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P13584 (CP4B1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 139. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 4B1

EC=1.14.14.1
Alternative name(s):
CYPIVB1
Cytochrome P450-HP
Gene names
Name:CYP4B1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length511 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Detected in the liver and lung (at protein level). Ref.4

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P13584-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P13584-2)

The sequence of this isoform differs from the canonical sequence as follows:
     206-206: H → HS

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 511510Cytochrome P450 4B1
PRO_0000051819

Sites

Metal binding4531Iron (heme axial ligand)
Binding site3151Heme (covalent; via 1 link) By similarity

Natural variations

Alternative sequence2061H → HS in isoform 2.
VSP_038419
Natural variant1111A → V. Ref.5
Corresponds to variant rs45559437 [ dbSNP | Ensembl ].
VAR_055377
Natural variant1731R → W in allele CYP4B1*3 and allele CYP4B1*6. Ref.3 Ref.5
Corresponds to variant rs4646487 [ dbSNP | Ensembl ].
VAR_018357
Natural variant2641R → W. Ref.5
Corresponds to variant rs45446505 [ dbSNP | Ensembl ].
VAR_048453
Natural variant2741R → Q. Ref.5
Corresponds to variant rs45578838 [ dbSNP | Ensembl ].
VAR_055378
Natural variant3221S → G in allele CYP4B1*4. Ref.3 Ref.5
Corresponds to variant rs45467195 [ dbSNP | Ensembl ].
VAR_018358
Natural variant3291Y → S. Ref.5
Corresponds to variant rs12094024 [ dbSNP | Ensembl ].
VAR_048454
Natural variant3311M → I in allele CYP4B1*2, allele CYP4B1*7 and allele CYP4B1*5. Ref.3 Ref.5
Corresponds to variant rs2297810 [ dbSNP | Ensembl ].
VAR_018359
Natural variant3401R → C in allele CYP4B1*2 and allele CYP4B1*7. Ref.3 Ref.5
Corresponds to variant rs4646491 [ dbSNP | Ensembl ].
VAR_018360
Natural variant3451V → I in allele CYP4B1*6.
VAR_018361
Natural variant3541F → C. Ref.5
Corresponds to variant rs17102592 [ dbSNP | Ensembl ].
VAR_048455
Natural variant3751R → C in allele CYP4B1*2. Ref.3 Ref.5
Corresponds to variant rs2297809 [ dbSNP | Ensembl ].
VAR_018362
Natural variant4821R → Q. Ref.5
Corresponds to variant rs45622937 [ dbSNP | Ensembl ].
VAR_048456

Experimental info

Sequence conflict371Q → R in AAA35712. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 7, 2004. Version 2.
Checksum: 91FED40949507EB8

FASTA51158,991
        10         20         30         40         50         60 
MVPSFLSLSF SSLGLWASGL ILVLGFLKLI HLLLRRQTLA KAMDKFPGPP THWLFGHALE 

        70         80         90        100        110        120 
IQETGSLDKV VSWAHQFPYA HPLWFGQFIG FLNIYEPDYA KAVYSRGDPK APDVYDFFLQ 

       130        140        150        160        170        180 
WIGRGLLVLE GPKWLQHRKL LTPGFHYDVL KPYVAVFTES TRIMLDKWEE KAREGKSFDI 

       190        200        210        220        230        240 
FCDVGHMALN TLMKCTFGRG DTGLGHRDSS YYLAVSDLTL LMQQRLVSFQ YHNDFIYWLT 

       250        260        270        280        290        300 
PHGRRFLRAC QVAHDHTDQV IRERKAALQD EKVRKKIQNR RHLDFLDILL GARDEDDIKL 

       310        320        330        340        350        360 
SDADLRAEVD TFMFEGHDTT TSGISWFLYC MALYPEHQHR CREEVREILG DQDFFQWDDL 

       370        380        390        400        410        420 
GKMTYLTMCI KESFRLYPPV PQVYRQLSKP VTFVDGRSLP AGSLISMHIY ALHRNSAVWP 

       430        440        450        460        470        480 
DPEVFDSLRF STENASKRHP FAFMPFSAGP RNCIGQQFAM SEMKVVTAMC LLRFEFSLDP 

       490        500        510 
SRLPIKMPQL VLRSKNGFHL HLKPLGPGSG K 

« Hide

Isoform 2 [UniParc].

Checksum: 1C5FB3436D612DD7
Show »

FASTA51259,078

References

« Hide 'large scale' references
[1]"Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping."
Nhamburo P.T., Gonzalez F.J., McBride O.W., Gelboin H.V., Kimura S.
Biochemistry 28:8060-8066(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Lung.
[2]"cDNA cloning of cytochrome P-450 related to P-450p-2 from the cDNA library of human placenta. Gene structure and expression."
Yokotani N., Sogawa K., Matsubara S., Gotoh O., Kusunose E., Kusunose M., Fujii-Kuriyama Y.
Eur. J. Biochem. 187:23-29(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Placenta.
[3]"Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant."
Lo-Guidice J.-M., Allorge D., Cauffiez C., Chevalier D., Lafitte J.-J., Lhermitte M., Broly F.
Pharmacogenetics 12:367-374(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS TRP-173; GLY-322; ILE-331; CYS-340 AND CYS-375.
[4]"Characterization of pulmonary CYP4B2, specific catalyst of methyl oxidation of 3-methylindole."
Carr B.A., Ramakanth S., Dannan G.A., Yost G.S.
Mol. Pharmacol. 63:1137-1147(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
Tissue: Lung.
[5]NIEHS SNPs program
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-111; TRP-173; TRP-264; GLN-274; GLY-322; SER-329; ILE-331; CYS-340; CYS-354; CYS-375 AND GLN-482.
[6]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J02871 mRNA. Translation: AAA35712.1.
X16699 mRNA. Translation: CAA34672.1.
AF491285 mRNA. Translation: AAM09532.1.
AY064485 mRNA. Translation: AAL57720.1.
AY064486 mRNA. Translation: AAL57721.1.
AY151048 mRNA. Translation: AAN72311.1.
DQ518907 Genomic DNA. Translation: ABF47106.1.
AL593856, AL356793 Genomic DNA. Translation: CAI16981.1.
AL593856, AL356793 Genomic DNA. Translation: CAI16982.1.
AL356793, AL593856 Genomic DNA. Translation: CAI22557.1.
AL356793, AL593856 Genomic DNA. Translation: CAI22559.1.
BC017758 mRNA. Translation: AAH17758.1.
CCDSCCDS41328.1. [P13584-2]
CCDS542.1. [P13584-1]
PIRO4HUB1. S07765.
RefSeqNP_000770.2. NM_000779.3. [P13584-1]
NP_001093242.1. NM_001099772.1. [P13584-2]
UniGeneHs.436317.

3D structure databases

ProteinModelPortalP13584.
SMRP13584. Positions 46-506.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000360991.

PTM databases

PhosphoSiteP13584.

Polymorphism databases

DMDM48429213.

Proteomic databases

PaxDbP13584.
PRIDEP13584.

Protocols and materials databases

DNASU1580.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000271153; ENSP00000271153; ENSG00000142973. [P13584-1]
ENST00000371923; ENSP00000360991; ENSG00000142973. [P13584-2]
GeneID1580.
KEGGhsa:1580.
UCSCuc001cqm.4. human. [P13584-1]
uc001cqn.4. human. [P13584-2]

Organism-specific databases

CTD1580.
GeneCardsGC01P047264.
HGNCHGNC:2644. CYP4B1.
HPAHPA004331.
MIM124075. gene.
neXtProtNX_P13584.
PharmGKBPA27119.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000233833.
HOVERGENHBG000182.
KOK07426.
OMAISMHIYA.
PhylomeDBP13584.
TreeFamTF105088.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressP13584.
BgeeP13584.
CleanExHS_CYP4B1.
GenevestigatorP13584.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCYP4B1. human.
GeneWikiCYP4B1.
GenomeRNAi1580.
NextBio6489.
PROP13584.
SOURCESearch...

Entry information

Entry nameCP4B1_HUMAN
AccessionPrimary (citable) accession number: P13584
Secondary accession number(s): Q1HBI2 expand/collapse secondary AC list , Q8TD85, Q8WWF2, Q8WWU9, Q8WWV0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: June 7, 2004
Last modified: July 9, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM