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Protein

Calcium-transporting ATPase 1

Gene

PMR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Has a role in the secretory pathway.

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3714-aspartylphosphate intermediateBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calcium ion binding Source: SGD
  • calcium-transporting ATPase activity Source: SGD
  • manganese-transporting ATPase activity Source: SGD

GO - Biological processi

  • calcium ion transport Source: SGD
  • cellular calcium ion homeostasis Source: UniProtKB
  • exocytosis Source: SGD
  • macroautophagy Source: SGD
  • manganese ion transport Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30655-MONOMER.
ReactomeiR-SCE-418359. Reduction of cytosolic Ca++ levels.
R-SCE-5578775. Ion homeostasis.
R-SCE-936837. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi3.A.3.2.3. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase 1 (EC:3.6.3.8)
Alternative name(s):
Bypass SOD defects protein 1
Golgi Ca(2+)-ATPase
Gene namesi
Name:PMR1
Synonyms:BSD1, SCC1
Ordered Locus Names:YGL167C
ORF Names:G1666
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL167C.
SGDiS000003135. PMR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 92CytoplasmicSequence analysisAdd BLAST91
Transmembranei93 – 111HelicalSequence analysisAdd BLAST19
Topological domaini112 – 116LumenalSequence analysis5
Transmembranei117 – 133HelicalSequence analysisAdd BLAST17
Topological domaini134 – 288CytoplasmicSequence analysisAdd BLAST155
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 323LumenalSequence analysisAdd BLAST14
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
Topological domaini345 – 814CytoplasmicSequence analysisAdd BLAST470
Transmembranei815 – 835HelicalSequence analysisAdd BLAST21
Topological domaini836 – 844LumenalSequence analysis9
Transmembranei845 – 862HelicalSequence analysisAdd BLAST18
Topological domaini863 – 884CytoplasmicSequence analysisAdd BLAST22
Transmembranei885 – 905HelicalSequence analysisAdd BLAST21
Topological domaini906 – 909LumenalSequence analysis4
Transmembranei910 – 930HelicalSequence analysisAdd BLAST21
Topological domaini931 – 950CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: SGD
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000462312 – 950Calcium-transporting ATPase 1Add BLAST949

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei227PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP13586.
PRIDEiP13586.

PTM databases

iPTMnetiP13586.

Interactioni

Protein-protein interaction databases

BioGridi33087. 536 interactors.
DIPiDIP-7899N.
IntActiP13586. 16 interactors.
MINTiMINT-2781235.

Structurei

3D structure databases

ProteinModelPortaliP13586.
SMRiP13586.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00850000132256.
HOGENOMiHOG000265621.
InParanoidiP13586.
KOiK01537.
OMAiERTNIAY.
OrthoDBiEOG092C12IX.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006413. P-type_ATPase_IIA_PMR1.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF217. PTHR24093:SF217. 1 hit.
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13586-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDNPFNASL LDEDSNRERE ILDATAEALS KPSPSLEYCT LSVDEALEKL
60 70 80 90 100
DTDKNGGLRS SNEANNRRSL YGPNEITVED DESLFKKFLS NFIEDRMILL
110 120 130 140 150
LIGSAVVSLF MGNIDDAVSI TLAIFIVVTV GFVQEYRSEK SLEALNKLVP
160 170 180 190 200
AECHLMRCGQ ESHVLASTLV PGDLVHFRIG DRIPADIRII EAIDLSIDES
210 220 230 240 250
NLTGENEPVH KTSQTIEKSS FNDQPNSIVP ISERSCIAYM GTLVKEGHGK
260 270 280 290 300
GIVVGTGTNT SFGAVFEMMN NIEKPKTPLQ LTMDKLGKDL SLVSFIVIGM
310 320 330 340 350
ICLVGIIQGR SWLEMFQISV SLAVAAIPEG LPIIVTVTLA LGVLRMAKRK
360 370 380 390 400
AIVRRLPSVE TLGSVNVICS DKTGTLTSNH MTVSKLWCLD SMSNKLNVLS
410 420 430 440 450
LDKNKKTKNS NGNLKNYLTE DVRETLTIGN LCNNASFSQE HAIFLGNPTD
460 470 480 490 500
VALLEQLANF EMPDIRNTVQ KVQELPFNSK RKLMATKILN PVDNKCTVYV
510 520 530 540 550
KGAFERILEY STSYLKSKGK KTEKLTEAQK ATINECANSM ASEGLRVFGF
560 570 580 590 600
AKLTLSDSST PLTEDLIKDL TFTGLIGMND PPRPNVKFAI EQLLQGGVHI
610 620 630 640 650
IMITGDSENT AVNIAKQIGI PVIDPKLSVL SGDKLDEMSD DQLANVIDHV
660 670 680 690 700
NIFARATPEH KLNIVRALRK RGDVVAMTGD GVNDAPALKL SDIGVSMGRI
710 720 730 740 750
GTDVAKEASD MVLTDDDFST ILTAIEEGKG IFNNIQNFLT FQLSTSVAAL
760 770 780 790 800
SLVALSTAFK LPNPLNAMQI LWINILMDGP PAQSLGVEPV DHEVMKKPPR
810 820 830 840 850
KRTDKILTHD VMKRLLTTAA CIIVGTVYIF VKEMAEDGKV TARDTTMTFT
860 870 880 890 900
CFVFFDMFNA LACRHNTKSI FEIGFFTNKM FNYAVGLSLL GQMCAIYIPF
910 920 930 940 950
FQSIFKTEKL GISDILLLLL ISSSVFIVDE LRKLWTRKKN EEDSTYFSNV
Length:950
Mass (Da):104,571
Last modified:January 1, 1990 - v1
Checksum:i0A88271FBD6870B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25488 Genomic DNA. Translation: AAA34884.1.
X85757 Genomic DNA. Translation: CAA59762.1.
Z72690 Genomic DNA. Translation: CAA96880.1.
X64319 Genomic DNA. Translation: CAA45599.1.
BK006941 Genomic DNA. Translation: DAA07946.1.
PIRiA30990. PWBYR1.
RefSeqiNP_011348.1. NM_001181032.1.

Genome annotation databases

EnsemblFungiiYGL167C; YGL167C; YGL167C.
GeneIDi852709.
KEGGisce:YGL167C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25488 Genomic DNA. Translation: AAA34884.1.
X85757 Genomic DNA. Translation: CAA59762.1.
Z72690 Genomic DNA. Translation: CAA96880.1.
X64319 Genomic DNA. Translation: CAA45599.1.
BK006941 Genomic DNA. Translation: DAA07946.1.
PIRiA30990. PWBYR1.
RefSeqiNP_011348.1. NM_001181032.1.

3D structure databases

ProteinModelPortaliP13586.
SMRiP13586.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33087. 536 interactors.
DIPiDIP-7899N.
IntActiP13586. 16 interactors.
MINTiMINT-2781235.

Protein family/group databases

TCDBi3.A.3.2.3. the p-type atpase (p-atpase) superfamily.

PTM databases

iPTMnetiP13586.

Proteomic databases

MaxQBiP13586.
PRIDEiP13586.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL167C; YGL167C; YGL167C.
GeneIDi852709.
KEGGisce:YGL167C.

Organism-specific databases

EuPathDBiFungiDB:YGL167C.
SGDiS000003135. PMR1.

Phylogenomic databases

GeneTreeiENSGT00850000132256.
HOGENOMiHOG000265621.
InParanoidiP13586.
KOiK01537.
OMAiERTNIAY.
OrthoDBiEOG092C12IX.

Enzyme and pathway databases

BioCyciYEAST:G3O-30655-MONOMER.
ReactomeiR-SCE-418359. Reduction of cytosolic Ca++ levels.
R-SCE-5578775. Ion homeostasis.
R-SCE-936837. Ion transport by P-type ATPases.

Miscellaneous databases

PROiP13586.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006413. P-type_ATPase_IIA_PMR1.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF217. PTHR24093:SF217. 1 hit.
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATC1_YEAST
AccessioniPrimary (citable) accession number: P13586
Secondary accession number(s): D6VTY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 2, 2016
This is version 172 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6900 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.