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P13562

- GON1_MOUSE

UniProt

P13562 - GON1_MOUSE

Protein

Progonadoliberin-1

Gene

Gnrh1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei24 – 241Appears to be essential for biological activity

    GO - Biological processi

    1. female pregnancy Source: Ensembl
    2. multicellular organismal development Source: MGI
    3. negative regulation of apoptotic process Source: Ensembl
    4. negative regulation of neuron migration Source: MGI
    5. ovulation cycle Source: Ensembl
    6. regulation of gene expression Source: MGI
    7. regulation of ovarian follicle development Source: MGI
    8. response to corticosteroid Source: Ensembl
    9. response to ethanol Source: MGI
    10. response to steroid hormone Source: MGI

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Progonadoliberin-1
    Alternative name(s):
    Progonadoliberin I
    Cleaved into the following 2 chains:
    Alternative name(s):
    Gonadoliberin I
    Gonadotropin-releasing hormone I
    Short name:
    GnRH-I
    Luliberin I
    Luteinizing hormone-releasing hormone I
    Short name:
    LH-RH I
    Alternative name(s):
    Prolactin release-inhibiting factor I
    Gene namesi
    Name:Gnrh1
    Synonyms:Gnrh
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:95789. Gnrh1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Add
    BLAST
    Chaini22 – 9069Progonadoliberin-1PRO_0000012404Add
    BLAST
    Peptidei22 – 3110Gonadoliberin-1PRO_0000012405
    Peptidei35 – 9056Prolactin release-inhibiting factor 1PRO_0000012406Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei22 – 221Pyrrolidone carboxylic acidBy similarity
    Modified residuei31 – 311Glycine amideBy similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

    Proteomic databases

    PRIDEiP13562.

    Expressioni

    Gene expression databases

    BgeeiP13562.
    CleanExiMM_GNRH1.
    GenevestigatoriP13562.

    Interactioni

    Protein-protein interaction databases

    IntActiP13562. 3 interactions.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GnRH family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39107.
    HOGENOMiHOG000033698.
    HOVERGENiHBG014746.
    InParanoidiP13562.
    KOiK05252.
    OMAiLTANESK.
    OrthoDBiEOG7JX36N.
    PhylomeDBiP13562.
    TreeFamiTF330934.

    Family and domain databases

    InterProiIPR002012. GnRH.
    IPR019792. Gonadoliberin_I.
    IPR004079. Gonadoliberin_I_precursor.
    [Graphical view]
    PANTHERiPTHR10522. PTHR10522. 1 hit.
    PfamiPF00446. GnRH. 1 hit.
    [Graphical view]
    PRINTSiPR01541. GONADOLIBRNI.
    PROSITEiPS00473. GNRH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P13562-1 [UniParc]FASTAAdd to Basket

    « Hide

    MILKLMAGIL LLTVCLEGCS SQHWSYGLRP GGKRNTEHLV ESFQEMGKEV   50
    DQMAEPQHFE CTVHWPRSPL RDLRGALESL IEEEARQKKM 90
    Length:90
    Mass (Da):10,337
    Last modified:January 1, 1990 - v1
    Checksum:i1C0766FA4826E4D9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M14872 Genomic DNA. Translation: AAA37717.1.
    CCDSiCCDS27231.1.
    PIRiA47578. RHMSG.
    RefSeqiNP_032171.1. NM_008145.2.
    UniGeneiMm.358309.

    Genome annotation databases

    EnsembliENSMUST00000111095; ENSMUSP00000106724; ENSMUSG00000015812.
    GeneIDi14714.
    KEGGimmu:14714.
    UCSCiuc007ulh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M14872 Genomic DNA. Translation: AAA37717.1 .
    CCDSi CCDS27231.1.
    PIRi A47578. RHMSG.
    RefSeqi NP_032171.1. NM_008145.2.
    UniGenei Mm.358309.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P13562. 3 interactions.

    Proteomic databases

    PRIDEi P13562.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000111095 ; ENSMUSP00000106724 ; ENSMUSG00000015812 .
    GeneIDi 14714.
    KEGGi mmu:14714.
    UCSCi uc007ulh.2. mouse.

    Organism-specific databases

    CTDi 2796.
    MGIi MGI:95789. Gnrh1.

    Phylogenomic databases

    eggNOGi NOG39107.
    HOGENOMi HOG000033698.
    HOVERGENi HBG014746.
    InParanoidi P13562.
    KOi K05252.
    OMAi LTANESK.
    OrthoDBi EOG7JX36N.
    PhylomeDBi P13562.
    TreeFami TF330934.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 286719.
    PROi P13562.
    SOURCEi Search...

    Gene expression databases

    Bgeei P13562.
    CleanExi MM_GNRH1.
    Genevestigatori P13562.

    Family and domain databases

    InterProi IPR002012. GnRH.
    IPR019792. Gonadoliberin_I.
    IPR004079. Gonadoliberin_I_precursor.
    [Graphical view ]
    PANTHERi PTHR10522. PTHR10522. 1 hit.
    Pfami PF00446. GnRH. 1 hit.
    [Graphical view ]
    PRINTSi PR01541. GONADOLIBRNI.
    PROSITEi PS00473. GNRH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse."
      Mason A.J., Hayflick J.S., Zoeller R.T., Young W.S. III, Phillips H.S., Nikolics K., Seeburg P.H.
      Science 234:1366-1371(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiGON1_MOUSE
    AccessioniPrimary (citable) accession number: P13562
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3