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P13588

- COX2_EMEND

UniProt

P13588 - COX2_EMEND

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Protein
Cytochrome c oxidase subunit 2
Gene
cox2, oxiB
Organism
Emericella nidulans (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi184 – 1841Copper A Inferred
Metal bindingi219 – 2191Copper A Inferred
Metal bindingi223 – 2231Copper A Inferred
Metal bindingi227 – 2271Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:cox2
Synonyms:oxiB
Encoded oniMitochondrion
OrganismiEmericella nidulans (Aspergillus nidulans)
Taxonomic identifieri162425 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei40 – 5920Helical; Reviewed prediction
Add
BLAST
Topological domaini60 – 8122Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei82 – 10524Helical; Reviewed prediction
Add
BLAST
Topological domaini106 – 252147Mitochondrial intermembrane Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Cytochrome c oxidase subunit 2
PRO_0000183592Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP13588.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13588-1 [UniParc]FASTAAdd to Basket

« Hide

MFLIMLKGHI LMDAPTPWGI FFQDSASPQM EGIMELHNNI MFYLAIILFT    50
VTWMMITIIR NFVAKKSPIA HKYMNHGTLI ELIWTITPAF ILILIAFPSF 100
KLLYLMDEVM DPSLVVYAEG HQWYWSYQYP DFTNEDNEFI EFDSYIVPES 150
DLEEGQFRML EVDNRVIIPE LTHTAFVISA DVIHSYACPS LGIKADAYPG 200
RLNQASVYIN GPGTFFGQCS EICGILHSSM NIAIQSVSIK DFLLWLRDQM 250
EG 252
Length:252
Mass (Da):28,931
Last modified:November 1, 1995 - v2
Checksum:i57F98767F8BDC24C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15441 Genomic DNA. Translation: CAA33481.1.
PIRiS05629.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15441 Genomic DNA. Translation: CAA33481.1 .
PIRi S05629.

3D structure databases

ProteinModelPortali P13588.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: yA2 pyroA4 cnxC3.

Entry informationi

Entry nameiCOX2_EMEND
AccessioniPrimary (citable) accession number: P13588
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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