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Protein

Cytochrome P450 4B1

Gene

CYP4B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei315Heme (covalent; via 1 link)By similarity1
Metal bindingi453Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-211935. Fatty acids.
R-HSA-211958. Miscellaneous substrates.
R-HSA-211979. Eicosanoids.
R-HSA-2142691. Synthesis of Leukotrienes (LT) and Eoxins (EX).

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4B1 (EC:1.14.14.1)
Alternative name(s):
CYPIVB1
Cytochrome P450-HP
Gene namesi
Name:CYP4B1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000142973.12.
HGNCiHGNC:2644. CYP4B1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi1580.
OpenTargetsiENSG00000142973.
PharmGKBiPA27119.

Chemistry databases

DrugBankiDB00683. Midazolam.
DB01174. Phenobarbital.
DB00152. Thiamine.

Polymorphism and mutation databases

BioMutaiCYP4B1.
DMDMi48429213.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000518191 – 511Cytochrome P450 4B1Add BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei436PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP13584.
PeptideAtlasiP13584.
PRIDEiP13584.

PTM databases

iPTMnetiP13584.
PhosphoSitePlusiP13584.

Expressioni

Tissue specificityi

Detected in the liver and lung (at protein level).1 Publication

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiENSG00000142973.
CleanExiHS_CYP4B1.
ExpressionAtlasiP13584. baseline and differential.
GenevisibleiP13584. HS.

Organism-specific databases

HPAiHPA004331.

Interactioni

Protein-protein interaction databases

BioGridi107952. 1 interactor.
STRINGi9606.ENSP00000360991.

Structurei

3D structure databases

ProteinModelPortaliP13584.
SMRiP13584.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00900000140829.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiP13584.
KOiK07426.
OMAiQEHLVKH.
OrthoDBiEOG091G06KN.
PhylomeDBiP13584.
TreeFamiTF105088.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR036396. Cyt_P450_sf.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P13584-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPSFLSLSF SSLGLWASGL ILVLGFLKLI HLLLRRQTLA KAMDKFPGPP
60 70 80 90 100
THWLFGHALE IQETGSLDKV VSWAHQFPYA HPLWFGQFIG FLNIYEPDYA
110 120 130 140 150
KAVYSRGDPK APDVYDFFLQ WIGRGLLVLE GPKWLQHRKL LTPGFHYDVL
160 170 180 190 200
KPYVAVFTES TRIMLDKWEE KAREGKSFDI FCDVGHMALN TLMKCTFGRG
210 220 230 240 250
DTGLGHRDSS YYLAVSDLTL LMQQRLVSFQ YHNDFIYWLT PHGRRFLRAC
260 270 280 290 300
QVAHDHTDQV IRERKAALQD EKVRKKIQNR RHLDFLDILL GARDEDDIKL
310 320 330 340 350
SDADLRAEVD TFMFEGHDTT TSGISWFLYC MALYPEHQHR CREEVREILG
360 370 380 390 400
DQDFFQWDDL GKMTYLTMCI KESFRLYPPV PQVYRQLSKP VTFVDGRSLP
410 420 430 440 450
AGSLISMHIY ALHRNSAVWP DPEVFDSLRF STENASKRHP FAFMPFSAGP
460 470 480 490 500
RNCIGQQFAM SEMKVVTAMC LLRFEFSLDP SRLPIKMPQL VLRSKNGFHL
510
HLKPLGPGSG K
Length:511
Mass (Da):58,991
Last modified:June 7, 2004 - v2
Checksum:i91FED40949507EB8
GO
Isoform 2 (identifier: P13584-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-206: H → HS

Show »
Length:512
Mass (Da):59,078
Checksum:i1C5FB3436D612DD7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37Q → R in AAA35712 (PubMed:2574990).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055377111A → V1 PublicationCorresponds to variant dbSNP:rs45559437Ensembl.1
Natural variantiVAR_018357173R → W in allele CYP4B1*3 and allele CYP4B1*6. 2 PublicationsCorresponds to variant dbSNP:rs4646487Ensembl.1
Natural variantiVAR_048453264R → W1 PublicationCorresponds to variant dbSNP:rs45446505Ensembl.1
Natural variantiVAR_055378274R → Q1 PublicationCorresponds to variant dbSNP:rs45578838Ensembl.1
Natural variantiVAR_018358322S → G in allele CYP4B1*4. 2 PublicationsCorresponds to variant dbSNP:rs45467195Ensembl.1
Natural variantiVAR_048454329Y → S1 PublicationCorresponds to variant dbSNP:rs12094024Ensembl.1
Natural variantiVAR_018359331M → I in allele CYP4B1*2, allele CYP4B1*7 and allele CYP4B1*5. 2 PublicationsCorresponds to variant dbSNP:rs2297810Ensembl.1
Natural variantiVAR_018360340R → C in allele CYP4B1*2 and allele CYP4B1*7. 2 PublicationsCorresponds to variant dbSNP:rs4646491Ensembl.1
Natural variantiVAR_018361345V → I in allele CYP4B1*6. 1
Natural variantiVAR_048455354F → C1 PublicationCorresponds to variant dbSNP:rs17102592Ensembl.1
Natural variantiVAR_018362375R → C in allele CYP4B1*2. 2 PublicationsCorresponds to variant dbSNP:rs2297809Ensembl.1
Natural variantiVAR_048456482R → Q1 PublicationCorresponds to variant dbSNP:rs45622937Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038419206H → HS in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02871 mRNA. Translation: AAA35712.1.
X16699 mRNA. Translation: CAA34672.1.
AF491285 mRNA. Translation: AAM09532.1.
AY064485 mRNA. Translation: AAL57720.1.
AY064486 mRNA. Translation: AAL57721.1.
AY151048 mRNA. Translation: AAN72311.1.
DQ518907 Genomic DNA. Translation: ABF47106.1.
AL593856, AL356793 Genomic DNA. Translation: CAI16981.1.
AL593856, AL356793 Genomic DNA. Translation: CAI16982.1.
AL356793, AL593856 Genomic DNA. Translation: CAI22557.1.
AL356793, AL593856 Genomic DNA. Translation: CAI22559.1.
BC017758 mRNA. Translation: AAH17758.1.
CCDSiCCDS41328.1. [P13584-2]
CCDS542.1. [P13584-1]
PIRiS07765. O4HUB1.
RefSeqiNP_000770.2. NM_000779.3. [P13584-1]
NP_001093242.1. NM_001099772.1. [P13584-2]
UniGeneiHs.436317.

Genome annotation databases

EnsembliENST00000271153; ENSP00000271153; ENSG00000142973. [P13584-1]
ENST00000371923; ENSP00000360991; ENSG00000142973. [P13584-2]
GeneIDi1580.
KEGGihsa:1580.
UCSCiuc001cqm.5. human. [P13584-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCP4B1_HUMAN
AccessioniPrimary (citable) accession number: P13584
Secondary accession number(s): Q1HBI2
, Q8TD85, Q8WWF2, Q8WWU9, Q8WWV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: June 7, 2004
Last modified: October 25, 2017
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families