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P13591

- NCAM1_HUMAN

UniProt

P13591 - NCAM1_HUMAN

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Protein

Neural cell adhesion molecule 1

Gene

NCAM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

GO - Molecular functioni

  1. identical protein binding Source: IntAct

GO - Biological processi

  1. axon guidance Source: Reactome
  2. cell adhesion Source: ProtInc
  3. cytokine-mediated signaling pathway Source: Reactome
  4. extracellular matrix organization Source: Reactome
  5. interferon-gamma-mediated signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_163906. ECM proteoglycans.
REACT_18312. NCAM1 interactions.
REACT_18334. NCAM signaling for neurite out-growth.
REACT_22272. Signal transduction by L1.
REACT_25078. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Neural cell adhesion molecule 1
Short name:
N-CAM-1
Short name:
NCAM-1
Alternative name(s):
CD_antigen: CD56
Gene namesi
Name:NCAM1
Synonyms:NCAM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:7656. NCAM1.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. cell surface Source: BHF-UCL
  3. cytoplasm Source: HPA
  4. external side of plasma membrane Source: MGI
  5. extracellular vesicular exosome Source: UniProt
  6. Golgi membrane Source: Reactome
  7. integral component of membrane Source: ProtInc
  8. membrane Source: UniProtKB
  9. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31459.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 858839Neural cell adhesion molecule 1PRO_0000015009Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 96Curated
Disulfide bondi139 ↔ 189Curated
Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi235 ↔ 287Curated
Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi329 ↔ 395Curated
Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi436 ↔ 489Curated
Glycosylationi459 – 4591N-linked (GlcNAc...)1 Publication
Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence Analysis
Modified residuei784 – 7841PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

MaxQBiP13591.
PaxDbiP13591.
PRIDEiP13591.

PTM databases

PhosphoSiteiP13591.

Expressioni

Gene expression databases

BgeeiP13591.
ExpressionAtlasiP13591. baseline and differential.
GenevestigatoriP13591.

Organism-specific databases

HPAiCAB000142.
CAB018071.
HPA039835.

Interactioni

Protein-protein interaction databases

BioGridi110764. 21 interactions.
DIPiDIP-59530N.
IntActiP13591. 7 interactions.
MINTiMINT-4103137.

Structurei

Secondary structure

1
858
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi414 – 4196
Beta strandi422 – 4265
Beta strandi432 – 44211
Beta strandi445 – 4506
Beta strandi453 – 4564
Beta strandi458 – 4603
Beta strandi462 – 4687
Beta strandi471 – 4766
Helixi481 – 4833
Beta strandi485 – 4928
Beta strandi497 – 50610
Beta strandi514 – 5207
Beta strandi525 – 5306
Beta strandi542 – 5498
Beta strandi556 – 5616
Helixi562 – 5687
Beta strandi569 – 5735
Beta strandi581 – 59010
Beta strandi601 – 6044
Beta strandi616 – 6216
Beta strandi628 – 6336
Beta strandi644 – 6518
Beta strandi660 – 6623
Beta strandi668 – 6714
Beta strandi679 – 68810
Beta strandi696 – 7016

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E3VX-ray1.95A/B/C510-619[»]
2HAZX-ray1.70A508-608[»]
2VKWX-ray2.30A/B506-702[»]
2VKXX-ray2.70A/B/C/D/E/F506-702[»]
3MTRX-ray1.80A/B414-611[»]
ProteinModelPortaliP13591.
SMRiP13591. Positions 20-706.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13591.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 718699ExtracellularSequence AnalysisAdd
BLAST
Topological domaini740 – 858119CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei719 – 73921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 11192Ig-like C2-type 1Add
BLAST
Domaini116 – 20590Ig-like C2-type 2Add
BLAST
Domaini212 – 30190Ig-like C2-type 3Add
BLAST
Domaini308 – 413106Ig-like C2-type 4Add
BLAST
Domaini416 – 50186Ig-like C2-type 5Add
BLAST
Domaini509 – 608100Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini611 – 70696Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG308439.
GeneTreeiENSGT00750000117404.
HOVERGENiHBG052579.
InParanoidiP13591.
KOiK06491.
PhylomeDBiP13591.
TreeFamiTF326195.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR009138. Neural_cell_adh.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 5 hits.
[Graphical view]
PRINTSiPR01838. NCAMFAMILY.
SMARTiSM00060. FN3. 2 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P13591-2) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLQTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK
60 70 80 90 100
DISWFSPNGE KLTPNQQRIS VVWNDDSSST LTIYNANIDD AGIYKCVVTG
110 120 130 140 150
EDGSESEATV NVKIFQKLMF KNAPTPQEFR EGEDAVIVCD VVSSLPPTII
160 170 180 190 200
WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK KTDEGTYRCE GRILARGEIN
210 220 230 240 250
FKDIQVIVNV PPTIQARQNI VNATANLGQS VTLVCDAEGF PEPTMSWTKD
260 270 280 290 300
GEQIEQEEDD EKYIFSDDSS QLTIKKVDKN DEAEYICIAE NKAGEQDATI
310 320 330 340 350
HLKVFAKPKI TYVENQTAME LEEQVTLTCE ASGDPIPSIT WRTSTRNISS
360 370 380 390 400
EEKASWTRPE KQETLDGHMV VRSHARVSSL TLKSIQYTDA GEYICTASNT
410 420 430 440 450
IGQDSQSMYL EVQYAPKLQG PVAVYTWEGN QVNITCEVFA YPSATISWFR
460 470 480 490 500
DGQLLPSSNY SNIKIYNTPS ASYLEVTPDS ENDFGNYNCT AVNRIGQESL
510 520 530 540 550
EFILVQADTP SSPSIDQVEP YSSTAQVQFD EPEATGGVPI LKYKAEWRAV
560 570 580 590 600
GEEVWHSKWY DAKEASMEGI VTIVGLKPET TYAVRLAALN GKGLGEISAA
610 620 630 640 650
SEFKTQPVQG EPSAPKLEGQ MGEDGNSIKV NLIKQDDGGS PIRHYLVRYR
660 670 680 690 700
ALSSEWKPEI RLPSGSDHVM LKSLDWNAEY EVYVVAENQQ GKSKAAHFVF
710 720 730 740 750
RTSAQPTAIP ANGSPTSGLS TGAIVGILIV IFVLLLVVVD ITCYFLNKCG
760 770 780 790 800
LFMCIAVNLC GKAGPGAKGK DMEEGKAAFS KDESKEPIVE VRTEEERTPN
810 820 830 840 850
HDGGKHTEPN ETTPLTEPEK GPVEAKPECQ ETETKPAPAE VKTVPNDATQ

TKENESKA
Length:858
Mass (Da):94,574
Last modified:July 22, 2008 - v3
Checksum:iFD3B9DE80D802554
GO
Isoform 2 (identifier: P13591-1) [UniParc]FASTAAdd to Basket

Also known as: N-CAM 140

The sequence of this isoform differs from the canonical sequence as follows:
     354-363: Missing.

Show »
Length:848
Mass (Da):93,361
Checksum:i68D2F0C0E6C1C2AD
GO
Isoform 3 (identifier: P13591-3) [UniParc] [UniParc]FASTAAdd to Basket

Also known as: N-CAM 120

The sequence of this isoform differs from the canonical sequence as follows:
     354-363: Missing.
     609-609: Q → HSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAK
     712-736: NGSPTSGLSTGAIVGILIVIFVLLL → TLGGNSASYTFVSLLFSAVTLLLLC
     737-858: Missing.

Note: GPI-anchor amidated asparagine on Asn-741.

Show »
Length:761
Mass (Da):83,770
Checksum:iF0CAD3292D7AB67E
GO
Isoform 4 (identifier: P13591-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     354-363: Missing.
     712-736: NGSPTSGLSTGAIVGILIVIFVLLL → TLGGNSASYTFVSLLFSAVTLLLLC
     737-858: Missing.

Note: GPI-anchor amidated asparagine on Asn-706.

Show »
Length:726
Mass (Da):80,312
Checksum:i1B6D55D0BF65200F
GO
Isoform 5 (identifier: P13591-5) [UniParc] [UniParc]FASTAAdd to Basket

Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     609-665: QGEPSAPKLE...WKPEIRLPSG → HSPPPPASAS...QAGLHNALMK
     666-858: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:665
Mass (Da):73,473
Checksum:iE496F232C162C614
GO
Isoform 6 (identifier: P13591-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     364-364: T → V
     365-858: Missing.

Show »
Length:364
Mass (Da):40,760
Checksum:iAC697008755FE6FD
GO

Sequence cautioni

The sequence BAD92680.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti215 – 2151Q → R in AAB04558. (PubMed:1710251)Curated
Sequence conflicti239 – 2391G → R in AAB04558. (PubMed:1710251)Curated
Sequence conflicti500 – 5001L → F in AAB04558. (PubMed:1710251)Curated
Sequence conflicti560 – 5601Y → H in BAF85142. (PubMed:14702039)Curated
Sequence conflicti609 – 6102QG → R in AAA59913. (PubMed:2887295)Curated
Sequence conflicti730 – 7312Missing in AAA59913. (PubMed:2887295)Curated
Sequence conflicti821 – 8211G → A in AAA59913. (PubMed:2887295)Curated
Sequence conflicti856 – 8561S → N in AAH47244. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71L → F.
Corresponds to variant rs7105734 [ dbSNP | Ensembl ].
VAR_061331
Natural varianti260 – 2601D → N.
Corresponds to variant rs17115160 [ dbSNP | Ensembl ].
VAR_049960
Natural varianti679 – 6791E → D.1 Publication
Corresponds to variant rs17115280 [ dbSNP | Ensembl ].
VAR_049961
Natural varianti834 – 8341T → M.
Corresponds to variant rs17174409 [ dbSNP | Ensembl ].
VAR_049962

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei354 – 36310Missing in isoform 2, isoform 3 and isoform 4. 5 PublicationsVSP_034818
Alternative sequencei364 – 3641T → V in isoform 6. 1 PublicationVSP_034819
Alternative sequencei365 – 858494Missing in isoform 6. 1 PublicationVSP_034820Add
BLAST
Alternative sequencei609 – 66557QGEPS…RLPSG → HSPPPPASASSSTPVPLSPP DTTWPLPALATTEPAKNIAQ NHCCNMFQAGLHNALMK in isoform 5. 1 PublicationVSP_034821Add
BLAST
Alternative sequencei609 – 6091Q → HSPPPPASASSSTPVPLSPP DTTWPLPALATTEPAK in isoform 3. 2 PublicationsVSP_034822
Alternative sequencei666 – 858193Missing in isoform 5. 1 PublicationVSP_034823Add
BLAST
Alternative sequencei712 – 73625NGSPT…FVLLL → TLGGNSASYTFVSLLFSAVT LLLLC in isoform 3 and isoform 4. 3 PublicationsVSP_034824Add
BLAST
Alternative sequencei737 – 858122Missing in isoform 3 and isoform 4. 3 PublicationsVSP_034825Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16841 mRNA. Translation: CAA34739.1.
U63041 mRNA. Translation: AAB04558.1.
S71824 mRNA. Translation: AAB31836.1.
AK292453 mRNA. Translation: BAF85142.1.
AB209443 mRNA. Translation: BAD92680.1. Different initiation.
BC014205 mRNA. Translation: AAH14205.2.
BC029119 mRNA. Translation: AAH29119.1.
BC047244 mRNA. Translation: AAH47244.1.
S73101 mRNA. Translation: AAB20698.1.
M17410 mRNA. Translation: AAA59913.1.
M17409 mRNA. Translation: AAA59912.1.
M22094 mRNA. Translation: AAA59910.1.
M22092, M22091 Genomic DNA. Translation: AAA59911.1.
CCDSiCCDS73385.1. [P13591-2]
CCDS73386.1. [P13591-3]
CCDS73387.1. [P13591-4]
CCDS73388.1. [P13591-1]
PIRiA31635.
I54773.
S07784. IJHUNG.
RefSeqiNP_000606.3. NM_000615.6. [P13591-1]
NP_001070150.1. NM_001076682.3. [P13591-3]
NP_001229537.1. NM_001242608.1. [P13591-4]
NP_851996.2. NM_181351.4. [P13591-2]
UniGeneiHs.503878.
Hs.711235.
Hs.733031.

Genome annotation databases

EnsembliENST00000316851; ENSP00000318472; ENSG00000149294. [P13591-2]
ENST00000529356; ENSP00000482205; ENSG00000149294. [P13591-6]
ENST00000531044; ENSP00000484943; ENSG00000149294. [P13591-1]
ENST00000531817; ENSP00000475074; ENSG00000149294.
ENST00000621128; ENSP00000481083; ENSG00000149294. [P13591-4]
ENST00000621850; ENSP00000480774; ENSG00000149294. [P13591-3]
GeneIDi4684.
KEGGihsa:4684.
UCSCiuc001pno.3. human. [P13591-6]
uc001pnp.3. human. [P13591-3]
uc001pnq.3. human. [P13591-2]
uc001pnr.3. human. [P13591-1]
uc021qqo.1. human. [P13591-4]

Polymorphism databases

DMDMi205830665.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

NCAM entry

Functional Glycomics Gateway - Glycan Binding

N-CAM 140

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16841 mRNA. Translation: CAA34739.1 .
U63041 mRNA. Translation: AAB04558.1 .
S71824 mRNA. Translation: AAB31836.1 .
AK292453 mRNA. Translation: BAF85142.1 .
AB209443 mRNA. Translation: BAD92680.1 . Different initiation.
BC014205 mRNA. Translation: AAH14205.2 .
BC029119 mRNA. Translation: AAH29119.1 .
BC047244 mRNA. Translation: AAH47244.1 .
S73101 mRNA. Translation: AAB20698.1 .
M17410 mRNA. Translation: AAA59913.1 .
M17409 mRNA. Translation: AAA59912.1 .
M22094 mRNA. Translation: AAA59910.1 .
M22092 , M22091 Genomic DNA. Translation: AAA59911.1 .
CCDSi CCDS73385.1. [P13591-2 ]
CCDS73386.1. [P13591-3 ]
CCDS73387.1. [P13591-4 ]
CCDS73388.1. [P13591-1 ]
PIRi A31635.
I54773.
S07784. IJHUNG.
RefSeqi NP_000606.3. NM_000615.6. [P13591-1 ]
NP_001070150.1. NM_001076682.3. [P13591-3 ]
NP_001229537.1. NM_001242608.1. [P13591-4 ]
NP_851996.2. NM_181351.4. [P13591-2 ]
UniGenei Hs.503878.
Hs.711235.
Hs.733031.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2E3V X-ray 1.95 A/B/C 510-619 [» ]
2HAZ X-ray 1.70 A 508-608 [» ]
2VKW X-ray 2.30 A/B 506-702 [» ]
2VKX X-ray 2.70 A/B/C/D/E/F 506-702 [» ]
3MTR X-ray 1.80 A/B 414-611 [» ]
ProteinModelPortali P13591.
SMRi P13591. Positions 20-706.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110764. 21 interactions.
DIPi DIP-59530N.
IntActi P13591. 7 interactions.
MINTi MINT-4103137.

PTM databases

PhosphoSitei P13591.

Polymorphism databases

DMDMi 205830665.

Proteomic databases

MaxQBi P13591.
PaxDbi P13591.
PRIDEi P13591.

Protocols and materials databases

DNASUi 4684.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316851 ; ENSP00000318472 ; ENSG00000149294 . [P13591-2 ]
ENST00000529356 ; ENSP00000482205 ; ENSG00000149294 . [P13591-6 ]
ENST00000531044 ; ENSP00000484943 ; ENSG00000149294 . [P13591-1 ]
ENST00000531817 ; ENSP00000475074 ; ENSG00000149294 .
ENST00000621128 ; ENSP00000481083 ; ENSG00000149294 . [P13591-4 ]
ENST00000621850 ; ENSP00000480774 ; ENSG00000149294 . [P13591-3 ]
GeneIDi 4684.
KEGGi hsa:4684.
UCSCi uc001pno.3. human. [P13591-6 ]
uc001pnp.3. human. [P13591-3 ]
uc001pnq.3. human. [P13591-2 ]
uc001pnr.3. human. [P13591-1 ]
uc021qqo.1. human. [P13591-4 ]

Organism-specific databases

CTDi 4684.
GeneCardsi GC11P112831.
HGNCi HGNC:7656. NCAM1.
HPAi CAB000142.
CAB018071.
HPA039835.
MIMi 116930. gene.
neXtProti NX_P13591.
PharmGKBi PA31459.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG308439.
GeneTreei ENSGT00750000117404.
HOVERGENi HBG052579.
InParanoidi P13591.
KOi K06491.
PhylomeDBi P13591.
TreeFami TF326195.

Enzyme and pathway databases

Reactomei REACT_163906. ECM proteoglycans.
REACT_18312. NCAM1 interactions.
REACT_18334. NCAM signaling for neurite out-growth.
REACT_22272. Signal transduction by L1.
REACT_25078. Interferon gamma signaling.

Miscellaneous databases

ChiTaRSi NCAM1. human.
EvolutionaryTracei P13591.
GeneWikii Neural_cell_adhesion_molecule.
GenomeRNAii 4684.
NextBioi 18060.
PROi P13591.
SOURCEi Search...

Gene expression databases

Bgeei P13591.
ExpressionAtlasi P13591. baseline and differential.
Genevestigatori P13591.

Family and domain databases

Gene3Di 2.60.40.10. 7 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR009138. Neural_cell_adh.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF07679. I-set. 5 hits.
[Graphical view ]
PRINTSi PR01838. NCAMFAMILY.
SMARTi SM00060. FN3. 2 hits.
SM00408. IGc2. 5 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
PROSITEi PS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence and in vitro expression of a tissue-specific phosphatidylinositol-linked N-CAM isoform from skeletal muscle."
    Barton C.H., Dickson G., Gower H.J., Rowett L.H., Putt W., Elsom V., Moore S.E., Goridis C., Walsh F.S.
    Development 104:165-173(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Skeletal muscle.
  2. "Molecular and functional analysis of human natural killer cell-associated neural cell adhesion molecule (N-CAM/CD56)."
    Lanier L.L., Chang C., Azuma M., Ruitenberg J.J., Hemperly J.J., Phillips J.H.
    J. Immunol. 146:4421-4426(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Complementary DNA sequence encoding the major neural cell adhesion molecule isoform in a human small cell lung cancer cell line."
    Saito S., Tanio Y., Tachibana I., Hayashi S., Kishimoto T., Kawase I.
    Lung Cancer 10:307-318(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  5. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Brain.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6), VARIANT ASP-679.
    Tissue: Brain, Kidney and Ovary.
  7. "Splicing of the VASE exon of neural cell adhesion molecule (NCAM) in human small-cell lung carcinoma (SCLC)."
    van Duijnhoven H.L., Helfrich W., de Leij L., Roebroek A.J., van de Ven W.J., Healey K., Culverwell A., Rossell R.J., Kemshead J.T., Patel K.
    Int. J. Cancer 50:118-123(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 347-369.
  8. "Human muscle neural cell adhesion molecule (N-CAM): identification of a muscle-specific sequence in the extracellular domain."
    Dickson G., Gower H.J., Barton C.H., Prentice H.M., Elsom V.L., Moore S.E., Cox R.D., Quinn C., Putt W., Walsh F.S.
    Cell 50:1119-1130(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 501-858 (ISOFORMS 1/2 AND 3).
    Tissue: Skeletal muscle.
  9. "Alternative splicing generates a secreted form of N-CAM in muscle and brain."
    Gower H.J., Barton C.H., Elsom V.L., Thompson J., Moore S.E., Dickson G., Walsh F.S.
    Cell 55:955-964(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 501-858 (ISOFORM 5).
  10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-459.
    Tissue: Plasma.

Entry informationi

Entry nameiNCAM1_HUMAN
AccessioniPrimary (citable) accession number: P13591
Secondary accession number(s): A8K8T8
, P13592, P13593, Q05C58, Q15829, Q16180, Q16209, Q59FL7, Q86X47, Q96CJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 22, 2008
Last modified: October 29, 2014
This is version 161 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3