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P13586

- ATC1_YEAST

UniProt

P13586 - ATC1_YEAST

Protein

Calcium-transporting ATPase 1

Gene

PMR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 152 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Has a role in the secretory pathway.

    Catalytic activityi

    ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei371 – 37114-aspartylphosphate intermediateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calcium ion binding Source: SGD
    3. calcium-transporting ATPase activity Source: SGD
    4. manganese-transporting ATPase activity Source: SGD

    GO - Biological processi

    1. calcium ion transmembrane transport Source: GOC
    2. calcium ion transport Source: SGD
    3. cellular calcium ion homeostasis Source: UniProtKB
    4. exocytosis Source: SGD
    5. manganese ion transmembrane transport Source: GOC
    6. manganese ion transport Source: SGD

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    ATP-binding, Calcium, Magnesium, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30655-MONOMER.
    ReactomeiREACT_96459. Ion transport by P-type ATPases.

    Protein family/group databases

    TCDBi3.A.3.2.3. the p-type atpase (p-atpase) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-transporting ATPase 1 (EC:3.6.3.8)
    Alternative name(s):
    Bypass SOD defects protein 1
    Golgi Ca(2+)-ATPase
    Gene namesi
    Name:PMR1
    Synonyms:BSD1, SCC1
    Ordered Locus Names:YGL167C
    ORF Names:G1666
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGL167c.
    SGDiS000003135. PMR1.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB
    2. Golgi membrane Source: SGD
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 950949Calcium-transporting ATPase 1PRO_0000046231Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei227 – 2271Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP13586.
    PaxDbiP13586.
    PeptideAtlasiP13586.

    Expressioni

    Gene expression databases

    GenevestigatoriP13586.

    Interactioni

    Protein-protein interaction databases

    BioGridi33087. 517 interactions.
    DIPiDIP-7899N.
    IntActiP13586. 16 interactions.
    MINTiMINT-2781235.
    STRINGi4932.YGL167C.

    Structurei

    3D structure databases

    ProteinModelPortaliP13586.
    SMRiP13586. Positions 31-937.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 9291CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini112 – 1165LumenalSequence Analysis
    Topological domaini134 – 288155CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini310 – 32314LumenalSequence AnalysisAdd
    BLAST
    Topological domaini345 – 814470CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini836 – 8449LumenalSequence Analysis
    Topological domaini863 – 88422CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini906 – 9094LumenalSequence Analysis
    Topological domaini931 – 95020CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei93 – 11119HelicalSequence AnalysisAdd
    BLAST
    Transmembranei117 – 13317HelicalSequence AnalysisAdd
    BLAST
    Transmembranei289 – 30921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei324 – 34421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei815 – 83521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei845 – 86218HelicalSequence AnalysisAdd
    BLAST
    Transmembranei885 – 90521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei910 – 93021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0474.
    GeneTreeiENSGT00560000076887.
    HOGENOMiHOG000265621.
    KOiK01537.
    OMAiIIQGRSW.
    OrthoDBiEOG7BS4JT.

    Family and domain databases

    Gene3Di1.20.1110.10. 3 hits.
    InterProiIPR006413. ATPase_P-typ_Ca-transp_PMR1.
    IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    PR00120. HATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P13586-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDNPFNASL LDEDSNRERE ILDATAEALS KPSPSLEYCT LSVDEALEKL    50
    DTDKNGGLRS SNEANNRRSL YGPNEITVED DESLFKKFLS NFIEDRMILL 100
    LIGSAVVSLF MGNIDDAVSI TLAIFIVVTV GFVQEYRSEK SLEALNKLVP 150
    AECHLMRCGQ ESHVLASTLV PGDLVHFRIG DRIPADIRII EAIDLSIDES 200
    NLTGENEPVH KTSQTIEKSS FNDQPNSIVP ISERSCIAYM GTLVKEGHGK 250
    GIVVGTGTNT SFGAVFEMMN NIEKPKTPLQ LTMDKLGKDL SLVSFIVIGM 300
    ICLVGIIQGR SWLEMFQISV SLAVAAIPEG LPIIVTVTLA LGVLRMAKRK 350
    AIVRRLPSVE TLGSVNVICS DKTGTLTSNH MTVSKLWCLD SMSNKLNVLS 400
    LDKNKKTKNS NGNLKNYLTE DVRETLTIGN LCNNASFSQE HAIFLGNPTD 450
    VALLEQLANF EMPDIRNTVQ KVQELPFNSK RKLMATKILN PVDNKCTVYV 500
    KGAFERILEY STSYLKSKGK KTEKLTEAQK ATINECANSM ASEGLRVFGF 550
    AKLTLSDSST PLTEDLIKDL TFTGLIGMND PPRPNVKFAI EQLLQGGVHI 600
    IMITGDSENT AVNIAKQIGI PVIDPKLSVL SGDKLDEMSD DQLANVIDHV 650
    NIFARATPEH KLNIVRALRK RGDVVAMTGD GVNDAPALKL SDIGVSMGRI 700
    GTDVAKEASD MVLTDDDFST ILTAIEEGKG IFNNIQNFLT FQLSTSVAAL 750
    SLVALSTAFK LPNPLNAMQI LWINILMDGP PAQSLGVEPV DHEVMKKPPR 800
    KRTDKILTHD VMKRLLTTAA CIIVGTVYIF VKEMAEDGKV TARDTTMTFT 850
    CFVFFDMFNA LACRHNTKSI FEIGFFTNKM FNYAVGLSLL GQMCAIYIPF 900
    FQSIFKTEKL GISDILLLLL ISSSVFIVDE LRKLWTRKKN EEDSTYFSNV 950
    Length:950
    Mass (Da):104,571
    Last modified:January 1, 1990 - v1
    Checksum:i0A88271FBD6870B8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25488 Genomic DNA. Translation: AAA34884.1.
    X85757 Genomic DNA. Translation: CAA59762.1.
    Z72690 Genomic DNA. Translation: CAA96880.1.
    X64319 Genomic DNA. Translation: CAA45599.1.
    BK006941 Genomic DNA. Translation: DAA07946.1.
    PIRiA30990. PWBYR1.
    RefSeqiNP_011348.1. NM_001181032.1.

    Genome annotation databases

    EnsemblFungiiYGL167C; YGL167C; YGL167C.
    GeneIDi852709.
    KEGGisce:YGL167C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25488 Genomic DNA. Translation: AAA34884.1 .
    X85757 Genomic DNA. Translation: CAA59762.1 .
    Z72690 Genomic DNA. Translation: CAA96880.1 .
    X64319 Genomic DNA. Translation: CAA45599.1 .
    BK006941 Genomic DNA. Translation: DAA07946.1 .
    PIRi A30990. PWBYR1.
    RefSeqi NP_011348.1. NM_001181032.1.

    3D structure databases

    ProteinModelPortali P13586.
    SMRi P13586. Positions 31-937.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33087. 517 interactions.
    DIPi DIP-7899N.
    IntActi P13586. 16 interactions.
    MINTi MINT-2781235.
    STRINGi 4932.YGL167C.

    Protein family/group databases

    TCDBi 3.A.3.2.3. the p-type atpase (p-atpase) superfamily.

    Proteomic databases

    MaxQBi P13586.
    PaxDbi P13586.
    PeptideAtlasi P13586.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGL167C ; YGL167C ; YGL167C .
    GeneIDi 852709.
    KEGGi sce:YGL167C.

    Organism-specific databases

    CYGDi YGL167c.
    SGDi S000003135. PMR1.

    Phylogenomic databases

    eggNOGi COG0474.
    GeneTreei ENSGT00560000076887.
    HOGENOMi HOG000265621.
    KOi K01537.
    OMAi IIQGRSW.
    OrthoDBi EOG7BS4JT.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30655-MONOMER.
    Reactomei REACT_96459. Ion transport by P-type ATPases.

    Miscellaneous databases

    NextBioi 972070.

    Gene expression databases

    Genevestigatori P13586.

    Family and domain databases

    Gene3Di 1.20.1110.10. 3 hits.
    InterProi IPR006413. ATPase_P-typ_Ca-transp_PMR1.
    IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    PR00120. HATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01522. ATPase-IIA2_Ca. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The yeast secretory pathway is perturbed by mutations in PMR1, a member of a Ca2+ ATPase family."
      Rudolph H.K., Antebi A., Fink G.R., Buckley C.M., Dorman T.E., Levitre J., Davidow L.S., Mao J.-I., Moir D.T.
      Cell 58:133-145(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "A putative helicase, the SUA5, PMR1, tRNALys1 genes and four open reading frames have been detected in the DNA sequence of an 8.8 kb fragment of the left arm of chromosome VII of Saccharomyces cerevisiae."
      Klima R., Coglievina M., Zaccaria P., Bertani I., Bruschi C.V.
      Yeast 12:1033-1040(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "Isolation and characterization of SUA5, a novel gene required for normal growth in Saccharomyces cerevisiae."
      Na J.G., Pinto I., Hampsey M.
      Genetics 131:791-801(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 863-950.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiATC1_YEAST
    AccessioniPrimary (citable) accession number: P13586
    Secondary accession number(s): D6VTY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 152 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 6900 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3