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Protein

F-actin-capping protein subunit beta

Gene

CAP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.1 Publication

Miscellaneous

Present with 6770 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • actin filament binding Source: SGD

GO - Biological processi

  • actin cytoskeleton organization Source: InterPro
  • barbed-end actin filament capping Source: SGD
  • cell morphogenesis Source: GO_Central
  • filamentous growth Source: SGD

Keywordsi

Molecular functionActin capping, Actin-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31306-MONOMER
ReactomeiR-SCE-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
F-actin-capping protein subunit beta
Gene namesi
Name:CAP2
Ordered Locus Names:YIL034C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIL034C
SGDiS000001296 CAP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002046422 – 287F-actin-capping protein subunit betaAdd BLAST286

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei85PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP13517
PaxDbiP13517
PRIDEiP13517

PTM databases

iPTMnetiP13517

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CAP1P284955EBI-4013,EBI-4003

GO - Molecular functioni

  • actin filament binding Source: SGD

Protein-protein interaction databases

BioGridi34956, 204 interactors
DIPiDIP-836N
IntActiP13517, 13 interactors
MINTiP13517
STRINGi4932.YIL034C

Structurei

3D structure databases

ProteinModelPortaliP13517
SMRiP13517
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000017957
HOGENOMiHOG000041208
InParanoidiP13517
KOiK10365
OMAiACDYNRD
OrthoDBiEOG092C4I8L

Family and domain databases

InterProiView protein in InterPro
IPR037282 CapZ_alpha/beta
IPR001698 CAPZB
IPR019771 F-actin_capping_bsu_CS
PANTHERiPTHR10619 PTHR10619, 1 hit
PfamiView protein in Pfam
PF01115 F_actin_cap_B, 1 hit
PRINTSiPR00192 FACTINCAPB
SUPFAMiSSF90096 SSF90096, 1 hit
PROSITEiView protein in PROSITE
PS00231 F_ACTIN_CAPPING_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13517-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDAQFDAAL DLLRRLNPTT LQENLNNLIE LQPNLAQDLL SSVDVPLSTQ
60 70 80 90 100
KDSADSNREY LCCDYNRDID SFRSPWSNTY YPELSPKDLQ DSPFPSAPLR
110 120 130 140 150
KLEILANDSF DVYRDLYYEG GISSVYLWDL NEEDFNGHDF AGVVLFKKNQ
160 170 180 190 200
SDHSNWDSIH VFEVTTSPSS PDSFNYRVTT TIILHLDKTK TDQNSHMMLS
210 220 230 240 250
GNLTRQTEKD IAIDMSRPLD VIFTSHVANL GSLIEDIESQ MRNLLETVYF
260 270 280
EKTRDIFHQT KNAAIASSAE EANKDAQAEV IRGLQSL
Length:287
Mass (Da):32,629
Last modified:November 1, 1991 - v3
Checksum:i6E669023D1378778
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140F → Y in AAA66935 (PubMed:2823100).Curated1
Sequence conflicti146 – 147FK → I in AAA66935 (PubMed:2823100).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62630 Genomic DNA Translation: CAA44497.1
Z46861 Genomic DNA Translation: CAA86917.1
M17223 Genomic DNA Translation: AAA66935.1
BK006942 Genomic DNA Translation: DAA08514.1
PIRiS49944
RefSeqiNP_012230.3, NM_001179384.3

Genome annotation databases

EnsemblFungiiYIL034C; YIL034C; YIL034C
GeneIDi854777
KEGGisce:YIL034C

Similar proteinsi

Entry informationi

Entry nameiCAPZB_YEAST
AccessioniPrimary (citable) accession number: P13517
Secondary accession number(s): D6VVP8, Q07082
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 1, 1991
Last modified: May 23, 2018
This is version 185 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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