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P13562

- GON1_MOUSE

UniProt

P13562 - GON1_MOUSE

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Protein
Progonadoliberin-1
Gene
Gnrh1, Gnrh
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei24 – 241Appears to be essential for biological activity

GO - Biological processi

  1. female pregnancy Source: Ensembl
  2. multicellular organismal development Source: MGI
  3. negative regulation of apoptotic process Source: Ensembl
  4. negative regulation of neuron migration Source: MGI
  5. ovulation cycle Source: Ensembl
  6. regulation of gene expression Source: MGI
  7. regulation of ovarian follicle development Source: MGI
  8. response to corticosteroid Source: Ensembl
  9. response to ethanol Source: MGI
  10. response to steroid hormone Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Progonadoliberin-1
Alternative name(s):
Progonadoliberin I
Cleaved into the following 2 chains:
Alternative name(s):
Gonadoliberin I
Gonadotropin-releasing hormone I
Short name:
GnRH-I
Luliberin I
Luteinizing hormone-releasing hormone I
Short name:
LH-RH I
Alternative name(s):
Prolactin release-inhibiting factor I
Gene namesi
Name:Gnrh1
Synonyms:Gnrh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:95789. Gnrh1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121
Add
BLAST
Chaini22 – 9069Progonadoliberin-1
PRO_0000012404Add
BLAST
Peptidei22 – 3110Gonadoliberin-1
PRO_0000012405
Peptidei35 – 9056Prolactin release-inhibiting factor 1
PRO_0000012406Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221Pyrrolidone carboxylic acid By similarity
Modified residuei31 – 311Glycine amide By similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiP13562.

Expressioni

Gene expression databases

BgeeiP13562.
CleanExiMM_GNRH1.
GenevestigatoriP13562.

Interactioni

Protein-protein interaction databases

IntActiP13562. 3 interactions.

Family & Domainsi

Sequence similaritiesi

Belongs to the GnRH family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39107.
HOGENOMiHOG000033698.
HOVERGENiHBG014746.
InParanoidiP13562.
KOiK05252.
OMAiLTANESK.
OrthoDBiEOG7JX36N.
PhylomeDBiP13562.
TreeFamiTF330934.

Family and domain databases

InterProiIPR002012. GnRH.
IPR019792. Gonadoliberin_I.
IPR004079. Gonadoliberin_I_precursor.
[Graphical view]
PANTHERiPTHR10522. PTHR10522. 1 hit.
PfamiPF00446. GnRH. 1 hit.
[Graphical view]
PRINTSiPR01541. GONADOLIBRNI.
PROSITEiPS00473. GNRH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13562-1 [UniParc]FASTAAdd to Basket

« Hide

MILKLMAGIL LLTVCLEGCS SQHWSYGLRP GGKRNTEHLV ESFQEMGKEV   50
DQMAEPQHFE CTVHWPRSPL RDLRGALESL IEEEARQKKM 90
Length:90
Mass (Da):10,337
Last modified:January 1, 1990 - v1
Checksum:i1C0766FA4826E4D9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M14872 Genomic DNA. Translation: AAA37717.1.
CCDSiCCDS27231.1.
PIRiA47578. RHMSG.
RefSeqiNP_032171.1. NM_008145.2.
UniGeneiMm.358309.

Genome annotation databases

EnsembliENSMUST00000111095; ENSMUSP00000106724; ENSMUSG00000015812.
GeneIDi14714.
KEGGimmu:14714.
UCSCiuc007ulh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M14872 Genomic DNA. Translation: AAA37717.1 .
CCDSi CCDS27231.1.
PIRi A47578. RHMSG.
RefSeqi NP_032171.1. NM_008145.2.
UniGenei Mm.358309.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P13562. 3 interactions.

Proteomic databases

PRIDEi P13562.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000111095 ; ENSMUSP00000106724 ; ENSMUSG00000015812 .
GeneIDi 14714.
KEGGi mmu:14714.
UCSCi uc007ulh.2. mouse.

Organism-specific databases

CTDi 2796.
MGIi MGI:95789. Gnrh1.

Phylogenomic databases

eggNOGi NOG39107.
HOGENOMi HOG000033698.
HOVERGENi HBG014746.
InParanoidi P13562.
KOi K05252.
OMAi LTANESK.
OrthoDBi EOG7JX36N.
PhylomeDBi P13562.
TreeFami TF330934.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 286719.
PROi P13562.
SOURCEi Search...

Gene expression databases

Bgeei P13562.
CleanExi MM_GNRH1.
Genevestigatori P13562.

Family and domain databases

InterProi IPR002012. GnRH.
IPR019792. Gonadoliberin_I.
IPR004079. Gonadoliberin_I_precursor.
[Graphical view ]
PANTHERi PTHR10522. PTHR10522. 1 hit.
Pfami PF00446. GnRH. 1 hit.
[Graphical view ]
PRINTSi PR01541. GONADOLIBRNI.
PROSITEi PS00473. GNRH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse."
    Mason A.J., Hayflick J.S., Zoeller R.T., Young W.S. III, Phillips H.S., Nikolics K., Seeburg P.H.
    Science 234:1366-1371(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGON1_MOUSE
AccessioniPrimary (citable) accession number: P13562
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: September 3, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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