE
110 120 130 140 150
SMNSNVSVYQ PPRQVILTLQ PTLVAVGKSF TIECRVPTVE PLDSLTLFLF
160 170 180 190 200
RGNETLHYET FGKAAPAPQE ATATFNSTAD REDGHRNFSC LAVLDLMSRG
210 220 230 240 250
GNIFHKHSAP KMLEIYEPVS DSQMVIIVTV VSVLLSLFVT SVLLCFIFGQ
260 270
HLRQQRMGTY GVRAAWRRLP QAFRP
Length:275
Mass (Da):30,654
Last modified:October 3, 2006 - v2
Checksum:iC54FB34D92A6FC38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65D → N (PubMed:2497351).Curated1
Sequence conflicti65D → N (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01465537A → T.Corresponds to variant rs5503dbSNPEnsembl.1
Natural variantiVAR_014656199R → H.Corresponds to variant rs5504dbSNPEnsembl.1
Natural variantiVAR_021920256R → Q.Corresponds to variant rs3764867dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15606 mRNA. Translation: CAA33630.1.
M32334
, M32331, M32332, M32333 Genomic DNA. Translation: AAA36035.1.
BC003097 mRNA. Translation: AAH03097.1.
CCDSiCCDS11657.1.
PIRiS03967.
RefSeqiNP_000864.2. NM_000873.3.
NP_001093256.1. NM_001099786.1.
NP_001093257.1. NM_001099787.1.
NP_001093258.1. NM_001099788.1.
NP_001093259.1. NM_001099789.1.
UniGeneiHs.431460.

Genome annotation databases

EnsembliENST00000412356; ENSP00000415283; ENSG00000108622.
ENST00000418105; ENSP00000388666; ENSG00000108622.
ENST00000449662; ENSP00000392634; ENSG00000108622.
ENST00000579687; ENSP00000462579; ENSG00000108622.
ENST00000579788; ENSP00000464665; ENSG00000108622.
GeneIDi3384.
KEGGihsa:3384.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

ICAM-2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15606 mRNA. Translation: CAA33630.1.
M32334
, M32331, M32332, M32333 Genomic DNA. Translation: AAA36035.1.
BC003097 mRNA. Translation: AAH03097.1.
CCDSiCCDS11657.1.
PIRiS03967.
RefSeqiNP_000864.2. NM_000873.3.
NP_001093256.1. NM_001099786.1.
NP_001093257.1. NM_001099787.1.
NP_001093258.1. NM_001099788.1.
NP_001093259.1. NM_001099789.1.
UniGeneiHs.431460.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZXQX-ray2.20A25-216[»]
ProteinModelPortaliP13598.
SMRiP13598.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109611. 18 interactors.
IntActiP13598. 6 interactors.
STRINGi9606.ENSP00000388666.

PTM databases

iPTMnetiP13598.
PhosphoSitePlusiP13598.
SwissPalmiP13598.
UniCarbKBiP13598.

Polymorphism and mutation databases

BioMutaiICAM2.
DMDMi115502404.

Proteomic databases

EPDiP13598.
PaxDbiP13598.
PeptideAtlasiP13598.
PRIDEiP13598.

Protocols and materials databases

DNASUi3384.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412356; ENSP00000415283; ENSG00000108622.
ENST00000418105; ENSP00000388666; ENSG00000108622.
ENST00000449662; ENSP00000392634; ENSG00000108622.
ENST00000579687; ENSP00000462579; ENSG00000108622.
ENST00000579788; ENSP00000464665; ENSG00000108622.
GeneIDi3384.
KEGGihsa:3384.

Organism-specific databases

CTDi3384.
DisGeNETi3384.
GeneCardsiICAM2.
H-InvDBHIX0014082.
HGNCiHGNC:5345. ICAM2.
HPAiHPA002020.
MIMi146630. gene.
neXtProtiNX_P13598.
OpenTargetsiENSG00000108622.
PharmGKBiPA29593.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH57. Eukaryota.
ENOG410Z9H1. LUCA.
GeneTreeiENSGT00530000063246.
HOVERGENiHBG052075.
InParanoidiP13598.
KOiK06523.
OMAiNFSCLAV.
OrthoDBiEOG091G022Y.
PhylomeDBiP13598.
TreeFamiTF333745.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108622-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-216083. Integrin cell surface interactions.
R-HSA-5621575. CD209 (DC-SIGN) signaling.

Miscellaneous databases

ChiTaRSiICAM2. human.
EvolutionaryTraceiP13598.
GeneWikiiICAM2.
GenomeRNAii3384.
PROiP13598.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108622.
CleanExiHS_ICAM2.
ExpressionAtlasiP13598. baseline and differential.
GenevisibleiP13598. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003988. ICAM.
IPR015653. ICAM2.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PANTHERiPTHR13771:SF3. PTHR13771:SF3. 1 hit.
PfamiPF03921. ICAM_N. 1 hit.
[Graphical view]
PRINTSiPR01473. ICAM.
PR01472. ICAMVCAM1.
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiICAM2_HUMAN
AccessioniPrimary (citable) accession number: P13598
Secondary accession number(s): Q14600
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 3, 2006
Last modified: November 2, 2016
This is version 177 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.