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P13439

- UMPS_MOUSE

UniProt

P13439 - UMPS_MOUSE

Protein

Uridine 5'-monophosphate synthase

Gene

Umps

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 3 (06 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
    Orotidine 5'-phosphate = UMP + CO2.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei314 – 3141For OMPdecase activityBy similarity
    Active sitei317 – 3171For OMPdecase activityBy similarity

    GO - Molecular functioni

    1. orotate phosphoribosyltransferase activity Source: UniProtKB-EC
    2. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
    3. cellular response to drug Source: Ensembl
    4. female pregnancy Source: Ensembl
    5. lactation Source: Ensembl

    Keywords - Molecular functioni

    Decarboxylase, Glycosyltransferase, Lyase, Transferase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00070; UER00119.
    UPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uridine 5'-monophosphate synthase
    Short name:
    UMP synthase
    Including the following 2 domains:
    Orotate phosphoribosyltransferase (EC:2.4.2.10)
    Short name:
    OPRTase
    Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
    Alternative name(s):
    OMPdecase
    Gene namesi
    Name:Umps
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1298388. Umps.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 481480Uridine 5'-monophosphate synthasePRO_0000139650Add
    BLAST

    Proteomic databases

    MaxQBiP13439.
    PaxDbiP13439.
    PRIDEiP13439.

    PTM databases

    PhosphoSiteiP13439.

    Expressioni

    Gene expression databases

    ArrayExpressiP13439.
    BgeeiP13439.
    CleanExiMM_UMPS.
    GenevestigatoriP13439.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    BioGridi204442. 1 interaction.
    IntActiP13439. 2 interactions.
    MINTiMINT-1852291.

    Structurei

    3D structure databases

    ProteinModelPortaliP13439.
    SMRiP13439. Positions 7-203, 223-480.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 214213OPRTaseAdd
    BLAST
    Regioni215 – 2206Domain linker
    Regioni221 – 481261OMPdecaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.Curated
    In the C-terminal section; belongs to the OMP decarboxylase family.Curated

    Phylogenomic databases

    eggNOGiCOG0284.
    HOVERGENiHBG000870.
    InParanoidiP13439.
    KOiK13421.
    OMAiSMKPEFL.
    OrthoDBiEOG754HPB.
    PhylomeDBiP13439.
    TreeFamiTF314694.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    3.40.50.2020. 1 hit.
    HAMAPiMF_01208. PyrE.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR023031. OPRT.
    IPR004467. Or_phspho_trans_dom.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    PF00156. Pribosyltran. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    SSF53271. SSF53271. 1 hit.
    TIGRFAMsiTIGR00336. pyrE. 1 hit.
    TIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P13439-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVASQALGP LVTELYDVQA FKFGSFVLKS GLSSPVYIDL RGIVSRPRLL    50
    SQVADILFQT AKNAGISFDS VCGVPYTALP LATVICSANH IPMLIRRKET 100
    KDYGTKRLVE GEINPGQTCL VIEDVVTSGA SVLETVEVLQ KEGLKVTDAI 150
    VLLDREQGGK DKLQAQGIRL HAVCTLSQML EILQQQEKID ADMVGRVKRF 200
    IQENVFSAAN HNGLPPPEKK ACKELSFGAR AELPGTHPLA SKLLRLMQKK 250
    ETNLCLSADV SEARELLQLA DALGPSICML KTHVDILNDF TLDVMEELTA 300
    LAKRHEFLIF EDRKFADIGN TVKKQYESGT FKIASWADIV NAHVVPGSGV 350
    VKGLQEVGLP LHRACLLIAE MSSAGSLATG NYTKAAVGMA EEHCEFVIGF 400
    ISGSRVSMKP EFLHLTPGVQ LETGGDHLGQ QYNSPQEVIG KRGSDVIIVG 450
    RGILAAANRL EAAEMYRKAA WEAYLSRLAV Q 481
    Length:481
    Mass (Da):52,292
    Last modified:June 6, 2002 - v3
    Checksum:i761C7EF7960C9C59
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC003887 mRNA. Translation: AAH03887.1.
    M29395 mRNA. Translation: AAA39859.1.
    CCDSiCCDS28136.1.
    PIRiA25323. DCMSOP.
    RefSeqiNP_033497.1. NM_009471.2.
    UniGeneiMm.13145.
    Mm.466951.

    Genome annotation databases

    EnsembliENSMUST00000023510; ENSMUSP00000023510; ENSMUSG00000022814.
    GeneIDi22247.
    KEGGimmu:22247.
    UCSCiuc007zap.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC003887 mRNA. Translation: AAH03887.1 .
    M29395 mRNA. Translation: AAA39859.1 .
    CCDSi CCDS28136.1.
    PIRi A25323. DCMSOP.
    RefSeqi NP_033497.1. NM_009471.2.
    UniGenei Mm.13145.
    Mm.466951.

    3D structure databases

    ProteinModelPortali P13439.
    SMRi P13439. Positions 7-203, 223-480.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204442. 1 interaction.
    IntActi P13439. 2 interactions.
    MINTi MINT-1852291.

    PTM databases

    PhosphoSitei P13439.

    Proteomic databases

    MaxQBi P13439.
    PaxDbi P13439.
    PRIDEi P13439.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023510 ; ENSMUSP00000023510 ; ENSMUSG00000022814 .
    GeneIDi 22247.
    KEGGi mmu:22247.
    UCSCi uc007zap.1. mouse.

    Organism-specific databases

    CTDi 7372.
    MGIi MGI:1298388. Umps.

    Phylogenomic databases

    eggNOGi COG0284.
    HOVERGENi HBG000870.
    InParanoidi P13439.
    KOi K13421.
    OMAi SMKPEFL.
    OrthoDBi EOG754HPB.
    PhylomeDBi P13439.
    TreeFami TF314694.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00119 .
    UPA00070 ; UER00120 .

    Miscellaneous databases

    NextBioi 302319.
    PROi P13439.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P13439.
    Bgeei P13439.
    CleanExi MM_UMPS.
    Genevestigatori P13439.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    3.40.50.2020. 1 hit.
    HAMAPi MF_01208. PyrE.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR023031. OPRT.
    IPR004467. Or_phspho_trans_dom.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    SSF53271. SSF53271. 1 hit.
    TIGRFAMsi TIGR00336. pyrE. 1 hit.
    TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Expression and sequence analysis of a cDNA encoding the orotidine-5'-monophosphate decarboxylase domain from Ehrlich ascites uridylate synthase."
      Ohmstede C.A., Langdon S.D., Chae C.B., Jones M.E.
      J. Biol. Chem. 261:4276-4282(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 216-481.

    Entry informationi

    Entry nameiUMPS_MOUSE
    AccessioniPrimary (citable) accession number: P13439
    Secondary accession number(s): Q99L26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: June 6, 2002
    Last modified: October 1, 2014
    This is version 127 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3