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Protein

Uridine 5'-monophosphate synthase

Gene

Umps

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
Orotidine 5'-phosphate = UMP + CO2.

Pathway:iUMP biosynthesis via de novo pathway

This protein is involved in step 1 and 2 of the subpathway that synthesizes UMP from orotate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Uridine 5'-monophosphate synthase (Umps)
  2. Uridine 5'-monophosphate synthase (Umps)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei314 – 3141For OMPdecase activityBy similarity
Active sitei317 – 3171For OMPdecase activityBy similarity

GO - Molecular functioni

GO - Biological processi

Keywords - Molecular functioni

Decarboxylase, Glycosyltransferase, Lyase, Transferase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

ReactomeiREACT_353601. Pyrimidine biosynthesis.
UniPathwayiUPA00070; UER00119.
UPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Including the following 2 domains:
Orotate phosphoribosyltransferase (EC:2.4.2.10)
Short name:
OPRTase
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMPdecase
Gene namesi
Name:Umps
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1298388. Umps.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 481480Uridine 5'-monophosphate synthasePRO_0000139650Add
BLAST

Proteomic databases

MaxQBiP13439.
PaxDbiP13439.
PRIDEiP13439.

PTM databases

PhosphoSiteiP13439.

Expressioni

Gene expression databases

BgeeiP13439.
CleanExiMM_UMPS.
ExpressionAtlasiP13439. baseline and differential.
GenevisibleiP13439. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi204442. 1 interaction.
IntActiP13439. 3 interactions.
MINTiMINT-1852291.
STRINGi10090.ENSMUSP00000023510.

Structurei

3D structure databases

ProteinModelPortaliP13439.
SMRiP13439. Positions 7-203, 223-480.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 214213OPRTaseAdd
BLAST
Regioni215 – 2206Domain linker
Regioni221 – 481261OMPdecaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.Curated
In the C-terminal section; belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

eggNOGiCOG0284.
GeneTreeiENSGT00390000001856.
HOVERGENiHBG000870.
InParanoidiP13439.
KOiK13421.
OMAiMYRKAAW.
OrthoDBiEOG754HPB.
PhylomeDBiP13439.
TreeFamiTF314694.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.40.50.2020. 1 hit.
HAMAPiMF_01208. PyrE.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR023031. OPRT.
IPR004467. Or_phspho_trans_dom.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR00336. pyrE. 1 hit.
TIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13439-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVASQALGP LVTELYDVQA FKFGSFVLKS GLSSPVYIDL RGIVSRPRLL
60 70 80 90 100
SQVADILFQT AKNAGISFDS VCGVPYTALP LATVICSANH IPMLIRRKET
110 120 130 140 150
KDYGTKRLVE GEINPGQTCL VIEDVVTSGA SVLETVEVLQ KEGLKVTDAI
160 170 180 190 200
VLLDREQGGK DKLQAQGIRL HAVCTLSQML EILQQQEKID ADMVGRVKRF
210 220 230 240 250
IQENVFSAAN HNGLPPPEKK ACKELSFGAR AELPGTHPLA SKLLRLMQKK
260 270 280 290 300
ETNLCLSADV SEARELLQLA DALGPSICML KTHVDILNDF TLDVMEELTA
310 320 330 340 350
LAKRHEFLIF EDRKFADIGN TVKKQYESGT FKIASWADIV NAHVVPGSGV
360 370 380 390 400
VKGLQEVGLP LHRACLLIAE MSSAGSLATG NYTKAAVGMA EEHCEFVIGF
410 420 430 440 450
ISGSRVSMKP EFLHLTPGVQ LETGGDHLGQ QYNSPQEVIG KRGSDVIIVG
460 470 480
RGILAAANRL EAAEMYRKAA WEAYLSRLAV Q
Length:481
Mass (Da):52,292
Last modified:June 6, 2002 - v3
Checksum:i761C7EF7960C9C59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003887 mRNA. Translation: AAH03887.1.
M29395 mRNA. Translation: AAA39859.1.
CCDSiCCDS28136.1.
PIRiA25323. DCMSOP.
RefSeqiNP_033497.1. NM_009471.2.
UniGeneiMm.13145.
Mm.466951.

Genome annotation databases

EnsembliENSMUST00000023510; ENSMUSP00000023510; ENSMUSG00000022814.
GeneIDi22247.
KEGGimmu:22247.
UCSCiuc007zap.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003887 mRNA. Translation: AAH03887.1.
M29395 mRNA. Translation: AAA39859.1.
CCDSiCCDS28136.1.
PIRiA25323. DCMSOP.
RefSeqiNP_033497.1. NM_009471.2.
UniGeneiMm.13145.
Mm.466951.

3D structure databases

ProteinModelPortaliP13439.
SMRiP13439. Positions 7-203, 223-480.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204442. 1 interaction.
IntActiP13439. 3 interactions.
MINTiMINT-1852291.
STRINGi10090.ENSMUSP00000023510.

PTM databases

PhosphoSiteiP13439.

Proteomic databases

MaxQBiP13439.
PaxDbiP13439.
PRIDEiP13439.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023510; ENSMUSP00000023510; ENSMUSG00000022814.
GeneIDi22247.
KEGGimmu:22247.
UCSCiuc007zap.1. mouse.

Organism-specific databases

CTDi7372.
MGIiMGI:1298388. Umps.

Phylogenomic databases

eggNOGiCOG0284.
GeneTreeiENSGT00390000001856.
HOVERGENiHBG000870.
InParanoidiP13439.
KOiK13421.
OMAiMYRKAAW.
OrthoDBiEOG754HPB.
PhylomeDBiP13439.
TreeFamiTF314694.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00119.
UPA00070; UER00120.
ReactomeiREACT_353601. Pyrimidine biosynthesis.

Miscellaneous databases

NextBioi302319.
PROiP13439.
SOURCEiSearch...

Gene expression databases

BgeeiP13439.
CleanExiMM_UMPS.
ExpressionAtlasiP13439. baseline and differential.
GenevisibleiP13439. MM.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.40.50.2020. 1 hit.
HAMAPiMF_01208. PyrE.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR023031. OPRT.
IPR004467. Or_phspho_trans_dom.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR00336. pyrE. 1 hit.
TIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Expression and sequence analysis of a cDNA encoding the orotidine-5'-monophosphate decarboxylase domain from Ehrlich ascites uridylate synthase."
    Ohmstede C.A., Langdon S.D., Chae C.B., Jones M.E.
    J. Biol. Chem. 261:4276-4282(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 216-481.

Entry informationi

Entry nameiUMPS_MOUSE
AccessioniPrimary (citable) accession number: P13439
Secondary accession number(s): Q99L26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: June 6, 2002
Last modified: July 22, 2015
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.