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P13439 (UMPS_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uridine 5'-monophosphate synthase

Short name=UMP synthase

Including the following 2 domains:

  1. Orotate phosphoribosyltransferase
    Short name=OPRTase
    EC=2.4.2.10
  2. Orotidine 5'-phosphate decarboxylase
    EC=4.1.1.23
    Alternative name(s):
    OMPdecase
Gene names
Name:Umps
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length481 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01208

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP-Rule MF_01208

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01208

Sequence similarities

In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

In the C-terminal section; belongs to the OMP decarboxylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 481480Uridine 5'-monophosphate synthase HAMAP-Rule MF_01208
PRO_0000139650

Regions

Region2 – 214213OPRTase HAMAP-Rule MF_01208
Region215 – 2206Domain linker HAMAP-Rule MF_01208
Region221 – 481261OMPdecase HAMAP-Rule MF_01208

Sites

Active site3141For OMPdecase activity By similarity
Active site3171For OMPdecase activity By similarity

Sequences

Sequence LengthMass (Da)Tools
P13439 [UniParc].

Last modified June 6, 2002. Version 3.
Checksum: 761C7EF7960C9C59

FASTA48152,292
        10         20         30         40         50         60 
MEVASQALGP LVTELYDVQA FKFGSFVLKS GLSSPVYIDL RGIVSRPRLL SQVADILFQT 

        70         80         90        100        110        120 
AKNAGISFDS VCGVPYTALP LATVICSANH IPMLIRRKET KDYGTKRLVE GEINPGQTCL 

       130        140        150        160        170        180 
VIEDVVTSGA SVLETVEVLQ KEGLKVTDAI VLLDREQGGK DKLQAQGIRL HAVCTLSQML 

       190        200        210        220        230        240 
EILQQQEKID ADMVGRVKRF IQENVFSAAN HNGLPPPEKK ACKELSFGAR AELPGTHPLA 

       250        260        270        280        290        300 
SKLLRLMQKK ETNLCLSADV SEARELLQLA DALGPSICML KTHVDILNDF TLDVMEELTA 

       310        320        330        340        350        360 
LAKRHEFLIF EDRKFADIGN TVKKQYESGT FKIASWADIV NAHVVPGSGV VKGLQEVGLP 

       370        380        390        400        410        420 
LHRACLLIAE MSSAGSLATG NYTKAAVGMA EEHCEFVIGF ISGSRVSMKP EFLHLTPGVQ 

       430        440        450        460        470        480 
LETGGDHLGQ QYNSPQEVIG KRGSDVIIVG RGILAAANRL EAAEMYRKAA WEAYLSRLAV 


Q 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Expression and sequence analysis of a cDNA encoding the orotidine-5'-monophosphate decarboxylase domain from Ehrlich ascites uridylate synthase."
Ohmstede C.A., Langdon S.D., Chae C.B., Jones M.E.
J. Biol. Chem. 261:4276-4282(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 216-481.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC003887 mRNA. Translation: AAH03887.1.
M29395 mRNA. Translation: AAA39859.1.
PIRDCMSOP. A25323.
RefSeqNP_033497.1. NM_009471.2.
UniGeneMm.13145.
Mm.466951.

3D structure databases

ProteinModelPortalP13439.
SMRP13439. Positions 7-203, 223-480.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP13439. 2 interactions.
MINTMINT-1852291.

PTM databases

PhosphoSiteP13439.

Proteomic databases

PaxDbP13439.
PRIDEP13439.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023510; ENSMUSP00000023510; ENSMUSG00000022814.
GeneID22247.
KEGGmmu:22247.
UCSCuc007zap.1. mouse.

Organism-specific databases

CTD7372.
MGIMGI:1298388. Umps.

Phylogenomic databases

eggNOGCOG0284.
HOVERGENHBG000870.
InParanoidP13439.
KOK13421.
OMAMKPEFLH.
OrthoDBEOG754HPB.
TreeFamTF314694.

Enzyme and pathway databases

UniPathwayUPA00070; UER00119.
UPA00070; UER00120.

Gene expression databases

ArrayExpressP13439.
BgeeP13439.
CleanExMM_UMPS.
GenevestigatorP13439.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01208. PyrE.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR023031. OPRT.
IPR004467. Or_phspho_trans_dom.
IPR000836. PRibTrfase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR00336. pyrE. 1 hit.
TIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio302319.
PROP13439.
SOURCESearch...

Entry information

Entry nameUMPS_MOUSE
AccessionPrimary (citable) accession number: P13439
Secondary accession number(s): Q99L26
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: June 6, 2002
Last modified: February 19, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot