P13598 (ICAM2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Intercellular adhesion molecule 2
Short name=ICAM-2

Alternative name(s):
CD_antigen=CD102

Gene names

Name:

ICAM2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the immunoglobulin superfamily. ICAM family. Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	cell-cell adhesion Inferred from electronic annotation. Source: InterPro regulation of immune response Traceable author statement. Source: Reactome
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	integrin binding Inferred from physical interaction. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

24

Ref.4

Chain

25 – 275

251

Intercellular adhesion molecule 2

PRO_0000014790

Regions

Topological domain

25 – 223

199

Extracellular Potential

Transmembrane

224 – 248

25

Helical; Potential

Topological domain

249 – 275

27

Cytoplasmic Potential

Domain

41 – 98

58

Ig-like C2-type 1

Domain

127 – 197

71

Ig-like C2-type 2

Amino acid modifications

Glycosylation

47

1

N-linked (GlcNAc...)

Glycosylation

82

1

N-linked (GlcNAc...) Ref.6

Glycosylation

105

1

N-linked (GlcNAc...) Ref.5 Ref.6

Glycosylation

153

1

N-linked (GlcNAc...) Ref.6

Glycosylation

176

1

N-linked (GlcNAc...) Ref.5 Ref.6

Glycosylation

187

1

N-linked (GlcNAc...)

Disulfide bond

48 ↔ 91

Disulfide bond

52 ↔ 95

Disulfide bond

134 ↔ 190

Natural variations

Natural variant

37

1

A → T.
Corresponds to variant rs5503 [ dbSNP | Ensembl ].

VAR_014655

Natural variant

199

1

R → H.
Corresponds to variant rs5504 [ dbSNP | Ensembl ].

VAR_014656

Natural variant

256

1

R → Q.
Corresponds to variant rs3764867 [ dbSNP | Ensembl ].

VAR_021920

Experimental info

Sequence conflict

65

1

D → N Ref.1

Sequence conflict

65

1

D → N Ref.3

Secondary structure

1

.

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275

Helix Strand Turn

Details...

Beta strand

29 – 38

10

Beta strand

42 – 51

10

Beta strand

56 – 61

6

Beta strand

63 – 72

10

Beta strand

75 – 83

9

Beta strand

87 – 95

9

Beta strand

98 – 108

11

Beta strand

116 – 125

10

Beta strand

128 – 136

9

Helix

142 – 144

3

Beta strand

145 – 151

7

Beta strand

154 – 160

7

Beta strand

171 – 178

8

Helix

181 – 185

5

Beta strand

188 – 195

8

Helix

197 – 199

3

Beta strand

203 – 207

5

Sequences

	Sequence		Length	Mass (Da)
	P13598 [UniParc]. Last modified October 3, 2006. Version 2. Checksum: C54FB34D92A6FC38	FASTA	275	30,654
	10 20 30 40 50 60 MSSFGYRTLT VALFTLICCP GSDEKVFEVH VRPKKLAVEP KGSLEVNCST TCNQPEVGGL 70 80 90 100 110 120 ETSLDKILLD EQAQWKHYLV SNISHDTVLQ CHFTCSGKQE SMNSNVSVYQ PPRQVILTLQ 130 140 150 160 170 180 PTLVAVGKSF TIECRVPTVE PLDSLTLFLF RGNETLHYET FGKAAPAPQE ATATFNSTAD 190 200 210 220 230 240 REDGHRNFSC LAVLDLMSRG GNIFHKHSAP KMLEIYEPVS DSQMVIIVTV VSVLLSLFVT 250 260 270 SVLLCFIFGQ HLRQQRMGTY GVRAAWRRLP QAFRP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1." Staunton D.E., Dustin M.L., Springer T.A. Nature 339:61-64(1989) [PubMed: 2497351] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Endothelial cell.
[2]	"Structure of the gene for the human intercellular adhesion molecule 2 (ICAM-2)." Garcia-Aguilar J., Staunton D., Springer T.A. Submitted (FEB-1990) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini." Xu G., Shin S.B., Jaffrey S.R. Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed: 19892738] [Abstract] Cited for: PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 25-33. Tissue: Leukemic T-cell.
[5]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-105 AND ASN-176, MASS SPECTROMETRY. Tissue: Plasma.
[6]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed: 19349973] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-82; ASN-105; ASN-153 AND ASN-176, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[7]	"Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface." Casasnovas J.M., Springer T.A., Liu J.-H., Harrison S.C., Wang J.-H. Nature 387:312-315(1997) [PubMed: 9153399] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 25-216.
+	Additional computationally mapped references.

Web resources

Functional Glycomics Gateway - Glycan Binding

ICAM-2

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X15606 mRNA. Translation: CAA33630.1.
M32334 , M32331, M32332, M32333 Genomic DNA. Translation: AAA36035.1.
BC003097 mRNA. Translation: AAH03097.1.

IPI

IPI00009477.

PIR

S03967.

RefSeq

NP_000864.2. NM_000873.3.
NP_001093256.1. NM_001099786.1.
NP_001093257.1. NM_001099787.1.
NP_001093258.1. NM_001099788.1.
NP_001093259.1. NM_001099789.1.

UniGene

Hs.431460.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1ZXQ	X-ray	2.20	A	25-216	[»]

ProteinModelPortal

P13598.

SMR

P13598. Positions 25-251.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-629N.

IntAct

P13598. 4 interactions.

STRING

P13598.

PTM databases

PhosphoSite

P13598.

Polymorphism databases

DMDM

115502404.

Proteomic databases

PRIDE

P13598.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000225760; ENSP00000225760; ENSG00000108622.
ENST00000412356; ENSP00000415283; ENSG00000108622.
ENST00000418105; ENSP00000388666; ENSG00000108622.
ENST00000425257; ENSP00000389507; ENSG00000108622.
ENST00000449662; ENSP00000392634; ENSG00000108622.

GeneID

3384.

KEGG

hsa:3384.

UCSC

uc002jdu.2. human.

Organism-specific databases

CTD

3384.

GeneCards

GC17M062079.

H-InvDB

HIX0014082.
HIX0014083.

HGNC

HGNC:5345. ICAM2.

HPA

HPA002020.

MIM

146630. gene.

neXtProt

NX_P13598.

PharmGKB

PA29593.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG18802.

HOVERGEN

HBG052075.

InParanoid

P13598.

OMA

QEATATF.

OrthoDB

EOG4HDSVH.

PhylomeDB

P13598.

Enzyme and pathway databases

Pathway_Interaction_DB

amb2_neutrophils_pathway. amb2 Integrin signaling.

Reactome

REACT_111102. Signal Transduction.
REACT_6900. Immune System.

Gene expression databases

ArrayExpress

P13598.

Bgee

P13598.

CleanEx

HS_ICAM2.

Genevestigator

P13598.

GermOnline

ENSG00000108622. Homo sapiens.

Family and domain databases

InterPro

IPR003988. ICAM.
IPR015653. ICAM2.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR013783. Ig-like_fold.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 2 hits.

KO

K06523.

PANTHER

PTHR13771:SF3. ICAM2. 1 hit.

Pfam

PF03921. ICAM_N. 1 hit.
[Graphical view]

PRINTS

PR01473. ICAM.
PR01472. ICAMVCAM1.

PROSITE

PS50835. IG_LIKE. False negative.
[Graphical view]

ProtoNet

Search...

Other

NextBio

13380.

SOURCE

Search...

Entry information

Entry name

ICAM2_HUMAN

Accession

Primary (citable) accession number: P13598
Secondary accession number(s): Q14600

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	October 3, 2006
Last modified:	January 25, 2012
This is version 132 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.