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Protein

Interleukin-1 receptor type 1

Gene

Il1r1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex (By similarity).By similarity
Isoform 2: Unable to mediate canonical IL-1 signaling. Cooperates with IL1RAP isoform 3 to mediate IL1B-induced neuronal activity including IL1B-potentiated NMDA-induced calcium influx mediated by Akt kinase activation.1 Publication

GO - Molecular functioni

  • interleukin-1, Type I, activating receptor activity Source: InterPro
  • interleukin-1 binding Source: MGI
  • interleukin-1 receptor activity Source: MGI
  • platelet-derived growth factor receptor binding Source: MGI
  • protease binding Source: BHF-UCL
  • signal transducer activity Source: MGI

GO - Biological processi

  • cytokine-mediated signaling pathway Source: MGI
  • interleukin-1-mediated signaling pathway Source: MGI
  • positive regulation of interleukin-1-mediated signaling pathway Source: MGI
  • positive regulation of neutrophil extravasation Source: MGI
  • regulation of inflammatory response Source: MGI
  • response to interleukin-1 Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-446652. Interleukin-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor type 1
Short name:
IL-1R-1
Short name:
IL-1RT-1
Short name:
IL-1RT1
Alternative name(s):
CD121 antigen-like family member A
Interleukin-1 receptor alpha
Short name:
IL-1R-alpha
Interleukin-1 receptor type I
p80
CD_antigen: CD121a
Cleaved into the following 2 chains:
Interleukin-1 receptor type 1, membrane form
Short name:
mIL-1R1
Short name:
mIL-1RI
Interleukin-1 receptor type 1, soluble form
Short name:
sIL-1R1
Short name:
sIL-1RI
Gene namesi
Name:Il1r1
Synonyms:Il-1r1, Il1ra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:96545. Il1r1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 338ExtracellularSequence analysisAdd BLAST319
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 576CytoplasmicSequence analysisAdd BLAST217

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • extracellular region Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2189148.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000001543620 – 576Interleukin-1 receptor type 1, membrane formAdd BLAST557
ChainiPRO_000041534520 – ?Interleukin-1 receptor type 1, soluble form

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 107PROSITE-ProRule annotation
Disulfide bondi46 ↔ 99PROSITE-ProRule annotation
Glycosylationi63N-linked (GlcNAc...)Sequence analysis1
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi145 ↔ 199PROSITE-ProRule annotation
Glycosylationi174N-linked (GlcNAc...)Sequence analysis1
Glycosylationi236N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi251 ↔ 315PROSITE-ProRule annotation
Glycosylationi252N-linked (GlcNAc...)Sequence analysis1
Glycosylationi266N-linked (GlcNAc...)Sequence analysis1
Glycosylationi300N-linked (GlcNAc...)Sequence analysis1
Modified residuei499PhosphotyrosineBy similarity1
Modified residuei556Phosphothreonine; by PKC1 Publication1

Post-translational modificationi

A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).By similarity
Rapidly phosphorylated on Tyr-499 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP13504.
PRIDEiP13504.

PTM databases

iPTMnetiP13504.
PhosphoSitePlusiP13504.

Expressioni

Tissue specificityi

Isoform 2 is expressed in various brain tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000026072.
CleanExiMM_IL1R1.
ExpressionAtlasiP13504. baseline and differential.
GenevisibleiP13504. MM.

Interactioni

Subunit structurei

The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1 (By similarity).By similarity

GO - Molecular functioni

  • interleukin-1 binding Source: MGI
  • platelet-derived growth factor receptor binding Source: MGI
  • protease binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi200625. 6 interactors.
DIPiDIP-40669N.
IntActiP13504. 5 interactors.
STRINGi10090.ENSMUSP00000027241.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OU3model-A25-334[»]
ProteinModelPortaliP13504.
SMRiP13504.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 115Ig-like C2-type 1Add BLAST91
Domaini121 – 213Ig-like C2-type 2Add BLAST93
Domaini229 – 329Ig-like C2-type 3Add BLAST101
Domaini386 – 544TIRPROSITE-ProRule annotationAdd BLAST159

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQBC. Eukaryota.
ENOG410Z3W1. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000253916.
HOVERGENiHBG052103.
InParanoidiP13504.
KOiK04386.
OMAiIQDYEKM.
OrthoDBiEOG091G03IT.
PhylomeDBiP13504.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004076. IL-1_rcpt_I-typ.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF13895. Ig_2. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01538. INTRLEUKN1R1.
PR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative promoter usage. AlignAdd to basket

Isoform 1 (identifier: P13504-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENMKVLLGL ICLMVPLLSL EIDVCTEYPN QIVLFLSVNE IDIRKCPLTP
60 70 80 90 100
NKMHGDTIIW YKNDSKTPIS ADRDSRIHQQ NEHLWFVPAK VEDSGYYYCI
110 120 130 140 150
VRNSTYCLKT KVTVTVLEND PGLCYSTQAT FPQRLHIAGD GSLVCPYVSY
160 170 180 190 200
FKDENNELPE VQWYKNCKPL LLDNVSFFGV KDKLLVRNVA EEHRGDYICR
210 220 230 240 250
MSYTFRGKQY PVTRVIQFIT IDENKRDRPV ILSPRNETIE ADPGSMIQLI
260 270 280 290 300
CNVTGQFSDL VYWKWNGSEI EWNDPFLAED YQFVEHPSTK RKYTLITTLN
310 320 330 340 350
ISEVKSQFYR YPFICVVKNT NIFESAHVQL IYPVPDFKNY LIGGFIILTA
360 370 380 390 400
TIVCCVCIYK VFKVDIVLWY RDSCSGFLPS KASDGKTYDA YILYPKTLGE
410 420 430 440 450
GSFSDLDTFV FKLLPEVLEG QFGYKLFIYG RDDYVGEDTI EVTNENVKKS
460 470 480 490 500
RRLIIILVRD MGGFSWLGQS SEEQIAIYNA LIQEGIKIVL LELEKIQDYE
510 520 530 540 550
KMPDSIQFIK QKHGVICWSG DFQERPQSAK TRFWKNLRYQ MPAQRRSPLS
560 570
KHRLLTLDPV RDTKEKLPAA THLPLG
Length:576
Mass (Da):66,698
Last modified:January 1, 1990 - v1
Checksum:i7AA8304C86412A16
GO
Isoform 2 (identifier: P13504-2) [UniParc]FASTAAdd to basket
Also known as: IL-1R3

The sequence of this isoform differs from the canonical sequence as follows:
     1-200: Missing.

Show »
Length:376
Mass (Da):43,628
Checksum:iDBCCC2094DC79512
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0581701 – 200Missing in isoform 2. Add BLAST200

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20658 mRNA. Translation: AAA39279.1.
CCDSiCCDS35547.1. [P13504-1]
PIRiA32604.
RefSeqiNP_032388.1. NM_008362.2. [P13504-1]
XP_006495776.1. XM_006495713.2. [P13504-1]
UniGeneiMm.896.

Genome annotation databases

EnsembliENSMUST00000027241; ENSMUSP00000027241; ENSMUSG00000026072. [P13504-1]
GeneIDi16177.
KEGGimmu:16177.
UCSCiuc007atv.1. mouse. [P13504-1]

Keywords - Coding sequence diversityi

Alternative promoter usage

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20658 mRNA. Translation: AAA39279.1.
CCDSiCCDS35547.1. [P13504-1]
PIRiA32604.
RefSeqiNP_032388.1. NM_008362.2. [P13504-1]
XP_006495776.1. XM_006495713.2. [P13504-1]
UniGeneiMm.896.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OU3model-A25-334[»]
ProteinModelPortaliP13504.
SMRiP13504.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200625. 6 interactors.
DIPiDIP-40669N.
IntActiP13504. 5 interactors.
STRINGi10090.ENSMUSP00000027241.

Chemistry databases

ChEMBLiCHEMBL2189148.

PTM databases

iPTMnetiP13504.
PhosphoSitePlusiP13504.

Proteomic databases

PaxDbiP13504.
PRIDEiP13504.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027241; ENSMUSP00000027241; ENSMUSG00000026072. [P13504-1]
GeneIDi16177.
KEGGimmu:16177.
UCSCiuc007atv.1. mouse. [P13504-1]

Organism-specific databases

CTDi3554.
MGIiMGI:96545. Il1r1.

Phylogenomic databases

eggNOGiENOG410IQBC. Eukaryota.
ENOG410Z3W1. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000253916.
HOVERGENiHBG052103.
InParanoidiP13504.
KOiK04386.
OMAiIQDYEKM.
OrthoDBiEOG091G03IT.
PhylomeDBiP13504.
TreeFamiTF325519.

Enzyme and pathway databases

ReactomeiR-MMU-446652. Interleukin-1 signaling.

Miscellaneous databases

PROiP13504.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026072.
CleanExiMM_IL1R1.
ExpressionAtlasiP13504. baseline and differential.
GenevisibleiP13504. MM.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004076. IL-1_rcpt_I-typ.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF13895. Ig_2. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01538. INTRLEUKN1R1.
PR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL1R1_MOUSE
AccessioniPrimary (citable) accession number: P13504
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 2, 2016
This is version 169 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.