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P13521

- SCG2_HUMAN

UniProt

P13521 - SCG2_HUMAN

Protein

Secretogranin-2

Gene

SCG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides.

    GO - Molecular functioni

    1. chemoattractant activity Source: HGNC
    2. cytokine activity Source: HGNC

    GO - Biological processi

    1. angiogenesis Source: HGNC
    2. cellular component movement Source: HGNC
    3. endothelial cell migration Source: HGNC
    4. eosinophil chemotaxis Source: HGNC
    5. induction of positive chemotaxis Source: HGNC
    6. inflammatory response Source: HGNC
    7. intracellular signal transduction Source: HGNC
    8. MAPK cascade Source: HGNC
    9. negative regulation of endothelial cell apoptotic process Source: BHF-UCL
    10. negative regulation of endothelial cell proliferation Source: HGNC
    11. negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
    12. positive chemotaxis Source: GOC
    13. positive regulation of endothelial cell proliferation Source: HGNC
    14. protein secretion Source: ProtInc

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Secretogranin-2
    Alternative name(s):
    Chromogranin-C
    Secretogranin II
    Short name:
    SgII
    Cleaved into the following chain:
    Secretoneurin
    Short name:
    SN
    Gene namesi
    Name:SCG2
    Synonyms:CHGC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:10575. SCG2.

    Subcellular locationi

    Secreted
    Note: Neuroendocrine and endocrine secretory granules.

    GO - Cellular componenti

    1. extracellular space Source: HGNC
    2. secretory granule Source: InterPro

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34987.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Propeptidei28 – 303Sequence AnalysisPRO_0000005452
    Chaini31 – 617587Secretogranin-2PRO_0000005453Add
    BLAST
    Peptidei182 – 21433SecretoneurinPRO_0000005454Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei151 – 1511Sulfotyrosine1 Publication

    Post-translational modificationi

    O-glycosylated.1 Publication

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein, Sulfation

    Proteomic databases

    PaxDbiP13521.
    PRIDEiP13521.

    PTM databases

    PhosphoSiteiP13521.

    Expressioni

    Gene expression databases

    ArrayExpressiP13521.
    BgeeiP13521.
    CleanExiHS_SCG2.
    GenevestigatoriP13521.

    Organism-specific databases

    HPAiCAB002519.
    HPA011893.

    Interactioni

    Protein-protein interaction databases

    BioGridi113611. 4 interactions.
    IntActiP13521. 6 interactions.
    MINTiMINT-2864303.
    STRINGi9606.ENSP00000304133.

    Structurei

    3D structure databases

    ProteinModelPortaliP13521.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni182 – 20019O-glycosylated at one siteAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47177.
    HOGENOMiHOG000059543.
    HOVERGENiHBG054148.
    InParanoidiP13521.
    OMAiEIVEEQY.
    OrthoDBiEOG7K0ZC3.
    PhylomeDBiP13521.
    TreeFamiTF334018.

    Family and domain databases

    InterProiIPR018054. Chromogranin_CS.
    IPR001990. Granin.
    [Graphical view]
    PfamiPF01271. Granin. 1 hit.
    [Graphical view]
    PROSITEiPS00422. GRANINS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P13521-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEAKTHWLG AALSLIPLIF LISGAEAASF QRNQLLQKEP DLRLENVQKF    50
    PSPEMIRALE YIENLRQQAH KEESSPDYNP YQGVSVPLQQ KENGDESHLP 100
    ERDSLSEEDW MRIILEALRQ AENEPQSAPK ENKPYALNSE KNFPMDMSDD 150
    YETQQWPERK LKHMQFPPMY EENSRDNPFK RTNEIVEEQY TPQSLATLES 200
    VFQELGKLTG PNNQKRERMD EEQKLYTDDE DDIYKANNIA YEDVVGGEDW 250
    NPVEEKIESQ TQEEVRDSKE NIEKNEQIND EMKRSGQLGI QEEDLRKESK 300
    DQLSDDVSKV IAYLKRLVNA AGSGRLQNGQ NGERATRLFE KPLDSQSIYQ 350
    LIEISRNLQI PPEDLIEMLK TGEKPNGSVE PERELDLPVD LDDISEADLD 400
    HPDLFQNRML SKSGYPKTPG RAGTEALPDG LSVEDILNLL GMESAANQKT 450
    SYFPNPYNQE KVLPRLPYGA GRSRSNQLPK AAWIPHVENR QMAYENLNDK 500
    DQELGEYLAR MLVKYPEIIN SNQVKRVPGQ GSSEDDLQEE EQIEQAIKEH 550
    LNQGSSQETD KLAPVSKRFP VGPPKNDDTP NRQYWDEDLL MKVLEYLNQE 600
    KAEKGREHIA KRAMENM 617
    Length:617
    Mass (Da):70,941
    Last modified:April 3, 2007 - v2
    Checksum:iA81C9C091DE9DF6B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti273 – 2731E → G in AAA36607. (PubMed:2745426)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti61 – 611Y → H.
    Corresponds to variant rs16864976 [ dbSNP | Ensembl ].
    VAR_031555
    Natural varianti196 – 1961A → V.
    Corresponds to variant rs1438157 [ dbSNP | Ensembl ].
    VAR_048755
    Natural varianti294 – 2941D → G.1 Publication
    Corresponds to variant rs17852053 [ dbSNP | Ensembl ].
    VAR_031556
    Natural varianti421 – 4211R → G.1 Publication
    Corresponds to variant rs17856669 [ dbSNP | Ensembl ].
    VAR_031557
    Natural varianti535 – 5351D → G.1 Publication
    Corresponds to variant rs17852054 [ dbSNP | Ensembl ].
    VAR_031558
    Natural varianti564 – 5641P → L.
    Corresponds to variant rs36043001 [ dbSNP | Ensembl ].
    VAR_031559

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25756 mRNA. Translation: AAA36607.1.
    AK312452 mRNA. Translation: BAG35359.1.
    AC012512 Genomic DNA. Translation: AAY24243.1.
    CH471063 Genomic DNA. Translation: EAW70811.1.
    BC022509 mRNA. Translation: AAH22509.1.
    CCDSiCCDS2457.1.
    PIRiA34174.
    RefSeqiNP_003460.2. NM_003469.4.
    UniGeneiHs.516726.

    Genome annotation databases

    EnsembliENST00000305409; ENSP00000304133; ENSG00000171951.
    GeneIDi7857.
    KEGGihsa:7857.
    UCSCiuc002vnm.3. human.

    Polymorphism databases

    DMDMi143811457.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25756 mRNA. Translation: AAA36607.1 .
    AK312452 mRNA. Translation: BAG35359.1 .
    AC012512 Genomic DNA. Translation: AAY24243.1 .
    CH471063 Genomic DNA. Translation: EAW70811.1 .
    BC022509 mRNA. Translation: AAH22509.1 .
    CCDSi CCDS2457.1.
    PIRi A34174.
    RefSeqi NP_003460.2. NM_003469.4.
    UniGenei Hs.516726.

    3D structure databases

    ProteinModelPortali P13521.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113611. 4 interactions.
    IntActi P13521. 6 interactions.
    MINTi MINT-2864303.
    STRINGi 9606.ENSP00000304133.

    PTM databases

    PhosphoSitei P13521.

    Polymorphism databases

    DMDMi 143811457.

    Proteomic databases

    PaxDbi P13521.
    PRIDEi P13521.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000305409 ; ENSP00000304133 ; ENSG00000171951 .
    GeneIDi 7857.
    KEGGi hsa:7857.
    UCSCi uc002vnm.3. human.

    Organism-specific databases

    CTDi 7857.
    GeneCardsi GC02M224425.
    H-InvDB HIX0002882.
    HGNCi HGNC:10575. SCG2.
    HPAi CAB002519.
    HPA011893.
    MIMi 118930. gene.
    neXtProti NX_P13521.
    PharmGKBi PA34987.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47177.
    HOGENOMi HOG000059543.
    HOVERGENi HBG054148.
    InParanoidi P13521.
    OMAi EIVEEQY.
    OrthoDBi EOG7K0ZC3.
    PhylomeDBi P13521.
    TreeFami TF334018.

    Miscellaneous databases

    ChiTaRSi SCG2. human.
    GeneWikii SCG2.
    GenomeRNAii 7857.
    NextBioi 30297.
    PROi P13521.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P13521.
    Bgeei P13521.
    CleanExi HS_SCG2.
    Genevestigatori P13521.

    Family and domain databases

    InterProi IPR018054. Chromogranin_CS.
    IPR001990. Granin.
    [Graphical view ]
    Pfami PF01271. Granin. 1 hit.
    [Graphical view ]
    PROSITEi PS00422. GRANINS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation."
      Gerdes H.-H., Rosa P., Phillips E., Baeuerle P.A., Frank R., Argos P., Huttner W.B.
      J. Biol. Chem. 264:12009-12015(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SULFATION AT TYR-151.
      Tissue: Pituitary.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Caudate nucleus.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-294; GLY-421 AND GLY-535.
      Tissue: Brain.
    6. "Formation and sequence analysis of secretoneurin, a neuropeptide derived from secretogranin II, in mammalian, bird, reptile, amphibian and fish brains."
      Leitner B., Schneitler C., Klocker H., Volknandt W., Zimmermann H., Winkler H., Fischer-Colbrie R.
      Neurosci. Lett. 248:105-108(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 182-214.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Pituitary.
    8. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
      Halim A., Ruetschi U., Larson G., Nilsson J.
      J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiSCG2_HUMAN
    AccessioniPrimary (citable) accession number: P13521
    Secondary accession number(s): B2R662, Q53T11, Q8TBH3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 132 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Binds calcium with a low-affinity.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3