Reviewed,
UniProtKB/Swiss-Prot P13563 (HAS1_XENLA)
Last modified
October 13, 2009.
Version 64.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Hyaluronan synthase 1 EC=2.4.1.212 Alternative name(s): Hyaluronate synthase 1 Hyaluronic acid synthase 1 Short name=HA synthase 1 Short name=xHAS1 DG42 protein | ||
| Gene names |
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| Organism | Xenopus laevis (African clawed frog) | ||
| Taxonomic identifier | 8355 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Protein attributes
| Sequence length | 588 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Plays a role in hyaluronan/hyaluronic acid (HA) synthesis By similarity. May play a role in signaling or pattern formation in embryonic development. |
| Catalytic activity | UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan). UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan). |
| Cofactor | Magnesium. |
| Pathway | |
| Subcellular location | Membrane; Multi-pass membrane protein Probable. |
| Tissue specificity | Embryo. |
| Developmental stage | During gastrula and early neurula stages. |
| Sequence similarities | Belongs to the nodC/HAS family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Transmembrane |
| Molecular function | Glycosyltransferase Transferase |
| Gene Ontology (GO) | |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | hyaluronan synthase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 588 | 588 | Hyaluronan synthase 1 | PRO_0000197171 | |||||
Regions | |||||||||
| Topological domain | 1 – 28 | 28 | Cytoplasmic Potential | ||||||
| Transmembrane | 29 – 49 | 21 | 1 Potential | ||||||
| Topological domain | 50 – 61 | 12 | Extracellular Potential | ||||||
| Transmembrane | 62 – 82 | 21 | 2 Potential | ||||||
| Topological domain | 83 – 411 | 329 | Cytoplasmic Potential | ||||||
| Transmembrane | 412 – 432 | 21 | 3 Potential | ||||||
| Topological domain | 433 | 1 | Extracellular Potential | ||||||
| Transmembrane | 434 – 454 | 21 | 4 Potential | ||||||
| Topological domain | 455 – 456 | 2 | Cytoplasmic Potential | ||||||
| Transmembrane | 457 – 477 | 21 | 5 Potential | ||||||
| Topological domain | 478 – 505 | 28 | Extracellular Potential | ||||||
| Transmembrane | 506 – 526 | 21 | 6 Potential | ||||||
| Topological domain | 527 – 543 | 17 | Cytoplasmic Potential | ||||||
| Transmembrane | 544 – 564 | 21 | 7 Potential | ||||||
| Topological domain | 565 – 588 | 24 | Extracellular Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Accumulation and decay of DG42 gene products follow a gradient pattern during Xenopus embryogenesis." Rosa F., Sargent T.D., Rebbert M.L., Michaels G.S., Jamrich M., Grunz H., Jonas E., Winkles J.A., Dawid I.B. Dev. Biol. 129:114-123(1988) [PubMed: 3410156] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | NIH - Xenopus Gene Collection (XGC) project Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo. |
Cross-references
Sequence databases | |
|---|---|
| M22249 mRNA. Translation: AAA49699.1. BC047963 mRNA. Translation: AAH47963.1. BC108480 mRNA. Translation: AAI08481.1. | |
| PIR | A43740. |
| RefSeq | NP_001079696.1. |
| UniGene | Xl.4517 |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | GT2. Glycosyltransferase Family 2. |
Genome annotation databases | |
| GeneID | 379383. |
| KEGG | xla:379383. |
Phylogenomic databases | |
| HOVERGEN | P13563. |
Enzyme and pathway databases | |
| BRENDA | 2.4.1.212. 648. |
Family and domain databases | |
| InterPro | IPR004835. Chitin_synth_fng. [Graphical view] |
| Pfam | PF03142. Chitin_synth_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | HAS1_XENLA | ||||||||
| Accession | Primary (citable) accession number: P13563 Secondary accession number(s): Q5D0A1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Xenopus annotation project | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


