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P13527

- CP6A1_MUSDO

UniProt

P13527 - CP6A1_MUSDO

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Protein

Cytochrome P450 6A1

Gene

CYP6A1

Organism
Musca domestica (House fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi449 – 4491Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 6A1 (EC:1.14.14.1)
Alternative name(s):
CYPVIA1
Gene namesi
Name:CYP6A1
OrganismiMusca domestica (House fly)
Taxonomic identifieri7370 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Cytochrome P450 6A1PRO_0000051865Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP13527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13527-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFGSFLLYA LGVLASLALY FVRWNFGYWK RRGIPHEEPH LVMGNVKGLR
60 70 80 90 100
SKYHIGEIIA DYYRKFKGSD PLPGIFLGHK PAAVVLDKEL RKRVLIKDFS
110 120 130 140 150
NFANRGLYYN EKDDPLTGHL VMVEGEKWRS LRTKLSPTFT AGKMKYMYNT
160 170 180 190 200
VLEVGQRLLE VMYEKLEVSS ELDMRDILAR FNTDVIGSVA FGIECNSLRN
210 220 230 240 250
PHDRFLAMGR KSIEVPRHNA LIMAFIDSFP ELSRKLGMRV LPEDVHQFFM
260 270 280 290 300
SSIKETVDYR EKNNIRRNDF LDLVLDLKNN PESISKLGGL TFNELAAQVF
310 320 330 340 350
VFFLGGFETS SSTMGFALYE LAQNQQLQDR LREEVNEVFD QFKEDNISYD
360 370 380 390 400
ALMNIPYLDQ VLNETLRKYP VGVGSALTRQ TLNDYVVPHN PKYVLPKGTL
410 420 430 440 450
VFIPVLGIHY DPELYPNPEE FDPERFSPEM VKQRDSVDWL GFGDGPRNCI
460 470 480 490 500
GMRFGKMQSR LGLALVIRHF RFTVCSRTDI PMQINPESLA WTPKNNLYLN

VQAIRKKIK
Length:509
Mass (Da):58,731
Last modified:January 1, 1990 - v1
Checksum:i229EF807F1DFF8F5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 734DPLP → GPFA in AAA29293. (PubMed:2922393)Curated
Sequence conflicti372 – 3732Missing in AAA29293. (PubMed:2922393)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L27242 Genomic DNA. Translation: AAA72423.1.
M25367 mRNA. Translation: AAA29293.1.
PIRiA32157.
RefSeqiNP_001274159.1. NM_001287230.1.

Genome annotation databases

GeneIDi101889365.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L27242 Genomic DNA. Translation: AAA72423.1 .
M25367 mRNA. Translation: AAA29293.1 .
PIRi A32157.
RefSeqi NP_001274159.1. NM_001287230.1.

3D structure databases

ProteinModelPortali P13527.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101889365.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and sequence of cDNA encoding a cytochrome P-450 from an insecticide-resistant strain of the house fly, Musca domestica."
    Feyereisen R., Koener J.F., Farnsworth D.E., Nebert D.W.
    Proc. Natl. Acad. Sci. U.S.A. 86:1465-1469(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCP6A1_MUSDO
AccessioniPrimary (citable) accession number: P13527
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3