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Protein

Transforming protein p54/c-ets-1

Gene

ETS1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable transcription factor.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi335 – 415ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming protein p54/c-ets-1
Gene namesi
Name:ETS1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002040721 – 441Transforming protein p54/c-ets-1Add BLAST441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38Phosphothreonine; by MAPKBy similarity1

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnetiP13474

Expressioni

Tissue specificityi

Thymus.

Interactioni

Subunit structurei

Binds DNA as a homodimer; homodimerization is required for transcription activation.By similarity

Structurei

3D structure databases

ProteinModelPortaliP13474
SMRiP13474
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 136PNTPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni130 – 243Activation domain; required for transcription activationBy similarityAdd BLAST114

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
HOGENOMiHOG000285953
HOVERGENiHBG003088
KOiK02678

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR016311 Transform_prot_C-ets
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit
PIRSFiPIRSF001698 Transforming_factor_C-ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. AlignAdd to basket

Isoform p54 (identifier: P13474-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKAAVDLKPT LTIIKTEKVD IDLFPSPDME CADVPLLTPS SKEMMSQALK
60 70 80 90 100
ATFSGFAKEQ QRLGIPKDPQ QWTETHVRDW VMWAVNEFSL KGVDFQKFCM
110 120 130 140 150
NGAALCALGK ECFLELRPDF VGDILWEHLE ILQKEEAKPY PANGVNAAYP
160 170 180 190 200
ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF ITESYQTLHP ISSEELLSLK
210 220 230 240 250
YENDYPSVIL RDPVQTDSLQ TDYFTIKQEV VTPDNMCMGR ASRGKLGGQD
260 270 280 290 300
SFESIESYDS CDRLTQSWSS QSSFQSLQRV PSYDSFDSED YPAALPNHKP
310 320 330 340 350
KGTFKDYVRD RADMNKDKPV IPAAALAGYT GSGPIQLWQF LLELLTDKSC
360 370 380 390 400
QSFISWTGDG WEFKLSDPDE VARRWGKRKN KPKMNYEKLS RGLRYYYDKN
410 420 430 440
IIHKTAGKRY VYRFVCDLQS LLGYTPEELH AMLDVKPDAD E
Length:441
Mass (Da):50,327
Last modified:January 1, 1990 - v1
Checksum:i5CF3C575CCE115F5
GO
Isoform p68 (identifier: P15062-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P15062.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:485
Mass (Da):55,021
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117R → A in AAA48764 (PubMed:2847407).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22462 mRNA Translation: AAA48764.1
X13026 mRNA Translation: CAA31441.1
X13027 mRNA Translation: CAA31442.1
PIRiA31285 TVCHTE
RefSeqiNP_990629.2, NM_205298.2 [P13474-1]
UniGeneiGga.13782

Genome annotation databases

GeneIDi396235
KEGGigga:396235

Keywords - Coding sequence diversityi

Alternative promoter usage

Similar proteinsi

Entry informationi

Entry nameiETS1A_CHICK
AccessioniPrimary (citable) accession number: P13474
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health