P13521 (SCG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Secretogranin-2

Alternative name(s):
Chromogranin-C
Secretogranin II
Short name=SgII

Cleaved into the following chain:

1. Secretoneurin
   Short name=SN

Gene names

Name:	SCG2
Synonyms:	CHGC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	617 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides.
Subcellular location	Secreted. Note: Neuroendocrine and endocrine secretory granules.
Post-translational modification	O-glycosylated. Ref.8
Miscellaneous	Binds calcium with a low-affinity.
Sequence similarities	Belongs to the chromogranin/secretogranin protein family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Ligand	Calcium
PTM	Cleavage on pair of basic residues Glycoprotein Sulfation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	MAPK cascade Inferred from direct assay PubMed 14970115. Source: HGNC angiogenesis Inferred from direct assay PubMed 14970115. Source: HGNC endothelial cell migration Traceable author statement PubMed 9473216. Source: HGNC eosinophil chemotaxis Inferred from direct assay PubMed 9473216. Source: HGNC induction of positive chemotaxis Inferred from direct assay PubMed 9473216. Source: HGNC inflammatory response Traceable author statement PubMed 14970115. Source: HGNC negative regulation of apoptotic process Inferred from direct assay PubMed 14970115. Source: HGNC negative regulation of endothelial cell proliferation Traceable author statement PubMed 9473216. Source: HGNC positive regulation of endothelial cell proliferation Inferred from direct assay PubMed 14970115. Source: HGNC protein secretion Traceable author statement Ref.1. Source: ProtInc
Cellular_component	extracellular space Inferred from direct assay PubMed 9473216. Source: HGNC secretory granule Inferred from electronic annotation. Source: InterPro
Molecular_function	chemoattractant activity Inferred from direct assay PubMed 9473216. Source: HGNC cytokine activity Inferred from direct assay PubMed 14970115. Source: HGNC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Propeptide	28 – 30	3	Potential		PRO_0000005452
	Chain	31 – 617	587	Secretogranin-2		PRO_0000005453
	Peptide	182 – 214	33	Secretoneurin		PRO_0000005454
Regions
	Region	182 – 200	19	O-glycosylated at one site
Amino acid modifications
	Modified residue	151	1	Sulfotyrosine
Natural variations
	Natural variant	61	1	Y → H. Corresponds to variant rs16864976 [ dbSNP | Ensembl ].		VAR_031555
	Natural variant	196	1	A → V. Corresponds to variant rs1438157 [ dbSNP | Ensembl ].		VAR_048755
	Natural variant	294	1	D → G. Ref.5 Corresponds to variant rs17852053 [ dbSNP | Ensembl ].		VAR_031556
	Natural variant	421	1	R → G. Ref.5 Corresponds to variant rs17856669 [ dbSNP | Ensembl ].		VAR_031557
	Natural variant	535	1	D → G. Ref.5 Corresponds to variant rs17852054 [ dbSNP | Ensembl ].		VAR_031558
	Natural variant	564	1	P → L. Corresponds to variant rs36043001 [ dbSNP | Ensembl ].		VAR_031559
Experimental info
	Sequence conflict	273	1	E → G in AAA36607. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P13521 [UniParc]. Last modified April 3, 2007. Version 2. Checksum: A81C9C091DE9DF6B	FASTA	617	70,941
	10 20 30 40 50 60 MAEAKTHWLG AALSLIPLIF LISGAEAASF QRNQLLQKEP DLRLENVQKF PSPEMIRALE 70 80 90 100 110 120 YIENLRQQAH KEESSPDYNP YQGVSVPLQQ KENGDESHLP ERDSLSEEDW MRIILEALRQ 130 140 150 160 170 180 AENEPQSAPK ENKPYALNSE KNFPMDMSDD YETQQWPERK LKHMQFPPMY EENSRDNPFK 190 200 210 220 230 240 RTNEIVEEQY TPQSLATLES VFQELGKLTG PNNQKRERMD EEQKLYTDDE DDIYKANNIA 250 260 270 280 290 300 YEDVVGGEDW NPVEEKIESQ TQEEVRDSKE NIEKNEQIND EMKRSGQLGI QEEDLRKESK 310 320 330 340 350 360 DQLSDDVSKV IAYLKRLVNA AGSGRLQNGQ NGERATRLFE KPLDSQSIYQ LIEISRNLQI 370 380 390 400 410 420 PPEDLIEMLK TGEKPNGSVE PERELDLPVD LDDISEADLD HPDLFQNRML SKSGYPKTPG 430 440 450 460 470 480 RAGTEALPDG LSVEDILNLL GMESAANQKT SYFPNPYNQE KVLPRLPYGA GRSRSNQLPK 490 500 510 520 530 540 AAWIPHVENR QMAYENLNDK DQELGEYLAR MLVKYPEIIN SNQVKRVPGQ GSSEDDLQEE 550 560 570 580 590 600 EQIEQAIKEH LNQGSSQETD KLAPVSKRFP VGPPKNDDTP NRQYWDEDLL MKVLEYLNQE 610 KAEKGREHIA KRAMENM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation." Gerdes H.-H., Rosa P., Phillips E., Baeuerle P.A., Frank R., Argos P., Huttner W.B. J. Biol. Chem. 264:12009-12015(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pituitary.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Caudate nucleus.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-294; GLY-421 AND GLY-535. Tissue: Brain.
[6]	"Formation and sequence analysis of secretoneurin, a neuropeptide derived from secretogranin II, in mammalian, bird, reptile, amphibian and fish brains." Leitner B., Schneitler C., Klocker H., Volknandt W., Zimmermann H., Winkler H., Fischer-Colbrie R. Neurosci. Lett. 248:105-108(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 182-214.
[7]	"Phosphoproteomic analysis of the human pituitary." Beranova-Giorgianni S., Zhao Y., Desiderio D.M., Giorgianni F. Pituitary 9:109-120(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Pituitary.
[8]	"LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins." Halim A., Ruetschi U., Larson G., Nilsson J. J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M25756 mRNA. Translation: AAA36607.1. AK312452 mRNA. Translation: BAG35359.1. AC012512 Genomic DNA. Translation: AAY24243.1. CH471063 Genomic DNA. Translation: EAW70811.1. BC022509 mRNA. Translation: AAH22509.1.
IPI	IPI00009362.
PIR	A34174.
RefSeq	NP_003460.2. NM_003469.4.
UniGene	Hs.516726.
3D structure databases
ProteinModelPortal	P13521.
ModBase	Search...
Protein-protein interaction databases
IntAct	P13521. 5 interactions.
MINT	MINT-2864303.
STRING	9606.ENSP00000304133.
PTM databases
PhosphoSite	P13521.
Polymorphism databases
DMDM	143811457.
Proteomic databases
PaxDb	P13521.
PRIDE	P13521.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000305409; ENSP00000304133; ENSG00000171951.
GeneID	7857.
KEGG	hsa:7857.
UCSC	uc002vnm.3. human.
Organism-specific databases
CTD	7857.
GeneCards	GC02M224425.
H-InvDB	HIX0002882.
HGNC	HGNC:10575. SCG2.
HPA	CAB002519. HPA011893.
MIM	118930. gene.
neXtProt	NX_P13521.
PharmGKB	PA34987.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47177.
HOGENOM	HOG000059543.
HOVERGEN	HBG054148.
InParanoid	P13521.
OMA	EIVEEQY.
OrthoDB	EOG4M0F1D.
PhylomeDB	P13521.
Gene expression databases
ArrayExpress	P13521.
Bgee	P13521.
CleanEx	HS_SCG2.
Genevestigator	P13521.
GermOnline	ENSG00000171951. Homo sapiens.
Family and domain databases
InterPro	IPR018054. Chromogranin_CS. IPR001990. Granin. [Graphical view]
Pfam	PF01271. Granin. 1 hit. [Graphical view]
PROSITE	PS00422. GRANINS_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SCG2. human.
GenomeRNAi	7857.
NextBio	30297.
SOURCE	Search...

Entry information

Entry name

SCG2_HUMAN

Accession

Primary (citable) accession number: P13521
Secondary accession number(s): B2R662, Q53T11, Q8TBH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	April 3, 2007
Last modified:	May 1, 2013
This is version 123 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.