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Protein

Myosin-6

Gene

MYH6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Muscle contraction.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi178 – 185ATP8

GO - Molecular functioni

  • actin-dependent ATPase activity Source: HGNC
  • ATPase activity Source: HGNC
  • ATP binding Source: UniProtKB-KW
  • microfilament motor activity Source: BHF-UCL
  • myosin phosphatase activity Source: Reactome
  • protein kinase binding Source: UniProtKB

GO - Biological processi

  • adult heart development Source: HGNC
  • ATP metabolic process Source: BHF-UCL
  • atrial cardiac muscle tissue morphogenesis Source: HGNC
  • BMP signaling pathway Source: Ensembl
  • canonical Wnt signaling pathway Source: Ensembl
  • cardiac muscle contraction Source: BHF-UCL
  • cardiac muscle fiber development Source: BHF-UCL
  • cardiac muscle hypertrophy in response to stress Source: Ensembl
  • in utero embryonic development Source: BHF-UCL
  • muscle contraction Source: HGNC
  • muscle filament sliding Source: HGNC
  • myofibril assembly Source: BHF-UCL
  • regulation of ATPase activity Source: BHF-UCL
  • regulation of blood pressure Source: BHF-UCL
  • regulation of heart contraction Source: BHF-UCL
  • regulation of heart growth Source: Ensembl
  • regulation of heart rate Source: HGNC
  • regulation of the force of heart contraction Source: BHF-UCL
  • sarcomere organization Source: BHF-UCL
  • striated muscle contraction Source: BHF-UCL
  • ventricular cardiac muscle tissue morphogenesis Source: HGNC
  • visceral muscle development Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:G66-33021-MONOMER.
ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-390522. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-6
Alternative name(s):
Myosin heavy chain 6
Myosin heavy chain, cardiac muscle alpha isoform
Short name:
MyHC-alpha
Gene namesi
Name:MYH6
Synonyms:MYHCA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:7576. MYH6.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • muscle myosin complex Source: UniProtKB
  • myofibril Source: BHF-UCL
  • myosin complex Source: HGNC
  • myosin filament Source: UniProtKB-KW
  • sarcomere Source: HGNC
  • stress fiber Source: Ensembl
  • Z disc Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Thick filament

Pathology & Biotechi

Involvement in diseasei

Atrial septal defect 3 (ASD3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria.
See also OMIM:614089
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031883820I → N in ASD3. 1 PublicationCorresponds to variant rs267606903dbSNPEnsembl.1
Cardiomyopathy, familial hypertrophic 14 (CMH14)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
See also OMIM:613251
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031882795R → Q in CMH14; late onset. 1 PublicationCorresponds to variant rs267606907dbSNPEnsembl.1
Natural variantiVAR_0635541065Q → H in CMH14. 1 PublicationCorresponds to variant rs267606904dbSNPEnsembl.1
Cardiomyopathy, dilated 1EE (CMD1EE)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
See also OMIM:613252
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063552830P → L in CMD1EE. 1 PublicationCorresponds to variant rs267606906dbSNPEnsembl.1
Natural variantiVAR_0635531004A → S in CMD1EE. 1 PublicationCorresponds to variant rs143978652dbSNPEnsembl.1
Natural variantiVAR_0635571457E → K in CMD1EE. 1 PublicationCorresponds to variant rs267606905dbSNPEnsembl.1
Sick sinus syndrome 3 (SSS3)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry. The lifetime risk of being diagnosed with sick sinus syndrome is higher for carriers of variant p.Arg721Trp than for non-carriers.1 Publication
Disease descriptionThe term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. Episodes of atrial tachycardias coexisting with sinus bradycardia ('tachycardia-bradycardia syndrome') are also common in this disorder. SSS occurs most often in the elderly associated with underlying heart disease or previous cardiac surgery, but can also occur in the fetus, infant, or child without heart disease or other contributing factors.
See also OMIM:614090
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065561721R → W in SSS3; rare variant predisposing to sick sinus syndrome. 1 PublicationCorresponds to variant rs387906656dbSNPEnsembl.1

Keywords - Diseasei

Atrial septal defect, Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNETi4624.
MalaCardsiMYH6.
MIMi613251. phenotype.
613252. phenotype.
614089. phenotype.
614090. phenotype.
OpenTargetsiENSG00000197616.
Orphaneti99103. Atrial septal defect, ostium secundum type.
154. Familial isolated dilated cardiomyopathy.
155. Familial isolated hypertrophic cardiomyopathy.
166282. Familial sick sinus syndrome.
PharmGKBiPA31373.

Polymorphism and mutation databases

BioMutaiMYH6.
DMDMi317373582.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234011 – 1939Myosin-6Add BLAST1939

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei129N6,N6,N6-trimethyllysineSequence analysis1
Modified residuei379PhosphothreonineBy similarity1
Modified residuei417PhosphoserineBy similarity1
Modified residuei1139PhosphoserineBy similarity1
Modified residuei1261PhosphotyrosineBy similarity1
Modified residuei1271PhosphoserineBy similarity1
Modified residuei1277PhosphothreonineBy similarity1
Modified residuei1284PhosphothreonineBy similarity1
Modified residuei1309PhosphoserineBy similarity1
Modified residuei1310PhosphotyrosineBy similarity1
Modified residuei1311PhosphothreonineBy similarity1
Modified residuei1512PhosphoserineBy similarity1
Modified residuei1515PhosphothreonineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiP13533.
MaxQBiP13533.
PaxDbiP13533.
PeptideAtlasiP13533.
PRIDEiP13533.

2D gel databases

UCD-2DPAGEP13533.

PTM databases

iPTMnetiP13533.
PhosphoSitePlusiP13533.

Expressioni

Gene expression databases

BgeeiENSG00000197616.
CleanExiHS_MYH6.
GenevisibleiP13533. HS.

Organism-specific databases

HPAiCAB075723.
CAB075724.
CAB075725.
HPA001239.
HPA001349.

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi110709. 33 interactors.
IntActiP13533. 25 interactors.
MINTiMINT-2801052.
STRINGi9606.ENSP00000348634.

Structurei

3D structure databases

ProteinModelPortaliP13533.
SMRiP13533.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 780Myosin motorAdd BLAST696
Domaini783 – 812IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni657 – 679Actin-bindingAdd BLAST23
Regioni759 – 773Actin-bindingAdd BLAST15

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili842 – 1939Sequence analysisAdd BLAST1098

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00760000118919.
HOGENOMiHOG000173959.
HOVERGENiHBG004704.
InParanoidiP13533.
KOiK17751.
OMAiMVEQTER.
OrthoDBiEOG091G07UM.
PhylomeDBiP13533.
TreeFamiTF314375.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13533-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDAQMADFG AAAQYLRKSE KERLEAQTRP FDIRTECFVP DDKEEFVKAK
60 70 80 90 100
ILSREGGKVI AETENGKTVT VKEDQVLQQN PPKFDKIEDM AMLTFLHEPA
110 120 130 140 150
VLFNLKERYA AWMIYTYSGL FCVTVNPYKW LPVYNAEVVA AYRGKKRSEA
160 170 180 190 200
PPHIFSISDN AYQYMLTDRE NQSILITGES GAGKTVNTKR VIQYFASIAA
210 220 230 240 250
IGDRGKKDNA NANKGTLEDQ IIQANPALEA FGNAKTVRND NSSRFGKFIR
260 270 280 290 300
IHFGATGKLA SADIETYLLE KSRVIFQLKA ERNYHIFYQI LSNKKPELLD
310 320 330 340 350
MLLVTNNPYD YAFVSQGEVS VASIDDSEEL MATDSAFDVL GFTSEEKAGV
360 370 380 390 400
YKLTGAIMHY GNMKFKQKQR EEQAEPDGTE DADKSAYLMG LNSADLLKGL
410 420 430 440 450
CHPRVKVGNE YVTKGQSVQQ VYYSIGALAK AVYEKMFNWM VTRINATLET
460 470 480 490 500
KQPRQYFIGV LDIAGFEIFD FNSFEQLCIN FTNEKLQQFF NHHMFVLEQE
510 520 530 540 550
EYKKEGIEWT FIDFGMDLQA CIDLIEKPMG IMSILEEECM FPKATDMTFK
560 570 580 590 600
AKLYDNHLGK SNNFQKPRNI KGKQEAHFSL IHYAGTVDYN ILGWLEKNKD
610 620 630 640 650
PLNETVVALY QKSSLKLMAT LFSSYATADT GDSGKSKGGK KKGSSFQTVS
660 670 680 690 700
ALHRENLNKL MTNLRTTHPH FVRCIIPNER KAPGVMDNPL VMHQLRCNGV
710 720 730 740 750
LEGIRICRKG FPNRILYGDF RQRYRILNPV AIPEGQFIDS RKGTEKLLSS
760 770 780 790 800
LDIDHNQYKF GHTKVFFKAG LLGLLEEMRD ERLSRIITRM QAQARGQLMR
810 820 830 840 850
IEFKKIVERR DALLVIQWNI RAFMGVKNWP WMKLYFKIKP LLKSAETEKE
860 870 880 890 900
MATMKEEFGR IKETLEKSEA RRKELEEKMV SLLQEKNDLQ LQVQAEQDNL
910 920 930 940 950
NDAEERCDQL IKNKIQLEAK VKEMNERLED EEEMNAELTA KKRKLEDECS
960 970 980 990 1000
ELKKDIDDLE LTLAKVEKEK HATENKVKNL TEEMAGLDEI IAKLTKEKKA
1010 1020 1030 1040 1050
LQEAHQQALD DLQVEEDKVN SLSKSKVKLE QQVDDLEGSL EQEKKVRMDL
1060 1070 1080 1090 1100
ERAKRKLEGD LKLTQESIMD LENDKLQLEE KLKKKEFDIN QQNSKIEDEQ
1110 1120 1130 1140 1150
VLALQLQKKL KENQARIEEL EEELEAERTA RAKVEKLRSD LSRELEEISE
1160 1170 1180 1190 1200
RLEEAGGATS VQIEMNKKRE AEFQKMRRDL EEATLQHEAT AAALRKKHAD
1210 1220 1230 1240 1250
SVAELGEQID NLQRVKQKLE KEKSEFKLEL DDVTSNMEQI IKAKANLEKV
1260 1270 1280 1290 1300
SRTLEDQANE YRVKLEEAQR SLNDFTTQRA KLQTENGELA RQLEEKEALI
1310 1320 1330 1340 1350
SQLTRGKLSY TQQMEDLKRQ LEEEGKAKNA LAHALQSARH DCDLLREQYE
1360 1370 1380 1390 1400
EETEAKAELQ RVLSKANSEV AQWRTKYETD AIQRTEELEE AKKKLAQRLQ
1410 1420 1430 1440 1450
DAEEAVEAVN AKCSSLEKTK HRLQNEIEDL MVDVERSNAA AAALDKKQRN
1460 1470 1480 1490 1500
FDKILAEWKQ KYEESQSELE SSQKEARSLS TELFKLKNAY EESLEHLETF
1510 1520 1530 1540 1550
KRENKNLQEE ISDLTEQLGE GGKNVHELEK VRKQLEVEKL ELQSALEEAE
1560 1570 1580 1590 1600
ASLEHEEGKI LRAQLEFNQI KAEIERKLAE KDEEMEQAKR NHQRVVDSLQ
1610 1620 1630 1640 1650
TSLDAETRSR NEVLRVKKKM EGDLNEMEIQ LSHANRMAAE AQKQVKSLQS
1660 1670 1680 1690 1700
LLKDTQIQLD DAVRANDDLK ENIAIVERRN NLLQAELEEL RAVVEQTERS
1710 1720 1730 1740 1750
RKLAEQELIE TSERVQLLHS QNTSLINQKK KMESDLTQLQ SEVEEAVQEC
1760 1770 1780 1790 1800
RNAEEKAKKA ITDAAMMAEE LKKEQDTSAH LERMKKNMEQ TIKDLQHRLD
1810 1820 1830 1840 1850
EAEQIALKGG KKQLQKLEAR VRELEGELEA EQKRNAESVK GMRKSERRIK
1860 1870 1880 1890 1900
ELTYQTEEDK KNLLRLQDLV DKLQLKVKAY KRQAEEAEEQ ANTNLSKFRK
1910 1920 1930
VQHELDEAEE RADIAESQVN KLRAKSRDIG AKQKMHDEE
Length:1,939
Mass (Da):223,735
Last modified:January 11, 2011 - v5
Checksum:i424211CC048C8004
GO

Sequence cautioni

The sequence CAA29120 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4A → S in CAA29120 (PubMed:3037493).Curated1
Sequence conflicti11 – 12AA → T in CAA29120 (PubMed:3037493).Curated2
Sequence conflicti574Q → P in BAA00791 (PubMed:1776652).Curated1
Sequence conflicti608A → G in BAA00791 (PubMed:1776652).Curated1
Sequence conflicti744T → A in BAA00791 (PubMed:1776652).Curated1
Sequence conflicti790M → I in BAA00791 (PubMed:1776652).Curated1
Sequence conflicti1014V → A in BAA00791 (PubMed:1776652).Curated1
Sequence conflicti1021S → T in BAA00791 (PubMed:1776652).Curated1
Sequence conflicti1290A → S in BAA00791 (PubMed:1776652).Curated1
Sequence conflicti1373W → C in BAA00791 (PubMed:1776652).Curated1
Sequence conflicti1533K → N in AAA36344 (PubMed:2969919).Curated1
Sequence conflicti1540L → M in AAA36344 (PubMed:2969919).Curated1
Sequence conflicti1577 – 1578KL → NV in AAA36344 (PubMed:2969919).Curated2
Sequence conflicti1705 – 1706EQ → DR in BAA00791 (PubMed:1776652).Curated2
Sequence conflicti1705 – 1706EQ → DR in AAA60387 (PubMed:2726733).Curated2
Sequence conflicti1733E → D in BAA00791 (PubMed:1776652).Curated1
Sequence conflicti1733E → D in AAA36344 (PubMed:2969919).Curated1
Sequence conflicti1734S → A in BAA00791 (PubMed:1776652).Curated1
Sequence conflicti1734S → A in AAA60387 (PubMed:2726733).Curated1
Sequence conflicti1734S → A in AAA36344 (PubMed:2969919).Curated1
Sequence conflicti1763D → H in BAA00791 (PubMed:1776652).Curated1
Sequence conflicti1788M → I in AAA60387 (PubMed:2726733).Curated1
Sequence conflicti1871D → N in AAA36344 (PubMed:2969919).Curated1
Sequence conflicti1882R → G in AAA36344 (PubMed:2969919).Curated1
Sequence conflicti1890Q → R in AAA36344 (PubMed:2969919).Curated1
Sequence conflicti1933Missing in AAA36344 (PubMed:2969919).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06355056G → R.1 PublicationCorresponds to variant rs28711516dbSNPEnsembl.1
Natural variantiVAR_03020388E → Q.2 PublicationsCorresponds to variant rs442275dbSNPEnsembl.1
Natural variantiVAR_063551275I → N.1 PublicationCorresponds to variant rs201327273dbSNPEnsembl.1
Natural variantiVAR_065561721R → W in SSS3; rare variant predisposing to sick sinus syndrome. 1 PublicationCorresponds to variant rs387906656dbSNPEnsembl.1
Natural variantiVAR_030204783L → M.Corresponds to variant rs11847151dbSNPEnsembl.1
Natural variantiVAR_031882795R → Q in CMH14; late onset. 1 PublicationCorresponds to variant rs267606907dbSNPEnsembl.1
Natural variantiVAR_031883820I → N in ASD3. 1 PublicationCorresponds to variant rs267606903dbSNPEnsembl.1
Natural variantiVAR_063552830P → L in CMD1EE. 1 PublicationCorresponds to variant rs267606906dbSNPEnsembl.1
Natural variantiVAR_0635531004A → S in CMD1EE. 1 PublicationCorresponds to variant rs143978652dbSNPEnsembl.1
Natural variantiVAR_0635541065Q → H in CMH14. 1 PublicationCorresponds to variant rs267606904dbSNPEnsembl.1
Natural variantiVAR_0302051101V → A.1 PublicationCorresponds to variant rs365990dbSNPEnsembl.1
Natural variantiVAR_0635551130A → T.1 PublicationCorresponds to variant rs28730771dbSNPEnsembl.1
Natural variantiVAR_0635561295E → Q.1 PublicationCorresponds to variant rs34935550dbSNPEnsembl.1
Natural variantiVAR_0635571457E → K in CMD1EE. 1 PublicationCorresponds to variant rs267606905dbSNPEnsembl.1
Natural variantiVAR_0635581502R → Q.1 PublicationCorresponds to variant rs199936506dbSNPEnsembl.1
Natural variantiVAR_0613641593Q → L.Corresponds to variant rs45574136dbSNPEnsembl.1
Natural variantiVAR_0302061737T → S.1 PublicationCorresponds to variant rs1059854dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00943 mRNA. Translation: BAA00791.1.
Z20656 Genomic DNA. Translation: CAA79675.1.
GU324919 Genomic DNA. Translation: ADL14490.1.
AL049829 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66154.1.
BC132667 mRNA. Translation: AAI32668.1.
M25140, M25162 Genomic DNA. Translation: AAA60386.1.
M25142, M25141 Genomic DNA. Translation: AAA60387.1.
X05632 Genomic DNA. Translation: CAA29120.1. Sequence problems.
M21664 mRNA. Translation: AAA36344.1.
CCDSiCCDS9600.1.
PIRiA46762.
RefSeqiNP_002462.2. NM_002471.3.
UniGeneiHs.278432.

Genome annotation databases

EnsembliENST00000356287; ENSP00000348634; ENSG00000197616.
ENST00000405093; ENSP00000386041; ENSG00000197616.
GeneIDi4624.
KEGGihsa:4624.
UCSCiuc001wjv.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00943 mRNA. Translation: BAA00791.1.
Z20656 Genomic DNA. Translation: CAA79675.1.
GU324919 Genomic DNA. Translation: ADL14490.1.
AL049829 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66154.1.
BC132667 mRNA. Translation: AAI32668.1.
M25140, M25162 Genomic DNA. Translation: AAA60386.1.
M25142, M25141 Genomic DNA. Translation: AAA60387.1.
X05632 Genomic DNA. Translation: CAA29120.1. Sequence problems.
M21664 mRNA. Translation: AAA36344.1.
CCDSiCCDS9600.1.
PIRiA46762.
RefSeqiNP_002462.2. NM_002471.3.
UniGeneiHs.278432.

3D structure databases

ProteinModelPortaliP13533.
SMRiP13533.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110709. 33 interactors.
IntActiP13533. 25 interactors.
MINTiMINT-2801052.
STRINGi9606.ENSP00000348634.

PTM databases

iPTMnetiP13533.
PhosphoSitePlusiP13533.

Polymorphism and mutation databases

BioMutaiMYH6.
DMDMi317373582.

2D gel databases

UCD-2DPAGEP13533.

Proteomic databases

EPDiP13533.
MaxQBiP13533.
PaxDbiP13533.
PeptideAtlasiP13533.
PRIDEiP13533.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356287; ENSP00000348634; ENSG00000197616.
ENST00000405093; ENSP00000386041; ENSG00000197616.
GeneIDi4624.
KEGGihsa:4624.
UCSCiuc001wjv.3. human.

Organism-specific databases

CTDi4624.
DisGeNETi4624.
GeneCardsiMYH6.
GeneReviewsiMYH6.
HGNCiHGNC:7576. MYH6.
HPAiCAB075723.
CAB075724.
CAB075725.
HPA001239.
HPA001349.
MalaCardsiMYH6.
MIMi160710. gene.
613251. phenotype.
613252. phenotype.
614089. phenotype.
614090. phenotype.
neXtProtiNX_P13533.
OpenTargetsiENSG00000197616.
Orphaneti99103. Atrial septal defect, ostium secundum type.
154. Familial isolated dilated cardiomyopathy.
155. Familial isolated hypertrophic cardiomyopathy.
166282. Familial sick sinus syndrome.
PharmGKBiPA31373.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00760000118919.
HOGENOMiHOG000173959.
HOVERGENiHBG004704.
InParanoidiP13533.
KOiK17751.
OMAiMVEQTER.
OrthoDBiEOG091G07UM.
PhylomeDBiP13533.
TreeFamiTF314375.

Enzyme and pathway databases

BioCyciZFISH:G66-33021-MONOMER.
ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-390522. Striated Muscle Contraction.

Miscellaneous databases

ChiTaRSiMYH6. human.
GeneWikiiMYH6.
GenomeRNAii4624.
PROiP13533.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197616.
CleanExiHS_MYH6.
GenevisibleiP13533. HS.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYH6_HUMAN
AccessioniPrimary (citable) accession number: P13533
Secondary accession number(s): A2RTX1
, D9YZU2, Q13943, Q14906, Q14907
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 177 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.

Caution

Represents a conventional myosin. This protein should not be confused with the unconventional myosin-6 (MYO6).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.