Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P13584

- CP4B1_HUMAN

UniProt

P13584 - CP4B1_HUMAN

Protein

Cytochrome P450 4B1

Gene

CYP4B1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 2 (07 Jun 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei315 – 3151Heme (covalent; via 1 link)By similarity
    Metal bindingi453 – 4531Iron (heme axial ligand)

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. drug binding Source: Ensembl
    3. fluorene oxygenase activity Source: Ensembl
    4. heme binding Source: InterPro
    5. iron ion binding Source: InterPro
    6. oxygen binding Source: ProtInc

    GO - Biological processi

    1. biphenyl metabolic process Source: Ensembl
    2. exogenous drug catabolic process Source: Ensembl
    3. fluorene metabolic process Source: Ensembl
    4. small molecule metabolic process Source: Reactome
    5. xenobiotic metabolic process Source: Reactome

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_13425. Miscellaneous substrates.
    REACT_13645. Eicosanoids.
    REACT_13814. Fatty acids.
    REACT_150420. Synthesis of Leukotrienes (LT) and Eoxins (EX).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 4B1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIVB1
    Cytochrome P450-HP
    Gene namesi
    Name:CYP4B1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:2644. CYP4B1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: Reactome

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27119.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 511510Cytochrome P450 4B1PRO_0000051819Add
    BLAST

    Proteomic databases

    PaxDbiP13584.
    PRIDEiP13584.

    PTM databases

    PhosphoSiteiP13584.

    Expressioni

    Tissue specificityi

    Detected in the liver and lung (at protein level).1 Publication

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Gene expression databases

    ArrayExpressiP13584.
    BgeeiP13584.
    CleanExiHS_CYP4B1.
    GenevestigatoriP13584.

    Organism-specific databases

    HPAiHPA004331.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000360991.

    Structurei

    3D structure databases

    ProteinModelPortaliP13584.
    SMRiP13584. Positions 46-506.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000233833.
    HOVERGENiHBG000182.
    KOiK07426.
    OMAiISMHIYA.
    PhylomeDBiP13584.
    TreeFamiTF105088.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P13584-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVPSFLSLSF SSLGLWASGL ILVLGFLKLI HLLLRRQTLA KAMDKFPGPP    50
    THWLFGHALE IQETGSLDKV VSWAHQFPYA HPLWFGQFIG FLNIYEPDYA 100
    KAVYSRGDPK APDVYDFFLQ WIGRGLLVLE GPKWLQHRKL LTPGFHYDVL 150
    KPYVAVFTES TRIMLDKWEE KAREGKSFDI FCDVGHMALN TLMKCTFGRG 200
    DTGLGHRDSS YYLAVSDLTL LMQQRLVSFQ YHNDFIYWLT PHGRRFLRAC 250
    QVAHDHTDQV IRERKAALQD EKVRKKIQNR RHLDFLDILL GARDEDDIKL 300
    SDADLRAEVD TFMFEGHDTT TSGISWFLYC MALYPEHQHR CREEVREILG 350
    DQDFFQWDDL GKMTYLTMCI KESFRLYPPV PQVYRQLSKP VTFVDGRSLP 400
    AGSLISMHIY ALHRNSAVWP DPEVFDSLRF STENASKRHP FAFMPFSAGP 450
    RNCIGQQFAM SEMKVVTAMC LLRFEFSLDP SRLPIKMPQL VLRSKNGFHL 500
    HLKPLGPGSG K 511
    Length:511
    Mass (Da):58,991
    Last modified:June 7, 2004 - v2
    Checksum:i91FED40949507EB8
    GO
    Isoform 2 (identifier: P13584-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         206-206: H → HS

    Show »
    Length:512
    Mass (Da):59,078
    Checksum:i1C5FB3436D612DD7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 371Q → R in AAA35712. (PubMed:2574990)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti111 – 1111A → V.1 Publication
    Corresponds to variant rs45559437 [ dbSNP | Ensembl ].
    VAR_055377
    Natural varianti173 – 1731R → W in allele CYP4B1*3 and allele CYP4B1*6. 2 Publications
    Corresponds to variant rs4646487 [ dbSNP | Ensembl ].
    VAR_018357
    Natural varianti264 – 2641R → W.1 Publication
    Corresponds to variant rs45446505 [ dbSNP | Ensembl ].
    VAR_048453
    Natural varianti274 – 2741R → Q.1 Publication
    Corresponds to variant rs45578838 [ dbSNP | Ensembl ].
    VAR_055378
    Natural varianti322 – 3221S → G in allele CYP4B1*4. 2 Publications
    Corresponds to variant rs45467195 [ dbSNP | Ensembl ].
    VAR_018358
    Natural varianti329 – 3291Y → S.1 Publication
    Corresponds to variant rs12094024 [ dbSNP | Ensembl ].
    VAR_048454
    Natural varianti331 – 3311M → I in allele CYP4B1*2, allele CYP4B1*7 and allele CYP4B1*5. 2 Publications
    Corresponds to variant rs2297810 [ dbSNP | Ensembl ].
    VAR_018359
    Natural varianti340 – 3401R → C in allele CYP4B1*2 and allele CYP4B1*7. 2 Publications
    Corresponds to variant rs4646491 [ dbSNP | Ensembl ].
    VAR_018360
    Natural varianti345 – 3451V → I in allele CYP4B1*6.
    VAR_018361
    Natural varianti354 – 3541F → C.1 Publication
    Corresponds to variant rs17102592 [ dbSNP | Ensembl ].
    VAR_048455
    Natural varianti375 – 3751R → C in allele CYP4B1*2. 2 Publications
    Corresponds to variant rs2297809 [ dbSNP | Ensembl ].
    VAR_018362
    Natural varianti482 – 4821R → Q.1 Publication
    Corresponds to variant rs45622937 [ dbSNP | Ensembl ].
    VAR_048456

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei206 – 2061H → HS in isoform 2. 2 PublicationsVSP_038419

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02871 mRNA. Translation: AAA35712.1.
    X16699 mRNA. Translation: CAA34672.1.
    AF491285 mRNA. Translation: AAM09532.1.
    AY064485 mRNA. Translation: AAL57720.1.
    AY064486 mRNA. Translation: AAL57721.1.
    AY151048 mRNA. Translation: AAN72311.1.
    DQ518907 Genomic DNA. Translation: ABF47106.1.
    AL593856, AL356793 Genomic DNA. Translation: CAI16981.1.
    AL593856, AL356793 Genomic DNA. Translation: CAI16982.1.
    AL356793, AL593856 Genomic DNA. Translation: CAI22557.1.
    AL356793, AL593856 Genomic DNA. Translation: CAI22559.1.
    BC017758 mRNA. Translation: AAH17758.1.
    CCDSiCCDS41328.1. [P13584-2]
    CCDS542.1. [P13584-1]
    PIRiS07765. O4HUB1.
    RefSeqiNP_000770.2. NM_000779.3. [P13584-1]
    NP_001093242.1. NM_001099772.1. [P13584-2]
    UniGeneiHs.436317.

    Genome annotation databases

    EnsembliENST00000271153; ENSP00000271153; ENSG00000142973. [P13584-1]
    ENST00000371923; ENSP00000360991; ENSG00000142973. [P13584-2]
    GeneIDi1580.
    KEGGihsa:1580.
    UCSCiuc001cqm.4. human. [P13584-1]
    uc001cqn.4. human. [P13584-2]

    Polymorphism databases

    DMDMi48429213.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Cytochrome P450 Allele Nomenclature Committee

    CYP4B1 alleles

    NIEHS-SNPs
    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02871 mRNA. Translation: AAA35712.1 .
    X16699 mRNA. Translation: CAA34672.1 .
    AF491285 mRNA. Translation: AAM09532.1 .
    AY064485 mRNA. Translation: AAL57720.1 .
    AY064486 mRNA. Translation: AAL57721.1 .
    AY151048 mRNA. Translation: AAN72311.1 .
    DQ518907 Genomic DNA. Translation: ABF47106.1 .
    AL593856 , AL356793 Genomic DNA. Translation: CAI16981.1 .
    AL593856 , AL356793 Genomic DNA. Translation: CAI16982.1 .
    AL356793 , AL593856 Genomic DNA. Translation: CAI22557.1 .
    AL356793 , AL593856 Genomic DNA. Translation: CAI22559.1 .
    BC017758 mRNA. Translation: AAH17758.1 .
    CCDSi CCDS41328.1. [P13584-2 ]
    CCDS542.1. [P13584-1 ]
    PIRi S07765. O4HUB1.
    RefSeqi NP_000770.2. NM_000779.3. [P13584-1 ]
    NP_001093242.1. NM_001099772.1. [P13584-2 ]
    UniGenei Hs.436317.

    3D structure databases

    ProteinModelPortali P13584.
    SMRi P13584. Positions 46-506.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000360991.

    PTM databases

    PhosphoSitei P13584.

    Polymorphism databases

    DMDMi 48429213.

    Proteomic databases

    PaxDbi P13584.
    PRIDEi P13584.

    Protocols and materials databases

    DNASUi 1580.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000271153 ; ENSP00000271153 ; ENSG00000142973 . [P13584-1 ]
    ENST00000371923 ; ENSP00000360991 ; ENSG00000142973 . [P13584-2 ]
    GeneIDi 1580.
    KEGGi hsa:1580.
    UCSCi uc001cqm.4. human. [P13584-1 ]
    uc001cqn.4. human. [P13584-2 ]

    Organism-specific databases

    CTDi 1580.
    GeneCardsi GC01P047264.
    HGNCi HGNC:2644. CYP4B1.
    HPAi HPA004331.
    MIMi 124075. gene.
    neXtProti NX_P13584.
    PharmGKBi PA27119.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000233833.
    HOVERGENi HBG000182.
    KOi K07426.
    OMAi ISMHIYA.
    PhylomeDBi P13584.
    TreeFami TF105088.

    Enzyme and pathway databases

    Reactomei REACT_13425. Miscellaneous substrates.
    REACT_13645. Eicosanoids.
    REACT_13814. Fatty acids.
    REACT_150420. Synthesis of Leukotrienes (LT) and Eoxins (EX).

    Miscellaneous databases

    ChiTaRSi CYP4B1. human.
    GeneWikii CYP4B1.
    GenomeRNAii 1580.
    NextBioi 6489.
    PROi P13584.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P13584.
    Bgeei P13584.
    CleanExi HS_CYP4B1.
    Genevestigatori P13584.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping."
      Nhamburo P.T., Gonzalez F.J., McBride O.W., Gelboin H.V., Kimura S.
      Biochemistry 28:8060-8066(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Lung.
    2. "cDNA cloning of cytochrome P-450 related to P-450p-2 from the cDNA library of human placenta. Gene structure and expression."
      Yokotani N., Sogawa K., Matsubara S., Gotoh O., Kusunose E., Kusunose M., Fujii-Kuriyama Y.
      Eur. J. Biochem. 187:23-29(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    3. "Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant."
      Lo-Guidice J.-M., Allorge D., Cauffiez C., Chevalier D., Lafitte J.-J., Lhermitte M., Broly F.
      Pharmacogenetics 12:367-374(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS TRP-173; GLY-322; ILE-331; CYS-340 AND CYS-375.
    4. "Characterization of pulmonary CYP4B2, specific catalyst of methyl oxidation of 3-methylindole."
      Carr B.A., Ramakanth S., Dannan G.A., Yost G.S.
      Mol. Pharmacol. 63:1137-1147(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
      Tissue: Lung.
    5. NIEHS SNPs program
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-111; TRP-173; TRP-264; GLN-274; GLY-322; SER-329; ILE-331; CYS-340; CYS-354; CYS-375 AND GLN-482.
    6. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Lung.

    Entry informationi

    Entry nameiCP4B1_HUMAN
    AccessioniPrimary (citable) accession number: P13584
    Secondary accession number(s): Q1HBI2
    , Q8TD85, Q8WWF2, Q8WWU9, Q8WWV0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 141 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3