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P13504

- IL1R1_MOUSE

UniProt

P13504 - IL1R1_MOUSE

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Protein
Interleukin-1 receptor type 1
Gene
Il1r1, Il-1r1, Il1ra
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex By similarity.

GO - Molecular functioni

  1. interleukin-1 receptor activity Source: MGI
  2. interleukin-1, Type I, activating receptor activity Source: InterPro
  3. protease binding Source: BHF-UCL
  4. protein binding Source: BHF-UCL
  5. signal transducer activity Source: MGI

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: MGI
  2. regulation of inflammatory response Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_224208. Interleukin-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor type 1
Short name:
IL-1R-1
Short name:
IL-1RT-1
Short name:
IL-1RT1
Alternative name(s):
CD121 antigen-like family member A
Interleukin-1 receptor alpha
Short name:
IL-1R-alpha
Interleukin-1 receptor type I
p80
CD_antigen: CD121a
Cleaved into the following 2 chains:
Interleukin-1 receptor type 1, membrane form
Short name:
mIL-1R1
Short name:
mIL-1RI
Interleukin-1 receptor type 1, soluble form
Short name:
sIL-1R1
Short name:
sIL-1RI
Gene namesi
Name:Il1r1
Synonyms:Il-1r1, Il1ra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:96545. Il1r1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 338319Extracellular Reviewed prediction
Add
BLAST
Transmembranei339 – 35921Helical; Reviewed prediction
Add
BLAST
Topological domaini360 – 576217Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. extracellular region Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 Publication
Add
BLAST
Chaini20 – 576557Interleukin-1 receptor type 1, membrane form
PRO_0000015436Add
BLAST
Chaini20 – ?Interleukin-1 receptor type 1, soluble formPRO_0000415345

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 107 By similarity
Disulfide bondi46 ↔ 99 By similarity
Glycosylationi63 – 631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi103 – 1031N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi145 ↔ 199 By similarity
Glycosylationi174 – 1741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi236 – 2361N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi251 ↔ 315 By similarity
Glycosylationi252 – 2521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi266 – 2661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi300 – 3001N-linked (GlcNAc...) Reviewed prediction
Modified residuei499 – 4991Phosphotyrosine By similarity
Modified residuei556 – 5561Phosphothreonine; by PKC1 Publication

Post-translational modificationi

A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding) By similarity.
Rapidly phosphorylated on Tyr-499 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1 By similarity.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP13504.

PTM databases

PhosphoSiteiP13504.

Expressioni

Gene expression databases

ArrayExpressiP13504.
BgeeiP13504.
CleanExiMM_IL1R1.
GenevestigatoriP13504.

Interactioni

Subunit structurei

The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1 By similarity.2 Publications

Protein-protein interaction databases

BioGridi200625. 6 interactions.
IntActiP13504. 5 interactions.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi35 – 373
Beta strandi59 – 613
Beta strandi73 – 797
Beta strandi81 – 855
Helixi91 – 933
Beta strandi98 – 1003
Beta strandi103 – 1053
Beta strandi115 – 1173
Beta strandi123 – 1253
Helixi127 – 1293
Beta strandi131 – 1366
Beta strandi141 – 1444
Turni149 – 1568
Beta strandi162 – 1654
Beta strandi174 – 1807
Beta strandi183 – 1886
Helixi191 – 1933
Beta strandi195 – 20511
Beta strandi208 – 22114
Beta strandi236 – 2405
Beta strandi243 – 2453
Beta strandi247 – 2559
Beta strandi260 – 26910
Beta strandi275 – 28410
Helixi290 – 2923
Beta strandi294 – 30310
Helixi306 – 3094
Beta strandi313 – 3186
Beta strandi323 – 3319

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OU3model-A25-334[»]
ProteinModelPortaliP13504.
SMRiP13504. Positions 25-334, 386-542.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 11591Ig-like C2-type 1
Add
BLAST
Domaini121 – 21393Ig-like C2-type 2
Add
BLAST
Domaini229 – 329101Ig-like C2-type 3
Add
BLAST
Domaini386 – 544159TIR
Add
BLAST

Sequence similaritiesi

Contains 1 TIR domain.

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40914.
HOGENOMiHOG000253916.
HOVERGENiHBG052103.
InParanoidiP13504.
KOiK04386.
OMAiIQDYEKM.
OrthoDBiEOG7H1JK3.
PhylomeDBiP13504.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004076. IL-1_rcpt_I-typ.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01538. INTRLEUKN1R1.
PR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13504-1 [UniParc]FASTAAdd to Basket

« Hide

MENMKVLLGL ICLMVPLLSL EIDVCTEYPN QIVLFLSVNE IDIRKCPLTP    50
NKMHGDTIIW YKNDSKTPIS ADRDSRIHQQ NEHLWFVPAK VEDSGYYYCI 100
VRNSTYCLKT KVTVTVLEND PGLCYSTQAT FPQRLHIAGD GSLVCPYVSY 150
FKDENNELPE VQWYKNCKPL LLDNVSFFGV KDKLLVRNVA EEHRGDYICR 200
MSYTFRGKQY PVTRVIQFIT IDENKRDRPV ILSPRNETIE ADPGSMIQLI 250
CNVTGQFSDL VYWKWNGSEI EWNDPFLAED YQFVEHPSTK RKYTLITTLN 300
ISEVKSQFYR YPFICVVKNT NIFESAHVQL IYPVPDFKNY LIGGFIILTA 350
TIVCCVCIYK VFKVDIVLWY RDSCSGFLPS KASDGKTYDA YILYPKTLGE 400
GSFSDLDTFV FKLLPEVLEG QFGYKLFIYG RDDYVGEDTI EVTNENVKKS 450
RRLIIILVRD MGGFSWLGQS SEEQIAIYNA LIQEGIKIVL LELEKIQDYE 500
KMPDSIQFIK QKHGVICWSG DFQERPQSAK TRFWKNLRYQ MPAQRRSPLS 550
KHRLLTLDPV RDTKEKLPAA THLPLG 576
Length:576
Mass (Da):66,698
Last modified:January 1, 1990 - v1
Checksum:i7AA8304C86412A16
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M20658 mRNA. Translation: AAA39279.1.
CCDSiCCDS35547.1.
PIRiA32604.
RefSeqiNP_032388.1. NM_008362.2.
XP_006495776.1. XM_006495713.1.
UniGeneiMm.896.

Genome annotation databases

EnsembliENSMUST00000027241; ENSMUSP00000027241; ENSMUSG00000026072.
GeneIDi16177.
KEGGimmu:16177.
UCSCiuc007atv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M20658 mRNA. Translation: AAA39279.1 .
CCDSi CCDS35547.1.
PIRi A32604.
RefSeqi NP_032388.1. NM_008362.2.
XP_006495776.1. XM_006495713.1.
UniGenei Mm.896.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OU3 model - A 25-334 [» ]
ProteinModelPortali P13504.
SMRi P13504. Positions 25-334, 386-542.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200625. 6 interactions.
IntActi P13504. 5 interactions.

Chemistry

ChEMBLi CHEMBL2189148.

PTM databases

PhosphoSitei P13504.

Proteomic databases

PRIDEi P13504.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027241 ; ENSMUSP00000027241 ; ENSMUSG00000026072 .
GeneIDi 16177.
KEGGi mmu:16177.
UCSCi uc007atv.1. mouse.

Organism-specific databases

CTDi 3554.
MGIi MGI:96545. Il1r1.

Phylogenomic databases

eggNOGi NOG40914.
HOGENOMi HOG000253916.
HOVERGENi HBG052103.
InParanoidi P13504.
KOi K04386.
OMAi IQDYEKM.
OrthoDBi EOG7H1JK3.
PhylomeDBi P13504.
TreeFami TF325519.

Enzyme and pathway databases

Reactomei REACT_224208. Interleukin-1 signaling.

Miscellaneous databases

NextBioi 289041.
PROi P13504.
SOURCEi Search...

Gene expression databases

ArrayExpressi P13504.
Bgeei P13504.
CleanExi MM_IL1R1.
Genevestigatori P13504.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004076. IL-1_rcpt_I-typ.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view ]
PANTHERi PTHR11890. PTHR11890. 1 hit.
Pfami PF07679. I-set. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view ]
PRINTSi PR01538. INTRLEUKN1R1.
PR01536. INTRLKN1R12F.
SMARTi SM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-45.
  2. "Phorbol ester induces phosphorylation of the 80 kilodalton murine interleukin 1 receptor at a single threonine residue."
    Bird T.A., Woodward A., Jackson J.L., Dower S.K., Sims J.E.
    Biochem. Biophys. Res. Commun. 177:61-67(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-556.
  3. "Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex."
    Greenfeder S.A., Nunes P., Kwee L., Labow M., Chizzonite R.A., Ju G.
    J. Biol. Chem. 270:13757-13765(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IL1RAP.
  4. "Tollip, a new component of the IL-1R1 pathway, links IRAK to the IL-1 receptor."
    Burns K., Clatworthy J., Martin L., Martinon F., Plumpton C., Maschera B., Lewis A., Ray K., Tschopp J., Volpe F.
    Nat. Cell Biol. 2:346-351(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TOLLIP; MYD88 AND IRAK1.
  5. Cited for: 3D-STRUCTURE MODELING OF 25-334.

Entry informationi

Entry nameiIL1R1_MOUSE
AccessioniPrimary (citable) accession number: P13504
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: September 3, 2014
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi