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P13591

- NCAM1_HUMAN

UniProt

P13591 - NCAM1_HUMAN

Protein

Neural cell adhesion molecule 1

Gene

NCAM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 160 (01 Oct 2014)
      Sequence version 3 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

    GO - Molecular functioni

    1. identical protein binding Source: IntAct

    GO - Biological processi

    1. axon guidance Source: Reactome
    2. cell adhesion Source: ProtInc
    3. cytokine-mediated signaling pathway Source: Reactome
    4. extracellular matrix organization Source: Reactome
    5. interferon-gamma-mediated signaling pathway Source: Reactome

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_163906. ECM proteoglycans.
    REACT_18312. NCAM1 interactions.
    REACT_18334. NCAM signaling for neurite out-growth.
    REACT_22272. Signal transduction by L1.
    REACT_25078. Interferon gamma signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neural cell adhesion molecule 1
    Short name:
    N-CAM-1
    Short name:
    NCAM-1
    Alternative name(s):
    CD_antigen: CD56
    Gene namesi
    Name:NCAM1
    Synonyms:NCAM
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:7656. NCAM1.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. cell surface Source: BHF-UCL
    3. cytoplasm Source: HPA
    4. external side of plasma membrane Source: MGI
    5. extracellular vesicular exosome Source: UniProt
    6. Golgi membrane Source: Reactome
    7. integral component of membrane Source: ProtInc
    8. membrane Source: UniProtKB
    9. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31459.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919By similarityAdd
    BLAST
    Chaini20 – 858839Neural cell adhesion molecule 1PRO_0000015009Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi41 ↔ 96Curated
    Disulfide bondi139 ↔ 189Curated
    Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi235 ↔ 287Curated
    Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi329 ↔ 395Curated
    Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi436 ↔ 489Curated
    Glycosylationi459 – 4591N-linked (GlcNAc...)1 Publication
    Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence Analysis
    Modified residuei784 – 7841PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP13591.
    PaxDbiP13591.
    PRIDEiP13591.

    PTM databases

    PhosphoSiteiP13591.

    Expressioni

    Gene expression databases

    ArrayExpressiP13591.
    BgeeiP13591.
    GenevestigatoriP13591.

    Organism-specific databases

    HPAiCAB000142.
    CAB018071.
    HPA039835.

    Interactioni

    Protein-protein interaction databases

    BioGridi110764. 12 interactions.
    DIPiDIP-59530N.
    IntActiP13591. 7 interactions.
    MINTiMINT-4103137.

    Structurei

    Secondary structure

    1
    858
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi414 – 4196
    Beta strandi422 – 4265
    Beta strandi432 – 44211
    Beta strandi445 – 4506
    Beta strandi453 – 4564
    Beta strandi458 – 4603
    Beta strandi462 – 4687
    Beta strandi471 – 4766
    Helixi481 – 4833
    Beta strandi485 – 4928
    Beta strandi497 – 50610
    Beta strandi514 – 5207
    Beta strandi525 – 5306
    Beta strandi542 – 5498
    Beta strandi556 – 5616
    Helixi562 – 5687
    Beta strandi569 – 5735
    Beta strandi581 – 59010
    Beta strandi601 – 6044
    Beta strandi616 – 6216
    Beta strandi628 – 6336
    Beta strandi644 – 6518
    Beta strandi660 – 6623
    Beta strandi668 – 6714
    Beta strandi679 – 68810
    Beta strandi696 – 7016

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2E3VX-ray1.95A/B/C510-619[»]
    2HAZX-ray1.70A508-608[»]
    2VKWX-ray2.30A/B506-702[»]
    2VKXX-ray2.70A/B/C/D/E/F506-702[»]
    3MTRX-ray1.80A/B414-611[»]
    ProteinModelPortaliP13591.
    SMRiP13591. Positions 20-706.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP13591.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 718699ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini740 – 858119CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei719 – 73921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 11192Ig-like C2-type 1Add
    BLAST
    Domaini116 – 20590Ig-like C2-type 2Add
    BLAST
    Domaini212 – 30190Ig-like C2-type 3Add
    BLAST
    Domaini308 – 413106Ig-like C2-type 4Add
    BLAST
    Domaini416 – 50186Ig-like C2-type 5Add
    BLAST
    Domaini509 – 608100Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini611 – 70696Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG308439.
    HOVERGENiHBG052579.
    InParanoidiP13591.
    KOiK06491.
    PhylomeDBiP13591.
    TreeFamiTF326195.

    Family and domain databases

    Gene3Di2.60.40.10. 7 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR009138. Neural_cell_adh.
    [Graphical view]
    PfamiPF00041. fn3. 2 hits.
    PF07679. I-set. 5 hits.
    [Graphical view]
    PRINTSiPR01838. NCAMFAMILY.
    SMARTiSM00060. FN3. 2 hits.
    SM00408. IGc2. 5 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    PROSITEiPS50853. FN3. 2 hits.
    PS50835. IG_LIKE. 5 hits.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P13591-2) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLQTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK    50
    DISWFSPNGE KLTPNQQRIS VVWNDDSSST LTIYNANIDD AGIYKCVVTG 100
    EDGSESEATV NVKIFQKLMF KNAPTPQEFR EGEDAVIVCD VVSSLPPTII 150
    WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK KTDEGTYRCE GRILARGEIN 200
    FKDIQVIVNV PPTIQARQNI VNATANLGQS VTLVCDAEGF PEPTMSWTKD 250
    GEQIEQEEDD EKYIFSDDSS QLTIKKVDKN DEAEYICIAE NKAGEQDATI 300
    HLKVFAKPKI TYVENQTAME LEEQVTLTCE ASGDPIPSIT WRTSTRNISS 350
    EEKASWTRPE KQETLDGHMV VRSHARVSSL TLKSIQYTDA GEYICTASNT 400
    IGQDSQSMYL EVQYAPKLQG PVAVYTWEGN QVNITCEVFA YPSATISWFR 450
    DGQLLPSSNY SNIKIYNTPS ASYLEVTPDS ENDFGNYNCT AVNRIGQESL 500
    EFILVQADTP SSPSIDQVEP YSSTAQVQFD EPEATGGVPI LKYKAEWRAV 550
    GEEVWHSKWY DAKEASMEGI VTIVGLKPET TYAVRLAALN GKGLGEISAA 600
    SEFKTQPVQG EPSAPKLEGQ MGEDGNSIKV NLIKQDDGGS PIRHYLVRYR 650
    ALSSEWKPEI RLPSGSDHVM LKSLDWNAEY EVYVVAENQQ GKSKAAHFVF 700
    RTSAQPTAIP ANGSPTSGLS TGAIVGILIV IFVLLLVVVD ITCYFLNKCG 750
    LFMCIAVNLC GKAGPGAKGK DMEEGKAAFS KDESKEPIVE VRTEEERTPN 800
    HDGGKHTEPN ETTPLTEPEK GPVEAKPECQ ETETKPAPAE VKTVPNDATQ 850
    TKENESKA 858
    Length:858
    Mass (Da):94,574
    Last modified:July 22, 2008 - v3
    Checksum:iFD3B9DE80D802554
    GO
    Isoform 2 (identifier: P13591-1) [UniParc]FASTAAdd to Basket

    Also known as: N-CAM 140

    The sequence of this isoform differs from the canonical sequence as follows:
         354-363: Missing.

    Show »
    Length:848
    Mass (Da):93,361
    Checksum:i68D2F0C0E6C1C2AD
    GO
    Isoform 3 (identifier: P13591-3) [UniParc] [UniParc]FASTAAdd to Basket

    Also known as: N-CAM 120

    The sequence of this isoform differs from the canonical sequence as follows:
         354-363: Missing.
         609-609: Q → HSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAK
         712-736: NGSPTSGLSTGAIVGILIVIFVLLL → TLGGNSASYTFVSLLFSAVTLLLLC
         737-858: Missing.

    Note: GPI-anchor amidated asparagine on Asn-741.

    Show »
    Length:761
    Mass (Da):83,770
    Checksum:iF0CAD3292D7AB67E
    GO
    Isoform 4 (identifier: P13591-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         354-363: Missing.
         712-736: NGSPTSGLSTGAIVGILIVIFVLLL → TLGGNSASYTFVSLLFSAVTLLLLC
         737-858: Missing.

    Note: GPI-anchor amidated asparagine on Asn-706.

    Show »
    Length:726
    Mass (Da):80,312
    Checksum:i1B6D55D0BF65200F
    GO
    Isoform 5 (identifier: P13591-5) [UniParc] [UniParc]FASTAAdd to Basket

    Also known as: C

    The sequence of this isoform differs from the canonical sequence as follows:
         609-665: QGEPSAPKLE...WKPEIRLPSG → HSPPPPASAS...QAGLHNALMK
         666-858: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:665
    Mass (Da):73,473
    Checksum:iE496F232C162C614
    GO
    Isoform 6 (identifier: P13591-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         364-364: T → V
         365-858: Missing.

    Show »
    Length:364
    Mass (Da):40,760
    Checksum:iAC697008755FE6FD
    GO

    Sequence cautioni

    The sequence BAD92680.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti215 – 2151Q → R in AAB04558. (PubMed:1710251)Curated
    Sequence conflicti239 – 2391G → R in AAB04558. (PubMed:1710251)Curated
    Sequence conflicti500 – 5001L → F in AAB04558. (PubMed:1710251)Curated
    Sequence conflicti560 – 5601Y → H in BAF85142. (PubMed:14702039)Curated
    Sequence conflicti609 – 6102QG → R in AAA59913. (PubMed:2887295)Curated
    Sequence conflicti730 – 7312Missing in AAA59913. (PubMed:2887295)Curated
    Sequence conflicti821 – 8211G → A in AAA59913. (PubMed:2887295)Curated
    Sequence conflicti856 – 8561S → N in AAH47244. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti7 – 71L → F.
    Corresponds to variant rs7105734 [ dbSNP | Ensembl ].
    VAR_061331
    Natural varianti260 – 2601D → N.
    Corresponds to variant rs17115160 [ dbSNP | Ensembl ].
    VAR_049960
    Natural varianti679 – 6791E → D.1 Publication
    Corresponds to variant rs17115280 [ dbSNP | Ensembl ].
    VAR_049961
    Natural varianti834 – 8341T → M.
    Corresponds to variant rs17174409 [ dbSNP | Ensembl ].
    VAR_049962

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei354 – 36310Missing in isoform 2, isoform 3 and isoform 4. 5 PublicationsVSP_034818
    Alternative sequencei364 – 3641T → V in isoform 6. 1 PublicationVSP_034819
    Alternative sequencei365 – 858494Missing in isoform 6. 1 PublicationVSP_034820Add
    BLAST
    Alternative sequencei609 – 66557QGEPS…RLPSG → HSPPPPASASSSTPVPLSPP DTTWPLPALATTEPAKNIAQ NHCCNMFQAGLHNALMK in isoform 5. 1 PublicationVSP_034821Add
    BLAST
    Alternative sequencei609 – 6091Q → HSPPPPASASSSTPVPLSPP DTTWPLPALATTEPAK in isoform 3. 2 PublicationsVSP_034822
    Alternative sequencei666 – 858193Missing in isoform 5. 1 PublicationVSP_034823Add
    BLAST
    Alternative sequencei712 – 73625NGSPT…FVLLL → TLGGNSASYTFVSLLFSAVT LLLLC in isoform 3 and isoform 4. 3 PublicationsVSP_034824Add
    BLAST
    Alternative sequencei737 – 858122Missing in isoform 3 and isoform 4. 3 PublicationsVSP_034825Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16841 mRNA. Translation: CAA34739.1.
    U63041 mRNA. Translation: AAB04558.1.
    S71824 mRNA. Translation: AAB31836.1.
    AK292453 mRNA. Translation: BAF85142.1.
    AB209443 mRNA. Translation: BAD92680.1. Different initiation.
    BC014205 mRNA. Translation: AAH14205.2.
    BC029119 mRNA. Translation: AAH29119.1.
    BC047244 mRNA. Translation: AAH47244.1.
    S73101 mRNA. Translation: AAB20698.1.
    M17410 mRNA. Translation: AAA59913.1.
    M17409 mRNA. Translation: AAA59912.1.
    M22094 mRNA. Translation: AAA59910.1.
    M22092, M22091 Genomic DNA. Translation: AAA59911.1.
    PIRiA31635.
    I54773.
    S07784. IJHUNG.
    RefSeqiNP_000606.3. NM_000615.6. [P13591-1]
    NP_001070150.1. NM_001076682.3. [P13591-3]
    NP_001229537.1. NM_001242608.1. [P13591-4]
    NP_851996.2. NM_181351.4. [P13591-2]
    UniGeneiHs.503878.
    Hs.711235.
    Hs.733031.

    Genome annotation databases

    EnsembliENST00000531817; ENSP00000475074; ENSG00000149294.
    GeneIDi4684.
    KEGGihsa:4684.
    UCSCiuc001pno.3. human. [P13591-6]
    uc001pnp.3. human. [P13591-3]
    uc001pnq.3. human. [P13591-2]
    uc001pnr.3. human. [P13591-1]
    uc021qqo.1. human. [P13591-4]

    Polymorphism databases

    DMDMi205830665.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    NCAM entry

    Functional Glycomics Gateway - Glycan Binding

    N-CAM 140

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16841 mRNA. Translation: CAA34739.1 .
    U63041 mRNA. Translation: AAB04558.1 .
    S71824 mRNA. Translation: AAB31836.1 .
    AK292453 mRNA. Translation: BAF85142.1 .
    AB209443 mRNA. Translation: BAD92680.1 . Different initiation.
    BC014205 mRNA. Translation: AAH14205.2 .
    BC029119 mRNA. Translation: AAH29119.1 .
    BC047244 mRNA. Translation: AAH47244.1 .
    S73101 mRNA. Translation: AAB20698.1 .
    M17410 mRNA. Translation: AAA59913.1 .
    M17409 mRNA. Translation: AAA59912.1 .
    M22094 mRNA. Translation: AAA59910.1 .
    M22092 , M22091 Genomic DNA. Translation: AAA59911.1 .
    PIRi A31635.
    I54773.
    S07784. IJHUNG.
    RefSeqi NP_000606.3. NM_000615.6. [P13591-1 ]
    NP_001070150.1. NM_001076682.3. [P13591-3 ]
    NP_001229537.1. NM_001242608.1. [P13591-4 ]
    NP_851996.2. NM_181351.4. [P13591-2 ]
    UniGenei Hs.503878.
    Hs.711235.
    Hs.733031.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2E3V X-ray 1.95 A/B/C 510-619 [» ]
    2HAZ X-ray 1.70 A 508-608 [» ]
    2VKW X-ray 2.30 A/B 506-702 [» ]
    2VKX X-ray 2.70 A/B/C/D/E/F 506-702 [» ]
    3MTR X-ray 1.80 A/B 414-611 [» ]
    ProteinModelPortali P13591.
    SMRi P13591. Positions 20-706.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110764. 12 interactions.
    DIPi DIP-59530N.
    IntActi P13591. 7 interactions.
    MINTi MINT-4103137.

    PTM databases

    PhosphoSitei P13591.

    Polymorphism databases

    DMDMi 205830665.

    Proteomic databases

    MaxQBi P13591.
    PaxDbi P13591.
    PRIDEi P13591.

    Protocols and materials databases

    DNASUi 4684.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000531817 ; ENSP00000475074 ; ENSG00000149294 .
    GeneIDi 4684.
    KEGGi hsa:4684.
    UCSCi uc001pno.3. human. [P13591-6 ]
    uc001pnp.3. human. [P13591-3 ]
    uc001pnq.3. human. [P13591-2 ]
    uc001pnr.3. human. [P13591-1 ]
    uc021qqo.1. human. [P13591-4 ]

    Organism-specific databases

    CTDi 4684.
    GeneCardsi GC11P112831.
    HGNCi HGNC:7656. NCAM1.
    HPAi CAB000142.
    CAB018071.
    HPA039835.
    MIMi 116930. gene.
    neXtProti NX_P13591.
    PharmGKBi PA31459.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG308439.
    HOVERGENi HBG052579.
    InParanoidi P13591.
    KOi K06491.
    PhylomeDBi P13591.
    TreeFami TF326195.

    Enzyme and pathway databases

    Reactomei REACT_163906. ECM proteoglycans.
    REACT_18312. NCAM1 interactions.
    REACT_18334. NCAM signaling for neurite out-growth.
    REACT_22272. Signal transduction by L1.
    REACT_25078. Interferon gamma signaling.

    Miscellaneous databases

    ChiTaRSi NCAM1. human.
    EvolutionaryTracei P13591.
    GeneWikii Neural_cell_adhesion_molecule.
    GenomeRNAii 4684.
    NextBioi 18060.
    PROi P13591.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P13591.
    Bgeei P13591.
    Genevestigatori P13591.

    Family and domain databases

    Gene3Di 2.60.40.10. 7 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR009138. Neural_cell_adh.
    [Graphical view ]
    Pfami PF00041. fn3. 2 hits.
    PF07679. I-set. 5 hits.
    [Graphical view ]
    PRINTSi PR01838. NCAMFAMILY.
    SMARTi SM00060. FN3. 2 hits.
    SM00408. IGc2. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    PROSITEi PS50853. FN3. 2 hits.
    PS50835. IG_LIKE. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence and in vitro expression of a tissue-specific phosphatidylinositol-linked N-CAM isoform from skeletal muscle."
      Barton C.H., Dickson G., Gower H.J., Rowett L.H., Putt W., Elsom V., Moore S.E., Goridis C., Walsh F.S.
      Development 104:165-173(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
      Tissue: Skeletal muscle.
    2. "Molecular and functional analysis of human natural killer cell-associated neural cell adhesion molecule (N-CAM/CD56)."
      Lanier L.L., Chang C., Azuma M., Ruitenberg J.J., Hemperly J.J., Phillips J.H.
      J. Immunol. 146:4421-4426(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Complementary DNA sequence encoding the major neural cell adhesion molecule isoform in a human small cell lung cancer cell line."
      Saito S., Tanio Y., Tachibana I., Hayashi S., Kishimoto T., Kawase I.
      Lung Cancer 10:307-318(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    5. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Brain.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6), VARIANT ASP-679.
      Tissue: Brain, Kidney and Ovary.
    7. "Splicing of the VASE exon of neural cell adhesion molecule (NCAM) in human small-cell lung carcinoma (SCLC)."
      van Duijnhoven H.L., Helfrich W., de Leij L., Roebroek A.J., van de Ven W.J., Healey K., Culverwell A., Rossell R.J., Kemshead J.T., Patel K.
      Int. J. Cancer 50:118-123(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 347-369.
    8. "Human muscle neural cell adhesion molecule (N-CAM): identification of a muscle-specific sequence in the extracellular domain."
      Dickson G., Gower H.J., Barton C.H., Prentice H.M., Elsom V.L., Moore S.E., Cox R.D., Quinn C., Putt W., Walsh F.S.
      Cell 50:1119-1130(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 501-858 (ISOFORMS 1/2 AND 3).
      Tissue: Skeletal muscle.
    9. "Alternative splicing generates a secreted form of N-CAM in muscle and brain."
      Gower H.J., Barton C.H., Elsom V.L., Thompson J., Moore S.E., Dickson G., Walsh F.S.
      Cell 55:955-964(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 501-858 (ISOFORM 5).
    10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-459.
      Tissue: Plasma.

    Entry informationi

    Entry nameiNCAM1_HUMAN
    AccessioniPrimary (citable) accession number: P13591
    Secondary accession number(s): A8K8T8
    , P13592, P13593, Q05C58, Q15829, Q16180, Q16209, Q59FL7, Q86X47, Q96CJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 160 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3