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Protein

Cytochrome c oxidase subunit 2

Gene

cox2

Organism
Emericella nidulans (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi184Copper ACurated1
Metal bindingi219Copper ACurated1
Metal bindingi223Copper ACurated1
Metal bindingi227Copper ACurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:cox2
Synonyms:oxiB
Encoded oniMitochondrion
OrganismiEmericella nidulans (Aspergillus nidulans)
Taxonomic identifieri162425 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39Mitochondrial intermembraneSequence analysisAdd BLAST39
Transmembranei40 – 59HelicalSequence analysisAdd BLAST20
Topological domaini60 – 81Mitochondrial matrixSequence analysisAdd BLAST22
Transmembranei82 – 105HelicalSequence analysisAdd BLAST24
Topological domaini106 – 252Mitochondrial intermembraneSequence analysisAdd BLAST147

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001835921 – 252Cytochrome c oxidase subunit 2Add BLAST252

Structurei

3D structure databases

ProteinModelPortaliP13588.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd13912. CcO_II_C. 1 hit.
Gene3Di2.60.40.420. 1 hit.
InterProiView protein in InterPro
IPR002429. CcO_II-like_C.
IPR034210. CcO_II_C.
IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
PfamiView protein in Pfam
PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiView protein in PROSITE
PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.

Sequencei

Sequence statusi: Complete.

P13588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLIMLKGHI LMDAPTPWGI FFQDSASPQM EGIMELHNNI MFYLAIILFT
60 70 80 90 100
VTWMMITIIR NFVAKKSPIA HKYMNHGTLI ELIWTITPAF ILILIAFPSF
110 120 130 140 150
KLLYLMDEVM DPSLVVYAEG HQWYWSYQYP DFTNEDNEFI EFDSYIVPES
160 170 180 190 200
DLEEGQFRML EVDNRVIIPE LTHTAFVISA DVIHSYACPS LGIKADAYPG
210 220 230 240 250
RLNQASVYIN GPGTFFGQCS EICGILHSSM NIAIQSVSIK DFLLWLRDQM

EG
Length:252
Mass (Da):28,931
Last modified:November 1, 1995 - v2
Checksum:i57F98767F8BDC24C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15441 Genomic DNA. Translation: CAA33481.1.
PIRiS05629.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCOX2_EMEND
AccessioniPrimary (citable) accession number: P13588
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 1, 1995
Last modified: May 10, 2017
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families