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P13516

- ACOD1_MOUSE

UniProt

P13516 - ACOD1_MOUSE

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Protein
Acyl-CoA desaturase 1
Gene
Scd1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O2 and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.

Catalytic activityi

Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.

Cofactori

Iron.

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. stearoyl-CoA 9-desaturase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. brown fat cell differentiation Source: MGI
  2. cholesterol esterification Source: MGI
  3. defense response to Gram-positive bacterium Source: MGI
  4. fatty acid biosynthetic process Source: MGI
  5. negative regulation of growth of symbiont in host Source: MGI
  6. positive regulation of cholesterol esterification Source: BHF-UCL
  7. white fat cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

Iron

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA desaturase 1 (EC:1.14.19.1)
Alternative name(s):
Delta(9)-desaturase 1
Short name:
Delta-9 desaturase 1
Fatty acid desaturase 1
Stearoyl-CoA desaturase 1
Gene namesi
Name:Scd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:98239. Scd1.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6767Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei68 – 8922Helical; Reviewed prediction
Add
BLAST
Topological domaini90 – 989Lumenal Reviewed prediction
Transmembranei99 – 11517Helical; Reviewed prediction
Add
BLAST
Topological domaini116 – 21297Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei213 – 23119Helical; Reviewed prediction
Add
BLAST
Topological domaini232 – 24615Lumenal Reviewed prediction
Add
BLAST
Transmembranei247 – 26923Helical; Reviewed prediction
Add
BLAST
Topological domaini270 – 35586Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of endoplasmic reticulum membrane Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355Acyl-CoA desaturase 1
PRO_0000185397Add
BLAST

Proteomic databases

MaxQBiP13516.
PaxDbiP13516.
PRIDEiP13516.

PTM databases

PhosphoSiteiP13516.

Expressioni

Gene expression databases

ArrayExpressiP13516.
BgeeiP13516.
CleanExiMM_SCD1.
GenevestigatoriP13516.

Interactioni

Protein-protein interaction databases

MINTiMINT-4996454.

Structurei

3D structure databases

ProteinModelPortaliP13516.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi116 – 1216Histidine box-1
Motifi153 – 1575Histidine box-2
Motifi294 – 2985Histidine box-3

Domaini

The histidine box domains may contain the active site and/or be involved in metal ion binding.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1398.
HOGENOMiHOG000270352.
HOVERGENiHBG003367.
InParanoidiP13516.
KOiK00507.
OMAiHILWIFD.
OrthoDBiEOG7ZPNKS.
PhylomeDBiP13516.
TreeFamiTF313251.

Family and domain databases

InterProiIPR005804. Fatty_acid_desaturase-1.
IPR001522. Fatty_acid_desaturase-1_C.
IPR015876. Fatty_acid_desaturase-1_core.
[Graphical view]
PfamiPF00487. FA_desaturase. 1 hit.
[Graphical view]
PRINTSiPR00075. FACDDSATRASE.
PROSITEiPS00476. FATTY_ACID_DESATUR_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13516-1 [UniParc]FASTAAdd to Basket

« Hide

MPAHMLQEIS SSYTTTTTIT APPSGNEREK VKTVPLHLEE DIRPEMKEDI    50
HDPTYQDEEG PPPKLEYVWR NIILMVLLHL GGLYGIILVP SCKLYTCLFG 100
IFYYMTSALG ITAGAHRLWS HRTYKARLPL RIFLIIANTM AFQNDVYEWA 150
RDHRAHHKFS ETHADPHNSR RGFFFSHVGW LLVRKHPAVK EKGGKLDMSD 200
LKAEKLVMFQ RRYYKPGLLL MCFILPTLVP WYCWGETFVN SLFVSTFLRY 250
TLVLNATWLV NSAAHLYGYR PYDKNIQSRE NILVSLGAVG EGFHNYHHTF 300
PFDYSASEYR WHINFTTFFI DCMAALGLAY DRKKVSKATV LARIKRTGDG 350
SHKSS 355
Length:355
Mass (Da):41,046
Last modified:June 6, 2002 - v2
Checksum:i00E2348C1898FE75
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971C → A in AAA40103. 1 Publication
Sequence conflicti148 – 1481E → D in AAA40103. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21285
, M21280, M21281, M21282, M21283, M21284 Genomic DNA. Translation: AAA40103.1.
BC007474 mRNA. Translation: AAH07474.1.
BC055453 mRNA. Translation: AAH55453.1.
CCDSiCCDS29850.1.
PIRiA32115.
RefSeqiNP_033153.2. NM_009127.4.
UniGeneiMm.267377.

Genome annotation databases

EnsembliENSMUST00000041331; ENSMUSP00000036936; ENSMUSG00000037071.
GeneIDi20249.
KEGGimmu:20249.
UCSCiuc008hpr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21285
, M21280 , M21281 , M21282 , M21283 , M21284 Genomic DNA. Translation: AAA40103.1 .
BC007474 mRNA. Translation: AAH07474.1 .
BC055453 mRNA. Translation: AAH55453.1 .
CCDSi CCDS29850.1.
PIRi A32115.
RefSeqi NP_033153.2. NM_009127.4.
UniGenei Mm.267377.

3D structure databases

ProteinModelPortali P13516.
ModBasei Search...

Protein-protein interaction databases

MINTi MINT-4996454.

Chemistry

BindingDBi P13516.
ChEMBLi CHEMBL5353.

PTM databases

PhosphoSitei P13516.

Proteomic databases

MaxQBi P13516.
PaxDbi P13516.
PRIDEi P13516.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000041331 ; ENSMUSP00000036936 ; ENSMUSG00000037071 .
GeneIDi 20249.
KEGGi mmu:20249.
UCSCi uc008hpr.2. mouse.

Organism-specific databases

CTDi 20249.
MGIi MGI:98239. Scd1.

Phylogenomic databases

eggNOGi COG1398.
HOGENOMi HOG000270352.
HOVERGENi HBG003367.
InParanoidi P13516.
KOi K00507.
OMAi HILWIFD.
OrthoDBi EOG7ZPNKS.
PhylomeDBi P13516.
TreeFami TF313251.

Miscellaneous databases

ChiTaRSi Scd1. mouse.
NextBioi 297897.
PROi P13516.
SOURCEi Search...

Gene expression databases

ArrayExpressi P13516.
Bgeei P13516.
CleanExi MM_SCD1.
Genevestigatori P13516.

Family and domain databases

InterProi IPR005804. Fatty_acid_desaturase-1.
IPR001522. Fatty_acid_desaturase-1_C.
IPR015876. Fatty_acid_desaturase-1_core.
[Graphical view ]
Pfami PF00487. FA_desaturase. 1 hit.
[Graphical view ]
PRINTSi PR00075. FACDDSATRASE.
PROSITEi PS00476. FATTY_ACID_DESATUR_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase."
    Ntambi J.M., Buhrow S.A., Kaestner K.H., Christy R.J., Sibley E., Kelly T.J. Jr., Lane M.D.
    J. Biol. Chem. 263:17291-17300(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Adipocyte.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  3. "Membrane topology of mouse stearoyl-CoA desaturase 1."
    Man W.C., Miyazaki M., Chu K., Ntambi J.M.
    J. Biol. Chem. 281:1251-1260(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, MEMBRANE TOPOLOGY.

Entry informationi

Entry nameiACOD1_MOUSE
AccessioniPrimary (citable) accession number: P13516
Secondary accession number(s): Q922I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: June 6, 2002
Last modified: July 9, 2014
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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