P13562 (GON1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Progonadoliberin-1

Alternative name(s):
Progonadoliberin I

Cleaved into the following 2 chains:

1. Gonadoliberin-1
   Alternative name(s):
   Gonadoliberin I
   Gonadotropin-releasing hormone I
   Short name=GnRH-I
   Luliberin I
   Luteinizing hormone-releasing hormone I
   Short name=LH-RH I
2. Prolactin release-inhibiting factor 1
   Alternative name(s):
   Prolactin release-inhibiting factor I

Gene names

Name:	Gnrh1
Synonyms:	Gnrh

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	90 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Subcellular location	Secreted.
Sequence similarities	Belongs to the GnRH family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues Pyrrolidone carboxylic acid
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	female pregnancy Inferred from electronic annotation. Source: Compara multicellular organismal development Inferred from direct assay PubMed 11738808. Source: MGI negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara ovulation cycle Inferred from electronic annotation. Source: Compara regulation of gene expression Inferred from mutant phenotype PubMed 17332066. Source: MGI regulation of ovarian follicle development Inferred from mutant phenotype PubMed 10803590. Source: MGI response to corticosteroid stimulus Inferred from electronic annotation. Source: Compara response to ethanol Inferred from direct assay PubMed 7771642. Source: MGI response to steroid hormone stimulus Inferred from mutant phenotype PubMed 17332066. Source: MGI
Cellular_component	extracellular space Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21
	Chain	22 – 90	69	Progonadoliberin-1		PRO_0000012404
	Peptide	22 – 31	10	Gonadoliberin-1		PRO_0000012405
	Peptide	35 – 90	56	Prolactin release-inhibiting factor 1		PRO_0000012406
Sites
	Site	24	1	Appears to be essential for biological activity
Amino acid modifications
	Modified residue	22	1	Pyrrolidone carboxylic acid
	Modified residue	31	1	Glycine amide

Sequences

	Sequence		Length	Mass (Da)
	P13562 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: 1C0766FA4826E4D9	FASTA	90	10,337
	10 20 30 40 50 60 MILKLMAGIL LLTVCLEGCS SQHWSYGLRP GGKRNTEHLV ESFQEMGKEV DQMAEPQHFE 70 80 90 CTVHWPRSPL RDLRGALESL IEEEARQKKM

References

[1]	"A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse." Mason A.J., Hayflick J.S., Zoeller R.T., Young W.S. III, Phillips H.S., Nikolics K., Seeburg P.H. Science 234:1366-1371(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M14872 Genomic DNA. Translation: AAA37717.1.
IPI	IPI00122857.
PIR	RHMSG. A47578.
RefSeq	NP_032171.1. NM_008145.2.
UniGene	Mm.358309.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P13562. 3 interactions.
Proteomic databases
PRIDE	P13562.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000111095; ENSMUSP00000106724; ENSMUSG00000015812.
GeneID	14714.
KEGG	mmu:14714.
UCSC	uc007ulh.2. mouse.
Organism-specific databases
CTD	2796.
MGI	MGI:95789. Gnrh1.
Phylogenomic databases
eggNOG	NOG39107.
HOGENOM	HOG000033698.
HOVERGEN	HBG014746.
InParanoid	P13562.
KO	K05252.
OMA	GCSSQHW.
OrthoDB	EOG4MCX1W.
Gene expression databases
ArrayExpress	P13562.
Bgee	P13562.
CleanEx	MM_GNRH1.
Genevestigator	P13562.
GermOnline	ENSMUSG00000015812. Mus musculus.
Family and domain databases
InterPro	IPR002012. GnRH. IPR019792. Gonadoliberin_I. IPR004079. Gonadoliberin_I_precursor. [Graphical view]
PANTHER	PTHR10522. PTHR10522. 1 hit.
Pfam	PF00446. GnRH. 1 hit. [Graphical view]
PRINTS	PR01541. GONADOLIBRNI.
PROSITE	PS00473. GNRH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	286719.
SOURCE	Search...

Entry information

Entry name

GON1_MOUSE

Accession

Primary (citable) accession number: P13562

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	May 29, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program