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P13500

- CCL2_HUMAN

UniProt

P13500 - CCL2_HUMAN

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Protein

C-C motif chemokine 2

Gene

CCL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei31 – 311Involved in dimerization
Sitei36 – 361Involved in dimerization, receptor binding and signaling
Sitei41 – 411Involved in GAG binding
Sitei42 – 421Involved in GAG binding
Sitei47 – 471Involved in GAG binding and receptor binding
Sitei58 – 581Involved in dimerization
Sitei61 – 611Involved in dimerization
Sitei72 – 721Involved in GAG binding and receptor binding
Sitei81 – 811Involved in GAG binding
Sitei89 – 891Involved in GAG binding

GO - Molecular functioni

  1. CCR2 chemokine receptor binding Source: BHF-UCL
  2. chemokine activity Source: ProtInc
  3. heparin binding Source: Ensembl
  4. protein kinase activity Source: ProtInc
  5. receptor binding Source: ProtInc

GO - Biological processi

  1. activation of signaling protein activity involved in unfolded protein response Source: Reactome
  2. aging Source: Ensembl
  3. angiogenesis Source: BHF-UCL
  4. astrocyte cell migration Source: BHF-UCL
  5. cell adhesion Source: ProtInc
  6. cell surface receptor signaling pathway Source: ProtInc
  7. cellular calcium ion homeostasis Source: Ensembl
  8. cellular homeostasis Source: BHF-UCL
  9. cellular protein metabolic process Source: Reactome
  10. cellular response to fibroblast growth factor stimulus Source: UniProtKB
  11. cellular response to interferon-gamma Source: UniProtKB
  12. cellular response to interleukin-1 Source: UniProtKB
  13. cellular response to lipopolysaccharide Source: BHF-UCL
  14. cellular response to organic cyclic compound Source: UniProtKB
  15. cellular response to tumor necrosis factor Source: UniProtKB
  16. chemokine-mediated signaling pathway Source: Ensembl
  17. chemotaxis Source: ProtInc
  18. cytokine-mediated signaling pathway Source: BHF-UCL
  19. cytoskeleton organization Source: UniProtKB
  20. endoplasmic reticulum unfolded protein response Source: Reactome
  21. G-protein coupled receptor signaling pathway Source: ProtInc
  22. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  23. helper T cell extravasation Source: BHF-UCL
  24. humoral immune response Source: ProtInc
  25. inflammatory response Source: UniProtKB
  26. JAK-STAT cascade Source: ProtInc
  27. lipopolysaccharide-mediated signaling pathway Source: UniProtKB
  28. lymphocyte chemotaxis Source: Ensembl
  29. macrophage chemotaxis Source: BHF-UCL
  30. MAPK cascade Source: UniProtKB
  31. maternal process involved in parturition Source: Ensembl
  32. monocyte chemotaxis Source: BHF-UCL
  33. negative regulation of angiogenesis Source: Ensembl
  34. negative regulation of glial cell apoptotic process Source: UniProtKB
  35. negative regulation of natural killer cell chemotaxis Source: UniProtKB
  36. negative regulation of neuron apoptotic process Source: UniProtKB
  37. neutrophil chemotaxis Source: Ensembl
  38. organ morphogenesis Source: ProtInc
  39. organ regeneration Source: Ensembl
  40. positive regulation of apoptotic cell clearance Source: BHF-UCL
  41. positive regulation of calcium ion import Source: BHF-UCL
  42. positive regulation of endothelial cell proliferation Source: Ensembl
  43. positive regulation of immune complex clearance by monocytes and macrophages Source: Ensembl
  44. positive regulation of macrophage chemotaxis Source: Ensembl
  45. positive regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
  46. positive regulation of synaptic transmission Source: Ensembl
  47. positive regulation of T cell activation Source: BHF-UCL
  48. protein kinase B signaling Source: UniProtKB
  49. protein phosphorylation Source: ProtInc
  50. regulation of cell shape Source: UniProtKB
  51. regulation of vascular endothelial growth factor production Source: Ensembl
  52. response to activity Source: Ensembl
  53. response to amino acid Source: Ensembl
  54. response to antibiotic Source: Ensembl
  55. response to bacterium Source: BHF-UCL
  56. response to drug Source: Ensembl
  57. response to ethanol Source: Ensembl
  58. response to gamma radiation Source: Ensembl
  59. response to glucocorticoid Source: Ensembl
  60. response to heat Source: Ensembl
  61. response to hypoxia Source: Ensembl
  62. response to mechanical stimulus Source: Ensembl
  63. response to progesterone Source: Ensembl
  64. response to vitamin B3 Source: Ensembl
  65. response to wounding Source: Ensembl
  66. signal transduction Source: ProtInc
  67. transforming growth factor beta receptor signaling pathway Source: Ensembl
  68. vascular endothelial growth factor receptor signaling pathway Source: Ensembl
  69. viral genome replication Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_18355. ATF4 activates genes.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 2
Alternative name(s):
HC11
Monocyte chemoattractant protein 1
Monocyte chemotactic and activating factor
Short name:
MCAF
Monocyte chemotactic protein 1
Short name:
MCP-1
Monocyte secretory protein JE
Small-inducible cytokine A2
Gene namesi
Name:CCL2
Synonyms:MCP1, SCYA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:10618. CCL2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular region Source: BHF-UCL
  3. extracellular space Source: ProtInc
  4. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi24 – 9168Missing: 83% reduction in activity. Add
BLAST
Mutagenesisi24 – 8562Missing: 90% reduction in activity. Add
BLAST
Mutagenesisi24 – 241Missing: Loss of activity.
Mutagenesisi25 – 317Missing: Loss of signaling. 1 Publication
Mutagenesisi26 – 261D → A: Reduction in activity. 1 Publication
Mutagenesisi28 – 281I → A: Slight reduction in activity. 1 Publication
Mutagenesisi29 – 291N → A: 50% reduction in activity. 1 Publication
Mutagenesisi31 – 311P → A: Loss of dimerization; slight reduction of activity. 2 Publications
Mutagenesisi32 – 321V → A: Slight reduction in activity. 2 Publications
Mutagenesisi32 – 321V → E: Slight reduction in affinity. 2 Publications
Mutagenesisi33 – 331T → A: Slight reduction in activity. 2 Publications
Mutagenesisi33 – 331T → E: Slight reduction in affinity. 2 Publications
Mutagenesisi36 – 361Y → A: Loss of activity. 1 Publication
Mutagenesisi47 – 471R → F: 95% reduction in activity; strong reduction of receptor binding.
Mutagenesisi50 – 501S → Q: 40% reduction in activity.
Mutagenesisi51 – 511Y → D: Loss of activity.
Mutagenesisi53 – 531R → L: Loss of activity.
Mutagenesisi79 – 791K → A: No effect on heparin binding.
Mutagenesisi81 – 811K → A: Strongly reduces heparin binding. 1 Publication
Mutagenesisi89 – 891H → A: Strongly reduces heparin binding. 1 Publication
Mutagenesisi91 – 911D → L: 90% reduction in activity.
Mutagenesisi95 – 995Missing: No effect on heparin binding. 1 Publication

Organism-specific databases

MIMi607948. phenotype.
PharmGKBiPA130413151.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 9976C-C motif chemokine 2PRO_0000005146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acid2 Publications
Disulfide bondi34 ↔ 59
Disulfide bondi35 ↔ 75
Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP13500.
PRIDEiP13500.

Miscellaneous databases

PMAP-CutDBP13500.

Expressioni

Inductioni

Up-regulated upon hypertonic conditions.1 Publication

Gene expression databases

BgeeiP13500.
CleanExiHS_CCL2.
ExpressionAtlasiP13500. baseline and differential.
GenevestigatoriP13500.

Organism-specific databases

HPAiCAB013676.
HPA019163.

Interactioni

Subunit structurei

Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans.1 Publication

Protein-protein interaction databases

BioGridi112251. 15 interactions.
DIPiDIP-5838N.
IntActiP13500. 1 interaction.
MINTiMINT-103269.
STRINGi9606.ENSP00000225831.

Structurei

Secondary structure

1
99
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi25 – 295Combined sources
Beta strandi32 – 343Combined sources
Helixi45 – 473Combined sources
Beta strandi48 – 547Combined sources
Beta strandi59 – 613Combined sources
Beta strandi63 – 686Combined sources
Beta strandi73 – 764Combined sources
Helixi81 – 9212Combined sources
Beta strandi93 – 953Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DOKX-ray1.85A/B24-99[»]
1DOLX-ray2.40A24-99[»]
1DOMNMR-A/B24-99[»]
1DONNMR-A/B24-99[»]
1MCAmodel-A/B24-96[»]
1ML0X-ray2.80D24-99[»]
2BDNX-ray2.53A24-99[»]
2NZ1X-ray2.50D/E/Y24-99[»]
3IFDX-ray1.90A24-99[»]
4DN4X-ray2.80M24-99[»]
ProteinModelPortaliP13500.
SMRiP13500. Positions 24-94.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13500.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46819.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP13500.
KOiK14624.
OMAiNKEICAD.
PhylomeDBiP13500.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13500-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVSAALLCL LLIAATFIPQ GLAQPDAINA PVTCCYNFTN RKISVQRLAS
60 70 80 90
YRRITSSKCP KEAVIFKTIV AKEICADPKQ KWVQDSMDHL DKQTQTPKT
Length:99
Mass (Da):11,025
Last modified:January 1, 1990 - v1
Checksum:i45EC72361435302F
GO

Polymorphismi

Genetic variations in CCL2 determine Mycobacterium tuberculosis susceptibility [MIMi:607948].

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24545 mRNA. Translation: AAA18164.1.
M28225, M28223, M28224 Genomic DNA. Translation: AAA60308.1.
M28226 mRNA. Translation: AAA60309.1.
M31626, M30816, M31625 Genomic DNA. Translation: AAA36330.1.
X14768 mRNA. Translation: CAA32876.1.
M37719 Genomic DNA. Translation: AAA18102.1.
S71513 mRNA. Translation: AAB20651.1.
S69738 mRNA. Translation: AAB29926.1.
Y18933 Genomic DNA. Translation: CAC14049.1.
A17786 mRNA. Translation: CAA01352.1.
BT007329 mRNA. Translation: AAP35993.1.
AF519531 Genomic DNA. Translation: AAM54046.1.
AK311960 mRNA. Translation: BAG34900.1.
CH471147 Genomic DNA. Translation: EAW80212.1.
BC009716 mRNA. Translation: AAH09716.1.
CCDSiCCDS11277.1.
PIRiA35474. A60299.
RefSeqiNP_002973.1. NM_002982.3.
UniGeneiHs.303649.

Genome annotation databases

EnsembliENST00000225831; ENSP00000225831; ENSG00000108691.
GeneIDi6347.
KEGGihsa:6347.
UCSCiuc002hhy.3. human.

Polymorphism databases

DMDMi126842.

Cross-referencesi

Web resourcesi

Wikipedia

CCL2 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24545 mRNA. Translation: AAA18164.1 .
M28225 , M28223 , M28224 Genomic DNA. Translation: AAA60308.1 .
M28226 mRNA. Translation: AAA60309.1 .
M31626 , M30816 , M31625 Genomic DNA. Translation: AAA36330.1 .
X14768 mRNA. Translation: CAA32876.1 .
M37719 Genomic DNA. Translation: AAA18102.1 .
S71513 mRNA. Translation: AAB20651.1 .
S69738 mRNA. Translation: AAB29926.1 .
Y18933 Genomic DNA. Translation: CAC14049.1 .
A17786 mRNA. Translation: CAA01352.1 .
BT007329 mRNA. Translation: AAP35993.1 .
AF519531 Genomic DNA. Translation: AAM54046.1 .
AK311960 mRNA. Translation: BAG34900.1 .
CH471147 Genomic DNA. Translation: EAW80212.1 .
BC009716 mRNA. Translation: AAH09716.1 .
CCDSi CCDS11277.1.
PIRi A35474. A60299.
RefSeqi NP_002973.1. NM_002982.3.
UniGenei Hs.303649.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1DOK X-ray 1.85 A/B 24-99 [» ]
1DOL X-ray 2.40 A 24-99 [» ]
1DOM NMR - A/B 24-99 [» ]
1DON NMR - A/B 24-99 [» ]
1MCA model - A/B 24-96 [» ]
1ML0 X-ray 2.80 D 24-99 [» ]
2BDN X-ray 2.53 A 24-99 [» ]
2NZ1 X-ray 2.50 D/E/Y 24-99 [» ]
3IFD X-ray 1.90 A 24-99 [» ]
4DN4 X-ray 2.80 M 24-99 [» ]
ProteinModelPortali P13500.
SMRi P13500. Positions 24-94.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112251. 15 interactions.
DIPi DIP-5838N.
IntActi P13500. 1 interaction.
MINTi MINT-103269.
STRINGi 9606.ENSP00000225831.

Chemistry

BindingDBi P13500.
ChEMBLi CHEMBL1649052.
DrugBanki DB01406. Danazol.
DB01055. Mimosine.

Polymorphism databases

DMDMi 126842.

Proteomic databases

PaxDbi P13500.
PRIDEi P13500.

Protocols and materials databases

DNASUi 6347.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000225831 ; ENSP00000225831 ; ENSG00000108691 .
GeneIDi 6347.
KEGGi hsa:6347.
UCSCi uc002hhy.3. human.

Organism-specific databases

CTDi 6347.
GeneCardsi GC17P032582.
HGNCi HGNC:10618. CCL2.
HPAi CAB013676.
HPA019163.
MIMi 158105. gene.
607948. phenotype.
neXtProti NX_P13500.
PharmGKBi PA130413151.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46819.
GeneTreei ENSGT00730000110714.
HOGENOMi HOG000036686.
HOVERGENi HBG017871.
InParanoidi P13500.
KOi K14624.
OMAi NKEICAD.
PhylomeDBi P13500.
TreeFami TF334888.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.
REACT_18355. ATF4 activates genes.

Miscellaneous databases

EvolutionaryTracei P13500.
GeneWikii CCL2.
GenomeRNAii 6347.
NextBioi 24660.
PMAP-CutDB P13500.
PROi P13500.
SOURCEi Search...

Gene expression databases

Bgeei P13500.
CleanExi HS_CCL2.
ExpressionAtlasi P13500. baseline and differential.
Genevestigatori P13500.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF)."
    Furutani Y., Nomura H., Notake M., Oyamada Y., Fukui T., Yamada M., Larsen C.G., Oppenheim J.J., Matsushima K.
    Biochem. Biophys. Res. Commun. 159:249-255(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The human homolog of the JE gene encodes a monocyte secretory protein."
    Rollins B.J., Stier P., Ernst T., Wong G.G.
    Mol. Cell. Biol. 9:4687-4695(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE."
    Yoshimura T., Yuhki N., Moore S.K., Appella E., Lerman M.I., Leonard E.J.
    FEBS Lett. 244:487-493(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Glial tumor.
  4. "Cloning and expression of a gamma-interferon-inducible gene in monocytes: a new member of a cytokine gene family."
    Chang H.C., Hsu F., Freeman G.J., Griffin J.D., Reinherz E.L.
    Int. Immunol. 1:388-397(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Structure of human monocyte chemotactic protein gene and its regulation by TPA."
    Shyy Y.J., Li Y.S., Kolattukudy P.E.
    Biochem. Biophys. Res. Commun. 169:346-351(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Human monocyte chemoattractant protein-1 (MCP-1)."
    Yoshimura T., Leonard E.J.
    Adv. Exp. Med. Biol. 305:47-56(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  7. "The expression of monocyte chemotactic protein (MCP-1) in human vascular endothelium in vitro and in vivo."
    Li Y.S., Shyy Y.J., Wright J.G., Valente A.J., Cornhill J.F., Kolattukudy P.E.
    Mol. Cell. Biochem. 126:61-68(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  8. "Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition."
    Finzer P., Soto U., Delius H., Patzelt A., Poustka A., Coy J.F., zur Hausen H., Roesl F.
    Oncogene 19:3235-3244(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  9. "Protein with cytokine activity, recombinant DNA, expression vector and hosts for obtaining it."
    Caput D., Ferrara P., Miloux B., Minty A., Vita N.
    Patent number EP0488900, 03-JUN-1992
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  10. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  11. SeattleSNPs variation discovery resource
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  12. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Urinary bladder.
  13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  14. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  15. "Complete amino acid sequence of a human monocyte chemoattractant, a putative mediator of cellular immune reactions."
    Robinson E.A., Yoshimura T., Leonard E.J., Tanaka S., Griffin P.R., Shabanowitz J., Hunt D.F., Appella E.
    Proc. Natl. Acad. Sci. U.S.A. 86:1850-1854(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-99, PYROGLUTAMATE FORMATION AT GLN-24.
  16. "Identification of the monocyte chemotactic protein from human osteosarcoma cells and monocytes: detection of a novel N-terminally processed form."
    Decock B., Conings R., Lenaerts J.-P., Biliau A., van Damme J.
    Biochem. Biophys. Res. Commun. 167:904-909(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-53 AND 82-92.
  17. "Assignment of the human small inducible cytokine A2 gene, SCYA2 (encoding JE or MCP-1), to 17q11.2-12: evolutionary relatedness of cytokines clustered at the same locus."
    Rollins B.J., Morton C.C., Ledbetter D.H., Eddy R.L. Jr., Shows T.B.
    Genomics 10:489-492(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE STRUCTURE.
  18. "Structure/activity analysis of human monocyte chemoattractant protein-1 (MCP-1) by mutagenesis. Identification of a mutated protein that inhibits MCP-1-mediated monocyte chemotaxis."
    Zhang Y.J., Rutledge B.J., Rollins B.J.
    J. Biol. Chem. 269:15918-15924(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS.
  19. "Deletion of the NH2-terminal residue converts monocyte chemotactic protein 1 from an activator of basophil mediator release to an eosinophil chemoattractant."
    Weber M., Uguccioni M., Baggiolini M., Clark-Lewis I., Dahinden C.A.
    J. Exp. Med. 183:681-685(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: EFFECT OF DELETION OF N-TERMINAL RESIDUES.
  20. "Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3."
    Kim K.-S., Rajarathnam K., Clark-Lewis I., Sykes B.D.
    FEBS Lett. 395:277-282(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  21. "Lysine 58 and histidine 66 at the C-terminal alpha-helix of monocyte chemoattractant protein-1 are essential for glycosaminoglycan binding."
    Chakravarty L., Rogers L., Quach T., Breckenridge S., Kolattukudy P.E.
    J. Biol. Chem. 273:29641-29647(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: GAG BINDING SITES LYS-81 AND HIS-89, MUTAGENESIS OF LYS-81; HIS-89 AND 95-GLN--THR-99.
  22. "Monomeric monocyte chemoattractant protein-1 (MCP-1) binds and activates the MCP-1 receptor CCR2B."
    Paavola C.D., Hemmerich S., Grunberger D., Polsky I., Bloom A., Freedman R., Mulkins M., Bhakta S., McCarley D., Wiesent L., Wong B., Jarnagin K., Handel T.M.
    J. Biol. Chem. 273:33157-33165(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: HOMODIMERIZATION, MUTAGENESIS OF PRO-31; VAL-32; THR-33 AND TYR-36.
  23. "Identification of surface residues of the monocyte chemotactic protein 1 that affect signaling through the receptor CCR2."
    Jarnagin K., Grunberger D., Mulkins M., Wong B., Hemmerich S., Paavola C., Bloom A., Bhakta S., Diehl F., Freedman R., McCarley D., Polsky I., Ping-Tsou A., Kosaka A., Handel T.M.
    Biochemistry 38:16167-16177(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF 25-PRO--PRO-31; ASP-26; ILE-28; ASN-29; PRO-31; VAL-32 AND THR-33.
  24. Cited for: IMPORTANCE OF TYR-36; ARG-47; LYS-58; LYS-61 AND LYS-72 FOR RECEPTOR BINDING, MUTAGENESIS.
  25. "Identification of the glycosaminoglycan binding site of the CC chemokine, MCP-1: implications for structure and function in vivo."
    Lau E.K., Paavola C.D., Johnson Z., Gaudry J.-P., Geretti E., Borlat F., Kungl A.J., Proudfoot A.E., Handel T.M.
    J. Biol. Chem. 279:22294-22305(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GAG BINDING SITES ARG-41; LYS-42 AND ARG-47, MUTAGENESIS.
  26. "Fat-specific protein 27 modulates nuclear factor of activated T cells 5 and the cellular response to stress."
    Ueno M., Shen W.J., Patel S., Greenberg A.S., Azhar S., Kraemer F.B.
    J. Lipid Res. 54:734-743(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY OSMOTIC STRESS.
  27. "Modeling the three-dimensional structure of the monocyte chemo-attractant and activating protein MCAF/MCP-1 on the basis of the solution structure of interleukin-8."
    Gronenborn A.M., Clore G.M.
    Protein Eng. 4:263-269(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING.
  28. "Heteronuclear (1H, 13C, 15N) NMR assignments and solution structure of the monocyte chemoattractant protein-1 (MCP-1) dimer."
    Handel T.M., Domaille P.J.
    Biochemistry 35:6569-6584(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  29. "The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions."
    Lubkowski J., Bujacz G., Domaille P.J., Handel T.M., Wlodawer A.
    Nat. Struct. Biol. 4:64-69(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
  30. "A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis."
    Flores-Villanueva P.O., Ruiz-Morales J.A., Song C.-H., Flores L.M., Jo E.-K., Montano M., Barnes P.F., Selman M., Granados J.
    J. Exp. Med. 202:1649-1658(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN MYCOBACTERIUM TUBERCULOSIS SUSCEPTIBILITY.

Entry informationi

Entry nameiCCL2_HUMAN
AccessioniPrimary (citable) accession number: P13500
Secondary accession number(s): B2R4V3, Q9UDF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 26, 2014
This is version 184 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3