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P13473

- LAMP2_HUMAN

UniProt

P13473 - LAMP2_HUMAN

Protein

Lysosome-associated membrane glycoprotein 2

Gene

LAMP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 163 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.1 Publication

    GO - Molecular functioni

    1. enzyme binding Source: UniProt

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. platelet activation Source: Reactome
    3. platelet degranulation Source: Reactome
    4. protein stabilization Source: UniProt

    Protein family/group databases

    TCDBi9.A.16.1.2. the lysosomal protein import (lpi) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosome-associated membrane glycoprotein 2
    Short name:
    LAMP-2
    Short name:
    Lysosome-associated membrane protein 2
    Alternative name(s):
    CD107 antigen-like family member B
    CD_antigen: CD107b
    Gene namesi
    Name:LAMP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:6501. LAMP2.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type I membrane protein 1 PublicationPROSITE-ProRule annotation. Endosome membrane 1 Publication; Single-pass type I membrane protein 1 PublicationPROSITE-ProRule annotation. Lysosome membrane 1 PublicationPROSITE-ProRule annotation; Single-pass type I membrane protein 1 PublicationPROSITE-ProRule annotation
    Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane.

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. late endosome Source: MGI
    4. late endosome membrane Source: MGI
    5. lysosomal membrane Source: UniProtKB
    6. lysosome Source: MGI
    7. membrane Source: MGI
    8. phagocytic vesicle membrane Source: Ensembl
    9. plasma membrane Source: Reactome
    10. platelet dense granule membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Endosome, Lysosome, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Danon disease (DAND) [MIM:300257]: DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti321 – 3211W → R in DAND. 2 Publications
    VAR_026230

    Keywords - Diseasei

    Disease mutation, Glycogen storage disease

    Organism-specific databases

    MIMi300257. phenotype.
    Orphaneti34587. Glycogen storage disease due to LAMP-2 deficiency.
    PharmGKBiPA30285.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 28283 PublicationsAdd
    BLAST
    Chaini29 – 410382Lysosome-associated membrane glycoprotein 2PRO_0000017110Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi32 – 321N-linked (GlcNAc...) (polylactosaminoglycan)2 Publications
    Glycosylationi38 – 381N-linked (GlcNAc...) (polylactosaminoglycan)2 Publications
    Disulfide bondi41 ↔ 79PROSITE-ProRule annotation
    Glycosylationi49 – 491N-linked (GlcNAc...)3 Publications
    Glycosylationi58 – 581N-linked (GlcNAc...)1 Publication
    Glycosylationi75 – 751N-linked (GlcNAc...)1 Publication
    Glycosylationi101 – 1011N-linked (GlcNAc...)4 Publications
    Glycosylationi123 – 1231N-linked (GlcNAc...)3 Publications
    Disulfide bondi153 ↔ 189PROSITE-ProRule annotation
    Glycosylationi179 – 1791N-linked (GlcNAc...)1 Publication
    Glycosylationi195 – 1951O-linked (GalNAc...)1 Publication
    Glycosylationi196 – 1961O-linked (GalNAc...)1 Publication
    Glycosylationi200 – 2001O-linked (GalNAc...)1 Publication
    Glycosylationi203 – 2031O-linked (GalNAc...)1 Publication
    Glycosylationi204 – 2041O-linked (GalNAc...)1 Publication
    Glycosylationi207 – 2071O-linked (GalNAc...); partial1 Publication
    Glycosylationi209 – 2091O-linked (GalNAc...); partial1 Publication
    Glycosylationi210 – 2101O-linked (GalNAc...)1 Publication
    Glycosylationi211 – 2111O-linked (GalNAc...)1 Publication
    Glycosylationi213 – 2131O-linked (GalNAc...); partial1 Publication
    Glycosylationi229 – 2291N-linked (GlcNAc...)1 Publication
    Disulfide bondi232 ↔ 265PROSITE-ProRule annotation
    Glycosylationi242 – 2421N-linked (GlcNAc...)1 Publication
    Glycosylationi257 – 2571N-linked (GlcNAc...)3 Publications
    Glycosylationi275 – 2751N-linked (GlcNAc...)1 Publication
    Glycosylationi300 – 3001N-linked (GlcNAc...)1 Publication
    Glycosylationi307 – 3071N-linked (GlcNAc...) (polylactosaminoglycan)1 Publication
    Glycosylationi317 – 3171N-linked (GlcNAc...)1 Publication
    Disulfide bondi331 ↔ 368PROSITE-ProRule annotation
    Glycosylationi356 – 3561N-linked (GlcNAc...)2 Publications

    Post-translational modificationi

    O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.4 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP13473.
    PaxDbiP13473.
    PRIDEiP13473.

    PTM databases

    PhosphoSiteiP13473.
    UniCarbKBiP13473.

    Miscellaneous databases

    PMAP-CutDBP13473.

    Expressioni

    Tissue specificityi

    Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver.

    Gene expression databases

    ArrayExpressiP13473.
    BgeeiP13473.
    CleanExiHS_LAMP2.
    GenevestigatoriP13473.

    Organism-specific databases

    HPAiCAB005272.
    HPA029100.

    Interactioni

    Protein-protein interaction databases

    BioGridi110114. 38 interactions.
    IntActiP13473. 13 interactions.
    MINTiMINT-5003281.
    STRINGi9606.ENSP00000408411.

    Structurei

    3D structure databases

    ProteinModelPortaliP13473.
    SMRiP13473. Positions 219-370.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – 375347LumenalSequence AnalysisAdd
    BLAST
    Topological domaini400 – 41011CytoplasmicPROSITE-ProRule annotationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei376 – 39924HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni29 – 192164First lumenal domainAdd
    BLAST
    Regioni193 – 22836HingeAdd
    BLAST
    Regioni229 – 375147Second lumenal domainAdd
    BLAST

    Sequence similaritiesi

    Belongs to the LAMP family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG301998.
    HOGENOMiHOG000230942.
    HOVERGENiHBG052303.
    KOiK06528.
    OMAiAEECFAD.
    OrthoDBiEOG7ZD1VH.
    PhylomeDBiP13473.
    TreeFamiTF316339.

    Family and domain databases

    InterProiIPR018134. LAMP_CS.
    IPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view]
    PANTHERiPTHR11506. PTHR11506. 1 hit.
    PfamiPF01299. Lamp. 1 hit.
    [Graphical view]
    PRINTSiPR00336. LYSASSOCTDMP.
    PROSITEiPS00310. LAMP_1. 1 hit.
    PS00311. LAMP_2. 1 hit.
    PS51407. LAMP_3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform LAMP-2A (identifier: P13473-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MVCFRLFPVP GSGLVLVCLV LGAVRSYALE LNLTDSENAT CLYAKWQMNF    50
    TVRYETTNKT YKTVTISDHG TVTYNGSICG DDQNGPKIAV QFGPGFSWIA 100
    NFTKAASTYS IDSVSFSYNT GDNTTFPDAE DKGILTVDEL LAIRIPLNDL 150
    FRCNSLSTLE KNDVVQHYWD VLVQAFVQNG TVSTNEFLCD KDKTSTVAPT 200
    IHTTVPSPTT TPTPKEKPEA GTYSVNNGND TCLLATMGLQ LNITQDKVAS 250
    VININPNTTH STGSCRSHTA LLRLNSSTIK YLDFVFAVKN ENRFYLKEVN 300
    ISMYLVNGSV FSIANNNLSY WDAPLGSSYM CNKEQTVSVS GAFQINTFDL 350
    RVQPFNVTQG KYSTAQDCSA DDDNFLVPIA VGAALAGVLI LVLLAYFIGL 400
    KHHHAGYEQF 410
    Length:410
    Mass (Da):44,961
    Last modified:October 1, 1996 - v2
    Checksum:i9E08E3B62D58F454
    GO
    Isoform LAMP-2B (identifier: P13473-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         367-410: DCSADDDNFL...KHHHAGYEQF → ECSLDDDTIL...RKSYAGYQTL

    Show »
    Length:410
    Mass (Da):44,956
    Checksum:i70B523369D40DEFA
    GO
    Isoform LAMP-2C (identifier: P13473-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         366-410: QDCSADDDNF...KHHHAGYEQF → EECSADSDLN...RKSRTGYQSV

    Show »
    Length:411
    Mass (Da):45,170
    Checksum:iB37AAC83BA1C3B1B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 136PVPGSG → RFRSGLR(PubMed:8407947)Curated
    Sequence conflicti53 – 531R → G(PubMed:8407947)Curated
    Sequence conflicti68 – 681D → V in AAB41647. (PubMed:8517882)Curated
    Sequence conflicti111 – 1111I → N in AAB41647. (PubMed:8517882)Curated
    Sequence conflicti143 – 1431I → Y in AAB41647. (PubMed:8517882)Curated
    Sequence conflicti220 – 2201A → P in AAB41647. (PubMed:8517882)Curated
    Sequence conflicti234 – 2341L → R in AAB41647. (PubMed:8517882)Curated
    Sequence conflicti263 – 2697GSCRSHT → AAAVSH(PubMed:8407947)Curated
    Sequence conflicti322 – 3265DAPLG → MPP in AAA60383. (PubMed:3198605)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti256 – 2561P → H.
    Corresponds to variant rs1043878 [ dbSNP | Ensembl ].
    VAR_011992
    Natural varianti321 – 3211W → R in DAND. 2 Publications
    VAR_026230

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei366 – 41045QDCSA…GYEQF → EECSADSDLNFLIPVAVGVA LGFLIIVVFISYMIGRRKSR TGYQSV in isoform LAMP-2C. 1 PublicationVSP_042519Add
    BLAST
    Alternative sequencei367 – 41044DCSAD…GYEQF → ECSLDDDTILIPIIVGAGLS GLIIVIVIAYVIGRRKSYAG YQTL in isoform LAMP-2B. 3 PublicationsVSP_003044Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04183 mRNA. Translation: AAA60383.1.
    L09717
    , L09709, L09710, L09711, L09712, L09713, L09714, L09715, L09716 Genomic DNA. Translation: AAB41647.1.
    X77196 mRNA. Translation: CAA54416.1.
    S79873 mRNA. Translation: AAB35426.1.
    U36336 mRNA. Translation: AAA91149.1.
    AY561849 mRNA. Translation: AAS67876.1.
    AK291090 mRNA. Translation: BAF83779.1.
    AC002476 Genomic DNA. Translation: AAB67313.1.
    AC002476 Genomic DNA. Translation: AAB67314.1.
    CH471107 Genomic DNA. Translation: EAX11881.1.
    CH471107 Genomic DNA. Translation: EAX11882.1.
    CH471107 Genomic DNA. Translation: EAX11883.1.
    CH471107 Genomic DNA. Translation: EAX11884.1.
    BC002965 mRNA. Translation: AAH02965.1.
    CCDSiCCDS14599.1. [P13473-1]
    CCDS14600.1. [P13473-2]
    CCDS48159.1. [P13473-3]
    PIRiJC2414. B31959.
    JC4317.
    RefSeqiNP_001116078.1. NM_001122606.1. [P13473-3]
    NP_002285.1. NM_002294.2. [P13473-1]
    NP_054701.1. NM_013995.2. [P13473-2]
    UniGeneiHs.496684.

    Genome annotation databases

    EnsembliENST00000200639; ENSP00000200639; ENSG00000005893. [P13473-1]
    ENST00000371335; ENSP00000360386; ENSG00000005893. [P13473-2]
    ENST00000434600; ENSP00000408411; ENSG00000005893. [P13473-3]
    GeneIDi3920.
    KEGGihsa:3920.
    UCSCiuc004ess.4. human. [P13473-3]
    uc004est.4. human. [P13473-1]
    uc010nqp.1. human. [P13473-2]

    Polymorphism databases

    DMDMi1708854.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04183 mRNA. Translation: AAA60383.1 .
    L09717
    , L09709 , L09710 , L09711 , L09712 , L09713 , L09714 , L09715 , L09716 Genomic DNA. Translation: AAB41647.1 .
    X77196 mRNA. Translation: CAA54416.1 .
    S79873 mRNA. Translation: AAB35426.1 .
    U36336 mRNA. Translation: AAA91149.1 .
    AY561849 mRNA. Translation: AAS67876.1 .
    AK291090 mRNA. Translation: BAF83779.1 .
    AC002476 Genomic DNA. Translation: AAB67313.1 .
    AC002476 Genomic DNA. Translation: AAB67314.1 .
    CH471107 Genomic DNA. Translation: EAX11881.1 .
    CH471107 Genomic DNA. Translation: EAX11882.1 .
    CH471107 Genomic DNA. Translation: EAX11883.1 .
    CH471107 Genomic DNA. Translation: EAX11884.1 .
    BC002965 mRNA. Translation: AAH02965.1 .
    CCDSi CCDS14599.1. [P13473-1 ]
    CCDS14600.1. [P13473-2 ]
    CCDS48159.1. [P13473-3 ]
    PIRi JC2414. B31959.
    JC4317.
    RefSeqi NP_001116078.1. NM_001122606.1. [P13473-3 ]
    NP_002285.1. NM_002294.2. [P13473-1 ]
    NP_054701.1. NM_013995.2. [P13473-2 ]
    UniGenei Hs.496684.

    3D structure databases

    ProteinModelPortali P13473.
    SMRi P13473. Positions 219-370.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110114. 38 interactions.
    IntActi P13473. 13 interactions.
    MINTi MINT-5003281.
    STRINGi 9606.ENSP00000408411.

    Protein family/group databases

    TCDBi 9.A.16.1.2. the lysosomal protein import (lpi) family.

    PTM databases

    PhosphoSitei P13473.
    UniCarbKBi P13473.

    Polymorphism databases

    DMDMi 1708854.

    Proteomic databases

    MaxQBi P13473.
    PaxDbi P13473.
    PRIDEi P13473.

    Protocols and materials databases

    DNASUi 3920.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000200639 ; ENSP00000200639 ; ENSG00000005893 . [P13473-1 ]
    ENST00000371335 ; ENSP00000360386 ; ENSG00000005893 . [P13473-2 ]
    ENST00000434600 ; ENSP00000408411 ; ENSG00000005893 . [P13473-3 ]
    GeneIDi 3920.
    KEGGi hsa:3920.
    UCSCi uc004ess.4. human. [P13473-3 ]
    uc004est.4. human. [P13473-1 ]
    uc010nqp.1. human. [P13473-2 ]

    Organism-specific databases

    CTDi 3920.
    GeneCardsi GC0XM119560.
    HGNCi HGNC:6501. LAMP2.
    HPAi CAB005272.
    HPA029100.
    MIMi 300257. phenotype.
    309060. gene.
    neXtProti NX_P13473.
    Orphaneti 34587. Glycogen storage disease due to LAMP-2 deficiency.
    PharmGKBi PA30285.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG301998.
    HOGENOMi HOG000230942.
    HOVERGENi HBG052303.
    KOi K06528.
    OMAi AEECFAD.
    OrthoDBi EOG7ZD1VH.
    PhylomeDBi P13473.
    TreeFami TF316339.

    Miscellaneous databases

    ChiTaRSi LAMP2. human.
    GeneWikii LAMP2.
    GenomeRNAii 3920.
    NextBioi 15399.
    PMAP-CutDB P13473.
    PROi P13473.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P13473.
    Bgeei P13473.
    CleanExi HS_LAMP2.
    Genevestigatori P13473.

    Family and domain databases

    InterProi IPR018134. LAMP_CS.
    IPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view ]
    PANTHERi PTHR11506. PTHR11506. 1 hit.
    Pfami PF01299. Lamp. 1 hit.
    [Graphical view ]
    PRINTSi PR00336. LYSASSOCTDMP.
    PROSITEi PS00310. LAMP_1. 1 hit.
    PS00311. LAMP_2. 1 hit.
    PS51407. LAMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences."
      Fukuda M., Viitala J., Matteson J., Carlsson S.R.
      J. Biol. Chem. 263:18920-18928(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LAMP-2A), PROTEIN SEQUENCE OF 29-64; 216-223 AND 238-256.
    2. "The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes."
      Sawada R., Jardine K.A., Fukuda M.
      J. Biol. Chem. 268:9014-9022(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM LAMP-2A).
      Tissue: Placenta.
    3. "Molecular and cellular characterization of Mex-/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains."
      Fritz G., Dosch J., Thielmann H.W., Kaina B.
      J. Biol. Chem. 268:21102-21112(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LAMP-2B), FUNCTION.
      Tissue: Fibroblast.
    4. "Complete cDNA sequence of human lysosome-associated membrane protein-2."
      Konecki D.S., Foetisch K., Schlotter M., Lichter-Konecki U.
      Biochem. Biophys. Res. Commun. 205:1-5(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LAMP-2A).
      Tissue: Liver.
    5. "An alternatively spliced form of the human lysosome-associated membrane protein-2 gene is expressed in a tissue-specific manner."
      Konecki D.S., Foetisch K., Zimmer K.P., Schlotter M., Lichter-Konecki U.
      Biochem. Biophys. Res. Commun. 215:757-767(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LAMP-2B).
    6. "Lamp-2 isoforms play different roles in lysosomal biogenesis."
      Zhou D., Blum J.S.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LAMP-2C).
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LAMP-2A).
    8. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LAMP-2B).
      Tissue: Lymph.
    11. "Purification and characterization of human lysosomal membrane glycoproteins."
      Mane S.M., Marzella L., Bainton D.F., Holt V.K., Cha Y., Hildreth J.E.K., August J.T.
      Arch. Biochem. Biophys. 268:360-378(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 29-66.
    12. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 29-43.
    13. "The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones."
      Carlsson S.R., Fukuda M.
      J. Biol. Chem. 265:20488-20495(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: POLYLACTOSAMINOGLYCANS.
    14. "Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2."
      Carlsson S.R., Lycksell P.-O., Fukuda M.
      Arch. Biochem. Biophys. 304:65-73(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION OF HINGE REGION, PROTEIN SEQUENCE OF 187-215.
    15. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H., Li X.-J., Martin D.B., Aebersold R.
      Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-49 AND ASN-101.
    16. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-32; ASN-38; ASN-49; ASN-101; ASN-123 AND ASN-257.
      Tissue: Plasma.
    17. Cited for: NOMENCLATURE.
    18. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Placenta.
    19. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-101; ASN-123; ASN-257 AND ASN-356.
      Tissue: Liver.
    20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    21. Cited for: VARIANT DAND ARG-321.
    22. "Asymptomatic hyperCKemia in a case of Danon disease due to a missense mutation in Lamp-2 gene."
      Musumeci O., Rodolico C., Nishino I., Di Guardo G., Migliorato A., Aguennouz M., Mazzeo A., Messina C., Vita G., Toscano A.
      Neuromuscul. Disord. 15:409-411(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT DAND ARG-321.

    Entry informationi

    Entry nameiLAMP2_HUMAN
    AccessioniPrimary (citable) accession number: P13473
    Secondary accession number(s): A8K4X5
    , D3DTF0, Q16641, Q6Q3G8, Q96J30, Q99534, Q9UD93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 163 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3