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Protein

Delta-hexatoxin-Hv1a

Gene
N/A
Organism
Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits tetrodotoxin-sensitive voltage-gated sodium channels (Nav) by binding to site 3. Slows the inactivation, and causes a prolongation of action potential duration resulting in repetitive firing in autonomic and motor nerve fibers. Does not depolarize the resting potential. Does not affect tetrodotoxin-resistant sodium channels. This lethal neurotoxin is active on both insect and mammalian voltage-gated sodium channels. Pan-neuronal expression in Drosophila is lethal but flies engineered to express the toxin only in pacemaker neurons have profound defects in circadian rhythm but a normal lifespan.7 Publications

Miscellaneous

Is the sole lethal toxin in male and female A.versutus venom.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Protein family/group databases

TCDBi8.B.6.2.1. the ca(2+) channel-targeting spider toxin (cst) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-hexatoxin-Hv1a
Short name:
Delta-HXTX-Hv1a
Alternative name(s):
Delta-atracotoxin-Hv1a
Short name:
Delta-AcTx-Hv1a
Versutoxin
OrganismiHadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
Taxonomic identifieri6904 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeMygalomorphaeHexathelidaeHadronyche

Organism-specific databases

ArachnoServeriAS000307. delta-hexatoxin-Hv1a.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 0.06 µg/kg by intracerebroventricular injection, and 0.2 mg/kg by subcutaneous injection into mice.1 Publication
Into crickets, LD50 is 770 pmol/g, and PD50 is 200 +-36 pmol/g. Into blowfly larvae, PD50 is 54 +- 14 pmol/g.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000876541 – 42Delta-hexatoxin-Hv1aAdd BLAST42

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi1 ↔ 15
Disulfide bondi8 ↔ 20
Disulfide bondi14 ↔ 31
Disulfide bondi16 ↔ 42

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi18 – 21Combined sources4
Beta strandi30 – 33Combined sources4
Helixi35 – 40Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VTXNMR-A1-42[»]
ProteinModelPortaliP13494.
SMRiP13494.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13494.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Sequence similaritiesi

Belongs to the delta-atracotoxin family.Curated

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR008017. Atracotoxin_delta.
PfamiView protein in Pfam
PF05353. Atracotoxin. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD026455. Atracotoxin. 1 hit.
PROSITEiView protein in PROSITE
PS60018. DELTA_ACTX. 1 hit.

Sequencei

Sequence statusi: Complete.

P13494-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
CAKKRNWCGK TEDCCCPMKC VYAWYNEQGS CQSTISALWK KC
Length:42
Mass (Da):4,856
Last modified:January 1, 1990 - v1
Checksum:i8CB1CEC225532A4E
GO

Mass spectrometryi

Molecular mass is 4847.2 Da from positions 1 - 42. Determined by ESI. 1 Publication

Sequence databases

PIRiS00343. NTIIV.

Similar proteinsi

Entry informationi

Entry nameiTXDT1_HADVE
AccessioniPrimary (citable) accession number: P13494
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families