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P13588 (COX2_EMEND) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:cox2
Synonyms:oxiB
Encoded onMitochondrion
OrganismEmericella nidulans (Aspergillus nidulans)
Taxonomic identifier162425 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length252 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 252252Cytochrome c oxidase subunit 2
PRO_0000183592

Regions

Topological domain1 – 3939Mitochondrial intermembrane Potential
Transmembrane40 – 5920Helical; Potential
Topological domain60 – 8122Mitochondrial matrix Potential
Transmembrane82 – 10524Helical; Potential
Topological domain106 – 252147Mitochondrial intermembrane Potential

Sites

Metal binding1841Copper A Probable
Metal binding2191Copper A Probable
Metal binding2231Copper A Probable
Metal binding2271Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P13588 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: 57F98767F8BDC24C

FASTA25228,931
        10         20         30         40         50         60 
MFLIMLKGHI LMDAPTPWGI FFQDSASPQM EGIMELHNNI MFYLAIILFT VTWMMITIIR 

        70         80         90        100        110        120 
NFVAKKSPIA HKYMNHGTLI ELIWTITPAF ILILIAFPSF KLLYLMDEVM DPSLVVYAEG 

       130        140        150        160        170        180 
HQWYWSYQYP DFTNEDNEFI EFDSYIVPES DLEEGQFRML EVDNRVIIPE LTHTAFVISA 

       190        200        210        220        230        240 
DVIHSYACPS LGIKADAYPG RLNQASVYIN GPGTFFGQCS EICGILHSSM NIAIQSVSIK 

       250 
DFLLWLRDQM EG 

« Hide

References

[1]"Processing of mitochondrial RNA in Aspergillus nidulans."
Dyson N.J., Brown T.A., Ray J.A., Waring R.B., Scazzocchio C., Davies R.W.
J. Mol. Biol. 208:587-599(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: yA2 pyroA4 cnxC3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X15441 Genomic DNA. Translation: CAA33481.1.
PIRS05629.

3D structure databases

ProteinModelPortalP13588.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_EMEND
AccessionPrimary (citable) accession number: P13588
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families