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Protein

Alpha-like toxin Bom3

Gene
N/A
Organism
Buthus occitanus mardochei (Moroccan scorpion)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds voltage-independently sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission. As it competes neither with the classical alpha-toxin AaH2 nor the beta-toxin Css2, this toxin is an alpha-like toxin.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-like toxin Bom3
Alternative name(s):
Bom III
Short name:
BomIII
OrganismiButhus occitanus mardochei (Moroccan scorpion)
Taxonomic identifieri6869 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeButhus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6666Alpha-like toxin Bom3PRO_0000066744Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi12 ↔ 65By similarity
Disulfide bondi16 ↔ 37By similarity
Disulfide bondi23 ↔ 47By similarity
Disulfide bondi27 ↔ 49By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP13488.
SMRiP13488. Positions 2-66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR003614. Scorpion_toxin-like.
IPR018218. Scorpion_toxinL.
IPR002061. Scorpion_toxinL/defensin.
[Graphical view]
PfamiPF00537. Toxin_3. 1 hit.
[Graphical view]
PRINTSiPR00285. SCORPNTOXIN.
SMARTiSM00505. Knot1. 1 hit.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.

Sequencei

Sequence statusi: Complete.

P13488-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GRDGYIAQPE NCVYHCFPGS SGCDTLCKEK GATSGHCGFL PGSGVACWCD
60
NLPNKVPIVV GGEKCH
Length:66
Mass (Da):6,872
Last modified:January 1, 1990 - v1
Checksum:i7A96DA393F89852F
GO

Sequence databases

PIRiA29386.

Cross-referencesi

Sequence databases

PIRiA29386.

3D structure databases

ProteinModelPortaliP13488.
SMRiP13488. Positions 2-66.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR003614. Scorpion_toxin-like.
IPR018218. Scorpion_toxinL.
IPR002061. Scorpion_toxinL/defensin.
[Graphical view]
PfamiPF00537. Toxin_3. 1 hit.
[Graphical view]
PRINTSiPR00285. SCORPNTOXIN.
SMARTiSM00505. Knot1. 1 hit.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Characterization of six toxins from the venom of the Moroccan scorpion Buthus occitanus mardochei."
    Vargas O., Martin M.-F., Rochat H.
    Eur. J. Biochem. 162:589-599(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Venom.

Entry informationi

Entry nameiSCX3_BUTOM
AccessioniPrimary (citable) accession number: P13488
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: January 7, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.