P13484 (TAGE_BACSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable poly(glycerol-phosphate) alpha-glucosyltransferase
EC=2.4.1.52

Alternative name(s):
Major teichoic acid biosynthesis protein E

Gene names

Name:	tagE
Synonyms:	gtaA, rodD
Ordered Locus Names:	BSU35730

Organism

Bacillus subtilis (strain 168) [Reference proteome] [HAMAP]

Taxonomic identifier

224308 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus subtilis group › Bacillus subtilis › Bacillus subtilis subsp. subtilis

Protein attributes

Sequence length	673 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	UDP-glucose + poly(glycerol phosphate) = UDP + O-(alpha-D-glucosyl)poly(glycerol phosphate).
Pathway	Cell wall biogenesis; poly(glycerol phosphate) teichoic acid biosynthesis.
Subcellular location	Cytoplasm Potential.
Induction	Positively regulated by YycF. Mainly expressed during exponential growth and rapidly shut off as cells enter the stationary phase. Ref.3
Sequence similarities	Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation Teichoic acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	teichoic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	poly(glycerol-phosphate) alpha-glucosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 673	673	Probable poly(glycerol-phosphate) alpha-glucosyltransferase		PRO_0000080308
Amino acid modifications
	Modified residue	2	1	Phosphoserine Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P13484 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: 6E8F6111553F7773	FASTA	673	78,304
	10 20 30 40 50 60 MSLHAVSESN IKQIPDMDYY FISGGLPSNY GGLTKSLLLR SKLFGEECNQ NTFFLTFRFD 70 80 90 100 110 120 LELSSKIDEL YSNGKIDKKF TSVINLFDDF LSVRTNGKRS YEERIGLDQI KKQVGMGKFA 130 140 150 160 170 180 KTLLRLFGKK NNEMSVVYYG DGETIRYVDY WNDKNQLIKR EEYTKNGNLV LVTHYDVQLN 190 200 210 220 230 240 KMYLQEYIND QNQVYLDKLY VWNNEEKDVQ LSHIIWYSLE GEIKVKDESE LRQYWIEYLQ 250 260 270 280 290 300 KQNDKPKLFL VDSRPQDKHV FKVKKSPSSY YGAIIHNKHY GSNKYQIKGR YKEVFSQMYN 310 320 330 340 350 360 LDAVFFITEE QLEDFKLISG EQETFFFTPH TIDKPLDPAV LNVPSEKYKA VIISRLASMK 370 380 390 400 410 420 NLIHAVKAFS LVVKEIPEAK LDIFGSGEDF EKIKKEIEDT KLQNNVFLKG YTDNPDSEFQ 430 440 450 460 470 480 KAWLTISTSH FEGFGLSNME ALSNGCPVVT YDYDYGARSL VTDGANGYVI EQYNIEKLGQ 490 500 510 520 530 540 AIISLMKDES THQKFSEQAF KMAEKYSRPN YIENWAFALN QMIEVRIERE KFSKKVGKKD 550 560 570 580 590 600 PSISSYTEDF DKTKIEIDIE NFDHNDIKKI RLVGLDRKNK AEIISTNLQN DQLFVIDLEK 610 620 630 640 650 660 DVNIEKIAAN KTQVIDFYIV FNANGHIKTM RRLSSEETKL SGNSIDTNNG YRVEPYTTVK 670 GNFSWRVTEI KES

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of the rodC operon of Bacillus subtilis." Honeyman A.L., Stewart G.C. Mol. Microbiol. 3:1257-1268(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[2]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
[3]	"Genes controlled by the essential YycG/YycF two-component system of Bacillus subtilis revealed through a novel hybrid regulator approach." Howell A., Dubrac S., Andersen K.K., Noone D., Fert J., Msadek T., Devine K. Mol. Microbiol. 49:1639-1655(2003) [PubMed] [Europe PMC] [Abstract] Cited for: REGULATION BY YYCF/YYCG.
[4]	"The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis." Macek B., Mijakovic I., Olsen J.V., Gnad F., Kumar C., Jensen P.R., Mann M. Mol. Cell. Proteomics 6:697-707(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, MASS SPECTROMETRY. Strain: 168.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X15200 Genomic DNA. Translation: CAA33270.1. AL009126 Genomic DNA. Translation: CAB15590.1.
PIR	S06048.
RefSeq	NP_391454.1. NC_000964.3.
3D structure databases
ProteinModelPortal	P13484.
ModBase	Search...
Protein-protein interaction databases
IntAct	P13484. 2 interactions.
STRING	224308.BSU35730.
Protein family/group databases
CAZy	GT4. Glycosyltransferase Family 4.
PTM databases
PhosSite	P0802248.
Proteomic databases
PaxDb	P13484.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAB15590; CAB15590; BSU35730.
GeneID	936804.
KEGG	bsu:BSU35730.
PATRIC	18979162. VBIBacSub10457_3743.
Organism-specific databases
GenoList	BSU35730. [Micado]
Phylogenomic databases
eggNOG	COG0438.
HOGENOM	HOG000011134.
KO	K00712.
OMA	NAYESAN.
ProtClustDB	CLSK887974.
Enzyme and pathway databases
BioCyc	BSUB:BSU35730-MONOMER. MetaCyc:MONOMER-8823.
UniPathway	UPA00827.
Family and domain databases
InterPro	IPR015397. DUF1975. IPR001296. Glyco_trans_1. [Graphical view]
Pfam	PF09318. DUF1975. 1 hit. PF00534. Glycos_transf_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TAGE_BACSU

Accession

Primary (citable) accession number: P13484

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program