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P13541

- MYH3_MOUSE

UniProt

P13541 - MYH3_MOUSE

Protein

Myosin-3

Gene

Myh3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Muscle contraction.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi179 – 1868ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. motor activity Source: InterPro

    Keywords - Molecular functioni

    Motor protein, Muscle protein, Myosin

    Keywords - Ligandi

    Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myosin-3
    Alternative name(s):
    Myosin heavy chain 3
    Gene namesi
    Name:Myh3
    Synonyms:Myhse
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1339709. Myh3.

    Subcellular locationi

    Cytoplasmmyofibril
    Note: Thick filaments of the myofibrils.

    GO - Cellular componenti

    1. contractile fiber Source: MGI
    2. myofibril Source: UniProtKB-SubCell
    3. myosin complex Source: MGI
    4. myosin filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Thick filament

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19401940Myosin-3PRO_0000123395Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei130 – 1301N6,N6,N6-trimethyllysineSequence Analysis

    Keywords - PTMi

    Methylation

    Proteomic databases

    MaxQBiP13541.
    PaxDbiP13541.
    PRIDEiP13541.

    PTM databases

    PhosphoSiteiP13541.

    Expressioni

    Gene expression databases

    BgeeiP13541.
    GenevestigatoriP13541.

    Interactioni

    Subunit structurei

    Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

    Protein-protein interaction databases

    BioGridi201647. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP13541.
    SMRiP13541. Positions 4-964.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini86 – 779694Myosin motorAdd
    BLAST
    Domaini782 – 81130IQPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni656 – 67823Actin-bindingBy similarityAdd
    BLAST
    Regioni758 – 77215Actin-bindingBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili841 – 19281088Sequence AnalysisAdd
    BLAST

    Domaini

    The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
    Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).

    Sequence similaritiesi

    Contains 1 IQ domain.PROSITE-ProRule annotation
    Contains 1 myosin motor domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5022.
    GeneTreeiENSGT00720000108596.
    HOGENOMiHOG000173959.
    HOVERGENiHBG004704.
    InParanoidiP13541.
    KOiK10352.
    OMAiDEQANAH.
    OrthoDBiEOG7RBZ7G.
    PhylomeDBiP13541.
    TreeFamiTF314375.

    Family and domain databases

    Gene3Di4.10.270.10. 1 hit.
    InterProiIPR000048. IQ_motif_EF-hand-BS.
    IPR027401. Myosin-like_IQ_dom.
    IPR001609. Myosin_head_motor_dom.
    IPR004009. Myosin_N.
    IPR002928. Myosin_tail.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00063. Myosin_head. 1 hit.
    PF02736. Myosin_N. 1 hit.
    PF01576. Myosin_tail_1. 1 hit.
    [Graphical view]
    PRINTSiPR00193. MYOSINHEAVY.
    SMARTiSM00015. IQ. 2 hits.
    SM00242. MYSc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS50096. IQ. 1 hit.
    PS51456. MYOSIN_MOTOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P13541-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSDTEMEVF GIAAPFLRKS EKERIEAQNQ PFDAKTYCFV VDSKEEYVKG     50
    KIKSSQDGKV TVETEDSRTL VVKPEDVYAM NPPKFDKIED MAMLTHLNEP 100
    AVLYNLKDRY TSWMIYTYSG LFCVTVNPYK WLPVYNPEVV DGYRGKKRQE 150
    APPHIFSISD NAYQFMLTDR ENQSILITGE SGAGKTVNTK RVIQYFATIA 200
    ATGDLAKKKD SKMKGTLEDQ IISANPLLEA FGNAKTVRND NSSRFGKFIR 250
    IHFGTTGKLA SADIETYLLE KSRVTFQLKA ERSYHIFYQI LSNKKPELIE 300
    LLLITTNPYD YPFISQGEIL VASIDDAEEL LATDSAIDIL GFTPEEKSGL 350
    YKLTGAVMHY GNMKFKQKQR EEQAEPDGTE VADKTAYLMG LNSSDLLKAL 400
    CFPRVKVGNE YVTKGQTVDQ VHHAVNALSK SVYEKLFLWM VTRINQQLDT 450
    KLPRQHFIGV LDIAGFEIFE YNSLEQLCIN FTNEKLQQFF NHHMFVLEQE 500
    EYKKEGIEWT FIDFGMDLAA CIELIEKPMG IFSILEEECM FPKATDTSFK 550
    NKLYDQHLGK SNNFQKPKVV KGKAEAHFSL VHYAGTVDYS VSGWLEKNKD 600
    PLNETVVGLY QKSSNRLLAH LYATFATTDA DGGKKKVAKK KGSSFQTVSA 650
    LFRENLNKLM SNLRTTHPHF VRCIIPNETK TPGAMEHSLV LHQLRCNGVL 700
    EGIRICRKGF PNRILYGDFK QRYRVLNASA IPEGQFIDSK KACEKLLASI 750
    DIDHTQYKFG HTKVFFKAGL LGTLEEMRDE RLAKLITRTQ AVCRGFLMRV 800
    EFQKMMQRRE SIFCIQYNIR AFMNVKHWPW MKLFFKIKPL LKSAETEKEM 850
    ATMKEEFQKT KDELAKSEAK RKELEEKLVT LVQEKNDLQL QVQAESENLL 900
    DAEERCDQLI KAKFQLEAKI KEVTERAEDE EEINAELTAK KRKLEDECSE 950
    LKKDIDDLEL TLAKVEKEKH ATENKVKNLT EELAGLDETI AKLTREKKAL 1000
    QEAHQQTLDD LQAEEDKVNS LSKLKSKLEQ QVDDLESSLE QEKKLRVDLE 1050
    RNKRKLEGDL KLAQESILDL ENDKQQLDER LKKKDFEYSQ LQSKVEDEQT 1100
    LSLQLQKKIK ELQARIEELE EEIEAERATR AKTEKQRSDY ARELEELSER 1150
    LEEAGGVTST QIELNKKREA EFLKLRRDLE EATLQHEATV ATLRKKHADS 1200
    AAELAEQIDN LQRVKQKLEK EKSEFKLEID DLSSSVESVS KSKANLEKIC 1250
    RTLEDQLSEA RGKNEEMQRS LSELTTQKSR LQTEAGELSR QLEEKESIVS 1300
    QLSRSKQAFT QQIEELKRQL EEENKAKNAL AHALQSSRHD CDLLREQYEE 1350
    EQEGKAELQR ALSKANSEVA QWRTKYETDA IQRTEELEEA KKKLAQRLQD 1400
    SEEQVEAVNA KCASLEKTKQ RLQGEVEDLM VDVERANSLA AALDKKQRNF 1450
    DKVLAEWKTK CEESQAELEA ALKESRSLST ELFKLKNAYE EALDQLETVK 1500
    RENKNLEQEI ADLTEQIAEN GKSIHELEKS RKQMELEKAD IQMALEEAEA 1550
    ALEHEEAKIL RIQLELTQVK SEIDRKIAEK DEEIEQLKRN YQRTVETMQG 1600
    ALDAEVRSRN EAIRLKKKME GDLNEIEIQL SHANRQAAET IKHLRSVQGQ 1650
    LKDTQLHLDD ALRGQEDLKE QLAIVERRAN LLQAEVEELR ATLEQTERAR 1700
    KLAEQELLDS NERVQLLHTQ NTSLIHTKKK LETDLTQLQS EVEDACRDAR 1750
    NAEEKAKKAI TDAAMMAEEL KKEQDTSAHL ERMKKNLEQT VKDLQHRLDE 1800
    AEQLALKGGK KQIQKLETRI RELEFELEGE QKRNTESVKG LRKYERRVKE 1850
    LTYQSEEDRK NVLRLQDLVD KLQVKVKSYK RQAEEADEQA NAHLTKFRKA 1900
    QHELEEAEER ADIAESQVNK LRAKTRDFTS SRMVVHESEE 1940
    Length:1,940
    Mass (Da):223,791
    Last modified:January 9, 2007 - v2
    Checksum:i9CF748702D8353C9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1747 – 17471R → Q in AAA39791. (PubMed:3864153)Curated
    Sequence conflicti1858 – 18581D → A in AAA39791. (PubMed:3864153)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL645988, AL596129 Genomic DNA. Translation: CAI25982.2.
    AL596129, AL645988 Genomic DNA. Translation: CAI24992.2.
    AK132623 mRNA. Translation: BAE21268.1.
    M11154 mRNA. Translation: AAA39791.1.
    CCDSiCCDS36184.1.
    PIRiA24733.
    RefSeqiNP_001093105.1. NM_001099635.1.
    XP_006532475.1. XM_006532412.1.
    UniGeneiMm.340090.

    Genome annotation databases

    EnsembliENSMUST00000007301; ENSMUSP00000007301; ENSMUSG00000020908.
    ENSMUST00000108689; ENSMUSP00000104329; ENSMUSG00000020908.
    ENSMUST00000165221; ENSMUSP00000131883; ENSMUSG00000020908.
    GeneIDi17883.
    KEGGimmu:17883.
    UCSCiuc007jlx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL645988 , AL596129 Genomic DNA. Translation: CAI25982.2 .
    AL596129 , AL645988 Genomic DNA. Translation: CAI24992.2 .
    AK132623 mRNA. Translation: BAE21268.1 .
    M11154 mRNA. Translation: AAA39791.1 .
    CCDSi CCDS36184.1.
    PIRi A24733.
    RefSeqi NP_001093105.1. NM_001099635.1.
    XP_006532475.1. XM_006532412.1.
    UniGenei Mm.340090.

    3D structure databases

    ProteinModelPortali P13541.
    SMRi P13541. Positions 4-964.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201647. 5 interactions.

    PTM databases

    PhosphoSitei P13541.

    Proteomic databases

    MaxQBi P13541.
    PaxDbi P13541.
    PRIDEi P13541.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000007301 ; ENSMUSP00000007301 ; ENSMUSG00000020908 .
    ENSMUST00000108689 ; ENSMUSP00000104329 ; ENSMUSG00000020908 .
    ENSMUST00000165221 ; ENSMUSP00000131883 ; ENSMUSG00000020908 .
    GeneIDi 17883.
    KEGGi mmu:17883.
    UCSCi uc007jlx.1. mouse.

    Organism-specific databases

    CTDi 4621.
    MGIi MGI:1339709. Myh3.

    Phylogenomic databases

    eggNOGi COG5022.
    GeneTreei ENSGT00720000108596.
    HOGENOMi HOG000173959.
    HOVERGENi HBG004704.
    InParanoidi P13541.
    KOi K10352.
    OMAi DEQANAH.
    OrthoDBi EOG7RBZ7G.
    PhylomeDBi P13541.
    TreeFami TF314375.

    Miscellaneous databases

    NextBioi 292685.
    PROi P13541.
    SOURCEi Search...

    Gene expression databases

    Bgeei P13541.
    Genevestigatori P13541.

    Family and domain databases

    Gene3Di 4.10.270.10. 1 hit.
    InterProi IPR000048. IQ_motif_EF-hand-BS.
    IPR027401. Myosin-like_IQ_dom.
    IPR001609. Myosin_head_motor_dom.
    IPR004009. Myosin_N.
    IPR002928. Myosin_tail.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00063. Myosin_head. 1 hit.
    PF02736. Myosin_N. 1 hit.
    PF01576. Myosin_tail_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00193. MYOSINHEAVY.
    SMARTi SM00015. IQ. 2 hits.
    SM00242. MYSc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS50096. IQ. 1 hit.
    PS51456. MYOSIN_MOTOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 523-1292.
      Strain: C57BL/6J.
      Tissue: Head.
    3. "Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene."
      Weydert A., Daubas P., Lazaridis I., Barton P., Garner I., Leader D.P., Bonhomme F., Catalan J., Simon D., Guenet J.-L., Gros F., Buckingham M.E.
      Proc. Natl. Acad. Sci. U.S.A. 82:7183-7187(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1747-1905.

    Entry informationi

    Entry nameiMYH3_MOUSE
    AccessioniPrimary (citable) accession number: P13541
    Secondary accession number(s): Q3V183, Q5SUD4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Represents a conventional myosin. This protein should not be confused with the unconventional myosin-3 (MYO3).Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3