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P13542

- MYH8_MOUSE

UniProt

P13542 - MYH8_MOUSE

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Protein

Myosin-8

Gene

Myh8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Muscle contraction.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi181 – 1888ATP

GO - Molecular functioni

  1. ATPase activity Source: Ensembl
  2. ATP binding Source: UniProtKB-KW
  3. microfilament motor activity Source: Ensembl

GO - Biological processi

  1. muscle filament sliding Source: Ensembl
  2. skeletal muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-8
Alternative name(s):
Myosin heavy chain 8
Myosin heavy chain, skeletal muscle, perinatal
Short name:
MyHC-perinatal
Gene namesi
Name:Myh8
Synonyms:Myhsp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1339712. Myh8.

Subcellular locationi

Cytoplasmmyofibril
Note: Thick filaments of the myofibrils.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. myosin complex Source: MGI
  3. myosin filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19371937Myosin-8PRO_0000123414Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei132 – 1321N6,N6,N6-trimethyllysineSequence Analysis

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiP13542.
PRIDEiP13542.

PTM databases

PhosphoSiteiP13542.

Expressioni

Gene expression databases

BgeeiP13542.
ExpressionAtlasiP13542. baseline and differential.
GenevestigatoriP13542.

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

Protein-protein interaction databases

BioGridi201649. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP13542.
SMRiP13542. Positions 6-966.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini88 – 781694Myosin motorAdd
BLAST
Domaini781 – 81333IQPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni658 – 68023Actin-bindingAdd
BLAST
Regioni760 – 77415Actin-bindingAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili842 – 19371096Sequence AnalysisAdd
BLAST

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00760000118919.
HOGENOMiHOG000173959.
HOVERGENiHBG004704.
InParanoidiP13542.
KOiK10352.
OMAiQLKRNHT.
OrthoDBiEOG7RBZ7G.
PhylomeDBiP13542.
TreeFamiTF314375.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13542-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAGSDAEMA IFGEAAPYLR KSEKERIEAQ NKPFDAKTSV FVAEPKESYV
60 70 80 90 100
KSVIQSKDGG KVTVKTESGA TLTVKEDQVF PMNPPKYDKI EDMAMMTHLH
110 120 130 140 150
EPGVLYNLKE RYAAWMIYTY SGLFCVTVNP YKWLPVYNPE VVAAYRGKKR
160 170 180 190 200
QEAPPHIFSI SDNAYQFMLT DRENQSILIT GESGAGKTVN TKRVIQYFAT
210 220 230 240 250
IAVTGDKKKE ESGKMQGTLE DQIISANPLL EAFGNAKTVR NDNSSRFGKF
260 270 280 290 300
IRIHFGTTGK LASADIETYL LEKSRVTFQL KAERSYHIFY QITSNKKPEL
310 320 330 340 350
IEMLLITTNP YDYAFVSQGE ITVPSIDDQE ELMATDSAID ILGFSPEEKV
360 370 380 390 400
SIYKLTGAVM HYGNMKFKQK QREEQAEPDG TEVADKAAYL QCLNSADLLK
410 420 430 440 450
ALCYPRVKVG NEYVTKGQTV QQVYNAVGAL AKAVYEKMFL WMVTRINQQL
460 470 480 490 500
DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC INFTNEKLQQ FFNHHMFVLE
510 520 530 540 550
QEEYKKEGIE WTFIDFGMDL AACIELIEKP LGIFSILEEE CMFPKATDTS
560 570 580 590 600
FKNKLYDQHL GKSNNFQKPK PTKGKAEAHF SLVHYAGTVD YNITGWLDKN
610 620 630 640 650
KDPLNDTVVG LYQKSAMKTL ASLFSTYASA EADGGAKKGA KKKGSSFQTV
660 670 680 690 700
SALFRENLNK LMTNLRSTHP HFVRCIIPNE TKTPGAMEHE LVLHQLRCNG
710 720 730 740 750
VLEGIRICRK GFPSRILYGD FKQRYKVLNA SAIPEGQFID SKKASEKLLG
760 770 780 790 800
SIDIDHTQYK FGHTKVFFKA GLLGLLEEMR DEKLAQIITR TQAVCRGYLM
810 820 830 840 850
RVEYQKMLLR RESIFCIQYN VRAFMNVKHW PWMKLFFKIK PLLKSAETEK
860 870 880 890 900
EMATMKEEFQ KTKDELAKSE AKRKELEEKM VTLLKEKNDL QLQVQSEADS
910 920 930 940 950
LADAEERCEQ LIKNKIQLEA KIKEVTERAE DEEEINAELT AKKRKLEDEC
960 970 980 990 1000
SELKKDIDDL ELTLAKVEKE KHATENKVKN LTEEMAGLDE NIAKLTKEKK
1010 1020 1030 1040 1050
ALQEAHQQTL DDLQAEEDKV NTLTKAKTKL EQQVDDLEGS LEQEKKLRMD
1060 1070 1080 1090 1100
LERAKRKLEG DLKLAQESTM DIENDKQQLD EKLKKKEFEI SNLISKIEDE
1110 1120 1130 1140 1150
QAVEIQLQKK IKELQARIEE LEEEIEAERA SRAKAEKQRS DLSRELEEIS
1160 1170 1180 1190 1200
ERLEEAGGAT SAQVEMNKKR ETEFQKLRRD LEEATLQHEA TAAALRKKHA
1210 1220 1230 1240 1250
DSVAELGEQI DNLQRVKQKL EKEKSELKME IDDLSSNAEA IAKAKGNLEK
1260 1270 1280 1290 1300
MCRTLEDQVS ELKSKEEEQQ RLINELTAQR ARLQTEAGEY SRQLDEKDAL
1310 1320 1330 1340 1350
VSQLSRSKQA STQQIEELKR QLEEETKAKN ALAHALQSSR HDCDLLREQY
1360 1370 1380 1390 1400
EEEQEGKAEL QRALSKANSE VAQWRTKYET DAIQRTEELE EAKKKLAQRL
1410 1420 1430 1440 1450
QAAEEHVEAV NAKCASLEKT KQRLQNEVED LMIDVERTNA ACAALDKKQR
1460 1470 1480 1490 1500
NFDKVLSEWR QKYEETQAEL ESCQKESRTL STELFKVKNA YEESLDHLET
1510 1520 1530 1540 1550
LRRENKNLQQ EISDLTEQIA EGGKHIHELE KIKKQVEQEK CEIQAALEEA
1560 1570 1580 1590 1600
EASLEHEEGK ILRIQLELNQ VKSEIDRKIA EKDEEIDQLK RNHVRVVETM
1610 1620 1630 1640 1650
QSTLDAEIRS RNDALRVKKK MEGDLNEMEI QLNHANRLAA ESLRNYRNTQ
1660 1670 1680 1690 1700
GILKDTQLHL DDALRGQEDL KEQLAIVERR ANLLQAEIEE LRATLEQTER
1710 1720 1730 1740 1750
SRKIAEQELL DASERVQLLH TQNTSLINTK KKLENDVSQL QSEVEEVIQE
1760 1770 1780 1790 1800
SRNAEEKAKK AITDAAMMAE ELKKEQDTSA HLERMKKNME QTVKDLQHRL
1810 1820 1830 1840 1850
DEAEQLALKG GKKQIQKLEA RVRELEGEVE NEQKRNAEAV KGLRKHERRV
1860 1870 1880 1890 1900
KELTYQTEED RKNVLRLQDL VDKLQAKVKS YKRQAEEAEE QSNANLAKFR
1910 1920 1930
KLQHELEEAE ERADIAESQV NKLRVKSREV HTKISAE
Length:1,937
Mass (Da):222,708
Last modified:August 30, 2005 - v2
Checksum:i5C215BC2757B64A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL596129 Genomic DNA. Translation: CAI24991.1.
M12289 mRNA. Translation: AAA39795.1.
CCDSiCCDS24857.1.
PIRiB24733.
RefSeqiNP_796343.2. NM_177369.3.
UniGeneiMm.340163.

Genome annotation databases

EnsembliENSMUST00000019625; ENSMUSP00000019625; ENSMUSG00000055775.
GeneIDi17885.
KEGGimmu:17885.
UCSCiuc007jmn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL596129 Genomic DNA. Translation: CAI24991.1 .
M12289 mRNA. Translation: AAA39795.1 .
CCDSi CCDS24857.1.
PIRi B24733.
RefSeqi NP_796343.2. NM_177369.3.
UniGenei Mm.340163.

3D structure databases

ProteinModelPortali P13542.
SMRi P13542. Positions 6-966.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201649. 1 interaction.

PTM databases

PhosphoSitei P13542.

Proteomic databases

MaxQBi P13542.
PRIDEi P13542.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019625 ; ENSMUSP00000019625 ; ENSMUSG00000055775 .
GeneIDi 17885.
KEGGi mmu:17885.
UCSCi uc007jmn.1. mouse.

Organism-specific databases

CTDi 4626.
MGIi MGI:1339712. Myh8.

Phylogenomic databases

GeneTreei ENSGT00760000118919.
HOGENOMi HOG000173959.
HOVERGENi HBG004704.
InParanoidi P13542.
KOi K10352.
OMAi QLKRNHT.
OrthoDBi EOG7RBZ7G.
PhylomeDBi P13542.
TreeFami TF314375.

Miscellaneous databases

NextBioi 292697.
PROi P13542.
SOURCEi Search...

Gene expression databases

Bgeei P13542.
ExpressionAtlasi P13542. baseline and differential.
Genevestigatori P13542.

Family and domain databases

Gene3Di 4.10.270.10. 1 hit.
InterProi IPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view ]
PRINTSi PR00193. MYOSINHEAVY.
SMARTi SM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene."
    Weydert A., Daubas P., Lazaridis I., Barton P., Garner I., Leader D.P., Bonhomme F., Catalan J., Simon D., Guenet J.-L., Gros F., Buckingham M.E.
    Proc. Natl. Acad. Sci. U.S.A. 82:7183-7187(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1824-1937.

Entry informationi

Entry nameiMYH8_MOUSE
AccessioniPrimary (citable) accession number: P13542
Secondary accession number(s): Q5SX36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: August 30, 2005
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3