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P13596

- NCAM1_RAT

UniProt

P13596 - NCAM1_RAT

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Protein

Neural cell adhesion molecule 1

Gene
Ncam1, Ncam
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

GO - Molecular functioni

  1. cytoskeletal protein binding Source: RGD
  2. fibroblast growth factor receptor binding Source: RGD
  3. heparin binding Source: UniProtKB-KW
  4. LRR domain binding Source: RGD
  5. phosphatase binding Source: RGD
  6. protein binding Source: IntAct

GO - Biological processi

  1. aging Source: RGD
  2. calcium-independent cell-cell adhesion Source: RGD
  3. cell adhesion Source: RGD
  4. cellular response to inorganic substance Source: RGD
  5. cellular response to molecule of bacterial origin Source: RGD
  6. learning or memory Source: RGD
  7. multicellular organismal response to stress Source: RGD
  8. negative regulation of cell death Source: RGD
  9. neuron development Source: RGD
  10. organ regeneration Source: RGD
  11. peripheral nervous system axon regeneration Source: RGD
  12. positive regulation of cardiac muscle cell proliferation Source: RGD
  13. regulation of sensory perception of pain Source: RGD
  14. response to cocaine Source: RGD
  15. response to fluoxetine Source: RGD
  16. response to inorganic substance Source: RGD
  17. response to lead ion Source: RGD
  18. thalamus development Source: RGD
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neural cell adhesion molecule 1
Short name:
N-CAM-1
Short name:
NCAM-1
Alternative name(s):
CD_antigen: CD56
Gene namesi
Name:Ncam1
Synonyms:Ncam
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi67378. Ncam1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 721702Extracellular Reviewed predictionAdd
BLAST
Transmembranei722 – 73918Helical; Reviewed predictionAdd
BLAST
Topological domaini740 – 858119Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. growth cone Source: RGD
  2. integral component of membrane Source: UniProtKB-KW
  3. neuronal cell body Source: RGD
  4. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 By similarityAdd
BLAST
Chaini20 – 858839Neural cell adhesion molecule 1PRO_0000015015Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 96 By similarity
Disulfide bondi139 ↔ 189 By similarity
Glycosylationi222 – 2221N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi235 ↔ 288 By similarity
Glycosylationi316 – 3161N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi330 ↔ 396 By similarity
Glycosylationi348 – 3481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi434 – 4341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi437 ↔ 490 By similarity
Glycosylationi460 – 4601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi489 – 4891N-linked (GlcNAc...) Reviewed prediction
Modified residuei784 – 7841Phosphoserine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP13596.
PRIDEiP13596.

PTM databases

PhosphoSiteiP13596.

Expressioni

Gene expression databases

GenevestigatoriP13596.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Fgfr1P160922EBI-916499,EBI-7953898From a different organism.
Fgfr2Q632372EBI-916499,EBI-8523405

Protein-protein interaction databases

BioGridi246729. 2 interactions.
IntActiP13596. 3 interactions.
MINTiMINT-2635713.
STRINGi10116.ENSRNOP00000046828.

Structurei

Secondary structure

1
858
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi22 – 3211
Beta strandi37 – 437
Beta strandi51 – 555
Beta strandi65 – 7511
Beta strandi78 – 836
Helixi88 – 903
Beta strandi92 – 998
Beta strandi105 – 11511
Beta strandi118 – 1225
Beta strandi125 – 1284
Beta strandi135 – 1373
Beta strandi140 – 1423
Beta strandi148 – 1536
Helixi158 – 1614
Beta strandi166 – 1683
Beta strandi174 – 1763
Helixi181 – 1833
Beta strandi185 – 1939
Helixi194 – 1963
Beta strandi198 – 20710
Beta strandi219 – 2246
Beta strandi231 – 24111
Beta strandi244 – 2496
Beta strandi262 – 2665
Beta strandi272 – 2754
Helixi280 – 2823
Beta strandi284 – 2929
Beta strandi295 – 30612
Beta strandi616 – 6227
Turni623 – 6264
Beta strandi627 – 6337
Beta strandi637 – 6393
Beta strandi642 – 65413
Beta strandi667 – 6737
Beta strandi679 – 68810
Beta strandi691 – 70111

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EPFX-ray1.85A/B/C/D20-208[»]
1LWRNMR-A612-705[»]
1QZ1X-ray2.00A20-308[»]
ProteinModelPortaliP13596.
SMRiP13596. Positions 20-308, 507-705.

Miscellaneous databases

EvolutionaryTraceiP13596.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 11192Ig-like C2-type 1Add
BLAST
Domaini116 – 20590Ig-like C2-type 2Add
BLAST
Domaini212 – 30291Ig-like C2-type 3Add
BLAST
Domaini309 – 414106Ig-like C2-type 4Add
BLAST
Domaini417 – 50286Ig-like C2-type 5Add
BLAST
Domaini510 – 609100Fibronectin type-III 1Add
BLAST
Domaini611 – 70696Fibronectin type-III 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni152 – 1565Heparin-binding Reviewed prediction
Regioni161 – 1655Heparin-binding Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG308439.
HOGENOMiHOG000074124.
HOVERGENiHBG052579.
KOiK06491.
PhylomeDBiP13596.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR009138. Neural_cell_adh.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 5 hits.
[Graphical view]
PRINTSiPR01838. NCAMFAMILY.
SMARTiSM00060. FN3. 2 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced.

Isoform 1 (identifier: P13596-1) [UniParc]FASTAAdd to Basket

Also known as: N-CAM 140

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLRTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK    50
DISWFSPNGE KLSPNQQRIS VVWNDDDSST LTIYNANIDD AGIYKCVVTA 100
EDGTQSEATV NVKIFQKLMF KNAPTPQEFK EGEDAVIVCD VVSSLPPTII 150
WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK KTDEGTYRCE GRILARGEIN 200
FKDIQVIVNV PPTVQARQSI VNATANLGQS VTLVCDADGF PEPTMSWTKD 250
GEPIENEEED DEKHIFSDDS SELTIRNVDK NDEAEYVCIA ENKAGEQDAS 300
IHLKVFAKPK ITYVENQTAM ELEEQVTLTC EASGDPIPSI TWRTSTRNIS 350
SEEKASWTRP EKQETLDGHM VVRSHARVSS LTLKSIQYTD AGEYICTASN 400
TIGQDSQSMY LEVQYAPKLQ GPVAVYTWEG NQVNITCEVF AYPSATISWF 450
RDGQLLPSSN YSNIKIYNTP SASYLEVTPD SENDFGNYNC TAVNRIGQES 500
LEFILVQADT PSSPSIDRVE PYSSTAQVQF DEPEATGGVP ILKYKAEWKS 550
LGEEAWHSKW YDAKEANMEG IVTIMGLKPE TRYAVRLAAL NGKGLGEISA 600
ATEFKTQPVR EPSAPKLEGQ MGEDGNSIKV NLIKQDDGGS PIRHYLVKYR 650
ALASEWKPEI RLPSGSDHVM LKSLDWNAEY EVYVVAENQQ GKSKAAHFVF 700
RTSAQPTAIP ANGSPTAGLS TGAIVGILIV IFVLLLVVMD ITCYFLNKCG 750
LLMCIAVNLC GKAGPGAKGK DMEEGKAAFS KDESKEPIVE VRTEEERTPN 800
HDGGKHTEPN ETTPLTEPEK GPVETKSEPQ ESEAKPAPTE VKTVPNEATQ 850
TKENESKA 858
Length:858
Mass (Da):94,658
Last modified:January 1, 1990 - v1
Checksum:iEA1A06A4EA0550F6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06564 mRNA. Translation: CAA29809.1.
M32611 Genomic DNA. Translation: AAA41679.1.
PIRiS00846. IJRTNC.
RefSeqiNP_113709.1. NM_031521.1. [P13596-1]
UniGeneiRn.11283.
Rn.214248.

Genome annotation databases

GeneIDi24586.
KEGGirno:24586.
UCSCiRGD:67378. rat. [P13596-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06564 mRNA. Translation: CAA29809.1 .
M32611 Genomic DNA. Translation: AAA41679.1 .
PIRi S00846. IJRTNC.
RefSeqi NP_113709.1. NM_031521.1. [P13596-1 ]
UniGenei Rn.11283.
Rn.214248.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EPF X-ray 1.85 A/B/C/D 20-208 [» ]
1LWR NMR - A 612-705 [» ]
1QZ1 X-ray 2.00 A 20-308 [» ]
ProteinModelPortali P13596.
SMRi P13596. Positions 20-308, 507-705.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 246729. 2 interactions.
IntActi P13596. 3 interactions.
MINTi MINT-2635713.
STRINGi 10116.ENSRNOP00000046828.

PTM databases

PhosphoSitei P13596.

Proteomic databases

PaxDbi P13596.
PRIDEi P13596.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 24586.
KEGGi rno:24586.
UCSCi RGD:67378. rat. [P13596-1 ]

Organism-specific databases

CTDi 4684.
RGDi 67378. Ncam1.

Phylogenomic databases

eggNOGi NOG308439.
HOGENOMi HOG000074124.
HOVERGENi HBG052579.
KOi K06491.
PhylomeDBi P13596.

Miscellaneous databases

EvolutionaryTracei P13596.
NextBioi 603762.

Gene expression databases

Genevestigatori P13596.

Family and domain databases

Gene3Di 2.60.40.10. 7 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR009138. Neural_cell_adh.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF07679. I-set. 5 hits.
[Graphical view ]
PRINTSi PR01838. NCAMFAMILY.
SMARTi SM00060. FN3. 2 hits.
SM00408. IGc2. 5 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
PROSITEi PS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a cDNA clone that contains the complete coding sequence for a 140-kD rat NCAM polypeptide."
    Small S.J., Shull G.E., Santoni M.-J., Akeson R.
    J. Cell Biol. 105:2335-2345(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Expression of the unique NCAM VASE exon is independently regulated in distinct tissues during development."
    Small S.J., Akeson R.
    J. Cell Biol. 111:2089-2096(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 340-381.
  3. "Polypeptide variation in an N-CAM extracellular immunoglobulin-like fold is developmentally regulated through alternative splicing."
    Small S.J., Haines S.L., Akeson R.A.
    Neuron 1:1007-1017(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 355-364.
  4. Lubec G., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 38-48 AND 594-605, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiNCAM1_RAT
AccessioniPrimary (citable) accession number: P13596
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: September 3, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi