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P13516 (ACOD1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 136. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acyl-CoA desaturase 1

EC=1.14.19.1
Alternative name(s):
Delta(9)-desaturase 1
Short name=Delta-9 desaturase 1
Fatty acid desaturase 1
Stearoyl-CoA desaturase 1
Gene names
Name:Scd1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O2 and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.

Catalytic activity

Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.

Cofactor

Iron.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.3.

Domain

The histidine box domains may contain the active site and/or be involved in metal ion binding.

Sequence similarities

Belongs to the fatty acid desaturase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355Acyl-CoA desaturase 1
PRO_0000185397

Regions

Topological domain1 – 6767Cytoplasmic Potential
Transmembrane68 – 8922Helical; Potential
Topological domain90 – 989Lumenal Potential
Transmembrane99 – 11517Helical; Potential
Topological domain116 – 21297Cytoplasmic Potential
Transmembrane213 – 23119Helical; Potential
Topological domain232 – 24615Lumenal Potential
Transmembrane247 – 26923Helical; Potential
Topological domain270 – 35586Cytoplasmic Potential
Motif116 – 1216Histidine box-1
Motif153 – 1575Histidine box-2
Motif294 – 2985Histidine box-3

Experimental info

Sequence conflict971C → A in AAA40103. Ref.1
Sequence conflict1481E → D in AAA40103. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P13516 [UniParc].

Last modified June 6, 2002. Version 2.
Checksum: 00E2348C1898FE75

FASTA35541,046
        10         20         30         40         50         60 
MPAHMLQEIS SSYTTTTTIT APPSGNEREK VKTVPLHLEE DIRPEMKEDI HDPTYQDEEG 

        70         80         90        100        110        120 
PPPKLEYVWR NIILMVLLHL GGLYGIILVP SCKLYTCLFG IFYYMTSALG ITAGAHRLWS 

       130        140        150        160        170        180 
HRTYKARLPL RIFLIIANTM AFQNDVYEWA RDHRAHHKFS ETHADPHNSR RGFFFSHVGW 

       190        200        210        220        230        240 
LLVRKHPAVK EKGGKLDMSD LKAEKLVMFQ RRYYKPGLLL MCFILPTLVP WYCWGETFVN 

       250        260        270        280        290        300 
SLFVSTFLRY TLVLNATWLV NSAAHLYGYR PYDKNIQSRE NILVSLGAVG EGFHNYHHTF 

       310        320        330        340        350 
PFDYSASEYR WHINFTTFFI DCMAALGLAY DRKKVSKATV LARIKRTGDG SHKSS 

« Hide

References

« Hide 'large scale' references
[1]"Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase."
Ntambi J.M., Buhrow S.A., Kaestner K.H., Christy R.J., Sibley E., Kelly T.J. Jr., Lane M.D.
J. Biol. Chem. 263:17291-17300(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Adipocyte.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
[3]"Membrane topology of mouse stearoyl-CoA desaturase 1."
Man W.C., Miyazaki M., Chu K., Ntambi J.M.
J. Biol. Chem. 281:1251-1260(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, MEMBRANE TOPOLOGY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M21285 expand/collapse EMBL AC list , M21280, M21281, M21282, M21283, M21284 Genomic DNA. Translation: AAA40103.1.
BC007474 mRNA. Translation: AAH07474.1.
BC055453 mRNA. Translation: AAH55453.1.
PIRA32115.
RefSeqNP_033153.2. NM_009127.4.
UniGeneMm.267377.

3D structure databases

ProteinModelPortalP13516.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4996454.

Chemistry

BindingDBP13516.
ChEMBLCHEMBL5353.

PTM databases

PhosphoSiteP13516.

Proteomic databases

PaxDbP13516.
PRIDEP13516.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000041331; ENSMUSP00000036936; ENSMUSG00000037071.
GeneID20249.
KEGGmmu:20249.
UCSCuc008hpr.2. mouse.

Organism-specific databases

CTD20249.
MGIMGI:98239. Scd1.

Phylogenomic databases

eggNOGCOG1398.
HOGENOMHOG000270352.
HOVERGENHBG003367.
InParanoidP13516.
KOK00507.
OMAWNETWTN.
OrthoDBEOG7ZPNKS.
PhylomeDBP13516.
TreeFamTF313251.

Gene expression databases

ArrayExpressP13516.
BgeeP13516.
CleanExMM_SCD1.
GenevestigatorP13516.

Family and domain databases

InterProIPR005804. Fatty_acid_desaturase-1.
IPR001522. Fatty_acid_desaturase-1_C.
IPR015876. Fatty_acid_desaturase-1_core.
[Graphical view]
PfamPF00487. FA_desaturase. 1 hit.
[Graphical view]
PRINTSPR00075. FACDDSATRASE.
PROSITEPS00476. FATTY_ACID_DESATUR_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSScd1. mouse.
NextBio297897.
PROP13516.
SOURCESearch...

Entry information

Entry nameACOD1_MOUSE
AccessionPrimary (citable) accession number: P13516
Secondary accession number(s): Q922I6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: June 6, 2002
Last modified: April 16, 2014
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot