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P13470

- GTFC_STRMU

UniProt

P13470 - GTFC_STRMU

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Protein

Glucosyltransferase-SI

Gene
gtfC, SMU_1005
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris.

Catalytic activityi

Sucrose + ((1->6)-alpha-D-glucosyl)(n) = D-fructose + ((1->6)-alpha-D-glucosyl)(n+1).

GO - Molecular functioni

  1. dextransucrase activity Source: UniProtKB-EC
  2. glucosyltransferase activity Source: InterPro

GO - Biological processi

  1. glucan biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-956-MONOMER.
SABIO-RKP13470.

Protein family/group databases

CAZyiGH70. Glycoside Hydrolase Family 70.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucosyltransferase-SI (EC:2.4.1.5)
Short name:
GTF-SI
Alternative name(s):
Dextransucrase
Sucrose 6-glucosyltransferase
Gene namesi
Name:gtfC
Ordered Locus Names:SMU_1005
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002512: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Dental caries

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Add
BLAST
Chaini35 – 14551421Glucosyltransferase-SIPRO_0000021386Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU.1005.

Structurei

Secondary structure

1
1455
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi246 – 2494
Beta strandi250 – 2523
Helixi256 – 2583
Beta strandi274 – 2796
Turni280 – 2823
Beta strandi283 – 2864
Helixi295 – 2973
Helixi303 – 31614
Helixi329 – 35022
Helixi354 – 36613
Helixi368 – 3703
Helixi372 – 3754
Beta strandi386 – 3894
Helixi394 – 3996
Turni411 – 4144
Beta strandi434 – 4385
Helixi443 – 45715
Helixi459 – 4646
Helixi467 – 4693
Beta strandi473 – 4764
Helixi479 – 4813
Helixi485 – 49814
Turni500 – 5023
Helixi504 – 5085
Helixi521 – 5288
Beta strandi530 – 5356
Helixi537 – 54610
Helixi551 – 5533
Helixi559 – 5624
Beta strandi563 – 5664
Beta strandi569 – 5713
Beta strandi580 – 5823
Turni589 – 5913
Helixi592 – 60211
Helixi614 – 62916
Beta strandi634 – 6363
Helixi640 – 6478
Beta strandi651 – 6588
Helixi659 – 6624
Beta strandi665 – 6684
Turni669 – 6713
Helixi677 – 69014
Beta strandi695 – 7028
Beta strandi705 – 7128
Helixi726 – 7294
Beta strandi733 – 7386
Beta strandi751 – 7544
Helixi757 – 7593
Beta strandi763 – 7708
Beta strandi772 – 7776
Helixi782 – 7876
Beta strandi795 – 7995
Turni801 – 8033
Beta strandi807 – 8115
Beta strandi813 – 8219
Helixi849 – 8524
Beta strandi856 – 8583
Helixi870 – 8723
Helixi874 – 8807
Helixi882 – 8876
Beta strandi892 – 8943
Helixi908 – 9103
Turni911 – 9133
Beta strandi915 – 9195
Beta strandi924 – 9285
Helixi935 – 94713
Beta strandi951 – 9566
Beta strandi959 – 9613
Beta strandi965 – 97511
Beta strandi988 – 99710
Beta strandi1000 – 10023
Helixi1003 – 10075
Turni1008 – 10114
Helixi1012 – 10187
Helixi1020 – 10245
Turni1028 – 10303
Helixi1045 – 10473
Beta strandi1048 – 10525
Turni1065 – 10684
Helixi1075 – 10773
Helixi1082 – 10854

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3AIBX-ray3.09A/B/C/D/E/F/G/H244-1087[»]
3AICX-ray3.11A/B/C/D/E/F/G/H244-1087[»]
3AIEX-ray2.10A/B/C/D/E/F/G/H244-1087[»]
ProteinModelPortaliP13470.

Miscellaneous databases

EvolutionaryTraceiP13470.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati184 – 20320Cell wall-binding 1Add
BLAST
Repeati205 – 22420Cell wall-binding 2Add
BLAST
Repeati1116 – 113520Cell wall-binding 3Add
BLAST
Repeati1136 – 115520Cell wall-binding 4Add
BLAST
Repeati1219 – 123921Cell wall-binding 5Add
BLAST
Repeati1242 – 126221Cell wall-binding 6Add
BLAST
Repeati1263 – 128220Cell wall-binding 7Add
BLAST
Repeati1307 – 132721Cell wall-binding 8Add
BLAST
Repeati1328 – 134720Cell wall-binding 9Add
BLAST
Repeati1372 – 139221Cell wall-binding 10Add
BLAST
Repeati1393 – 141220Cell wall-binding 11Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni250 – 1050801Catalytic; approximateAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG5263.
KOiK00689.
OMAiNSKGEWF.
OrthoDBiEOG60PH6T.
PhylomeDBiP13470.

Family and domain databases

Gene3Di3.20.20.80. 4 hits.
InterProiIPR018337. Cell_wall/Cho-bd_repeat.
IPR027636. Glucan-bd_rpt.
IPR003318. Glyco_hydro70cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR022263. KxYKxGKxW.
[Graphical view]
PfamiPF01473. CW_binding_1. 2 hits.
PF02324. Glyco_hydro_70. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 4 hits.
TIGRFAMsiTIGR04035. glucan_65_rpt. 4 hits.
TIGR03715. KxYKxGKxW. 1 hit.
PROSITEiPS51170. CW. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13470-1 [UniParc]FASTAAdd to Basket

« Hide

MEKKVRFKLR KVKKRWVTVS VASAVVTLTS LSGSLVKADS TDDRQQAVTE     50
SQASLVTTSE AAKETLTATD TSTATSATSQ PTATVTDNVS TTNQSTNTTA 100
NTANFDVKPT TTSEQSKTDN SDKIIATSKA VNRLTATGKF VPANNNTAHS 150
RTVTDKIVPI KPKIGKLKQP SSLSQDDIAA LGNVKNIRKV NGKYYYYKED 200
GTLQKNYALN INGKTFFFDE TGALSNNTLP SKKGNITNND NTNSFAQYNQ 250
VYSTDAANFE HVDHYLTAES WYRPKYILKD GKTWTQSTEK DFRPLLMTWW 300
PDQETQRQYV NYMNAQLGIH QTYNTATSPL QLNLAAQTIQ TKIEEKITAE 350
KNTNWLRQTI SAFVKTQSAW NSDSEKPFDD HLQKGALLYS NNSKLTSQAN 400
SNYRILNRTP TNQTGKKDPR YTADRTIGGY EFLLANDVDN SNPVVQAEQL 450
NWLHFLMNFG NIYANDPDAN FDSIRVDAVD NVDADLLQIA GDYLKAAKGI 500
HKNDKAANDH LSILEAWSYN DTPYLHDDGD NMINMDNRLR LSLLYSLAKP 550
LNQRSGMNPL ITNSLVNRTD DNAETAAVPS YSFIRAHDSE VQDLIRNIIR 600
AEINPNVVGY SFTMEEIKKA FEIYNKDLLA TEKKYTHYNT ALSYALLLTN 650
KSSVPRVYYG DMFTDDGQYM AHKTINYEAI ETLLKARIKY VSGGQAMRNQ 700
QVGNSEIITS VRYGKGALKA TDTGDRTTRT SGVAVIEGNN PSLRLKASDR 750
VVVNMGAAHK NQAYRPLLLT TDNGIKAYHS DQEAAGLVRY TNDRGELIFT 800
AADIKGYANP QVSGYLGVWV PVGAAADQDV RVAASTAPST DGKSVHQNAA 850
LDSRVMFEGF SNFQAFATKK EEYTNVVIAK NVDKFAEWGV TDFEMAPQYV 900
SSTDGSFLDS VIQNGYAFTD RYDLGISKPN KYGTADDLVK AIKALHSKGI 950
KVMADWVPDQ MYALPEKEVV TATRVDKYGT PVAGSQIKNT LYVVDGKSSG 1000
KDQQAKYGGA FLEELQAKYP ELFARKQIST GVPMDPSVKI KQWSAKYFNG 1050
TNILGRGAGY VLKDQATNTY FSLVSDNTFL PKSLVNPNHG TSSSVTGLVF 1100
DGKGYVYYST SGNQAKNAFI SLGNNWYYFD NNGYMVTGAQ SINGANYYFL 1150
SNGIQLRNAI YDNGNKVLSY YGNDGRRYEN GYYLFGQQWR YFQNGIMAVG 1200
LTRIHGAVQY FDASGFQAKG QFITTADGKL RYFDRDSGNQ ISNRFVRNSK 1250
GEWFLFDHNG VAVTGTVTFN GQRLYFKPNG VQAKGEFIRD ADGHLRYYDP 1300
NSGNEVRNRF VRNSKGEWFL FDHNGIAVTG TRVVNGQRLY FKSNGVQAKG 1350
ELITERKGRI KYYDPNSGNE VRNRYVRTSS GNWYYFGNDG YALIGWHVVE 1400
GRRVYFDENG VYRYASHDQR NHWDYDYRRD FGRGSSSAVR FRHSRNGFFD 1450
NFFRF 1455
Length:1,455
Mass (Da):162,966
Last modified:November 28, 2002 - v2
Checksum:i3CB455A99A4FEC86
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211V → I in strain: GS-5.
Natural varianti81 – 811P → L in strain: MT4239.
Natural varianti106 – 1061D → V in strain: GS-5.
Natural varianti116 – 1161S → A in strain: GS-5 and MT4467.
Natural varianti126 – 1261A → T in strain: GS-5.
Natural varianti150 – 1512SR → PK in strain: GS-5, MT4239 and MT4467.
Natural varianti256 – 2561A → V in strain: GS-5 and MT4467.
Natural varianti425 – 4251R → N in strain: MT4251.
Natural varianti519 – 5191Y → D in strain: MT4245 and MT4251.
Natural varianti538 – 5381R → K in strain: MT4245 and MT4251.
Natural varianti545 – 5451Y → F in strain: MT4245 and MT4251.
Natural varianti597 – 5971N → D in strain: MT4245, MT4251, MT4467 and MT8148.
Natural varianti600 – 6001R → K in strain: MT4245, MT4251, MT4467 and MT8148.
Natural varianti601 – 6011A → T in strain: GS-5.
Natural varianti614 – 6141M → T in strain: GS-5.
Natural varianti727 – 7271T → I in strain: MT8148.
Natural varianti734 – 7341A → V in strain: MT8148.
Natural varianti964 – 9641L → F in strain: MT4239.
Natural varianti1113 – 11131N → Y in strain: MT4239.
Natural varianti1118 – 11181A → T in strain: MT4239.
Natural varianti1204 – 12041I → V in strain: GS-5, MT4239, MT4467 and MT8148.
Natural varianti1208 – 12081V → I in strain: MT8148.
Natural varianti1292 – 12943DGH → NGY in strain: GS-5, MT4467 and sMT8148.
Natural varianti1305 – 136965Missing in strain: MT4245.
Add
BLAST
Natural varianti1326 – 13261I → V in strain: MT8148.
Natural varianti1331 – 13311T → A in strain: GS-5, MT4239, MT4467 and MT8148.
Natural varianti1377 – 13771R → K in strain: MT8148.
Natural varianti1398 – 13981V → I in strain: MT8148.
Natural varianti1424 – 14241D → N in strain: MT4239.
Natural varianti1439 – 14391V → I in strain: MT4239 and MT8148.
Natural varianti1444 – 14441S → P in strain: MT8148.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1337 – 1455119QRLYF…NFFRF → HASILSLMVFRLRESSLQSV KVVSNTMILIPEMKFVIVM in AAA88592. 1 PublicationAdd
BLAST
Sequence conflicti1337 – 1455119QRLYF…NFFRF → HASILSLMVFRLRESSLQSV KVVSNTMILIPEMKFVIVM in BAA26102. 1 PublicationAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22054 Genomic DNA. Translation: AAA88592.1.
D88652 Genomic DNA. Translation: BAA26102.1.
D88655 Genomic DNA. Translation: BAA26106.1.
D88658 Genomic DNA. Translation: BAA26110.1.
D88661 Genomic DNA. Translation: BAA26114.1.
D89978 Genomic DNA. Translation: BAA26120.1.
AE014133 Genomic DNA. Translation: AAN58706.1.
M17361 Genomic DNA. Translation: AAA88589.1.
PIRiJT0345.
RefSeqiNP_721400.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58706; AAN58706; SMU_1005.
GeneIDi1028343.
KEGGismu:SMU_1005.
PATRICi19664131. VBIStrMut61772_0898.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22054 Genomic DNA. Translation: AAA88592.1 .
D88652 Genomic DNA. Translation: BAA26102.1 .
D88655 Genomic DNA. Translation: BAA26106.1 .
D88658 Genomic DNA. Translation: BAA26110.1 .
D88661 Genomic DNA. Translation: BAA26114.1 .
D89978 Genomic DNA. Translation: BAA26120.1 .
AE014133 Genomic DNA. Translation: AAN58706.1 .
M17361 Genomic DNA. Translation: AAA88589.1 .
PIRi JT0345.
RefSeqi NP_721400.1. NC_004350.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3AIB X-ray 3.09 A/B/C/D/E/F/G/H 244-1087 [» ]
3AIC X-ray 3.11 A/B/C/D/E/F/G/H 244-1087 [» ]
3AIE X-ray 2.10 A/B/C/D/E/F/G/H 244-1087 [» ]
ProteinModelPortali P13470.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 210007.SMU.1005.

Protein family/group databases

CAZyi GH70. Glycoside Hydrolase Family 70.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN58706 ; AAN58706 ; SMU_1005 .
GeneIDi 1028343.
KEGGi smu:SMU_1005.
PATRICi 19664131. VBIStrMut61772_0898.

Phylogenomic databases

eggNOGi COG5263.
KOi K00689.
OMAi NSKGEWF.
OrthoDBi EOG60PH6T.
PhylomeDBi P13470.

Enzyme and pathway databases

BioCyci SMUT210007:GC7Z-956-MONOMER.
SABIO-RK P13470.

Miscellaneous databases

EvolutionaryTracei P13470.

Family and domain databases

Gene3Di 3.20.20.80. 4 hits.
InterProi IPR018337. Cell_wall/Cho-bd_repeat.
IPR027636. Glucan-bd_rpt.
IPR003318. Glyco_hydro70cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR022263. KxYKxGKxW.
[Graphical view ]
Pfami PF01473. CW_binding_1. 2 hits.
PF02324. Glyco_hydro_70. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 4 hits.
TIGRFAMsi TIGR04035. glucan_65_rpt. 4 hits.
TIGR03715. KxYKxGKxW. 1 hit.
PROSITEi PS51170. CW. 11 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the gtfC gene from Streptococcus mutans GS-5."
    Ueda S., Shiroza T., Kuramitsu H.K.
    Gene 69:101-109(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: GS-5.
  2. "Molecular analyses of glucosyltransferase genes among strains of Streptococcus mutans."
    Fujiwara T., Terao Y., Hoshino T., Kawabata S., Ooshima T., Sobue S., Kimura S., Hamada S.
    FEMS Microbiol. Lett. 161:331-336(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: MT4239 / Serotype c, MT4245 / Serotype e, MT4251 / Serotype f, MT4467 / Serotype e and MT8148 / Serotype c.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.
  4. "Sequence analysis of the gtfB gene from Streptococcus mutans."
    Shiroza T., Ueda S., Kuramitsu H.K.
    J. Bacteriol. 169:4263-4270(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-349.
    Strain: GS-5.

Entry informationi

Entry nameiGTFC_STRMU
AccessioniPrimary (citable) accession number: P13470
Secondary accession number(s): O69382
, O69385, O69388, O69391, O69397, P05427
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 28, 2002
Last modified: July 9, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

GTF-I synthesizes water-insoluble glucans (alpha 1,3-linked glucose and some 1,6 linkages), GTF-S synthesizes water-soluble glucans (alpha 1,6-glucose). GTF-SI synthesizes both forms of glucans.

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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