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Protein

Multidrug resistance protein

Gene

MDR1

Organism
Plasmodium falciparum (isolate FC27 / Papua New Guinea)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

Miscellaneous

P.falciparum resistant to the drug chloroquine have multiple copies of the gene coding for MDR.

Catalytic activityi

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi413 – 420ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1161 – 1168ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Protein family/group databases

TCDBi3.A.1.201.4. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein (EC:3.6.3.44)
Alternative name(s):
Chloroquine resistance protein
Gene namesi
Name:MDR1
OrganismiPlasmodium falciparum (isolate FC27 / Papua New Guinea)
Taxonomic identifieri5837 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 55CytoplasmicSequence analysisAdd BLAST55
Transmembranei56 – 82HelicalPROSITE-ProRule annotationAdd BLAST27
Transmembranei91 – 116HelicalPROSITE-ProRule annotationAdd BLAST26
Transmembranei160 – 188HelicalPROSITE-ProRule annotationAdd BLAST29
Transmembranei194 – 212HelicalPROSITE-ProRule annotationAdd BLAST19
Transmembranei279 – 298HelicalPROSITE-ProRule annotationAdd BLAST20
Transmembranei314 – 338HelicalPROSITE-ProRule annotationAdd BLAST25
Topological domaini339 – 788CytoplasmicSequence analysisAdd BLAST450
Transmembranei789 – 809HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei830 – 850HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei908 – 928HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei929 – 949HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1028 – 1048HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1063 – 1083HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini1084 – 1419CytoplasmicSequence analysisAdd BLAST336

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933441 – 1419Multidrug resistance proteinAdd BLAST1419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi228N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi964N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP13568.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 345ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST289
Domaini378 – 662ABC transporter 1PROSITE-ProRule annotationAdd BLAST285
Domaini789 – 1089ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST301
Domaini1126 – 1416ABC transporter 2PROSITE-ProRule annotationAdd BLAST291

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi643 – 661Poly-AsnAdd BLAST19

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 3 hits.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

P13568-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKEQKEKKD GNLSIKEEVE KELNKKSTAE LFRKIKNEKI SFFLPFKCLP
60 70 80 90 100
AQHRKLLFIS FVCAVLSGGT LPFFISVFGV ILKNMNLGDD INPIILSLVS
110 120 130 140 150
IGLVQFILSM ISSYCMDVIT SKILKTLKLE YLRSVFYQDG QFHDNNPGSK
160 170 180 190 200
LRSDLDFYLE QVSSGIGTKF ITIFTYASSF LGLYIWSLIK NARLTLCITC
210 220 230 240 250
VFPLIYVCGV ICNKKVKLNK KTSLLYNNNT MSIIEEALMG IRTVASYCGE
260 270 280 290 300
KTILNKFNLS ETFYSKYILK ANFVEALHIG LINGLILVSY AFGFWYGTRI
310 320 330 340 350
IINSATNQYP NNDFNGASVI SILLGVLISM FMLTIILPNI TEYMKALEAT
360 370 380 390 400
NSLYEIINRK PLVENNDDGE TLPNIKKIEF KNVRFHYDTR KDVEIYKDLS
410 420 430 440 450
FTLKEGKTYA FVGESGCGKS TILKLIERLY DPTEGDIIVN DSHNLKDINL
460 470 480 490 500
KWWRSKIGVV SQDPLLFSNS IKNNIKYSLY SLKDLEAMEN YYEENTNDTY
510 520 530 540 550
ENKNFSLISN SMTSNELLEM KKEYQTIKDS DVVDVSKKVL IHDFVSSLPD
560 570 580 590 600
KYDTLVGSNA SKLSGGQKQR ISIARAIMRN PKILILDEAT SSLDNKSEYL
610 620 630 640 650
VQKTINNLKG NENRITIIIA HRLSTIRYAN TIFVLSNRER SDNNNNNNND
660 670 680 690 700
DNNNNNNNNN NKINNEGSYI IEQGTHDSLM KNKNGIYHLM INNQKISSNK
710 720 730 740 750
SSNNGNDNGS DNKSSAYKDS DTGNDADNMN SLSIHENENI SNNRNCKNTA
760 770 780 790 800
ENEKEEKVPF FKRMFRRKKK APNNLRIIYK EIFSYKKDVT IIFFSILVAG
810 820 830 840 850
GLYPVFALLY ARYVSTLFDF ANLEYNSNKY SIYILLIAIA MFISETLKNY
860 870 880 890 900
YNNKIGEKVE KTMKRRLFEN ILYQEMSFFD QDKNTPGVLS AHINRDVHLL
910 920 930 940 950
KTGLVNNIVI FSHFIMLFLV SMVMSFYFCP IVAAVLTFIY FINMRVFAVR
960 970 980 990 1000
ARLTKSKEIE KKENMSSGVF AFSSDDEMFK DPSFLIQEAF YNMHTVINYG
1010 1020 1030 1040 1050
LEDYFCNLIE KAIDYKNKGQ KRRIIVNAAL WGFSQSAQLF INSFAYWFGS
1060 1070 1080 1090 1100
FLIKRGTILV DDFMKSLFTF IFTGSYAGKL MSLKGDSENA KLSFEKYYPL
1110 1120 1130 1140 1150
MIRKSNIDVR DDGGIRINKN LIKGKVDIKD VNFRYISRPN VPIYKNLSFT
1160 1170 1180 1190 1200
CDSKKTTAIV GETGSGKSTF MNLLLRFYDL KNDHIILKND MTNFQDYQNN
1210 1220 1230 1240 1250
NNNSLVLKNV NEFSNQSGSA EDYTVFNNNG EILLDDINIC DYNLRDLRNL
1260 1270 1280 1290 1300
FSIVSQEPML FNMSIYENIK FGREDATLED VKRVSKFAAI DEFIESLPNK
1310 1320 1330 1340 1350
YDTNVGPYGK SLSGGQKQRI AIARALLREP KILLLDEATS SLDSNSEKLI
1360 1370 1380 1390 1400
EKTIVDIKDK ADKTIITIAH RIASIKRSDK IVVFNNPDRN GTFVQSHGTH
1410
DELLSAQDGI YKKYVKLAK
Length:1,419
Mass (Da):162,252
Last modified:January 1, 1990 - v1
Checksum:i0F96C7C1850B33D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29154 Genomic DNA. Translation: AAA29646.1.
X56851 Genomic DNA. Translation: CAA40180.1.
S53996 Genomic DNA. Translation: AAD13870.1.
PIRiS18204. DVZQF.

Similar proteinsi

Entry informationi

Entry nameiMDR_PLAFF
AccessioniPrimary (citable) accession number: P13568
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: May 10, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families