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P13527 (CP6A1_MUSDO) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 6A1

EC=1.14.14.1
Alternative name(s):
CYPVIA1
Gene names
Name:CYP6A1
OrganismMusca domestica (House fly)
Taxonomic identifier7370 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 509509Cytochrome P450 6A1
PRO_0000051865

Sites

Metal binding4491Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict70 – 734DPLP → GPFA in AAA29293. Ref.1
Sequence conflict372 – 3732Missing in AAA29293. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P13527 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: 229EF807F1DFF8F5

FASTA50958,731
        10         20         30         40         50         60 
MDFGSFLLYA LGVLASLALY FVRWNFGYWK RRGIPHEEPH LVMGNVKGLR SKYHIGEIIA 

        70         80         90        100        110        120 
DYYRKFKGSD PLPGIFLGHK PAAVVLDKEL RKRVLIKDFS NFANRGLYYN EKDDPLTGHL 

       130        140        150        160        170        180 
VMVEGEKWRS LRTKLSPTFT AGKMKYMYNT VLEVGQRLLE VMYEKLEVSS ELDMRDILAR 

       190        200        210        220        230        240 
FNTDVIGSVA FGIECNSLRN PHDRFLAMGR KSIEVPRHNA LIMAFIDSFP ELSRKLGMRV 

       250        260        270        280        290        300 
LPEDVHQFFM SSIKETVDYR EKNNIRRNDF LDLVLDLKNN PESISKLGGL TFNELAAQVF 

       310        320        330        340        350        360 
VFFLGGFETS SSTMGFALYE LAQNQQLQDR LREEVNEVFD QFKEDNISYD ALMNIPYLDQ 

       370        380        390        400        410        420 
VLNETLRKYP VGVGSALTRQ TLNDYVVPHN PKYVLPKGTL VFIPVLGIHY DPELYPNPEE 

       430        440        450        460        470        480 
FDPERFSPEM VKQRDSVDWL GFGDGPRNCI GMRFGKMQSR LGLALVIRHF RFTVCSRTDI 

       490        500 
PMQINPESLA WTPKNNLYLN VQAIRKKIK 

« Hide

References

[1]"Isolation and sequence of cDNA encoding a cytochrome P-450 from an insecticide-resistant strain of the house fly, Musca domestica."
Feyereisen R., Koener J.F., Farnsworth D.E., Nebert D.W.
Proc. Natl. Acad. Sci. U.S.A. 86:1465-1469(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L27242 Genomic DNA. Translation: AAA72423.1.
M25367 mRNA. Translation: AAA29293.1.
PIRA32157.
RefSeqNP_001274159.1. NM_001287230.1.

3D structure databases

ProteinModelPortalP13527.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID101889365.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP6A1_MUSDO
AccessionPrimary (citable) accession number: P13527
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: March 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families