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Protein

Cytochrome P450 6A1

Gene

CYP6A1

Organism
Musca domestica (House fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi449Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 6A1 (EC:1.14.14.1)
Alternative name(s):
CYPVIA1
Gene namesi
Name:CYP6A1
OrganismiMusca domestica (House fly)
Taxonomic identifieri7370 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca
Proteomesi
  • UP000095301 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000518651 – 509Cytochrome P450 6A1Add BLAST509

Structurei

3D structure databases

ProteinModelPortaliP13527.
SMRiP13527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

KOiK14999.

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

P13527-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFGSFLLYA LGVLASLALY FVRWNFGYWK RRGIPHEEPH LVMGNVKGLR
60 70 80 90 100
SKYHIGEIIA DYYRKFKGSD PLPGIFLGHK PAAVVLDKEL RKRVLIKDFS
110 120 130 140 150
NFANRGLYYN EKDDPLTGHL VMVEGEKWRS LRTKLSPTFT AGKMKYMYNT
160 170 180 190 200
VLEVGQRLLE VMYEKLEVSS ELDMRDILAR FNTDVIGSVA FGIECNSLRN
210 220 230 240 250
PHDRFLAMGR KSIEVPRHNA LIMAFIDSFP ELSRKLGMRV LPEDVHQFFM
260 270 280 290 300
SSIKETVDYR EKNNIRRNDF LDLVLDLKNN PESISKLGGL TFNELAAQVF
310 320 330 340 350
VFFLGGFETS SSTMGFALYE LAQNQQLQDR LREEVNEVFD QFKEDNISYD
360 370 380 390 400
ALMNIPYLDQ VLNETLRKYP VGVGSALTRQ TLNDYVVPHN PKYVLPKGTL
410 420 430 440 450
VFIPVLGIHY DPELYPNPEE FDPERFSPEM VKQRDSVDWL GFGDGPRNCI
460 470 480 490 500
GMRFGKMQSR LGLALVIRHF RFTVCSRTDI PMQINPESLA WTPKNNLYLN

VQAIRKKIK
Length:509
Mass (Da):58,731
Last modified:January 1, 1990 - v1
Checksum:i229EF807F1DFF8F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70 – 73DPLP → GPFA in AAA29293 (PubMed:2922393).Curated4
Sequence conflicti372 – 373Missing in AAA29293 (PubMed:2922393).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27242 Genomic DNA. Translation: AAA72423.1.
M25367 mRNA. Translation: AAA29293.1.
PIRiA32157.
RefSeqiNP_001274159.1. NM_001287230.1.

Genome annotation databases

GeneIDi101889365.
KEGGimde:101889365.

Similar proteinsi

Entry informationi

Entry nameiCP6A1_MUSDO
AccessioniPrimary (citable) accession number: P13527
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: August 30, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families