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Protein

Neural cell adhesion molecule 1

Gene

NCAM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
(Microbial infection) Acts as a receptor for rabies virus.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Receptor

Keywords - Biological processi

Cell adhesion, Host-virus interaction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149294-MONOMER.
ReactomeiR-HSA-3000178. ECM proteoglycans.
R-HSA-375165. NCAM signaling for neurite out-growth.
R-HSA-419037. NCAM1 interactions.
R-HSA-445144. Signal transduction by L1.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Neural cell adhesion molecule 1
Short name:
N-CAM-1
Short name:
NCAM-1
Alternative name(s):
CD_antigen: CD56
Gene namesi
Name:NCAM1
Synonyms:NCAM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:7656. NCAM1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 718ExtracellularSequence analysisAdd BLAST699
Transmembranei719 – 739HelicalSequence analysisAdd BLAST21
Topological domaini740 – 858CytoplasmicSequence analysisAdd BLAST119

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • cell surface Source: BHF-UCL
  • cytoplasm Source: HPA
  • external side of plasma membrane Source: MGI
  • extracellular exosome Source: UniProtKB
  • Golgi membrane Source: Reactome
  • integral component of membrane Source: ProtInc
  • membrane Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4684.
OpenTargetsiENSG00000149294.
PharmGKBiPA31459.

Polymorphism and mutation databases

BioMutaiNCAM1.
DMDMi205830665.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000001500920 – 858Neural cell adhesion molecule 1Add BLAST839

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 96By similarity
Disulfide bondi139 ↔ 189By similarity
Glycosylationi222N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi235 ↔ 287By similarity
Glycosylationi315N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi329 ↔ 395Curated
Glycosylationi347N-linked (GlcNAc...)Sequence analysis1
Glycosylationi433N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi436 ↔ 489Curated
Glycosylationi459N-linked (GlcNAc...)1 Publication1
Glycosylationi488N-linked (GlcNAc...)Sequence analysis1
Modified residuei780PhosphoserineBy similarity1
Modified residuei784PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

EPDiP13591.
PaxDbiP13591.
PeptideAtlasiP13591.
PRIDEiP13591.

PTM databases

iPTMnetiP13591.
PhosphoSitePlusiP13591.
SwissPalmiP13591.

Expressioni

Gene expression databases

BgeeiENSG00000149294.
ExpressionAtlasiP13591. baseline and differential.
GenevisibleiP13591. HS.

Organism-specific databases

HPAiCAB000142.
CAB018071.
HPA039835.

Interactioni

Subunit structurei

(Microbial infection) Interacts with rabies virus glycoprotein.1 Publication

Protein-protein interaction databases

BioGridi110764. 30 interactors.
DIPiDIP-59530N.
IntActiP13591. 7 interactors.
MINTiMINT-4103137.
STRINGi9606.ENSP00000318472.

Structurei

Secondary structure

1858
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 32Combined sources12
Beta strandi37 – 45Combined sources9
Beta strandi51 – 55Combined sources5
Beta strandi69 – 75Combined sources7
Beta strandi78 – 83Combined sources6
Helixi88 – 90Combined sources3
Beta strandi92 – 99Combined sources8
Beta strandi105 – 115Combined sources11
Beta strandi414 – 419Combined sources6
Beta strandi422 – 426Combined sources5
Beta strandi432 – 442Combined sources11
Beta strandi445 – 450Combined sources6
Beta strandi453 – 456Combined sources4
Beta strandi458 – 460Combined sources3
Beta strandi462 – 468Combined sources7
Beta strandi471 – 476Combined sources6
Helixi481 – 483Combined sources3
Beta strandi485 – 492Combined sources8
Beta strandi497 – 506Combined sources10
Beta strandi514 – 520Combined sources7
Beta strandi525 – 530Combined sources6
Beta strandi542 – 549Combined sources8
Beta strandi556 – 561Combined sources6
Helixi562 – 568Combined sources7
Beta strandi569 – 573Combined sources5
Beta strandi581 – 590Combined sources10
Beta strandi601 – 604Combined sources4
Beta strandi616 – 621Combined sources6
Beta strandi628 – 633Combined sources6
Beta strandi638 – 640Combined sources3
Beta strandi644 – 651Combined sources8
Beta strandi660 – 662Combined sources3
Beta strandi668 – 671Combined sources4
Beta strandi676 – 678Combined sources3
Beta strandi679 – 688Combined sources10
Beta strandi696 – 701Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E3VX-ray1.95A/B/C510-619[»]
2HAZX-ray1.70A508-608[»]
2VKWX-ray2.30A/B506-702[»]
2VKXX-ray2.70A/B/C/D/E/F506-702[»]
3MTRX-ray1.80A/B414-611[»]
5AEAX-ray1.90A/B20-116[»]
5LKNNMR-A611-702[»]
ProteinModelPortaliP13591.
SMRiP13591.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13591.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 111Ig-like C2-type 1Add BLAST92
Domaini116 – 205Ig-like C2-type 2Add BLAST90
Domaini212 – 301Ig-like C2-type 3Add BLAST90
Domaini308 – 413Ig-like C2-type 4Add BLAST106
Domaini416 – 501Ig-like C2-type 5Add BLAST86
Domaini509 – 608Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST100
Domaini611 – 706Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQJI. Eukaryota.
ENOG410XTGB. LUCA.
GeneTreeiENSGT00860000133697.
HOVERGENiHBG052579.
InParanoidiP13591.
KOiK06491.
PhylomeDBiP13591.
TreeFamiTF326195.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 7 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR033019. Ncam1.
IPR009138. Neural_cell_adh.
[Graphical view]
PANTHERiPTHR10489:SF34. PTHR10489:SF34. 2 hits.
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 3 hits.
[Graphical view]
PRINTSiPR01838. NCAMFAMILY.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P13591-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLQTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK
60 70 80 90 100
DISWFSPNGE KLTPNQQRIS VVWNDDSSST LTIYNANIDD AGIYKCVVTG
110 120 130 140 150
EDGSESEATV NVKIFQKLMF KNAPTPQEFR EGEDAVIVCD VVSSLPPTII
160 170 180 190 200
WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK KTDEGTYRCE GRILARGEIN
210 220 230 240 250
FKDIQVIVNV PPTIQARQNI VNATANLGQS VTLVCDAEGF PEPTMSWTKD
260 270 280 290 300
GEQIEQEEDD EKYIFSDDSS QLTIKKVDKN DEAEYICIAE NKAGEQDATI
310 320 330 340 350
HLKVFAKPKI TYVENQTAME LEEQVTLTCE ASGDPIPSIT WRTSTRNISS
360 370 380 390 400
EEKASWTRPE KQETLDGHMV VRSHARVSSL TLKSIQYTDA GEYICTASNT
410 420 430 440 450
IGQDSQSMYL EVQYAPKLQG PVAVYTWEGN QVNITCEVFA YPSATISWFR
460 470 480 490 500
DGQLLPSSNY SNIKIYNTPS ASYLEVTPDS ENDFGNYNCT AVNRIGQESL
510 520 530 540 550
EFILVQADTP SSPSIDQVEP YSSTAQVQFD EPEATGGVPI LKYKAEWRAV
560 570 580 590 600
GEEVWHSKWY DAKEASMEGI VTIVGLKPET TYAVRLAALN GKGLGEISAA
610 620 630 640 650
SEFKTQPVQG EPSAPKLEGQ MGEDGNSIKV NLIKQDDGGS PIRHYLVRYR
660 670 680 690 700
ALSSEWKPEI RLPSGSDHVM LKSLDWNAEY EVYVVAENQQ GKSKAAHFVF
710 720 730 740 750
RTSAQPTAIP ANGSPTSGLS TGAIVGILIV IFVLLLVVVD ITCYFLNKCG
760 770 780 790 800
LFMCIAVNLC GKAGPGAKGK DMEEGKAAFS KDESKEPIVE VRTEEERTPN
810 820 830 840 850
HDGGKHTEPN ETTPLTEPEK GPVEAKPECQ ETETKPAPAE VKTVPNDATQ

TKENESKA
Length:858
Mass (Da):94,574
Last modified:July 22, 2008 - v3
Checksum:iFD3B9DE80D802554
GO
Isoform 2 (identifier: P13591-1) [UniParc]FASTAAdd to basket
Also known as: N-CAM 140

The sequence of this isoform differs from the canonical sequence as follows:
     354-363: Missing.

Show »
Length:848
Mass (Da):93,361
Checksum:i68D2F0C0E6C1C2AD
GO
Isoform 3 (identifier: P13591-3) [UniParc] [UniParc]FASTAAdd to basket
Also known as: N-CAM 120

The sequence of this isoform differs from the canonical sequence as follows:
     354-363: Missing.
     609-609: Q → HSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAK
     712-736: NGSPTSGLSTGAIVGILIVIFVLLL → TLGGNSASYTFVSLLFSAVTLLLLC
     737-858: Missing.

Note: GPI-anchor amidated asparagine on Asn-741.
Show »
Length:761
Mass (Da):83,770
Checksum:iF0CAD3292D7AB67E
GO
Isoform 4 (identifier: P13591-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     354-363: Missing.
     712-736: NGSPTSGLSTGAIVGILIVIFVLLL → TLGGNSASYTFVSLLFSAVTLLLLC
     737-858: Missing.

Note: GPI-anchor amidated asparagine on Asn-706.
Show »
Length:726
Mass (Da):80,312
Checksum:i1B6D55D0BF65200F
GO
Isoform 5 (identifier: P13591-5) [UniParc] [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     609-665: QGEPSAPKLE...WKPEIRLPSG → HSPPPPASAS...QAGLHNALMK
     666-858: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:665
Mass (Da):73,473
Checksum:iE496F232C162C614
GO
Isoform 6 (identifier: P13591-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     364-364: T → V
     365-858: Missing.

Show »
Length:364
Mass (Da):40,760
Checksum:iAC697008755FE6FD
GO

Sequence cautioni

The sequence BAD92680 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti215Q → R in AAB04558 (PubMed:1710251).Curated1
Sequence conflicti239G → R in AAB04558 (PubMed:1710251).Curated1
Sequence conflicti500L → F in AAB04558 (PubMed:1710251).Curated1
Sequence conflicti560Y → H in BAF85142 (PubMed:14702039).Curated1
Sequence conflicti609 – 610QG → R in AAA59913 (PubMed:2887295).Curated2
Sequence conflicti730 – 731Missing in AAA59913 (PubMed:2887295).Curated2
Sequence conflicti821G → A in AAA59913 (PubMed:2887295).Curated1
Sequence conflicti856S → N in AAH47244 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0613317L → F.Corresponds to variant rs7105734dbSNPEnsembl.1
Natural variantiVAR_049960260D → N.Corresponds to variant rs17115160dbSNPEnsembl.1
Natural variantiVAR_049961679E → D.1 PublicationCorresponds to variant rs17115280dbSNPEnsembl.1
Natural variantiVAR_049962834T → M.Corresponds to variant rs17174409dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034818354 – 363Missing in isoform 2, isoform 3 and isoform 4. 5 Publications10
Alternative sequenceiVSP_034819364T → V in isoform 6. 1 Publication1
Alternative sequenceiVSP_034820365 – 858Missing in isoform 6. 1 PublicationAdd BLAST494
Alternative sequenceiVSP_034821609 – 665QGEPS…RLPSG → HSPPPPASASSSTPVPLSPP DTTWPLPALATTEPAKNIAQ NHCCNMFQAGLHNALMK in isoform 5. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_034822609Q → HSPPPPASASSSTPVPLSPP DTTWPLPALATTEPAK in isoform 3. 2 Publications1
Alternative sequenceiVSP_034823666 – 858Missing in isoform 5. 1 PublicationAdd BLAST193
Alternative sequenceiVSP_034824712 – 736NGSPT…FVLLL → TLGGNSASYTFVSLLFSAVT LLLLC in isoform 3 and isoform 4. 3 PublicationsAdd BLAST25
Alternative sequenceiVSP_034825737 – 858Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST122

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16841 mRNA. Translation: CAA34739.1.
U63041 mRNA. Translation: AAB04558.1.
S71824 mRNA. Translation: AAB31836.1.
AK292453 mRNA. Translation: BAF85142.1.
AB209443 mRNA. Translation: BAD92680.1. Different initiation.
BC014205 mRNA. Translation: AAH14205.2.
BC029119 mRNA. Translation: AAH29119.1.
BC047244 mRNA. Translation: AAH47244.1.
S73101 mRNA. Translation: AAB20698.1.
M17410 mRNA. Translation: AAA59913.1.
M17409 mRNA. Translation: AAA59912.1.
M22094 mRNA. Translation: AAA59910.1.
M22092, M22091 Genomic DNA. Translation: AAA59911.1.
CCDSiCCDS73385.1. [P13591-2]
CCDS73386.1. [P13591-3]
CCDS73387.1. [P13591-4]
CCDS73388.1. [P13591-1]
PIRiA31635.
I54773.
S07784. IJHUNG.
RefSeqiNP_000606.3. NM_000615.6. [P13591-1]
NP_001070150.1. NM_001076682.3. [P13591-3]
NP_001229537.1. NM_001242608.1. [P13591-4]
NP_851996.2. NM_181351.4. [P13591-2]
UniGeneiHs.503878.
Hs.711235.
Hs.733031.

Genome annotation databases

EnsembliENST00000316851; ENSP00000318472; ENSG00000149294. [P13591-2]
ENST00000529356; ENSP00000482205; ENSG00000149294. [P13591-6]
ENST00000531044; ENSP00000484943; ENSG00000149294. [P13591-1]
ENST00000621128; ENSP00000481083; ENSG00000149294. [P13591-4]
ENST00000621850; ENSP00000480774; ENSG00000149294. [P13591-3]
GeneIDi4684.
KEGGihsa:4684.
UCSCiuc031yfh.2. human. [P13591-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

NCAM entry

Functional Glycomics Gateway - Glycan Binding

N-CAM 140

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16841 mRNA. Translation: CAA34739.1.
U63041 mRNA. Translation: AAB04558.1.
S71824 mRNA. Translation: AAB31836.1.
AK292453 mRNA. Translation: BAF85142.1.
AB209443 mRNA. Translation: BAD92680.1. Different initiation.
BC014205 mRNA. Translation: AAH14205.2.
BC029119 mRNA. Translation: AAH29119.1.
BC047244 mRNA. Translation: AAH47244.1.
S73101 mRNA. Translation: AAB20698.1.
M17410 mRNA. Translation: AAA59913.1.
M17409 mRNA. Translation: AAA59912.1.
M22094 mRNA. Translation: AAA59910.1.
M22092, M22091 Genomic DNA. Translation: AAA59911.1.
CCDSiCCDS73385.1. [P13591-2]
CCDS73386.1. [P13591-3]
CCDS73387.1. [P13591-4]
CCDS73388.1. [P13591-1]
PIRiA31635.
I54773.
S07784. IJHUNG.
RefSeqiNP_000606.3. NM_000615.6. [P13591-1]
NP_001070150.1. NM_001076682.3. [P13591-3]
NP_001229537.1. NM_001242608.1. [P13591-4]
NP_851996.2. NM_181351.4. [P13591-2]
UniGeneiHs.503878.
Hs.711235.
Hs.733031.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E3VX-ray1.95A/B/C510-619[»]
2HAZX-ray1.70A508-608[»]
2VKWX-ray2.30A/B506-702[»]
2VKXX-ray2.70A/B/C/D/E/F506-702[»]
3MTRX-ray1.80A/B414-611[»]
5AEAX-ray1.90A/B20-116[»]
5LKNNMR-A611-702[»]
ProteinModelPortaliP13591.
SMRiP13591.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110764. 30 interactors.
DIPiDIP-59530N.
IntActiP13591. 7 interactors.
MINTiMINT-4103137.
STRINGi9606.ENSP00000318472.

PTM databases

iPTMnetiP13591.
PhosphoSitePlusiP13591.
SwissPalmiP13591.

Polymorphism and mutation databases

BioMutaiNCAM1.
DMDMi205830665.

Proteomic databases

EPDiP13591.
PaxDbiP13591.
PeptideAtlasiP13591.
PRIDEiP13591.

Protocols and materials databases

DNASUi4684.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316851; ENSP00000318472; ENSG00000149294. [P13591-2]
ENST00000529356; ENSP00000482205; ENSG00000149294. [P13591-6]
ENST00000531044; ENSP00000484943; ENSG00000149294. [P13591-1]
ENST00000621128; ENSP00000481083; ENSG00000149294. [P13591-4]
ENST00000621850; ENSP00000480774; ENSG00000149294. [P13591-3]
GeneIDi4684.
KEGGihsa:4684.
UCSCiuc031yfh.2. human. [P13591-2]

Organism-specific databases

CTDi4684.
DisGeNETi4684.
GeneCardsiNCAM1.
HGNCiHGNC:7656. NCAM1.
HPAiCAB000142.
CAB018071.
HPA039835.
MIMi116930. gene.
neXtProtiNX_P13591.
OpenTargetsiENSG00000149294.
PharmGKBiPA31459.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQJI. Eukaryota.
ENOG410XTGB. LUCA.
GeneTreeiENSGT00860000133697.
HOVERGENiHBG052579.
InParanoidiP13591.
KOiK06491.
PhylomeDBiP13591.
TreeFamiTF326195.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149294-MONOMER.
ReactomeiR-HSA-3000178. ECM proteoglycans.
R-HSA-375165. NCAM signaling for neurite out-growth.
R-HSA-419037. NCAM1 interactions.
R-HSA-445144. Signal transduction by L1.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-877300. Interferon gamma signaling.

Miscellaneous databases

ChiTaRSiNCAM1. human.
EvolutionaryTraceiP13591.
GeneWikiiNeural_cell_adhesion_molecule.
GenomeRNAii4684.
PROiP13591.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149294.
ExpressionAtlasiP13591. baseline and differential.
GenevisibleiP13591. HS.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 7 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR033019. Ncam1.
IPR009138. Neural_cell_adh.
[Graphical view]
PANTHERiPTHR10489:SF34. PTHR10489:SF34. 2 hits.
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 3 hits.
[Graphical view]
PRINTSiPR01838. NCAMFAMILY.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNCAM1_HUMAN
AccessioniPrimary (citable) accession number: P13591
Secondary accession number(s): A8K8T8
, P13592, P13593, Q05C58, Q15829, Q16180, Q16209, Q59FL7, Q86X47, Q96CJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 22, 2008
Last modified: November 30, 2016
This is version 183 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.