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Protein

Secretogranin-2

Gene

SCG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides.

GO - Molecular functioni

  • chemoattractant activity Source: HGNC
  • cytokine activity Source: HGNC

GO - Biological processi

  • angiogenesis Source: HGNC
  • endothelial cell migration Source: HGNC
  • eosinophil chemotaxis Source: HGNC
  • induction of positive chemotaxis Source: HGNC
  • inflammatory response Source: HGNC
  • intracellular signal transduction Source: HGNC
  • MAPK cascade Source: HGNC
  • negative regulation of endothelial cell apoptotic process Source: BHF-UCL
  • negative regulation of endothelial cell proliferation Source: HGNC
  • negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
  • positive chemotaxis Source: BHF-UCL
  • positive regulation of endothelial cell proliferation Source: HGNC
  • protein secretion Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171951-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Secretogranin-2
Alternative name(s):
Chromogranin-C
Secretogranin II
Short name:
SgII
Cleaved into the following 2 chains:
Secretoneurin
Short name:
SN
Gene namesi
Name:SCG2
Synonyms:CHGC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:10575. SCG2.

Subcellular locationi

  • Secreted

  • Note: Neuroendocrine and endocrine secretory granules.

GO - Cellular componenti

  • dense core granule Source: Ensembl
  • extracellular space Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7857.
OpenTargetsiENSG00000171951.
PharmGKBiPA34987.

Polymorphism and mutation databases

BioMutaiSCG2.
DMDMi143811457.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
PropeptideiPRO_000000545228 – 30Sequence analysis3
ChainiPRO_000000545331 – 617Secretogranin-2Add BLAST587
PeptideiPRO_0000005454182 – 214SecretoneurinAdd BLAST33
PeptideiPRO_0000432735527 – 566ManserinBy similarityAdd BLAST40

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei151Sulfotyrosine1 Publication1
Modified residuei174PhosphoserineBy similarity1
Modified residuei268PhosphoserineBy similarity1
Modified residuei432PhosphoserineBy similarity1
Modified residuei532PhosphoserineBy similarity1
Modified residuei555PhosphoserineBy similarity1
Modified residuei556PhosphoserineBy similarity1

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

MaxQBiP13521.
PaxDbiP13521.
PeptideAtlasiP13521.
PRIDEiP13521.

PTM databases

iPTMnetiP13521.
PhosphoSitePlusiP13521.

Expressioni

Gene expression databases

BgeeiENSG00000171951.
CleanExiHS_SCG2.
ExpressionAtlasiP13521. baseline and differential.
GenevisibleiP13521. HS.

Organism-specific databases

HPAiCAB002519.
HPA011893.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ATRIPQ8WXE13EBI-947132,EBI-747353

GO - Molecular functioni

  • cytokine activity Source: HGNC

Protein-protein interaction databases

BioGridi113611. 5 interactors.
IntActiP13521. 7 interactors.
MINTiMINT-2864303.
STRINGi9606.ENSP00000304133.

Structurei

3D structure databases

ProteinModelPortaliP13521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni182 – 200O-glycosylated at one siteAdd BLAST19

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFXN. Eukaryota.
ENOG4111F4G. LUCA.
GeneTreeiENSGT00390000010895.
HOGENOMiHOG000059543.
HOVERGENiHBG054148.
InParanoidiP13521.
OMAiEIVEEQY.
OrthoDBiEOG091G03GC.
PhylomeDBiP13521.
TreeFamiTF334018.

Family and domain databases

InterProiIPR018054. Chromogranin_CS.
IPR001990. Granin.
[Graphical view]
PfamiPF01271. Granin. 1 hit.
[Graphical view]
PROSITEiPS00422. GRANINS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13521-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAKTHWLG AALSLIPLIF LISGAEAASF QRNQLLQKEP DLRLENVQKF
60 70 80 90 100
PSPEMIRALE YIENLRQQAH KEESSPDYNP YQGVSVPLQQ KENGDESHLP
110 120 130 140 150
ERDSLSEEDW MRIILEALRQ AENEPQSAPK ENKPYALNSE KNFPMDMSDD
160 170 180 190 200
YETQQWPERK LKHMQFPPMY EENSRDNPFK RTNEIVEEQY TPQSLATLES
210 220 230 240 250
VFQELGKLTG PNNQKRERMD EEQKLYTDDE DDIYKANNIA YEDVVGGEDW
260 270 280 290 300
NPVEEKIESQ TQEEVRDSKE NIEKNEQIND EMKRSGQLGI QEEDLRKESK
310 320 330 340 350
DQLSDDVSKV IAYLKRLVNA AGSGRLQNGQ NGERATRLFE KPLDSQSIYQ
360 370 380 390 400
LIEISRNLQI PPEDLIEMLK TGEKPNGSVE PERELDLPVD LDDISEADLD
410 420 430 440 450
HPDLFQNRML SKSGYPKTPG RAGTEALPDG LSVEDILNLL GMESAANQKT
460 470 480 490 500
SYFPNPYNQE KVLPRLPYGA GRSRSNQLPK AAWIPHVENR QMAYENLNDK
510 520 530 540 550
DQELGEYLAR MLVKYPEIIN SNQVKRVPGQ GSSEDDLQEE EQIEQAIKEH
560 570 580 590 600
LNQGSSQETD KLAPVSKRFP VGPPKNDDTP NRQYWDEDLL MKVLEYLNQE
610
KAEKGREHIA KRAMENM
Length:617
Mass (Da):70,941
Last modified:April 3, 2007 - v2
Checksum:iA81C9C091DE9DF6B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti273E → G in AAA36607 (PubMed:2745426).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03155561Y → H.Corresponds to variant rs16864976dbSNPEnsembl.1
Natural variantiVAR_048755196A → V.Corresponds to variant rs1438157dbSNPEnsembl.1
Natural variantiVAR_031556294D → G.1 PublicationCorresponds to variant rs17852053dbSNPEnsembl.1
Natural variantiVAR_031557421R → G.1 PublicationCorresponds to variant rs17856669dbSNPEnsembl.1
Natural variantiVAR_031558535D → G.1 PublicationCorresponds to variant rs17852054dbSNPEnsembl.1
Natural variantiVAR_031559564P → L.Corresponds to variant rs36043001dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25756 mRNA. Translation: AAA36607.1.
AK312452 mRNA. Translation: BAG35359.1.
AC012512 Genomic DNA. Translation: AAY24243.1.
CH471063 Genomic DNA. Translation: EAW70811.1.
BC022509 mRNA. Translation: AAH22509.1.
CCDSiCCDS2457.1.
PIRiA34174.
RefSeqiNP_003460.2. NM_003469.4.
UniGeneiHs.516726.

Genome annotation databases

EnsembliENST00000305409; ENSP00000304133; ENSG00000171951.
GeneIDi7857.
KEGGihsa:7857.
UCSCiuc002vnm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25756 mRNA. Translation: AAA36607.1.
AK312452 mRNA. Translation: BAG35359.1.
AC012512 Genomic DNA. Translation: AAY24243.1.
CH471063 Genomic DNA. Translation: EAW70811.1.
BC022509 mRNA. Translation: AAH22509.1.
CCDSiCCDS2457.1.
PIRiA34174.
RefSeqiNP_003460.2. NM_003469.4.
UniGeneiHs.516726.

3D structure databases

ProteinModelPortaliP13521.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113611. 5 interactors.
IntActiP13521. 7 interactors.
MINTiMINT-2864303.
STRINGi9606.ENSP00000304133.

PTM databases

iPTMnetiP13521.
PhosphoSitePlusiP13521.

Polymorphism and mutation databases

BioMutaiSCG2.
DMDMi143811457.

Proteomic databases

MaxQBiP13521.
PaxDbiP13521.
PeptideAtlasiP13521.
PRIDEiP13521.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305409; ENSP00000304133; ENSG00000171951.
GeneIDi7857.
KEGGihsa:7857.
UCSCiuc002vnm.4. human.

Organism-specific databases

CTDi7857.
DisGeNETi7857.
GeneCardsiSCG2.
H-InvDBHIX0002882.
HGNCiHGNC:10575. SCG2.
HPAiCAB002519.
HPA011893.
MIMi118930. gene.
neXtProtiNX_P13521.
OpenTargetsiENSG00000171951.
PharmGKBiPA34987.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFXN. Eukaryota.
ENOG4111F4G. LUCA.
GeneTreeiENSGT00390000010895.
HOGENOMiHOG000059543.
HOVERGENiHBG054148.
InParanoidiP13521.
OMAiEIVEEQY.
OrthoDBiEOG091G03GC.
PhylomeDBiP13521.
TreeFamiTF334018.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171951-MONOMER.

Miscellaneous databases

ChiTaRSiSCG2. human.
GeneWikiiSCG2.
GenomeRNAii7857.
PROiP13521.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171951.
CleanExiHS_SCG2.
ExpressionAtlasiP13521. baseline and differential.
GenevisibleiP13521. HS.

Family and domain databases

InterProiIPR018054. Chromogranin_CS.
IPR001990. Granin.
[Graphical view]
PfamiPF01271. Granin. 1 hit.
[Graphical view]
PROSITEiPS00422. GRANINS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCG2_HUMAN
AccessioniPrimary (citable) accession number: P13521
Secondary accession number(s): B2R662, Q53T11, Q8TBH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 3, 2007
Last modified: November 2, 2016
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Binds calcium with a low-affinity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.