UniProtKB - P13504 (IL1R1_MOUSE)
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Protein
Interleukin-1 receptor type 1
Gene
Il1r1
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex (By similarity).By similarity
Isoform 2: Unable to mediate canonical IL-1 signaling. Cooperates with IL1RAP isoform 3 to mediate IL1B-induced neuronal activity including IL1B-potentiated NMDA-induced calcium influx mediated by Akt kinase activation.1 Publication
GO - Molecular functioni
- interleukin-1, Type I, activating receptor activity Source: InterPro
- interleukin-1 binding Source: MGI
- interleukin-1 receptor activity Source: MGI
- platelet-derived growth factor receptor binding Source: MGI
- protease binding Source: BHF-UCL
- signal transducer activity Source: MGI
GO - Biological processi
- cytokine-mediated signaling pathway Source: MGI
- interleukin-1-mediated signaling pathway Source: MGI
- positive regulation of interleukin-1-mediated signaling pathway Source: MGI
- positive regulation of neutrophil extravasation Source: MGI
- regulation of inflammatory response Source: MGI
- response to interleukin-1 Source: MGI
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
Reactomei | R-MMU-9020702 Interleukin-1 signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-1 receptor type 1Short name: IL-1R-1 Short name: IL-1RT-1 Short name: IL-1RT1 Alternative name(s): CD121 antigen-like family member A Interleukin-1 receptor alpha Short name: IL-1R-alpha Interleukin-1 receptor type I p80 CD_antigen: CD121a Cleaved into the following 2 chains: |
Gene namesi | Name:Il1r1 Synonyms:Il-1r1, Il1ra |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96545 Il1r1 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 338 | ExtracellularSequence analysisAdd BLAST | 319 | |
Transmembranei | 339 – 359 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 360 – 576 | CytoplasmicSequence analysisAdd BLAST | 217 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | 1 PublicationAdd BLAST | 19 | |
ChainiPRO_0000015436 | 20 – 576 | Interleukin-1 receptor type 1, membrane formAdd BLAST | 557 | |
ChainiPRO_0000415345 | 20 – ? | Interleukin-1 receptor type 1, soluble form |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 25 ↔ 107 | PROSITE-ProRule annotation | ||
Disulfide bondi | 46 ↔ 99 | PROSITE-ProRule annotation | ||
Glycosylationi | 63 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 103 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 145 ↔ 199 | PROSITE-ProRule annotation | ||
Glycosylationi | 174 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 236 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 251 ↔ 315 | PROSITE-ProRule annotation | ||
Glycosylationi | 252 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 266 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 300 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 499 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 556 | Phosphothreonine; by PKC1 Publication | 1 |
Post-translational modificationi
A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).By similarity
Rapidly phosphorylated on Tyr-499 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P13504 |
PRIDEi | P13504 |
PTM databases
iPTMneti | P13504 |
PhosphoSitePlusi | P13504 |
Expressioni
Tissue specificityi
Isoform 2 is expressed in various brain tissues.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000026072 |
CleanExi | MM_IL1R1 |
ExpressionAtlasi | P13504 baseline and differential |
Genevisiblei | P13504 MM |
Interactioni
Subunit structurei
The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1 (By similarity).By similarity
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
Myd88 | P22366 | 2 | EBI-1782675,EBI-525108 |
GO - Molecular functioni
- interleukin-1 binding Source: MGI
- platelet-derived growth factor receptor binding Source: MGI
- protease binding Source: BHF-UCL
Protein-protein interaction databases
BioGridi | 2006256 interactors. |
DIPi | DIP-40669N |
IntActi | P13504 5 interactors. |
STRINGi | 10090.ENSMUSP00000027241 |
Structurei
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1OU3 | model | - | A | 25-334 | [»] | |
ProteinModelPortali | P13504 | |||||
SMRi | P13504 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 115 | Ig-like C2-type 1Add BLAST | 91 | |
Domaini | 121 – 213 | Ig-like C2-type 2Add BLAST | 93 | |
Domaini | 229 – 329 | Ig-like C2-type 3Add BLAST | 101 | |
Domaini | 386 – 544 | TIRPROSITE-ProRule annotationAdd BLAST | 159 |
Sequence similaritiesi
Belongs to the interleukin-1 receptor family.Curated
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IQBC Eukaryota ENOG410Z3W1 LUCA |
GeneTreei | ENSGT00760000119071 |
HOGENOMi | HOG000253916 |
HOVERGENi | HBG052103 |
InParanoidi | P13504 |
KOi | K04386 |
OMAi | IQDYEKM |
OrthoDBi | EOG091G03IT |
PhylomeDBi | P13504 |
TreeFami | TF325519 |
Family and domain databases
Gene3Di | 2.60.40.103 hits 3.40.50.101401 hit |
InterProi | View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR015621 IL-1_rcpt_fam IPR004076 IL-1_rcpt_I-typ IPR004074 IL-1_rcpt_I/II-typ IPR000157 TIR_dom IPR035897 Toll_tir_struct_dom_sf |
PANTHERi | PTHR11890 PTHR11890, 1 hit |
Pfami | View protein in Pfam PF07679 I-set, 1 hit PF13895 Ig_2, 1 hit PF01582 TIR, 1 hit |
PRINTSi | PR01538 INTRLEUKN1R1 PR01536 INTRLKN1R12F |
SMARTi | View protein in SMART SM00409 IG, 3 hits SM00255 TIR, 1 hit |
SUPFAMi | SSF48726 SSF48726, 3 hits SSF52200 SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS50835 IG_LIKE, 3 hits PS50104 TIR, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative promoter usage. AlignAdd to basket
Isoform 1 (identifier: P13504-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MENMKVLLGL ICLMVPLLSL EIDVCTEYPN QIVLFLSVNE IDIRKCPLTP
60 70 80 90 100
NKMHGDTIIW YKNDSKTPIS ADRDSRIHQQ NEHLWFVPAK VEDSGYYYCI
110 120 130 140 150
VRNSTYCLKT KVTVTVLEND PGLCYSTQAT FPQRLHIAGD GSLVCPYVSY
160 170 180 190 200
FKDENNELPE VQWYKNCKPL LLDNVSFFGV KDKLLVRNVA EEHRGDYICR
210 220 230 240 250
MSYTFRGKQY PVTRVIQFIT IDENKRDRPV ILSPRNETIE ADPGSMIQLI
260 270 280 290 300
CNVTGQFSDL VYWKWNGSEI EWNDPFLAED YQFVEHPSTK RKYTLITTLN
310 320 330 340 350
ISEVKSQFYR YPFICVVKNT NIFESAHVQL IYPVPDFKNY LIGGFIILTA
360 370 380 390 400
TIVCCVCIYK VFKVDIVLWY RDSCSGFLPS KASDGKTYDA YILYPKTLGE
410 420 430 440 450
GSFSDLDTFV FKLLPEVLEG QFGYKLFIYG RDDYVGEDTI EVTNENVKKS
460 470 480 490 500
RRLIIILVRD MGGFSWLGQS SEEQIAIYNA LIQEGIKIVL LELEKIQDYE
510 520 530 540 550
KMPDSIQFIK QKHGVICWSG DFQERPQSAK TRFWKNLRYQ MPAQRRSPLS
560 570
KHRLLTLDPV RDTKEKLPAA THLPLG
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_058170 | 1 – 200 | Missing in isoform 2. Add BLAST | 200 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M20658 mRNA Translation: AAA39279.1 |
CCDSi | CCDS35547.1 [P13504-1] |
PIRi | A32604 |
RefSeqi | NP_032388.1, NM_008362.2 [P13504-1] XP_006495776.1, XM_006495713.2 [P13504-1] |
UniGenei | Mm.896 |
Genome annotation databases
Ensembli | ENSMUST00000027241; ENSMUSP00000027241; ENSMUSG00000026072 [P13504-1] |
GeneIDi | 16177 |
KEGGi | mmu:16177 |
UCSCi | uc007atv.1 mouse [P13504-1] |
Keywords - Coding sequence diversityi
Alternative promoter usageSimilar proteinsi
Entry informationi
Entry namei | IL1R1_MOUSE | |
Accessioni | P13504Primary (citable) accession number: P13504 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | January 1, 1990 | |
Last modified: | February 28, 2018 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |