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P13521

- SCG2_HUMAN

UniProt

P13521 - SCG2_HUMAN

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Protein
Secretogranin-2
Gene
SCG2, CHGC
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides.

GO - Molecular functioni

  1. chemoattractant activity Source: HGNC
  2. cytokine activity Source: HGNC

GO - Biological processi

  1. MAPK cascade Source: HGNC
  2. angiogenesis Source: HGNC
  3. cellular component movement Source: HGNC
  4. endothelial cell migration Source: HGNC
  5. eosinophil chemotaxis Source: HGNC
  6. induction of positive chemotaxis Source: HGNC
  7. inflammatory response Source: HGNC
  8. intracellular signal transduction Source: HGNC
  9. negative regulation of endothelial cell apoptotic process Source: BHF-UCL
  10. negative regulation of endothelial cell proliferation Source: HGNC
  11. negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
  12. positive chemotaxis Source: GOC
  13. positive regulation of endothelial cell proliferation Source: HGNC
  14. protein secretion Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Secretogranin-2
Alternative name(s):
Chromogranin-C
Secretogranin II
Short name:
SgII
Cleaved into the following chain:
Secretoneurin
Short name:
SN
Gene namesi
Name:SCG2
Synonyms:CHGC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:10575. SCG2.

Subcellular locationi

Secreted
Note: Neuroendocrine and endocrine secretory granules.

GO - Cellular componenti

  1. extracellular space Source: HGNC
  2. secretory granule Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34987.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed prediction
Add
BLAST
Propeptidei28 – 303 Reviewed prediction
PRO_0000005452
Chaini31 – 617587Secretogranin-2
PRO_0000005453Add
BLAST
Peptidei182 – 21433Secretoneurin
PRO_0000005454Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511Sulfotyrosine1 Publication

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Sulfation

Proteomic databases

PaxDbiP13521.
PRIDEiP13521.

PTM databases

PhosphoSiteiP13521.

Expressioni

Gene expression databases

ArrayExpressiP13521.
BgeeiP13521.
CleanExiHS_SCG2.
GenevestigatoriP13521.

Organism-specific databases

HPAiCAB002519.
HPA011893.

Interactioni

Protein-protein interaction databases

BioGridi113611. 4 interactions.
IntActiP13521. 6 interactions.
MINTiMINT-2864303.
STRINGi9606.ENSP00000304133.

Structurei

3D structure databases

ProteinModelPortaliP13521.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni182 – 20019O-glycosylated at one site
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47177.
HOGENOMiHOG000059543.
HOVERGENiHBG054148.
InParanoidiP13521.
OMAiEIVEEQY.
OrthoDBiEOG7K0ZC3.
PhylomeDBiP13521.
TreeFamiTF334018.

Family and domain databases

InterProiIPR018054. Chromogranin_CS.
IPR001990. Granin.
[Graphical view]
PfamiPF01271. Granin. 1 hit.
[Graphical view]
PROSITEiPS00422. GRANINS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13521-1 [UniParc]FASTAAdd to Basket

« Hide

MAEAKTHWLG AALSLIPLIF LISGAEAASF QRNQLLQKEP DLRLENVQKF    50
PSPEMIRALE YIENLRQQAH KEESSPDYNP YQGVSVPLQQ KENGDESHLP 100
ERDSLSEEDW MRIILEALRQ AENEPQSAPK ENKPYALNSE KNFPMDMSDD 150
YETQQWPERK LKHMQFPPMY EENSRDNPFK RTNEIVEEQY TPQSLATLES 200
VFQELGKLTG PNNQKRERMD EEQKLYTDDE DDIYKANNIA YEDVVGGEDW 250
NPVEEKIESQ TQEEVRDSKE NIEKNEQIND EMKRSGQLGI QEEDLRKESK 300
DQLSDDVSKV IAYLKRLVNA AGSGRLQNGQ NGERATRLFE KPLDSQSIYQ 350
LIEISRNLQI PPEDLIEMLK TGEKPNGSVE PERELDLPVD LDDISEADLD 400
HPDLFQNRML SKSGYPKTPG RAGTEALPDG LSVEDILNLL GMESAANQKT 450
SYFPNPYNQE KVLPRLPYGA GRSRSNQLPK AAWIPHVENR QMAYENLNDK 500
DQELGEYLAR MLVKYPEIIN SNQVKRVPGQ GSSEDDLQEE EQIEQAIKEH 550
LNQGSSQETD KLAPVSKRFP VGPPKNDDTP NRQYWDEDLL MKVLEYLNQE 600
KAEKGREHIA KRAMENM 617
Length:617
Mass (Da):70,941
Last modified:April 3, 2007 - v2
Checksum:iA81C9C091DE9DF6B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611Y → H.
Corresponds to variant rs16864976 [ dbSNP | Ensembl ].
VAR_031555
Natural varianti196 – 1961A → V.
Corresponds to variant rs1438157 [ dbSNP | Ensembl ].
VAR_048755
Natural varianti294 – 2941D → G.1 Publication
Corresponds to variant rs17852053 [ dbSNP | Ensembl ].
VAR_031556
Natural varianti421 – 4211R → G.1 Publication
Corresponds to variant rs17856669 [ dbSNP | Ensembl ].
VAR_031557
Natural varianti535 – 5351D → G.1 Publication
Corresponds to variant rs17852054 [ dbSNP | Ensembl ].
VAR_031558
Natural varianti564 – 5641P → L.
Corresponds to variant rs36043001 [ dbSNP | Ensembl ].
VAR_031559

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti273 – 2731E → G in AAA36607. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25756 mRNA. Translation: AAA36607.1.
AK312452 mRNA. Translation: BAG35359.1.
AC012512 Genomic DNA. Translation: AAY24243.1.
CH471063 Genomic DNA. Translation: EAW70811.1.
BC022509 mRNA. Translation: AAH22509.1.
CCDSiCCDS2457.1.
PIRiA34174.
RefSeqiNP_003460.2. NM_003469.4.
UniGeneiHs.516726.

Genome annotation databases

EnsembliENST00000305409; ENSP00000304133; ENSG00000171951.
GeneIDi7857.
KEGGihsa:7857.
UCSCiuc002vnm.3. human.

Polymorphism databases

DMDMi143811457.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25756 mRNA. Translation: AAA36607.1 .
AK312452 mRNA. Translation: BAG35359.1 .
AC012512 Genomic DNA. Translation: AAY24243.1 .
CH471063 Genomic DNA. Translation: EAW70811.1 .
BC022509 mRNA. Translation: AAH22509.1 .
CCDSi CCDS2457.1.
PIRi A34174.
RefSeqi NP_003460.2. NM_003469.4.
UniGenei Hs.516726.

3D structure databases

ProteinModelPortali P13521.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113611. 4 interactions.
IntActi P13521. 6 interactions.
MINTi MINT-2864303.
STRINGi 9606.ENSP00000304133.

PTM databases

PhosphoSitei P13521.

Polymorphism databases

DMDMi 143811457.

Proteomic databases

PaxDbi P13521.
PRIDEi P13521.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305409 ; ENSP00000304133 ; ENSG00000171951 .
GeneIDi 7857.
KEGGi hsa:7857.
UCSCi uc002vnm.3. human.

Organism-specific databases

CTDi 7857.
GeneCardsi GC02M224425.
H-InvDB HIX0002882.
HGNCi HGNC:10575. SCG2.
HPAi CAB002519.
HPA011893.
MIMi 118930. gene.
neXtProti NX_P13521.
PharmGKBi PA34987.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47177.
HOGENOMi HOG000059543.
HOVERGENi HBG054148.
InParanoidi P13521.
OMAi EIVEEQY.
OrthoDBi EOG7K0ZC3.
PhylomeDBi P13521.
TreeFami TF334018.

Miscellaneous databases

ChiTaRSi SCG2. human.
GeneWikii SCG2.
GenomeRNAii 7857.
NextBioi 30297.
PROi P13521.
SOURCEi Search...

Gene expression databases

ArrayExpressi P13521.
Bgeei P13521.
CleanExi HS_SCG2.
Genevestigatori P13521.

Family and domain databases

InterProi IPR018054. Chromogranin_CS.
IPR001990. Granin.
[Graphical view ]
Pfami PF01271. Granin. 1 hit.
[Graphical view ]
PROSITEi PS00422. GRANINS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation."
    Gerdes H.-H., Rosa P., Phillips E., Baeuerle P.A., Frank R., Argos P., Huttner W.B.
    J. Biol. Chem. 264:12009-12015(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SULFATION AT TYR-151.
    Tissue: Pituitary.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Caudate nucleus.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-294; GLY-421 AND GLY-535.
    Tissue: Brain.
  6. "Formation and sequence analysis of secretoneurin, a neuropeptide derived from secretogranin II, in mammalian, bird, reptile, amphibian and fish brains."
    Leitner B., Schneitler C., Klocker H., Volknandt W., Zimmermann H., Winkler H., Fischer-Colbrie R.
    Neurosci. Lett. 248:105-108(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 182-214.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Pituitary.
  8. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
    Halim A., Ruetschi U., Larson G., Nilsson J.
    J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiSCG2_HUMAN
AccessioniPrimary (citable) accession number: P13521
Secondary accession number(s): B2R662, Q53T11, Q8TBH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 3, 2007
Last modified: July 9, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Binds calcium with a low-affinity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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