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P13542

- MYH8_MOUSE

UniProt

P13542 - MYH8_MOUSE

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Protein
Myosin-8
Gene
Myh8, Myhsp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Muscle contraction.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi181 – 1888ATP

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. motor activity Source: InterPro
  3. protein binding Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-8
Alternative name(s):
Myosin heavy chain 8
Myosin heavy chain, skeletal muscle, perinatal
Short name:
MyHC-perinatal
Gene namesi
Name:Myh8
Synonyms:Myhsp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1339712. Myh8.

Subcellular locationi

Cytoplasmmyofibril
Note: Thick filaments of the myofibrils.

GO - Cellular componenti

  1. focal adhesion Source: Ensembl
  2. myofibril Source: UniProtKB-SubCell
  3. myosin complex Source: MGI
  4. myosin filament Source: UniProtKB-KW
  5. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19371937Myosin-8
PRO_0000123414Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei132 – 1321N6,N6,N6-trimethyllysine Reviewed prediction

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiP13542.
PRIDEiP13542.

PTM databases

PhosphoSiteiP13542.

Expressioni

Gene expression databases

BgeeiP13542.
GenevestigatoriP13542.

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

Protein-protein interaction databases

BioGridi201649. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP13542.
SMRiP13542. Positions 6-966.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini88 – 781694Myosin motor
Add
BLAST
Domaini781 – 81333IQ
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni658 – 68023Actin-binding
Add
BLAST
Regioni760 – 77415Actin-binding
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili842 – 19371096 Reviewed prediction
Add
BLAST

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).

Sequence similaritiesi

Contains 1 IQ domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00720000108596.
HOGENOMiHOG000173959.
HOVERGENiHBG004704.
InParanoidiP13542.
KOiK10352.
OMAiQLKRNHT.
OrthoDBiEOG7RBZ7G.
PhylomeDBiP13542.
TreeFamiTF314375.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13542-1 [UniParc]FASTAAdd to Basket

« Hide

MSAGSDAEMA IFGEAAPYLR KSEKERIEAQ NKPFDAKTSV FVAEPKESYV     50
KSVIQSKDGG KVTVKTESGA TLTVKEDQVF PMNPPKYDKI EDMAMMTHLH 100
EPGVLYNLKE RYAAWMIYTY SGLFCVTVNP YKWLPVYNPE VVAAYRGKKR 150
QEAPPHIFSI SDNAYQFMLT DRENQSILIT GESGAGKTVN TKRVIQYFAT 200
IAVTGDKKKE ESGKMQGTLE DQIISANPLL EAFGNAKTVR NDNSSRFGKF 250
IRIHFGTTGK LASADIETYL LEKSRVTFQL KAERSYHIFY QITSNKKPEL 300
IEMLLITTNP YDYAFVSQGE ITVPSIDDQE ELMATDSAID ILGFSPEEKV 350
SIYKLTGAVM HYGNMKFKQK QREEQAEPDG TEVADKAAYL QCLNSADLLK 400
ALCYPRVKVG NEYVTKGQTV QQVYNAVGAL AKAVYEKMFL WMVTRINQQL 450
DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC INFTNEKLQQ FFNHHMFVLE 500
QEEYKKEGIE WTFIDFGMDL AACIELIEKP LGIFSILEEE CMFPKATDTS 550
FKNKLYDQHL GKSNNFQKPK PTKGKAEAHF SLVHYAGTVD YNITGWLDKN 600
KDPLNDTVVG LYQKSAMKTL ASLFSTYASA EADGGAKKGA KKKGSSFQTV 650
SALFRENLNK LMTNLRSTHP HFVRCIIPNE TKTPGAMEHE LVLHQLRCNG 700
VLEGIRICRK GFPSRILYGD FKQRYKVLNA SAIPEGQFID SKKASEKLLG 750
SIDIDHTQYK FGHTKVFFKA GLLGLLEEMR DEKLAQIITR TQAVCRGYLM 800
RVEYQKMLLR RESIFCIQYN VRAFMNVKHW PWMKLFFKIK PLLKSAETEK 850
EMATMKEEFQ KTKDELAKSE AKRKELEEKM VTLLKEKNDL QLQVQSEADS 900
LADAEERCEQ LIKNKIQLEA KIKEVTERAE DEEEINAELT AKKRKLEDEC 950
SELKKDIDDL ELTLAKVEKE KHATENKVKN LTEEMAGLDE NIAKLTKEKK 1000
ALQEAHQQTL DDLQAEEDKV NTLTKAKTKL EQQVDDLEGS LEQEKKLRMD 1050
LERAKRKLEG DLKLAQESTM DIENDKQQLD EKLKKKEFEI SNLISKIEDE 1100
QAVEIQLQKK IKELQARIEE LEEEIEAERA SRAKAEKQRS DLSRELEEIS 1150
ERLEEAGGAT SAQVEMNKKR ETEFQKLRRD LEEATLQHEA TAAALRKKHA 1200
DSVAELGEQI DNLQRVKQKL EKEKSELKME IDDLSSNAEA IAKAKGNLEK 1250
MCRTLEDQVS ELKSKEEEQQ RLINELTAQR ARLQTEAGEY SRQLDEKDAL 1300
VSQLSRSKQA STQQIEELKR QLEEETKAKN ALAHALQSSR HDCDLLREQY 1350
EEEQEGKAEL QRALSKANSE VAQWRTKYET DAIQRTEELE EAKKKLAQRL 1400
QAAEEHVEAV NAKCASLEKT KQRLQNEVED LMIDVERTNA ACAALDKKQR 1450
NFDKVLSEWR QKYEETQAEL ESCQKESRTL STELFKVKNA YEESLDHLET 1500
LRRENKNLQQ EISDLTEQIA EGGKHIHELE KIKKQVEQEK CEIQAALEEA 1550
EASLEHEEGK ILRIQLELNQ VKSEIDRKIA EKDEEIDQLK RNHVRVVETM 1600
QSTLDAEIRS RNDALRVKKK MEGDLNEMEI QLNHANRLAA ESLRNYRNTQ 1650
GILKDTQLHL DDALRGQEDL KEQLAIVERR ANLLQAEIEE LRATLEQTER 1700
SRKIAEQELL DASERVQLLH TQNTSLINTK KKLENDVSQL QSEVEEVIQE 1750
SRNAEEKAKK AITDAAMMAE ELKKEQDTSA HLERMKKNME QTVKDLQHRL 1800
DEAEQLALKG GKKQIQKLEA RVRELEGEVE NEQKRNAEAV KGLRKHERRV 1850
KELTYQTEED RKNVLRLQDL VDKLQAKVKS YKRQAEEAEE QSNANLAKFR 1900
KLQHELEEAE ERADIAESQV NKLRVKSREV HTKISAE 1937
Length:1,937
Mass (Da):222,708
Last modified:August 30, 2005 - v2
Checksum:i5C215BC2757B64A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL596129 Genomic DNA. Translation: CAI24991.1.
M12289 mRNA. Translation: AAA39795.1.
CCDSiCCDS24857.1.
PIRiB24733.
RefSeqiNP_796343.2. NM_177369.3.
UniGeneiMm.340163.

Genome annotation databases

EnsembliENSMUST00000019625; ENSMUSP00000019625; ENSMUSG00000055775.
GeneIDi17885.
KEGGimmu:17885.
UCSCiuc007jmn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL596129 Genomic DNA. Translation: CAI24991.1 .
M12289 mRNA. Translation: AAA39795.1 .
CCDSi CCDS24857.1.
PIRi B24733.
RefSeqi NP_796343.2. NM_177369.3.
UniGenei Mm.340163.

3D structure databases

ProteinModelPortali P13542.
SMRi P13542. Positions 6-966.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201649. 1 interaction.

PTM databases

PhosphoSitei P13542.

Proteomic databases

MaxQBi P13542.
PRIDEi P13542.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019625 ; ENSMUSP00000019625 ; ENSMUSG00000055775 .
GeneIDi 17885.
KEGGi mmu:17885.
UCSCi uc007jmn.1. mouse.

Organism-specific databases

CTDi 4626.
MGIi MGI:1339712. Myh8.

Phylogenomic databases

GeneTreei ENSGT00720000108596.
HOGENOMi HOG000173959.
HOVERGENi HBG004704.
InParanoidi P13542.
KOi K10352.
OMAi QLKRNHT.
OrthoDBi EOG7RBZ7G.
PhylomeDBi P13542.
TreeFami TF314375.

Miscellaneous databases

NextBioi 292697.
PROi P13542.
SOURCEi Search...

Gene expression databases

Bgeei P13542.
Genevestigatori P13542.

Family and domain databases

Gene3Di 4.10.270.10. 1 hit.
InterProi IPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view ]
PRINTSi PR00193. MYOSINHEAVY.
SMARTi SM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene."
    Weydert A., Daubas P., Lazaridis I., Barton P., Garner I., Leader D.P., Bonhomme F., Catalan J., Simon D., Guenet J.-L., Gros F., Buckingham M.E.
    Proc. Natl. Acad. Sci. U.S.A. 82:7183-7187(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1824-1937.

Entry informationi

Entry nameiMYH8_MOUSE
AccessioniPrimary (citable) accession number: P13542
Secondary accession number(s): Q5SX36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: August 30, 2005
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi