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Protein

Calcium-transporting ATPase 1

Gene

PMR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Has a role in the secretory pathway.

Miscellaneous

Present with 6900 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3714-aspartylphosphate intermediateBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calcium ion binding Source: SGD
  • calcium-transporting ATPase activity Source: SGD
  • manganese-transporting ATPase activity Source: SGD

GO - Biological processi

  • calcium ion transport Source: SGD
  • cellular calcium ion homeostasis Source: UniProtKB
  • cellular manganese ion homeostasis Source: SGD
  • macroautophagy Source: SGD
  • manganese ion transport Source: SGD

Keywordsi

Molecular functionHydrolase
Biological processCalcium transport, Ion transport, Transport
LigandATP-binding, Calcium, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30655-MONOMER
ReactomeiR-SCE-418359 Reduction of cytosolic Ca++ levels
R-SCE-5578775 Ion homeostasis
R-SCE-936837 Ion transport by P-type ATPases

Protein family/group databases

TCDBi3.A.3.2.3 the p-type atpase (p-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase 1 (EC:3.6.3.8)
Alternative name(s):
Bypass SOD defects protein 1
Golgi Ca(2+)-ATPase
Gene namesi
Name:PMR1
Synonyms:BSD1, SCC1
Ordered Locus Names:YGL167C
ORF Names:G1666
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL167C
SGDiS000003135 PMR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 92CytoplasmicSequence analysisAdd BLAST91
Transmembranei93 – 111HelicalSequence analysisAdd BLAST19
Topological domaini112 – 116LumenalSequence analysis5
Transmembranei117 – 133HelicalSequence analysisAdd BLAST17
Topological domaini134 – 288CytoplasmicSequence analysisAdd BLAST155
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 323LumenalSequence analysisAdd BLAST14
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
Topological domaini345 – 814CytoplasmicSequence analysisAdd BLAST470
Transmembranei815 – 835HelicalSequence analysisAdd BLAST21
Topological domaini836 – 844LumenalSequence analysis9
Transmembranei845 – 862HelicalSequence analysisAdd BLAST18
Topological domaini863 – 884CytoplasmicSequence analysisAdd BLAST22
Transmembranei885 – 905HelicalSequence analysisAdd BLAST21
Topological domaini906 – 909LumenalSequence analysis4
Transmembranei910 – 930HelicalSequence analysisAdd BLAST21
Topological domaini931 – 950CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000462312 – 950Calcium-transporting ATPase 1Add BLAST949

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei227PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP13586
PaxDbiP13586
PRIDEiP13586

PTM databases

iPTMnetiP13586

Interactioni

Protein-protein interaction databases

BioGridi33087, 803 interactors
DIPiDIP-7899N
IntActiP13586, 18 interactors
MINTiP13586
STRINGi4932.YGL167C

Structurei

3D structure databases

ProteinModelPortaliP13586
SMRiP13586
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00890000139334
HOGENOMiHOG000265621
InParanoidiP13586
KOiK01537
OMAiCRSESKS
OrthoDBiEOG092C12IX

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006413 P-type_ATPase_IIA_PMR1
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01522 ATPase-IIA2_Ca, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13586-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDNPFNASL LDEDSNRERE ILDATAEALS KPSPSLEYCT LSVDEALEKL
60 70 80 90 100
DTDKNGGLRS SNEANNRRSL YGPNEITVED DESLFKKFLS NFIEDRMILL
110 120 130 140 150
LIGSAVVSLF MGNIDDAVSI TLAIFIVVTV GFVQEYRSEK SLEALNKLVP
160 170 180 190 200
AECHLMRCGQ ESHVLASTLV PGDLVHFRIG DRIPADIRII EAIDLSIDES
210 220 230 240 250
NLTGENEPVH KTSQTIEKSS FNDQPNSIVP ISERSCIAYM GTLVKEGHGK
260 270 280 290 300
GIVVGTGTNT SFGAVFEMMN NIEKPKTPLQ LTMDKLGKDL SLVSFIVIGM
310 320 330 340 350
ICLVGIIQGR SWLEMFQISV SLAVAAIPEG LPIIVTVTLA LGVLRMAKRK
360 370 380 390 400
AIVRRLPSVE TLGSVNVICS DKTGTLTSNH MTVSKLWCLD SMSNKLNVLS
410 420 430 440 450
LDKNKKTKNS NGNLKNYLTE DVRETLTIGN LCNNASFSQE HAIFLGNPTD
460 470 480 490 500
VALLEQLANF EMPDIRNTVQ KVQELPFNSK RKLMATKILN PVDNKCTVYV
510 520 530 540 550
KGAFERILEY STSYLKSKGK KTEKLTEAQK ATINECANSM ASEGLRVFGF
560 570 580 590 600
AKLTLSDSST PLTEDLIKDL TFTGLIGMND PPRPNVKFAI EQLLQGGVHI
610 620 630 640 650
IMITGDSENT AVNIAKQIGI PVIDPKLSVL SGDKLDEMSD DQLANVIDHV
660 670 680 690 700
NIFARATPEH KLNIVRALRK RGDVVAMTGD GVNDAPALKL SDIGVSMGRI
710 720 730 740 750
GTDVAKEASD MVLTDDDFST ILTAIEEGKG IFNNIQNFLT FQLSTSVAAL
760 770 780 790 800
SLVALSTAFK LPNPLNAMQI LWINILMDGP PAQSLGVEPV DHEVMKKPPR
810 820 830 840 850
KRTDKILTHD VMKRLLTTAA CIIVGTVYIF VKEMAEDGKV TARDTTMTFT
860 870 880 890 900
CFVFFDMFNA LACRHNTKSI FEIGFFTNKM FNYAVGLSLL GQMCAIYIPF
910 920 930 940 950
FQSIFKTEKL GISDILLLLL ISSSVFIVDE LRKLWTRKKN EEDSTYFSNV
Length:950
Mass (Da):104,571
Last modified:January 1, 1990 - v1
Checksum:i0A88271FBD6870B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25488 Genomic DNA Translation: AAA34884.1
X85757 Genomic DNA Translation: CAA59762.1
Z72690 Genomic DNA Translation: CAA96880.1
X64319 Genomic DNA Translation: CAA45599.1
BK006941 Genomic DNA Translation: DAA07946.1
PIRiA30990 PWBYR1
RefSeqiNP_011348.1, NM_001181032.1

Genome annotation databases

EnsemblFungiiYGL167C; YGL167C; YGL167C
GeneIDi852709
KEGGisce:YGL167C

Similar proteinsi

Entry informationi

Entry nameiATC1_YEAST
AccessioniPrimary (citable) accession number: P13586
Secondary accession number(s): D6VTY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: June 20, 2018
This is version 188 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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