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P13504

- IL1R1_MOUSE

UniProt

P13504 - IL1R1_MOUSE

Protein

Interleukin-1 receptor type 1

Gene

Il1r1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 148 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex By similarity.By similarity

    GO - Molecular functioni

    1. interleukin-1, Type I, activating receptor activity Source: InterPro
    2. interleukin-1 receptor activity Source: MGI
    3. protease binding Source: BHF-UCL
    4. protein binding Source: BHF-UCL
    5. signal transducer activity Source: MGI

    GO - Biological processi

    1. cytokine-mediated signaling pathway Source: MGI
    2. regulation of inflammatory response Source: MGI

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_224208. Interleukin-1 signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-1 receptor type 1
    Short name:
    IL-1R-1
    Short name:
    IL-1RT-1
    Short name:
    IL-1RT1
    Alternative name(s):
    CD121 antigen-like family member A
    Interleukin-1 receptor alpha
    Short name:
    IL-1R-alpha
    Interleukin-1 receptor type I
    p80
    CD_antigen: CD121a
    Cleaved into the following 2 chains:
    Interleukin-1 receptor type 1, membrane form
    Short name:
    mIL-1R1
    Short name:
    mIL-1RI
    Interleukin-1 receptor type 1, soluble form
    Short name:
    sIL-1R1
    Short name:
    sIL-1RI
    Gene namesi
    Name:Il1r1
    Synonyms:Il-1r1, Il1ra
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:96545. Il1r1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProtKB
    2. extracellular region Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19191 PublicationAdd
    BLAST
    Chaini20 – 576557Interleukin-1 receptor type 1, membrane formPRO_0000015436Add
    BLAST
    Chaini20 – ?Interleukin-1 receptor type 1, soluble formPRO_0000415345

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi25 ↔ 107PROSITE-ProRule annotation
    Disulfide bondi46 ↔ 99PROSITE-ProRule annotation
    Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi145 ↔ 199PROSITE-ProRule annotation
    Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi236 – 2361N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi251 ↔ 315PROSITE-ProRule annotation
    Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
    Modified residuei499 – 4991PhosphotyrosineBy similarity
    Modified residuei556 – 5561Phosphothreonine; by PKC1 Publication

    Post-translational modificationi

    A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).By similarity
    Rapidly phosphorylated on Tyr-499 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiP13504.

    PTM databases

    PhosphoSiteiP13504.

    Expressioni

    Gene expression databases

    ArrayExpressiP13504.
    BgeeiP13504.
    CleanExiMM_IL1R1.
    GenevestigatoriP13504.

    Interactioni

    Subunit structurei

    The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi200625. 6 interactions.
    IntActiP13504. 5 interactions.

    Structurei

    Secondary structure

    1
    576
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi35 – 373
    Beta strandi59 – 613
    Beta strandi73 – 797
    Beta strandi81 – 855
    Helixi91 – 933
    Beta strandi98 – 1003
    Beta strandi103 – 1053
    Beta strandi115 – 1173
    Beta strandi123 – 1253
    Helixi127 – 1293
    Beta strandi131 – 1366
    Beta strandi141 – 1444
    Turni149 – 1568
    Beta strandi162 – 1654
    Beta strandi174 – 1807
    Beta strandi183 – 1886
    Helixi191 – 1933
    Beta strandi195 – 20511
    Beta strandi208 – 22114
    Beta strandi236 – 2405
    Beta strandi243 – 2453
    Beta strandi247 – 2559
    Beta strandi260 – 26910
    Beta strandi275 – 28410
    Helixi290 – 2923
    Beta strandi294 – 30310
    Helixi306 – 3094
    Beta strandi313 – 3186
    Beta strandi323 – 3319

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OU3model-A25-334[»]
    ProteinModelPortaliP13504.
    SMRiP13504. Positions 25-334, 386-542.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 338319ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini360 – 576217CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei339 – 35921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 11591Ig-like C2-type 1Add
    BLAST
    Domaini121 – 21393Ig-like C2-type 2Add
    BLAST
    Domaini229 – 329101Ig-like C2-type 3Add
    BLAST
    Domaini386 – 544159TIRPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the interleukin-1 receptor family.Curated
    Contains 1 TIR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40914.
    HOGENOMiHOG000253916.
    HOVERGENiHBG052103.
    InParanoidiP13504.
    KOiK04386.
    OMAiIQDYEKM.
    OrthoDBiEOG7H1JK3.
    PhylomeDBiP13504.
    TreeFamiTF325519.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    3.40.50.10140. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR015621. IL-1_rcpt_fam.
    IPR004076. IL-1_rcpt_I-typ.
    IPR004074. IL-1_rcpt_I/II-typ.
    IPR000157. TIR_dom.
    [Graphical view]
    PANTHERiPTHR11890. PTHR11890. 1 hit.
    PfamiPF07679. I-set. 1 hit.
    PF01582. TIR. 1 hit.
    [Graphical view]
    PRINTSiPR01538. INTRLEUKN1R1.
    PR01536. INTRLKN1R12F.
    SMARTiSM00409. IG. 2 hits.
    SM00255. TIR. 1 hit.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS50835. IG_LIKE. 3 hits.
    PS50104. TIR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P13504-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENMKVLLGL ICLMVPLLSL EIDVCTEYPN QIVLFLSVNE IDIRKCPLTP    50
    NKMHGDTIIW YKNDSKTPIS ADRDSRIHQQ NEHLWFVPAK VEDSGYYYCI 100
    VRNSTYCLKT KVTVTVLEND PGLCYSTQAT FPQRLHIAGD GSLVCPYVSY 150
    FKDENNELPE VQWYKNCKPL LLDNVSFFGV KDKLLVRNVA EEHRGDYICR 200
    MSYTFRGKQY PVTRVIQFIT IDENKRDRPV ILSPRNETIE ADPGSMIQLI 250
    CNVTGQFSDL VYWKWNGSEI EWNDPFLAED YQFVEHPSTK RKYTLITTLN 300
    ISEVKSQFYR YPFICVVKNT NIFESAHVQL IYPVPDFKNY LIGGFIILTA 350
    TIVCCVCIYK VFKVDIVLWY RDSCSGFLPS KASDGKTYDA YILYPKTLGE 400
    GSFSDLDTFV FKLLPEVLEG QFGYKLFIYG RDDYVGEDTI EVTNENVKKS 450
    RRLIIILVRD MGGFSWLGQS SEEQIAIYNA LIQEGIKIVL LELEKIQDYE 500
    KMPDSIQFIK QKHGVICWSG DFQERPQSAK TRFWKNLRYQ MPAQRRSPLS 550
    KHRLLTLDPV RDTKEKLPAA THLPLG 576
    Length:576
    Mass (Da):66,698
    Last modified:January 1, 1990 - v1
    Checksum:i7AA8304C86412A16
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M20658 mRNA. Translation: AAA39279.1.
    CCDSiCCDS35547.1.
    PIRiA32604.
    RefSeqiNP_032388.1. NM_008362.2.
    XP_006495776.1. XM_006495713.1.
    UniGeneiMm.896.

    Genome annotation databases

    EnsembliENSMUST00000027241; ENSMUSP00000027241; ENSMUSG00000026072.
    GeneIDi16177.
    KEGGimmu:16177.
    UCSCiuc007atv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M20658 mRNA. Translation: AAA39279.1 .
    CCDSi CCDS35547.1.
    PIRi A32604.
    RefSeqi NP_032388.1. NM_008362.2.
    XP_006495776.1. XM_006495713.1.
    UniGenei Mm.896.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OU3 model - A 25-334 [» ]
    ProteinModelPortali P13504.
    SMRi P13504. Positions 25-334, 386-542.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200625. 6 interactions.
    IntActi P13504. 5 interactions.

    Chemistry

    ChEMBLi CHEMBL2189148.

    PTM databases

    PhosphoSitei P13504.

    Proteomic databases

    PRIDEi P13504.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027241 ; ENSMUSP00000027241 ; ENSMUSG00000026072 .
    GeneIDi 16177.
    KEGGi mmu:16177.
    UCSCi uc007atv.1. mouse.

    Organism-specific databases

    CTDi 3554.
    MGIi MGI:96545. Il1r1.

    Phylogenomic databases

    eggNOGi NOG40914.
    HOGENOMi HOG000253916.
    HOVERGENi HBG052103.
    InParanoidi P13504.
    KOi K04386.
    OMAi IQDYEKM.
    OrthoDBi EOG7H1JK3.
    PhylomeDBi P13504.
    TreeFami TF325519.

    Enzyme and pathway databases

    Reactomei REACT_224208. Interleukin-1 signaling.

    Miscellaneous databases

    NextBioi 289041.
    PROi P13504.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P13504.
    Bgeei P13504.
    CleanExi MM_IL1R1.
    Genevestigatori P13504.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    3.40.50.10140. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR015621. IL-1_rcpt_fam.
    IPR004076. IL-1_rcpt_I-typ.
    IPR004074. IL-1_rcpt_I/II-typ.
    IPR000157. TIR_dom.
    [Graphical view ]
    PANTHERi PTHR11890. PTHR11890. 1 hit.
    Pfami PF07679. I-set. 1 hit.
    PF01582. TIR. 1 hit.
    [Graphical view ]
    PRINTSi PR01538. INTRLEUKN1R1.
    PR01536. INTRLKN1R12F.
    SMARTi SM00409. IG. 2 hits.
    SM00255. TIR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS50835. IG_LIKE. 3 hits.
    PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-45.
    2. "Phorbol ester induces phosphorylation of the 80 kilodalton murine interleukin 1 receptor at a single threonine residue."
      Bird T.A., Woodward A., Jackson J.L., Dower S.K., Sims J.E.
      Biochem. Biophys. Res. Commun. 177:61-67(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT THR-556.
    3. "Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex."
      Greenfeder S.A., Nunes P., Kwee L., Labow M., Chizzonite R.A., Ju G.
      J. Biol. Chem. 270:13757-13765(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IL1RAP.
    4. "Tollip, a new component of the IL-1R1 pathway, links IRAK to the IL-1 receptor."
      Burns K., Clatworthy J., Martin L., Martinon F., Plumpton C., Maschera B., Lewis A., Ray K., Tschopp J., Volpe F.
      Nat. Cell Biol. 2:346-351(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TOLLIP; MYD88 AND IRAK1.
    5. Cited for: 3D-STRUCTURE MODELING OF 25-334.

    Entry informationi

    Entry nameiIL1R1_MOUSE
    AccessioniPrimary (citable) accession number: P13504
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 148 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3