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P13562 (GON1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Progonadoliberin-1
Alternative name(s):
Progonadoliberin I

Cleaved into the following 2 chains:

  1. Gonadoliberin-1
    Alternative name(s):
    Gonadoliberin I
    Gonadotropin-releasing hormone I
    Short name=GnRH-I
    Luliberin I
    Luteinizing hormone-releasing hormone I
    Short name=LH-RH I
  2. Prolactin release-inhibiting factor 1
    Alternative name(s):
    Prolactin release-inhibiting factor I
Gene names
Name:Gnrh1
Synonyms:Gnrh
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length90 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

Subcellular location

Secreted.

Sequence similarities

Belongs to the GnRH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121
Chain22 – 9069Progonadoliberin-1
PRO_0000012404
Peptide22 – 3110Gonadoliberin-1
PRO_0000012405
Peptide35 – 9056Prolactin release-inhibiting factor 1
PRO_0000012406

Sites

Site241Appears to be essential for biological activity

Amino acid modifications

Modified residue221Pyrrolidone carboxylic acid
Modified residue311Glycine amide

Sequences

Sequence LengthMass (Da)Tools
P13562 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: 1C0766FA4826E4D9

FASTA9010,337
        10         20         30         40         50         60 
MILKLMAGIL LLTVCLEGCS SQHWSYGLRP GGKRNTEHLV ESFQEMGKEV DQMAEPQHFE 

        70         80         90 
CTVHWPRSPL RDLRGALESL IEEEARQKKM 

« Hide

References

[1]"A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse."
Mason A.J., Hayflick J.S., Zoeller R.T., Young W.S. III, Phillips H.S., Nikolics K., Seeburg P.H.
Science 234:1366-1371(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M14872 Genomic DNA. Translation: AAA37717.1.
PIRRHMSG. A47578.
RefSeqNP_032171.1. NM_008145.2.
UniGeneMm.358309.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP13562. 3 interactions.

Proteomic databases

PRIDEP13562.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000111095; ENSMUSP00000106724; ENSMUSG00000015812.
GeneID14714.
KEGGmmu:14714.
UCSCuc007ulh.2. mouse.

Organism-specific databases

CTD2796.
MGIMGI:95789. Gnrh1.

Phylogenomic databases

eggNOGNOG39107.
HOGENOMHOG000033698.
HOVERGENHBG014746.
InParanoidP13562.
KOK05252.
OMAGCSSQHW.
OrthoDBEOG7JX36N.
PhylomeDBP13562.
TreeFamTF330934.

Gene expression databases

BgeeP13562.
CleanExMM_GNRH1.
GenevestigatorP13562.

Family and domain databases

InterProIPR002012. GnRH.
IPR019792. Gonadoliberin_I.
IPR004079. Gonadoliberin_I_precursor.
[Graphical view]
PANTHERPTHR10522. PTHR10522. 1 hit.
PfamPF00446. GnRH. 1 hit.
[Graphical view]
PRINTSPR01541. GONADOLIBRNI.
PROSITEPS00473. GNRH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286719.
PROP13562.
SOURCESearch...

Entry information

Entry nameGON1_MOUSE
AccessionPrimary (citable) accession number: P13562
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot