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P13541

- MYH3_MOUSE

UniProt

P13541 - MYH3_MOUSE

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Protein

Myosin-3

Gene
Myh3, Myhse
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Muscle contraction.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi179 – 1868ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. motor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-3
Alternative name(s):
Myosin heavy chain 3
Gene namesi
Name:Myh3
Synonyms:Myhse
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1339709. Myh3.

Subcellular locationi

Cytoplasmmyofibril
Note: Thick filaments of the myofibrils.

GO - Cellular componenti

  1. contractile fiber Source: MGI
  2. myofibril Source: UniProtKB-SubCell
  3. myosin complex Source: MGI
  4. myosin filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19401940Myosin-3PRO_0000123395Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei130 – 1301N6,N6,N6-trimethyllysine Reviewed prediction

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiP13541.
PaxDbiP13541.
PRIDEiP13541.

PTM databases

PhosphoSiteiP13541.

Expressioni

Gene expression databases

BgeeiP13541.
GenevestigatoriP13541.

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

Protein-protein interaction databases

BioGridi201647. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliP13541.
SMRiP13541. Positions 4-964.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 779694Myosin motorAdd
BLAST
Domaini782 – 81130IQAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni656 – 67823Actin-binding By similarityAdd
BLAST
Regioni758 – 77215Actin-binding By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili841 – 19281088 Reviewed predictionAdd
BLAST

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).

Sequence similaritiesi

Contains 1 IQ domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00720000108596.
HOGENOMiHOG000173959.
HOVERGENiHBG004704.
InParanoidiP13541.
KOiK10352.
OMAiDEQANAH.
OrthoDBiEOG7RBZ7G.
PhylomeDBiP13541.
TreeFamiTF314375.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 2 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13541-1 [UniParc]FASTAAdd to Basket

« Hide

MSSDTEMEVF GIAAPFLRKS EKERIEAQNQ PFDAKTYCFV VDSKEEYVKG     50
KIKSSQDGKV TVETEDSRTL VVKPEDVYAM NPPKFDKIED MAMLTHLNEP 100
AVLYNLKDRY TSWMIYTYSG LFCVTVNPYK WLPVYNPEVV DGYRGKKRQE 150
APPHIFSISD NAYQFMLTDR ENQSILITGE SGAGKTVNTK RVIQYFATIA 200
ATGDLAKKKD SKMKGTLEDQ IISANPLLEA FGNAKTVRND NSSRFGKFIR 250
IHFGTTGKLA SADIETYLLE KSRVTFQLKA ERSYHIFYQI LSNKKPELIE 300
LLLITTNPYD YPFISQGEIL VASIDDAEEL LATDSAIDIL GFTPEEKSGL 350
YKLTGAVMHY GNMKFKQKQR EEQAEPDGTE VADKTAYLMG LNSSDLLKAL 400
CFPRVKVGNE YVTKGQTVDQ VHHAVNALSK SVYEKLFLWM VTRINQQLDT 450
KLPRQHFIGV LDIAGFEIFE YNSLEQLCIN FTNEKLQQFF NHHMFVLEQE 500
EYKKEGIEWT FIDFGMDLAA CIELIEKPMG IFSILEEECM FPKATDTSFK 550
NKLYDQHLGK SNNFQKPKVV KGKAEAHFSL VHYAGTVDYS VSGWLEKNKD 600
PLNETVVGLY QKSSNRLLAH LYATFATTDA DGGKKKVAKK KGSSFQTVSA 650
LFRENLNKLM SNLRTTHPHF VRCIIPNETK TPGAMEHSLV LHQLRCNGVL 700
EGIRICRKGF PNRILYGDFK QRYRVLNASA IPEGQFIDSK KACEKLLASI 750
DIDHTQYKFG HTKVFFKAGL LGTLEEMRDE RLAKLITRTQ AVCRGFLMRV 800
EFQKMMQRRE SIFCIQYNIR AFMNVKHWPW MKLFFKIKPL LKSAETEKEM 850
ATMKEEFQKT KDELAKSEAK RKELEEKLVT LVQEKNDLQL QVQAESENLL 900
DAEERCDQLI KAKFQLEAKI KEVTERAEDE EEINAELTAK KRKLEDECSE 950
LKKDIDDLEL TLAKVEKEKH ATENKVKNLT EELAGLDETI AKLTREKKAL 1000
QEAHQQTLDD LQAEEDKVNS LSKLKSKLEQ QVDDLESSLE QEKKLRVDLE 1050
RNKRKLEGDL KLAQESILDL ENDKQQLDER LKKKDFEYSQ LQSKVEDEQT 1100
LSLQLQKKIK ELQARIEELE EEIEAERATR AKTEKQRSDY ARELEELSER 1150
LEEAGGVTST QIELNKKREA EFLKLRRDLE EATLQHEATV ATLRKKHADS 1200
AAELAEQIDN LQRVKQKLEK EKSEFKLEID DLSSSVESVS KSKANLEKIC 1250
RTLEDQLSEA RGKNEEMQRS LSELTTQKSR LQTEAGELSR QLEEKESIVS 1300
QLSRSKQAFT QQIEELKRQL EEENKAKNAL AHALQSSRHD CDLLREQYEE 1350
EQEGKAELQR ALSKANSEVA QWRTKYETDA IQRTEELEEA KKKLAQRLQD 1400
SEEQVEAVNA KCASLEKTKQ RLQGEVEDLM VDVERANSLA AALDKKQRNF 1450
DKVLAEWKTK CEESQAELEA ALKESRSLST ELFKLKNAYE EALDQLETVK 1500
RENKNLEQEI ADLTEQIAEN GKSIHELEKS RKQMELEKAD IQMALEEAEA 1550
ALEHEEAKIL RIQLELTQVK SEIDRKIAEK DEEIEQLKRN YQRTVETMQG 1600
ALDAEVRSRN EAIRLKKKME GDLNEIEIQL SHANRQAAET IKHLRSVQGQ 1650
LKDTQLHLDD ALRGQEDLKE QLAIVERRAN LLQAEVEELR ATLEQTERAR 1700
KLAEQELLDS NERVQLLHTQ NTSLIHTKKK LETDLTQLQS EVEDACRDAR 1750
NAEEKAKKAI TDAAMMAEEL KKEQDTSAHL ERMKKNLEQT VKDLQHRLDE 1800
AEQLALKGGK KQIQKLETRI RELEFELEGE QKRNTESVKG LRKYERRVKE 1850
LTYQSEEDRK NVLRLQDLVD KLQVKVKSYK RQAEEADEQA NAHLTKFRKA 1900
QHELEEAEER ADIAESQVNK LRAKTRDFTS SRMVVHESEE 1940
Length:1,940
Mass (Da):223,791
Last modified:January 9, 2007 - v2
Checksum:i9CF748702D8353C9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1747 – 17471R → Q in AAA39791. 1 Publication
Sequence conflicti1858 – 18581D → A in AAA39791. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL645988, AL596129 Genomic DNA. Translation: CAI25982.2.
AL596129, AL645988 Genomic DNA. Translation: CAI24992.2.
AK132623 mRNA. Translation: BAE21268.1.
M11154 mRNA. Translation: AAA39791.1.
CCDSiCCDS36184.1.
PIRiA24733.
RefSeqiNP_001093105.1. NM_001099635.1.
XP_006532475.1. XM_006532412.1.
UniGeneiMm.340090.

Genome annotation databases

EnsembliENSMUST00000007301; ENSMUSP00000007301; ENSMUSG00000020908.
ENSMUST00000108689; ENSMUSP00000104329; ENSMUSG00000020908.
ENSMUST00000165221; ENSMUSP00000131883; ENSMUSG00000020908.
GeneIDi17883.
KEGGimmu:17883.
UCSCiuc007jlx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL645988 , AL596129 Genomic DNA. Translation: CAI25982.2 .
AL596129 , AL645988 Genomic DNA. Translation: CAI24992.2 .
AK132623 mRNA. Translation: BAE21268.1 .
M11154 mRNA. Translation: AAA39791.1 .
CCDSi CCDS36184.1.
PIRi A24733.
RefSeqi NP_001093105.1. NM_001099635.1.
XP_006532475.1. XM_006532412.1.
UniGenei Mm.340090.

3D structure databases

ProteinModelPortali P13541.
SMRi P13541. Positions 4-964.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201647. 5 interactions.

PTM databases

PhosphoSitei P13541.

Proteomic databases

MaxQBi P13541.
PaxDbi P13541.
PRIDEi P13541.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000007301 ; ENSMUSP00000007301 ; ENSMUSG00000020908 .
ENSMUST00000108689 ; ENSMUSP00000104329 ; ENSMUSG00000020908 .
ENSMUST00000165221 ; ENSMUSP00000131883 ; ENSMUSG00000020908 .
GeneIDi 17883.
KEGGi mmu:17883.
UCSCi uc007jlx.1. mouse.

Organism-specific databases

CTDi 4621.
MGIi MGI:1339709. Myh3.

Phylogenomic databases

eggNOGi COG5022.
GeneTreei ENSGT00720000108596.
HOGENOMi HOG000173959.
HOVERGENi HBG004704.
InParanoidi P13541.
KOi K10352.
OMAi DEQANAH.
OrthoDBi EOG7RBZ7G.
PhylomeDBi P13541.
TreeFami TF314375.

Miscellaneous databases

NextBioi 292685.
PROi P13541.
SOURCEi Search...

Gene expression databases

Bgeei P13541.
Genevestigatori P13541.

Family and domain databases

Gene3Di 4.10.270.10. 1 hit.
InterProi IPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view ]
PRINTSi PR00193. MYOSINHEAVY.
SMARTi SM00015. IQ. 2 hits.
SM00242. MYSc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 523-1292.
    Strain: C57BL/6J.
    Tissue: Head.
  3. "Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene."
    Weydert A., Daubas P., Lazaridis I., Barton P., Garner I., Leader D.P., Bonhomme F., Catalan J., Simon D., Guenet J.-L., Gros F., Buckingham M.E.
    Proc. Natl. Acad. Sci. U.S.A. 82:7183-7187(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1747-1905.

Entry informationi

Entry nameiMYH3_MOUSE
AccessioniPrimary (citable) accession number: P13541
Secondary accession number(s): Q3V183, Q5SUD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 9, 2007
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Represents a conventional myosin. This protein should not be confused with the unconventional myosin-3 (MYO3).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi