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P13488

- SCX3_BUTOM

UniProt

P13488 - SCX3_BUTOM

Protein

Alpha-like toxin Bom3

Gene
N/A
Organism
Buthus occitanus mardochei (Moroccan scorpion)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds voltage-independently sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission. As it competes neither with the classical alpha-toxin AaH2 nor the beta-toxin Css2, this toxin is an alpha-like toxin.

    GO - Molecular functioni

    1. ion channel inhibitor activity Source: InterPro

    GO - Biological processi

    1. defense response Source: InterPro

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-like toxin Bom3
    Alternative name(s):
    Bom III
    Short name:
    BomIII
    OrganismiButhus occitanus mardochei (Moroccan scorpion)
    Taxonomic identifieri6869 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeButhus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6666Alpha-like toxin Bom3PRO_0000066744Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi12 ↔ 65By similarity
    Disulfide bondi16 ↔ 37By similarity
    Disulfide bondi23 ↔ 47By similarity
    Disulfide bondi27 ↔ 49By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Structurei

    3D structure databases

    ProteinModelPortaliP13488.
    SMRiP13488. Positions 2-66.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.30.30.10. 1 hit.
    InterProiIPR003614. Scorpion_toxin-like.
    IPR018218. Scorpion_toxinL.
    IPR002061. Scorpion_toxinL/defensin.
    [Graphical view]
    PfamiPF00537. Toxin_3. 1 hit.
    [Graphical view]
    PRINTSiPR00285. SCORPNTOXIN.
    SMARTiSM00505. Knot1. 1 hit.
    [Graphical view]
    SUPFAMiSSF57095. SSF57095. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P13488-1 [UniParc]FASTAAdd to Basket

    « Hide

    GRDGYIAQPE NCVYHCFPGS SGCDTLCKEK GATSGHCGFL PGSGVACWCD   50
    NLPNKVPIVV GGEKCH 66
    Length:66
    Mass (Da):6,872
    Last modified:January 1, 1990 - v1
    Checksum:i7A96DA393F89852F
    GO

    Sequence databases

    PIRiA29386.

    Cross-referencesi

    Sequence databases

    PIRi A29386.

    3D structure databases

    ProteinModelPortali P13488.
    SMRi P13488. Positions 2-66.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.30.30.10. 1 hit.
    InterProi IPR003614. Scorpion_toxin-like.
    IPR018218. Scorpion_toxinL.
    IPR002061. Scorpion_toxinL/defensin.
    [Graphical view ]
    Pfami PF00537. Toxin_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00285. SCORPNTOXIN.
    SMARTi SM00505. Knot1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57095. SSF57095. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of six toxins from the venom of the Moroccan scorpion Buthus occitanus mardochei."
      Vargas O., Martin M.-F., Rochat H.
      Eur. J. Biochem. 162:589-599(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Venom.

    Entry informationi

    Entry nameiSCX3_BUTOM
    AccessioniPrimary (citable) accession number: P13488
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3