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Protein

Interleukin-1 receptor type 1

Gene

Il1r1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex (By similarity).By similarity
Isoform 2: Unable to mediate canonical IL-1 signaling. Cooperates with IL1RAP isoform 3 to mediate IL1B-induced neuronal activity including IL1B-potentiated NMDA-induced calcium influx mediated by Akt kinase activation.1 Publication

GO - Molecular functioni

  • interleukin-1, Type I, activating receptor activity Source: InterPro
  • interleukin-1 binding Source: MGI
  • interleukin-1 receptor activity Source: MGI
  • platelet-derived growth factor receptor binding Source: MGI
  • protease binding Source: BHF-UCL
  • signal transducer activity Source: MGI

GO - Biological processi

  • cytokine-mediated signaling pathway Source: MGI
  • interleukin-1-mediated signaling pathway Source: MGI
  • positive regulation of interleukin-1-mediated signaling pathway Source: MGI
  • positive regulation of neutrophil extravasation Source: MGI
  • regulation of inflammatory response Source: MGI
  • response to interleukin-1 Source: MGI

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-9020702 Interleukin-1 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor type 1
Short name:
IL-1R-1
Short name:
IL-1RT-1
Short name:
IL-1RT1
Alternative name(s):
CD121 antigen-like family member A
Interleukin-1 receptor alpha
Short name:
IL-1R-alpha
Interleukin-1 receptor type I
p80
CD_antigen: CD121a
Cleaved into the following 2 chains:
Interleukin-1 receptor type 1, membrane form
Short name:
mIL-1R1
Short name:
mIL-1RI
Interleukin-1 receptor type 1, soluble form
Short name:
sIL-1R1
Short name:
sIL-1RI
Gene namesi
Name:Il1r1
Synonyms:Il-1r1, Il1ra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:96545 Il1r1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 338ExtracellularSequence analysisAdd BLAST319
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 576CytoplasmicSequence analysisAdd BLAST217

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2189148

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000001543620 – 576Interleukin-1 receptor type 1, membrane formAdd BLAST557
ChainiPRO_000041534520 – ?Interleukin-1 receptor type 1, soluble form

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 107PROSITE-ProRule annotation
Disulfide bondi46 ↔ 99PROSITE-ProRule annotation
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi145 ↔ 199PROSITE-ProRule annotation
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi236N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi251 ↔ 315PROSITE-ProRule annotation
Glycosylationi252N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei499PhosphotyrosineBy similarity1
Modified residuei556Phosphothreonine; by PKC1 Publication1

Post-translational modificationi

A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).By similarity
Rapidly phosphorylated on Tyr-499 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP13504
PRIDEiP13504

PTM databases

iPTMnetiP13504
PhosphoSitePlusiP13504

Expressioni

Tissue specificityi

Isoform 2 is expressed in various brain tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000026072
CleanExiMM_IL1R1
ExpressionAtlasiP13504 baseline and differential
GenevisibleiP13504 MM

Interactioni

Subunit structurei

The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Myd88P223662EBI-1782675,EBI-525108

GO - Molecular functioni

  • interleukin-1 binding Source: MGI
  • platelet-derived growth factor receptor binding Source: MGI
  • protease binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi2006256 interactors.
DIPiDIP-40669N
IntActiP13504 5 interactors.
STRINGi10090.ENSMUSP00000027241

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OU3model-A25-334[»]
ProteinModelPortaliP13504
SMRiP13504
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 115Ig-like C2-type 1Add BLAST91
Domaini121 – 213Ig-like C2-type 2Add BLAST93
Domaini229 – 329Ig-like C2-type 3Add BLAST101
Domaini386 – 544TIRPROSITE-ProRule annotationAdd BLAST159

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQBC Eukaryota
ENOG410Z3W1 LUCA
GeneTreeiENSGT00760000119071
HOGENOMiHOG000253916
HOVERGENiHBG052103
InParanoidiP13504
KOiK04386
OMAiIQDYEKM
OrthoDBiEOG091G03IT
PhylomeDBiP13504
TreeFamiTF325519

Family and domain databases

Gene3Di2.60.40.103 hits
3.40.50.101401 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR015621 IL-1_rcpt_fam
IPR004076 IL-1_rcpt_I-typ
IPR004074 IL-1_rcpt_I/II-typ
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF13895 Ig_2, 1 hit
PF01582 TIR, 1 hit
PRINTSiPR01538 INTRLEUKN1R1
PR01536 INTRLKN1R12F
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00255 TIR, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS50104 TIR, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative promoter usage. AlignAdd to basket

Isoform 1 (identifier: P13504-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENMKVLLGL ICLMVPLLSL EIDVCTEYPN QIVLFLSVNE IDIRKCPLTP
60 70 80 90 100
NKMHGDTIIW YKNDSKTPIS ADRDSRIHQQ NEHLWFVPAK VEDSGYYYCI
110 120 130 140 150
VRNSTYCLKT KVTVTVLEND PGLCYSTQAT FPQRLHIAGD GSLVCPYVSY
160 170 180 190 200
FKDENNELPE VQWYKNCKPL LLDNVSFFGV KDKLLVRNVA EEHRGDYICR
210 220 230 240 250
MSYTFRGKQY PVTRVIQFIT IDENKRDRPV ILSPRNETIE ADPGSMIQLI
260 270 280 290 300
CNVTGQFSDL VYWKWNGSEI EWNDPFLAED YQFVEHPSTK RKYTLITTLN
310 320 330 340 350
ISEVKSQFYR YPFICVVKNT NIFESAHVQL IYPVPDFKNY LIGGFIILTA
360 370 380 390 400
TIVCCVCIYK VFKVDIVLWY RDSCSGFLPS KASDGKTYDA YILYPKTLGE
410 420 430 440 450
GSFSDLDTFV FKLLPEVLEG QFGYKLFIYG RDDYVGEDTI EVTNENVKKS
460 470 480 490 500
RRLIIILVRD MGGFSWLGQS SEEQIAIYNA LIQEGIKIVL LELEKIQDYE
510 520 530 540 550
KMPDSIQFIK QKHGVICWSG DFQERPQSAK TRFWKNLRYQ MPAQRRSPLS
560 570
KHRLLTLDPV RDTKEKLPAA THLPLG
Length:576
Mass (Da):66,698
Last modified:January 1, 1990 - v1
Checksum:i7AA8304C86412A16
GO
Isoform 2 (identifier: P13504-2) [UniParc]FASTAAdd to basket
Also known as: IL-1R3

The sequence of this isoform differs from the canonical sequence as follows:
     1-200: Missing.

Show »
Length:376
Mass (Da):43,628
Checksum:iDBCCC2094DC79512
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0581701 – 200Missing in isoform 2. Add BLAST200

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20658 mRNA Translation: AAA39279.1
CCDSiCCDS35547.1 [P13504-1]
PIRiA32604
RefSeqiNP_032388.1, NM_008362.2 [P13504-1]
XP_006495776.1, XM_006495713.2 [P13504-1]
UniGeneiMm.896

Genome annotation databases

EnsembliENSMUST00000027241; ENSMUSP00000027241; ENSMUSG00000026072 [P13504-1]
GeneIDi16177
KEGGimmu:16177
UCSCiuc007atv.1 mouse [P13504-1]

Keywords - Coding sequence diversityi

Alternative promoter usage

Similar proteinsi

Entry informationi

Entry nameiIL1R1_MOUSE
AccessioniPrimary (citable) accession number: P13504
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: February 28, 2018
This is version 177 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome