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P13521 (SCG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Secretogranin-2
Alternative name(s):
Chromogranin-C
Secretogranin II
Short name=SgII

Cleaved into the following chain:

  1. Secretoneurin
    Short name=SN
Gene names
Name:SCG2
Synonyms:CHGC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length617 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides.

Subcellular location

Secreted. Note: Neuroendocrine and endocrine secretory granules.

Post-translational modification

O-glycosylated. Ref.8

Miscellaneous

Binds calcium with a low-affinity.

Sequence similarities

Belongs to the chromogranin/secretogranin protein family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   LigandCalcium
   PTMCleavage on pair of basic residues
Glycoprotein
Sulfation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processMAPK cascade

Inferred from direct assay PubMed 14970115. Source: HGNC

angiogenesis

Inferred from direct assay PubMed 14970115. Source: HGNC

cellular component movement

Inferred from direct assay PubMed 9473216. Source: HGNC

endothelial cell migration

Traceable author statement PubMed 9473216. Source: HGNC

eosinophil chemotaxis

Inferred from direct assay PubMed 9473216. Source: HGNC

induction of positive chemotaxis

Inferred from direct assay PubMed 9473216. Source: HGNC

inflammatory response

Traceable author statement PubMed 14970115. Source: HGNC

intracellular signal transduction

Inferred from direct assay PubMed 9473216. Source: HGNC

negative regulation of endothelial cell apoptotic process

Inferred from direct assay PubMed 14970115. Source: BHF-UCL

negative regulation of endothelial cell proliferation

Traceable author statement PubMed 9473216. Source: HGNC

negative regulation of extrinsic apoptotic signaling pathway

Inferred from direct assay PubMed 14970115. Source: BHF-UCL

positive chemotaxis

Inferred from direct assay PubMed 9473216. Source: GOC

positive regulation of endothelial cell proliferation

Inferred from direct assay PubMed 14970115. Source: HGNC

protein secretion

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentextracellular space

Inferred from direct assay PubMed 9473216. Source: HGNC

secretory granule

Inferred from electronic annotation. Source: InterPro

   Molecular_functionchemoattractant activity

Inferred from direct assay PubMed 9473216. Source: HGNC

cytokine activity

Inferred from direct assay PubMed 14970115. Source: HGNC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Propeptide28 – 303 Potential
PRO_0000005452
Chain31 – 617587Secretogranin-2
PRO_0000005453
Peptide182 – 21433Secretoneurin
PRO_0000005454

Regions

Region182 – 20019O-glycosylated at one site

Amino acid modifications

Modified residue1511Sulfotyrosine Ref.1

Natural variations

Natural variant611Y → H.
Corresponds to variant rs16864976 [ dbSNP | Ensembl ].
VAR_031555
Natural variant1961A → V.
Corresponds to variant rs1438157 [ dbSNP | Ensembl ].
VAR_048755
Natural variant2941D → G. Ref.5
Corresponds to variant rs17852053 [ dbSNP | Ensembl ].
VAR_031556
Natural variant4211R → G. Ref.5
Corresponds to variant rs17856669 [ dbSNP | Ensembl ].
VAR_031557
Natural variant5351D → G. Ref.5
Corresponds to variant rs17852054 [ dbSNP | Ensembl ].
VAR_031558
Natural variant5641P → L.
Corresponds to variant rs36043001 [ dbSNP | Ensembl ].
VAR_031559

Experimental info

Sequence conflict2731E → G in AAA36607. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P13521 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: A81C9C091DE9DF6B

FASTA61770,941
        10         20         30         40         50         60 
MAEAKTHWLG AALSLIPLIF LISGAEAASF QRNQLLQKEP DLRLENVQKF PSPEMIRALE 

        70         80         90        100        110        120 
YIENLRQQAH KEESSPDYNP YQGVSVPLQQ KENGDESHLP ERDSLSEEDW MRIILEALRQ 

       130        140        150        160        170        180 
AENEPQSAPK ENKPYALNSE KNFPMDMSDD YETQQWPERK LKHMQFPPMY EENSRDNPFK 

       190        200        210        220        230        240 
RTNEIVEEQY TPQSLATLES VFQELGKLTG PNNQKRERMD EEQKLYTDDE DDIYKANNIA 

       250        260        270        280        290        300 
YEDVVGGEDW NPVEEKIESQ TQEEVRDSKE NIEKNEQIND EMKRSGQLGI QEEDLRKESK 

       310        320        330        340        350        360 
DQLSDDVSKV IAYLKRLVNA AGSGRLQNGQ NGERATRLFE KPLDSQSIYQ LIEISRNLQI 

       370        380        390        400        410        420 
PPEDLIEMLK TGEKPNGSVE PERELDLPVD LDDISEADLD HPDLFQNRML SKSGYPKTPG 

       430        440        450        460        470        480 
RAGTEALPDG LSVEDILNLL GMESAANQKT SYFPNPYNQE KVLPRLPYGA GRSRSNQLPK 

       490        500        510        520        530        540 
AAWIPHVENR QMAYENLNDK DQELGEYLAR MLVKYPEIIN SNQVKRVPGQ GSSEDDLQEE 

       550        560        570        580        590        600 
EQIEQAIKEH LNQGSSQETD KLAPVSKRFP VGPPKNDDTP NRQYWDEDLL MKVLEYLNQE 

       610 
KAEKGREHIA KRAMENM 

« Hide

References

« Hide 'large scale' references
[1]"The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation."
Gerdes H.-H., Rosa P., Phillips E., Baeuerle P.A., Frank R., Argos P., Huttner W.B.
J. Biol. Chem. 264:12009-12015(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SULFATION AT TYR-151.
Tissue: Pituitary.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Caudate nucleus.
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-294; GLY-421 AND GLY-535.
Tissue: Brain.
[6]"Formation and sequence analysis of secretoneurin, a neuropeptide derived from secretogranin II, in mammalian, bird, reptile, amphibian and fish brains."
Leitner B., Schneitler C., Klocker H., Volknandt W., Zimmermann H., Winkler H., Fischer-Colbrie R.
Neurosci. Lett. 248:105-108(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 182-214.
[7]"Phosphoproteomic analysis of the human pituitary."
Beranova-Giorgianni S., Zhao Y., Desiderio D.M., Giorgianni F.
Pituitary 9:109-120(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Pituitary.
[8]"LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
Halim A., Ruetschi U., Larson G., Nilsson J.
J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M25756 mRNA. Translation: AAA36607.1.
AK312452 mRNA. Translation: BAG35359.1.
AC012512 Genomic DNA. Translation: AAY24243.1.
CH471063 Genomic DNA. Translation: EAW70811.1.
BC022509 mRNA. Translation: AAH22509.1.
PIRA34174.
RefSeqNP_003460.2. NM_003469.4.
UniGeneHs.516726.

3D structure databases

ProteinModelPortalP13521.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113611. 4 interactions.
IntActP13521. 6 interactions.
MINTMINT-2864303.
STRING9606.ENSP00000304133.

PTM databases

PhosphoSiteP13521.

Polymorphism databases

DMDM143811457.

Proteomic databases

PaxDbP13521.
PRIDEP13521.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000305409; ENSP00000304133; ENSG00000171951.
GeneID7857.
KEGGhsa:7857.
UCSCuc002vnm.3. human.

Organism-specific databases

CTD7857.
GeneCardsGC02M224425.
H-InvDBHIX0002882.
HGNCHGNC:10575. SCG2.
HPACAB002519.
HPA011893.
MIM118930. gene.
neXtProtNX_P13521.
PharmGKBPA34987.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47177.
HOGENOMHOG000059543.
HOVERGENHBG054148.
InParanoidP13521.
OMAEIVEEQY.
OrthoDBEOG7K0ZC3.
PhylomeDBP13521.
TreeFamTF334018.

Gene expression databases

ArrayExpressP13521.
BgeeP13521.
CleanExHS_SCG2.
GenevestigatorP13521.

Family and domain databases

InterProIPR018054. Chromogranin_CS.
IPR001990. Granin.
[Graphical view]
PfamPF01271. Granin. 1 hit.
[Graphical view]
PROSITEPS00422. GRANINS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSCG2. human.
GeneWikiSCG2.
GenomeRNAi7857.
NextBio30297.
PROP13521.
SOURCESearch...

Entry information

Entry nameSCG2_HUMAN
AccessionPrimary (citable) accession number: P13521
Secondary accession number(s): B2R662, Q53T11, Q8TBH3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 3, 2007
Last modified: April 16, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM