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P13516

- ACOD1_MOUSE

UniProt

P13516 - ACOD1_MOUSE

Protein

Acyl-CoA desaturase 1

Gene

Scd1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 2 (06 Jun 2002)
      Previous versions | rss
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    Functioni

    Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O2 and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.

    Catalytic activityi

    Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.

    Cofactori

    Iron.

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. stearoyl-CoA 9-desaturase activity Source: UniProtKB-EC

    GO - Biological processi

    1. brown fat cell differentiation Source: MGI
    2. cholesterol esterification Source: MGI
    3. defense response to Gram-positive bacterium Source: MGI
    4. fatty acid biosynthetic process Source: MGI
    5. negative regulation of growth of symbiont in host Source: MGI
    6. positive regulation of cholesterol esterification Source: BHF-UCL
    7. white fat cell differentiation Source: MGI

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    Iron

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acyl-CoA desaturase 1 (EC:1.14.19.1)
    Alternative name(s):
    Delta(9)-desaturase 1
    Short name:
    Delta-9 desaturase 1
    Fatty acid desaturase 1
    Stearoyl-CoA desaturase 1
    Gene namesi
    Name:Scd1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:98239. Scd1.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of endoplasmic reticulum membrane Source: WormBase

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 355355Acyl-CoA desaturase 1PRO_0000185397Add
    BLAST

    Proteomic databases

    MaxQBiP13516.
    PaxDbiP13516.
    PRIDEiP13516.

    PTM databases

    PhosphoSiteiP13516.

    Expressioni

    Gene expression databases

    ArrayExpressiP13516.
    BgeeiP13516.
    CleanExiMM_SCD1.
    GenevestigatoriP13516.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4996454.

    Structurei

    3D structure databases

    ProteinModelPortaliP13516.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6767CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini90 – 989LumenalSequence Analysis
    Topological domaini116 – 21297CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini232 – 24615LumenalSequence AnalysisAdd
    BLAST
    Topological domaini270 – 35586CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei68 – 8922HelicalSequence AnalysisAdd
    BLAST
    Transmembranei99 – 11517HelicalSequence AnalysisAdd
    BLAST
    Transmembranei213 – 23119HelicalSequence AnalysisAdd
    BLAST
    Transmembranei247 – 26923HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi116 – 1216Histidine box-1
    Motifi153 – 1575Histidine box-2
    Motifi294 – 2985Histidine box-3

    Domaini

    The histidine box domains may contain the active site and/or be involved in metal ion binding.

    Sequence similaritiesi

    Belongs to the fatty acid desaturase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1398.
    HOGENOMiHOG000270352.
    HOVERGENiHBG003367.
    InParanoidiP13516.
    KOiK00507.
    OMAiHILWIFD.
    OrthoDBiEOG7ZPNKS.
    PhylomeDBiP13516.
    TreeFamiTF313251.

    Family and domain databases

    InterProiIPR005804. Fatty_acid_desaturase-1.
    IPR001522. Fatty_acid_desaturase-1_C.
    IPR015876. Fatty_acid_desaturase-1_core.
    [Graphical view]
    PfamiPF00487. FA_desaturase. 1 hit.
    [Graphical view]
    PRINTSiPR00075. FACDDSATRASE.
    PROSITEiPS00476. FATTY_ACID_DESATUR_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P13516-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAHMLQEIS SSYTTTTTIT APPSGNEREK VKTVPLHLEE DIRPEMKEDI    50
    HDPTYQDEEG PPPKLEYVWR NIILMVLLHL GGLYGIILVP SCKLYTCLFG 100
    IFYYMTSALG ITAGAHRLWS HRTYKARLPL RIFLIIANTM AFQNDVYEWA 150
    RDHRAHHKFS ETHADPHNSR RGFFFSHVGW LLVRKHPAVK EKGGKLDMSD 200
    LKAEKLVMFQ RRYYKPGLLL MCFILPTLVP WYCWGETFVN SLFVSTFLRY 250
    TLVLNATWLV NSAAHLYGYR PYDKNIQSRE NILVSLGAVG EGFHNYHHTF 300
    PFDYSASEYR WHINFTTFFI DCMAALGLAY DRKKVSKATV LARIKRTGDG 350
    SHKSS 355
    Length:355
    Mass (Da):41,046
    Last modified:June 6, 2002 - v2
    Checksum:i00E2348C1898FE75
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti97 – 971C → A in AAA40103. (PubMed:2903162)Curated
    Sequence conflicti148 – 1481E → D in AAA40103. (PubMed:2903162)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21285
    , M21280, M21281, M21282, M21283, M21284 Genomic DNA. Translation: AAA40103.1.
    BC007474 mRNA. Translation: AAH07474.1.
    BC055453 mRNA. Translation: AAH55453.1.
    CCDSiCCDS29850.1.
    PIRiA32115.
    RefSeqiNP_033153.2. NM_009127.4.
    UniGeneiMm.267377.

    Genome annotation databases

    EnsembliENSMUST00000041331; ENSMUSP00000036936; ENSMUSG00000037071.
    GeneIDi20249.
    KEGGimmu:20249.
    UCSCiuc008hpr.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21285
    , M21280 , M21281 , M21282 , M21283 , M21284 Genomic DNA. Translation: AAA40103.1 .
    BC007474 mRNA. Translation: AAH07474.1 .
    BC055453 mRNA. Translation: AAH55453.1 .
    CCDSi CCDS29850.1.
    PIRi A32115.
    RefSeqi NP_033153.2. NM_009127.4.
    UniGenei Mm.267377.

    3D structure databases

    ProteinModelPortali P13516.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4996454.

    Chemistry

    BindingDBi P13516.
    ChEMBLi CHEMBL5353.

    PTM databases

    PhosphoSitei P13516.

    Proteomic databases

    MaxQBi P13516.
    PaxDbi P13516.
    PRIDEi P13516.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041331 ; ENSMUSP00000036936 ; ENSMUSG00000037071 .
    GeneIDi 20249.
    KEGGi mmu:20249.
    UCSCi uc008hpr.2. mouse.

    Organism-specific databases

    CTDi 20249.
    MGIi MGI:98239. Scd1.

    Phylogenomic databases

    eggNOGi COG1398.
    HOGENOMi HOG000270352.
    HOVERGENi HBG003367.
    InParanoidi P13516.
    KOi K00507.
    OMAi HILWIFD.
    OrthoDBi EOG7ZPNKS.
    PhylomeDBi P13516.
    TreeFami TF313251.

    Miscellaneous databases

    ChiTaRSi Scd1. mouse.
    NextBioi 297897.
    PROi P13516.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P13516.
    Bgeei P13516.
    CleanExi MM_SCD1.
    Genevestigatori P13516.

    Family and domain databases

    InterProi IPR005804. Fatty_acid_desaturase-1.
    IPR001522. Fatty_acid_desaturase-1_C.
    IPR015876. Fatty_acid_desaturase-1_core.
    [Graphical view ]
    Pfami PF00487. FA_desaturase. 1 hit.
    [Graphical view ]
    PRINTSi PR00075. FACDDSATRASE.
    PROSITEi PS00476. FATTY_ACID_DESATUR_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase."
      Ntambi J.M., Buhrow S.A., Kaestner K.H., Christy R.J., Sibley E., Kelly T.J. Jr., Lane M.D.
      J. Biol. Chem. 263:17291-17300(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Adipocyte.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.
    3. "Membrane topology of mouse stearoyl-CoA desaturase 1."
      Man W.C., Miyazaki M., Chu K., Ntambi J.M.
      J. Biol. Chem. 281:1251-1260(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, MEMBRANE TOPOLOGY.

    Entry informationi

    Entry nameiACOD1_MOUSE
    AccessioniPrimary (citable) accession number: P13516
    Secondary accession number(s): Q922I6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: June 6, 2002
    Last modified: October 1, 2014
    This is version 139 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3