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P13527

- CP6A1_MUSDO

UniProt

P13527 - CP6A1_MUSDO

Protein

Cytochrome P450 6A1

Gene

CYP6A1

Organism
Musca domestica (House fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi449 – 4491Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 6A1 (EC:1.14.14.1)
    Alternative name(s):
    CYPVIA1
    Gene namesi
    Name:CYP6A1
    OrganismiMusca domestica (House fly)
    Taxonomic identifieri7370 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 509509Cytochrome P450 6A1PRO_0000051865Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP13527.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P13527-1 [UniParc]FASTAAdd to Basket

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    MDFGSFLLYA LGVLASLALY FVRWNFGYWK RRGIPHEEPH LVMGNVKGLR    50
    SKYHIGEIIA DYYRKFKGSD PLPGIFLGHK PAAVVLDKEL RKRVLIKDFS 100
    NFANRGLYYN EKDDPLTGHL VMVEGEKWRS LRTKLSPTFT AGKMKYMYNT 150
    VLEVGQRLLE VMYEKLEVSS ELDMRDILAR FNTDVIGSVA FGIECNSLRN 200
    PHDRFLAMGR KSIEVPRHNA LIMAFIDSFP ELSRKLGMRV LPEDVHQFFM 250
    SSIKETVDYR EKNNIRRNDF LDLVLDLKNN PESISKLGGL TFNELAAQVF 300
    VFFLGGFETS SSTMGFALYE LAQNQQLQDR LREEVNEVFD QFKEDNISYD 350
    ALMNIPYLDQ VLNETLRKYP VGVGSALTRQ TLNDYVVPHN PKYVLPKGTL 400
    VFIPVLGIHY DPELYPNPEE FDPERFSPEM VKQRDSVDWL GFGDGPRNCI 450
    GMRFGKMQSR LGLALVIRHF RFTVCSRTDI PMQINPESLA WTPKNNLYLN 500
    VQAIRKKIK 509
    Length:509
    Mass (Da):58,731
    Last modified:January 1, 1990 - v1
    Checksum:i229EF807F1DFF8F5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti70 – 734DPLP → GPFA in AAA29293. (PubMed:2922393)Curated
    Sequence conflicti372 – 3732Missing in AAA29293. (PubMed:2922393)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L27242 Genomic DNA. Translation: AAA72423.1.
    M25367 mRNA. Translation: AAA29293.1.
    PIRiA32157.
    RefSeqiNP_001274159.1. NM_001287230.1.

    Genome annotation databases

    GeneIDi101889365.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L27242 Genomic DNA. Translation: AAA72423.1 .
    M25367 mRNA. Translation: AAA29293.1 .
    PIRi A32157.
    RefSeqi NP_001274159.1. NM_001287230.1.

    3D structure databases

    ProteinModelPortali P13527.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 101889365.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and sequence of cDNA encoding a cytochrome P-450 from an insecticide-resistant strain of the house fly, Musca domestica."
      Feyereisen R., Koener J.F., Farnsworth D.E., Nebert D.W.
      Proc. Natl. Acad. Sci. U.S.A. 86:1465-1469(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCP6A1_MUSDO
    AccessioniPrimary (citable) accession number: P13527
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3