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Protein

Myosin regulatory light chain, striated adductor muscle

Gene
N/A
Organism
Argopecten irradians (Bay scallop) (Aequipecten irradians)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

In molluscan muscle, calcium regulation is associated with myosin rather than with actin. Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca2+ dependent binding and Ca2+ dependent Mg-ATPase activity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi29 – 40Add BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin regulatory light chain, striated adductor muscle
Short name:
R-LC
OrganismiArgopecten irradians (Bay scallop) (Aequipecten irradians)
Taxonomic identifieri31199 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaPectinoidaPectinoideaPectinidaeArgopecten

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001987512 – 157Myosin regulatory light chain, striated adductor muscleAdd BLAST156

Structurei

Secondary structure

1157
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 10Combined sources3
Helixi15 – 28Combined sources14
Beta strandi33 – 35Combined sources3
Helixi38 – 48Combined sources11
Helixi54 – 61Combined sources8
Beta strandi64 – 66Combined sources3
Helixi70 – 80Combined sources11
Turni81 – 83Combined sources3
Helixi87 – 95Combined sources9
Beta strandi103 – 106Combined sources4
Helixi107 – 116Combined sources10
Beta strandi117 – 119Combined sources3
Helixi123 – 132Combined sources10
Beta strandi137 – 140Combined sources4
Helixi142 – 150Combined sources9
Beta strandi152 – 155Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B7TX-ray2.50Y2-157[»]
1DFKX-ray4.20Y13-151[»]
1DFLX-ray4.20W/Y13-151[»]
1KK7X-ray3.20Y2-157[»]
1KK8X-ray2.30B14-152[»]
1KQMX-ray3.00B2-157[»]
1KWOX-ray3.80B2-157[»]
1L2OX-ray2.80B2-157[»]
1QVIX-ray2.54Y2-157[»]
1S5GX-ray3.10Y2-157[»]
1SCMX-ray2.80B13-157[»]
1SR6X-ray2.75B2-157[»]
1WDCX-ray2.00B2-157[»]
2W4Telectron microscopy35.00Y16-151[»]
2W4Velectron microscopy35.00Y16-151[»]
2W4Welectron microscopy35.00Y16-151[»]
3JTDX-ray2.57B2-157[»]
3JVTX-ray2.10B2-157[»]
ProteinModelPortaliP13543.
SMRiP13543.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13543.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 51EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini85 – 120EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13543-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKAASGVL TKLPQKQIQE MKEAFSMIDV DRDGFVSKED IKAISEQLGR
60 70 80 90 100
APDDKELTAM LKEAPGPLNF TMFLSIFSDK LSGTDSEETI RNAFAMFDEQ
110 120 130 140 150
ETKKLNIEYI KDLLENMGDN FNKDEMRMTF KEAPVEGGKF DYVKFTAMIK

GSGEEEA
Length:157
Mass (Da):17,671
Last modified:January 23, 2007 - v3
Checksum:i243CE69DB02A7772
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17208 mRNA. Translation: AAA27715.1. Sequence problems.
PIRiB29786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17208 mRNA. Translation: AAA27715.1. Sequence problems.
PIRiB29786.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B7TX-ray2.50Y2-157[»]
1DFKX-ray4.20Y13-151[»]
1DFLX-ray4.20W/Y13-151[»]
1KK7X-ray3.20Y2-157[»]
1KK8X-ray2.30B14-152[»]
1KQMX-ray3.00B2-157[»]
1KWOX-ray3.80B2-157[»]
1L2OX-ray2.80B2-157[»]
1QVIX-ray2.54Y2-157[»]
1S5GX-ray3.10Y2-157[»]
1SCMX-ray2.80B13-157[»]
1SR6X-ray2.75B2-157[»]
1WDCX-ray2.00B2-157[»]
2W4Telectron microscopy35.00Y16-151[»]
2W4Velectron microscopy35.00Y16-151[»]
2W4Welectron microscopy35.00Y16-151[»]
3JTDX-ray2.57B2-157[»]
3JVTX-ray2.10B2-157[»]
ProteinModelPortaliP13543.
SMRiP13543.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP13543.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMLR_ARGIR
AccessioniPrimary (citable) accession number: P13543
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

This chain binds calcium.

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.