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P13473

- LAMP2_HUMAN

UniProt

P13473 - LAMP2_HUMAN

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Protein

Lysosome-associated membrane glycoprotein 2

Gene
LAMP2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.1 Publication

GO - Molecular functioni

  1. enzyme binding Source: UniProt

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. platelet activation Source: Reactome
  3. platelet degranulation Source: Reactome
  4. protein stabilization Source: UniProt
Complete GO annotation...

Protein family/group databases

TCDBi9.A.16.1.2. the lysosomal protein import (lpi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 2
Short name:
LAMP-2
Short name:
Lysosome-associated membrane protein 2
Alternative name(s):
CD107 antigen-like family member B
CD_antigen: CD107b
Gene namesi
Name:LAMP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:6501. LAMP2.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein
Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 375347Lumenal Reviewed predictionAdd
BLAST
Transmembranei376 – 39924Helical; Reviewed predictionAdd
BLAST
Topological domaini400 – 41011Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
  3. late endosome Source: MGI
  4. late endosome membrane Source: MGI
  5. lysosomal membrane Source: UniProtKB
  6. lysosome Source: MGI
  7. membrane Source: MGI
  8. phagocytic vesicle membrane Source: Ensembl
  9. plasma membrane Source: Reactome
  10. platelet dense granule membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

Pathology & Biotechi

Involvement in diseasei

Danon disease (DAND) [MIM:300257]: DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti321 – 3211W → R in DAND. 2 Publications
VAR_026230

Keywords - Diseasei

Disease mutation, Glycogen storage disease

Organism-specific databases

MIMi300257. phenotype.
Orphaneti34587. Glycogen storage disease due to LAMP-2 deficiency.
PharmGKBiPA30285.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28283 PublicationsAdd
BLAST
Chaini29 – 410382Lysosome-associated membrane glycoprotein 2PRO_0000017110Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi32 – 321N-linked (GlcNAc...) (polylactosaminoglycan)2 Publications
Glycosylationi38 – 381N-linked (GlcNAc...) (polylactosaminoglycan)2 Publications
Disulfide bondi41 ↔ 79 By similarity
Glycosylationi49 – 491N-linked (GlcNAc...)2 Publications
Glycosylationi58 – 581N-linked (GlcNAc...)
Glycosylationi75 – 751N-linked (GlcNAc...)
Glycosylationi101 – 1011N-linked (GlcNAc...)3 Publications
Glycosylationi123 – 1231N-linked (GlcNAc...)2 Publications
Disulfide bondi153 ↔ 189 By similarity
Glycosylationi179 – 1791N-linked (GlcNAc...)
Glycosylationi195 – 1951O-linked (GalNAc...)1 Publication
Glycosylationi196 – 1961O-linked (GalNAc...)1 Publication
Glycosylationi200 – 2001O-linked (GalNAc...)1 Publication
Glycosylationi203 – 2031O-linked (GalNAc...)1 Publication
Glycosylationi204 – 2041O-linked (GalNAc...)1 Publication
Glycosylationi207 – 2071O-linked (GalNAc...); partial1 Publication
Glycosylationi209 – 2091O-linked (GalNAc...); partial1 Publication
Glycosylationi210 – 2101O-linked (GalNAc...)1 Publication
Glycosylationi211 – 2111O-linked (GalNAc...)1 Publication
Glycosylationi213 – 2131O-linked (GalNAc...); partial
Glycosylationi229 – 2291N-linked (GlcNAc...)
Disulfide bondi232 ↔ 265 By similarity
Glycosylationi242 – 2421N-linked (GlcNAc...)
Glycosylationi257 – 2571N-linked (GlcNAc...)2 Publications
Glycosylationi275 – 2751N-linked (GlcNAc...)
Glycosylationi300 – 3001N-linked (GlcNAc...)
Glycosylationi307 – 3071N-linked (GlcNAc...) (polylactosaminoglycan)1 Publication
Glycosylationi317 – 3171N-linked (GlcNAc...)
Disulfide bondi331 ↔ 368 By similarity
Glycosylationi356 – 3561N-linked (GlcNAc...)1 Publication

Post-translational modificationi

O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP13473.
PaxDbiP13473.
PRIDEiP13473.

PTM databases

PhosphoSiteiP13473.
UniCarbKBiP13473.

Miscellaneous databases

PMAP-CutDBP13473.

Expressioni

Tissue specificityi

Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver.

Gene expression databases

ArrayExpressiP13473.
BgeeiP13473.
CleanExiHS_LAMP2.
GenevestigatoriP13473.

Organism-specific databases

HPAiCAB005272.
HPA029100.

Interactioni

Protein-protein interaction databases

BioGridi110114. 38 interactions.
IntActiP13473. 13 interactions.
MINTiMINT-5003281.
STRINGi9606.ENSP00000408411.

Structurei

3D structure databases

ProteinModelPortaliP13473.
SMRiP13473. Positions 219-370.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni29 – 192164First lumenal domainAdd
BLAST
Regioni193 – 22836HingeAdd
BLAST
Regioni229 – 375147Second lumenal domainAdd
BLAST

Sequence similaritiesi

Belongs to the LAMP family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301998.
HOGENOMiHOG000230942.
HOVERGENiHBG052303.
KOiK06528.
OMAiAEECFAD.
OrthoDBiEOG7ZD1VH.
PhylomeDBiP13473.
TreeFamiTF316339.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 1 hit.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform LAMP-2A (identifier: P13473-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVCFRLFPVP GSGLVLVCLV LGAVRSYALE LNLTDSENAT CLYAKWQMNF    50
TVRYETTNKT YKTVTISDHG TVTYNGSICG DDQNGPKIAV QFGPGFSWIA 100
NFTKAASTYS IDSVSFSYNT GDNTTFPDAE DKGILTVDEL LAIRIPLNDL 150
FRCNSLSTLE KNDVVQHYWD VLVQAFVQNG TVSTNEFLCD KDKTSTVAPT 200
IHTTVPSPTT TPTPKEKPEA GTYSVNNGND TCLLATMGLQ LNITQDKVAS 250
VININPNTTH STGSCRSHTA LLRLNSSTIK YLDFVFAVKN ENRFYLKEVN 300
ISMYLVNGSV FSIANNNLSY WDAPLGSSYM CNKEQTVSVS GAFQINTFDL 350
RVQPFNVTQG KYSTAQDCSA DDDNFLVPIA VGAALAGVLI LVLLAYFIGL 400
KHHHAGYEQF 410
Length:410
Mass (Da):44,961
Last modified:October 1, 1996 - v2
Checksum:i9E08E3B62D58F454
GO
Isoform LAMP-2B (identifier: P13473-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     367-410: DCSADDDNFL...KHHHAGYEQF → ECSLDDDTIL...RKSYAGYQTL

Show »
Length:410
Mass (Da):44,956
Checksum:i70B523369D40DEFA
GO
Isoform LAMP-2C (identifier: P13473-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     366-410: QDCSADDDNF...KHHHAGYEQF → EECSADSDLN...RKSRTGYQSV

Show »
Length:411
Mass (Da):45,170
Checksum:iB37AAC83BA1C3B1B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti256 – 2561P → H.
Corresponds to variant rs1043878 [ dbSNP | Ensembl ].
VAR_011992
Natural varianti321 – 3211W → R in DAND. 2 Publications
VAR_026230

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei366 – 41045QDCSA…GYEQF → EECSADSDLNFLIPVAVGVA LGFLIIVVFISYMIGRRKSR TGYQSV in isoform LAMP-2C. VSP_042519Add
BLAST
Alternative sequencei367 – 41044DCSAD…GYEQF → ECSLDDDTILIPIIVGAGLS GLIIVIVIAYVIGRRKSYAG YQTL in isoform LAMP-2B. VSP_003044Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 136PVPGSG → RFRSGLR1 Publication
Sequence conflicti53 – 531R → G1 Publication
Sequence conflicti68 – 681D → V in AAB41647. 1 Publication
Sequence conflicti111 – 1111I → N in AAB41647. 1 Publication
Sequence conflicti143 – 1431I → Y in AAB41647. 1 Publication
Sequence conflicti220 – 2201A → P in AAB41647. 1 Publication
Sequence conflicti234 – 2341L → R in AAB41647. 1 Publication
Sequence conflicti263 – 2697GSCRSHT → AAAVSH1 Publication
Sequence conflicti322 – 3265DAPLG → MPP in AAA60383. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04183 mRNA. Translation: AAA60383.1.
L09717
, L09709, L09710, L09711, L09712, L09713, L09714, L09715, L09716 Genomic DNA. Translation: AAB41647.1.
X77196 mRNA. Translation: CAA54416.1.
S79873 mRNA. Translation: AAB35426.1.
U36336 mRNA. Translation: AAA91149.1.
AY561849 mRNA. Translation: AAS67876.1.
AK291090 mRNA. Translation: BAF83779.1.
AC002476 Genomic DNA. Translation: AAB67313.1.
AC002476 Genomic DNA. Translation: AAB67314.1.
CH471107 Genomic DNA. Translation: EAX11881.1.
CH471107 Genomic DNA. Translation: EAX11882.1.
CH471107 Genomic DNA. Translation: EAX11883.1.
CH471107 Genomic DNA. Translation: EAX11884.1.
BC002965 mRNA. Translation: AAH02965.1.
CCDSiCCDS14599.1. [P13473-1]
CCDS14600.1. [P13473-2]
CCDS48159.1. [P13473-3]
PIRiJC2414. B31959.
JC4317.
RefSeqiNP_001116078.1. NM_001122606.1. [P13473-3]
NP_002285.1. NM_002294.2. [P13473-1]
NP_054701.1. NM_013995.2. [P13473-2]
UniGeneiHs.496684.

Genome annotation databases

EnsembliENST00000200639; ENSP00000200639; ENSG00000005893. [P13473-1]
ENST00000371335; ENSP00000360386; ENSG00000005893. [P13473-2]
ENST00000434600; ENSP00000408411; ENSG00000005893. [P13473-3]
GeneIDi3920.
KEGGihsa:3920.
UCSCiuc004ess.4. human. [P13473-3]
uc004est.4. human. [P13473-1]
uc010nqp.1. human. [P13473-2]

Polymorphism databases

DMDMi1708854.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04183 mRNA. Translation: AAA60383.1 .
L09717
, L09709 , L09710 , L09711 , L09712 , L09713 , L09714 , L09715 , L09716 Genomic DNA. Translation: AAB41647.1 .
X77196 mRNA. Translation: CAA54416.1 .
S79873 mRNA. Translation: AAB35426.1 .
U36336 mRNA. Translation: AAA91149.1 .
AY561849 mRNA. Translation: AAS67876.1 .
AK291090 mRNA. Translation: BAF83779.1 .
AC002476 Genomic DNA. Translation: AAB67313.1 .
AC002476 Genomic DNA. Translation: AAB67314.1 .
CH471107 Genomic DNA. Translation: EAX11881.1 .
CH471107 Genomic DNA. Translation: EAX11882.1 .
CH471107 Genomic DNA. Translation: EAX11883.1 .
CH471107 Genomic DNA. Translation: EAX11884.1 .
BC002965 mRNA. Translation: AAH02965.1 .
CCDSi CCDS14599.1. [P13473-1 ]
CCDS14600.1. [P13473-2 ]
CCDS48159.1. [P13473-3 ]
PIRi JC2414. B31959.
JC4317.
RefSeqi NP_001116078.1. NM_001122606.1. [P13473-3 ]
NP_002285.1. NM_002294.2. [P13473-1 ]
NP_054701.1. NM_013995.2. [P13473-2 ]
UniGenei Hs.496684.

3D structure databases

ProteinModelPortali P13473.
SMRi P13473. Positions 219-370.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110114. 38 interactions.
IntActi P13473. 13 interactions.
MINTi MINT-5003281.
STRINGi 9606.ENSP00000408411.

Protein family/group databases

TCDBi 9.A.16.1.2. the lysosomal protein import (lpi) family.

PTM databases

PhosphoSitei P13473.
UniCarbKBi P13473.

Polymorphism databases

DMDMi 1708854.

Proteomic databases

MaxQBi P13473.
PaxDbi P13473.
PRIDEi P13473.

Protocols and materials databases

DNASUi 3920.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000200639 ; ENSP00000200639 ; ENSG00000005893 . [P13473-1 ]
ENST00000371335 ; ENSP00000360386 ; ENSG00000005893 . [P13473-2 ]
ENST00000434600 ; ENSP00000408411 ; ENSG00000005893 . [P13473-3 ]
GeneIDi 3920.
KEGGi hsa:3920.
UCSCi uc004ess.4. human. [P13473-3 ]
uc004est.4. human. [P13473-1 ]
uc010nqp.1. human. [P13473-2 ]

Organism-specific databases

CTDi 3920.
GeneCardsi GC0XM119560.
HGNCi HGNC:6501. LAMP2.
HPAi CAB005272.
HPA029100.
MIMi 300257. phenotype.
309060. gene.
neXtProti NX_P13473.
Orphaneti 34587. Glycogen storage disease due to LAMP-2 deficiency.
PharmGKBi PA30285.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG301998.
HOGENOMi HOG000230942.
HOVERGENi HBG052303.
KOi K06528.
OMAi AEECFAD.
OrthoDBi EOG7ZD1VH.
PhylomeDBi P13473.
TreeFami TF316339.

Miscellaneous databases

ChiTaRSi LAMP2. human.
GeneWikii LAMP2.
GenomeRNAii 3920.
NextBioi 15399.
PMAP-CutDB P13473.
PROi P13473.
SOURCEi Search...

Gene expression databases

ArrayExpressi P13473.
Bgeei P13473.
CleanExi HS_LAMP2.
Genevestigatori P13473.

Family and domain databases

InterProi IPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view ]
PANTHERi PTHR11506. PTHR11506. 1 hit.
Pfami PF01299. Lamp. 1 hit.
[Graphical view ]
PRINTSi PR00336. LYSASSOCTDMP.
PROSITEi PS00310. LAMP_1. 1 hit.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences."
    Fukuda M., Viitala J., Matteson J., Carlsson S.R.
    J. Biol. Chem. 263:18920-18928(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LAMP-2A), PROTEIN SEQUENCE OF 29-64; 216-223 AND 238-256.
  2. "The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes."
    Sawada R., Jardine K.A., Fukuda M.
    J. Biol. Chem. 268:9014-9022(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM LAMP-2A).
    Tissue: Placenta.
  3. "Molecular and cellular characterization of Mex-/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains."
    Fritz G., Dosch J., Thielmann H.W., Kaina B.
    J. Biol. Chem. 268:21102-21112(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LAMP-2B), FUNCTION.
    Tissue: Fibroblast.
  4. "Complete cDNA sequence of human lysosome-associated membrane protein-2."
    Konecki D.S., Foetisch K., Schlotter M., Lichter-Konecki U.
    Biochem. Biophys. Res. Commun. 205:1-5(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LAMP-2A).
    Tissue: Liver.
  5. "An alternatively spliced form of the human lysosome-associated membrane protein-2 gene is expressed in a tissue-specific manner."
    Konecki D.S., Foetisch K., Zimmer K.P., Schlotter M., Lichter-Konecki U.
    Biochem. Biophys. Res. Commun. 215:757-767(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LAMP-2B).
  6. "Lamp-2 isoforms play different roles in lysosomal biogenesis."
    Zhou D., Blum J.S.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LAMP-2C).
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LAMP-2A).
  8. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LAMP-2B).
    Tissue: Lymph.
  11. "Purification and characterization of human lysosomal membrane glycoproteins."
    Mane S.M., Marzella L., Bainton D.F., Holt V.K., Cha Y., Hildreth J.E.K., August J.T.
    Arch. Biochem. Biophys. 268:360-378(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-66.
  12. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-43.
  13. "The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones."
    Carlsson S.R., Fukuda M.
    J. Biol. Chem. 265:20488-20495(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYLACTOSAMINOGLYCANS.
  14. "Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2."
    Carlsson S.R., Lycksell P.-O., Fukuda M.
    Arch. Biochem. Biophys. 304:65-73(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION OF HINGE REGION, PROTEIN SEQUENCE OF 187-215.
  15. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
    Zhang H., Li X.-J., Martin D.B., Aebersold R.
    Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-49 AND ASN-101.
  16. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-32; ASN-38; ASN-49; ASN-101; ASN-123 AND ASN-257.
    Tissue: Plasma.
  17. Cited for: NOMENCLATURE.
  18. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Placenta.
  19. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-101; ASN-123; ASN-257 AND ASN-356.
    Tissue: Liver.
  20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  21. Cited for: VARIANT DAND ARG-321.
  22. "Asymptomatic hyperCKemia in a case of Danon disease due to a missense mutation in Lamp-2 gene."
    Musumeci O., Rodolico C., Nishino I., Di Guardo G., Migliorato A., Aguennouz M., Mazzeo A., Messina C., Vita G., Toscano A.
    Neuromuscul. Disord. 15:409-411(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT DAND ARG-321.

Entry informationi

Entry nameiLAMP2_HUMAN
AccessioniPrimary (citable) accession number: P13473
Secondary accession number(s): A8K4X5
, D3DTF0, Q16641, Q6Q3G8, Q96J30, Q99534, Q9UD93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 162 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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