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P13528 (UNC86_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 133. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor unc-86
Alternative name(s):
Uncoordinated protein 86
Gene names
Name:unc-86
ORF Names:C30A5.7
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length467 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Transcription factor involved in cell lineages and cell differentiation.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the POU transcription factor family. Class-4 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Sequence caution

The sequence CCD62655.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CCD62656.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform b (identifier: P13528-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform a (identifier: P13528-2)

The sequence of this isoform differs from the canonical sequence as follows:
     129-134: FNNSLF → DFILFI
     135-172: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 467467Transcription factor unc-86
PRO_0000100780

Regions

Domain265 – 34278POU-specific
DNA binding363 – 42260Homeobox
Motif145 – 15410POU-IV box

Natural variations

Alternative sequence129 – 1346FNNSLF → DFILFI in isoform a.
VSP_002343
Alternative sequence135 – 17238Missing in isoform a.
VSP_002344

Sequences

Sequence LengthMass (Da)Tools
Isoform b [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: 86C3507584C91AC2

FASTA46752,315
        10         20         30         40         50         60 
MEKAHRFRLP FCSFFPVPLL VSVLIFHHSA PFLIQLFFPS PLFNPLLRPS KISRGSENGA 

        70         80         90        100        110        120 
CTSHSTLQRT RKIIQWELPK RGGDQDIGDP RPFRIHLSPP SFKVPLFSTD MQNTAPVPTT 

       130        140        150        160        170        180 
TTASKMQPFN NSLFGSFDDP ILNARAAQVA LADIDVKNVP QLTNPLMRPH DMFSYSNYFS 

       190        200        210        220        230        240 
GIHDTSAATN IYQGLPSSSE PFDASVVVPT SSDDQMTPLQ QVMAMQQSYG APPPFQYNMT 

       250        260        270        280        290        300 
HPFSTTSIAS SNNLARYPIA PPTSDMDTDP RQLETFAEHF KQRRIKLGVT QADVGKALAH 

       310        320        330        340        350        360 
LKMPGVGSLS QSTICRFESL TLSHNNMVAL KPILHSWLEK AEEAMKQKDT IGDINGILPN 

       370        380        390        400        410        420 
TDKKRKRTSI AAPEKRELEQ FFKQQPRPSG ERIASIADRL DLKKNVVRVW FCNQRQKQKR 

       430        440        450        460 
DFRSQFRARS AAAVMGPRVM PVLNGNNSNN NLKQGQTTYN GLPGFFD 

« Hide

Isoform a [UniParc].

Checksum: 4389449360DC5FC9
Show »

FASTA42948,214

References

« Hide 'large scale' references
[1]"The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors."
Finney M., Ruvkun G., Horvitz H.R.
Cell 55:757-769(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A AND B).
[2]"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans."
Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L. expand/collapse author list , Gardner A., Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., Wohldman P.
Nature 368:32-38(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
[3]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M22363 Genomic DNA. Translation: AAA28158.1.
M22363 Genomic DNA. Translation: AAA28159.1.
FO080290 Genomic DNA. Translation: CCD62655.1. Sequence problems.
FO080290 Genomic DNA. Translation: CCD62656.1. Sequence problems.
PIRA30042.
S44778.
RefSeqNP_001021191.2. NM_001026020.4.
NP_498795.2. NM_066394.2.
UniGeneCel.24958.

3D structure databases

ProteinModelPortalP13528.
SMRP13528. Positions 269-420.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP13528. 1 interaction.
STRING6239.C30A5.7b.

Proteomic databases

PaxDbP13528.
PRIDEP13528.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID176157.
KEGGcel:CELE_C30A5.7.
UCSCC30A5.7b. c. elegans. [P13528-1]

Organism-specific databases

CTD176157.
WormBaseC30A5.7a; CE45098; WBGene00006818; unc-86.
C30A5.7b; CE45067; WBGene00006818; unc-86.

Phylogenomic databases

eggNOGNOG289030.
HOGENOMHOG000116305.
InParanoidP13528.
OrthoDBEOG7RV9G7.
PhylomeDBP13528.

Enzyme and pathway databases

SignaLinkP13528.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR015584. POU4-related.
IPR000327. POU_specific.
[Graphical view]
PANTHERPTHR11636:SF10. PTHR11636:SF10. 1 hit.
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio891370.

Entry information

Entry nameUNC86_CAEEL
AccessionPrimary (citable) accession number: P13528
Secondary accession number(s): D7SFI2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: June 11, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase