P13488 (SCX3_BUTOM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Alpha-like toxin Bom3 Alternative name(s): Bom III Short name=BomIII
Organism	Buthus occitanus mardochei (Moroccan scorpion)
Taxonomic identifier	6869 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Buthus › Buthus occitanus

Protein attributes

Sequence length	66 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds voltage-independently sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission. As it competes neither with the classical alpha-toxin AaH2 nor the beta-toxin Css2, this toxin is an alpha-like toxin.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Ion channel impairing toxin Neurotoxin Sodium channel inhibitor Toxin
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	defense response Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sodium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 66	66	Alpha-like toxin Bom3		PRO_0000066744
Amino acid modifications
	Disulfide bond	12 ↔ 65		By similarity
	Disulfide bond	16 ↔ 37		By similarity
	Disulfide bond	23 ↔ 47		By similarity
	Disulfide bond	27 ↔ 49		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P13488 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: 7A96DA393F89852F	FASTA	66	6,872
	10 20 30 40 50 60 GRDGYIAQPE NCVYHCFPGS SGCDTLCKEK GATSGHCGFL PGSGVACWCD NLPNKVPIVV GGEKCH

References

[1]	"Characterization of six toxins from the venom of the Moroccan scorpion Buthus occitanus mardochei." Vargas O., Martin M.-F., Rochat H. Eur. J. Biochem. 162:589-599(1987) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Venom.

Cross-references

Sequence databases
PIR	A29386.
3D structure databases
ProteinModelPortal	P13488.
SMR	P13488. Positions 2-66.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.30.30.10. 1 hit.
InterPro	IPR003614. Scorpion_toxin-like. IPR018218. Scorpion_toxinL. IPR002061. Scorpion_toxinL/defesin. [Graphical view]
Pfam	PF00537. Toxin_3. 1 hit. [Graphical view]
PRINTS	PR00285. SCORPNTOXIN.
SMART	SM00505. Knot1. 1 hit. [Graphical view]
SUPFAM	SSF57095. SSF57095. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SCX3_BUTOM

Accession

Primary (citable) accession number: P13488

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program