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P13437 (THIM_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-ketoacyl-CoA thiolase, mitochondrial

EC=2.3.1.16
Alternative name(s):
Acetyl-CoA acyltransferase
Beta-ketothiolase
Mitochondrial 3-oxoacyl-CoA thiolase
Gene names
Name:Acaa2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Abolishes BNIP3-mediated apoptosis and mitochondrial damage By similarity.

Catalytic activity

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.

Pathway

Lipid metabolism; fatty acid metabolism.

Subunit structure

Homotetramer. Interacts with BNIP3 By similarity.

Subcellular location

Mitochondrion By similarity. Note: Colocalizes with BNIP3 in the mitochondria By similarity.

Sequence similarities

Belongs to the thiolase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3973973-ketoacyl-CoA thiolase, mitochondrial
PRO_0000223301
Transit peptide1 – 1616Mitochondrion; not cleaved

Sites

Active site921Acyl-thioester intermediate By similarity
Active site3521Proton acceptor By similarity
Active site3821Proton acceptor By similarity

Amino acid modifications

Modified residue251N6-acetyllysine; alternate By similarity
Modified residue251N6-succinyllysine; alternate By similarity
Modified residue451N6-succinyllysine By similarity
Modified residue1191Phosphothreonine By similarity
Modified residue1211Phosphoserine By similarity
Modified residue1271Phosphotyrosine By similarity
Modified residue1371N6-acetyllysine; alternate By similarity
Modified residue1371N6-succinyllysine; alternate By similarity
Modified residue1431N6-acetyllysine; alternate By similarity
Modified residue1431N6-succinyllysine; alternate By similarity
Modified residue1581N6-acetyllysine; alternate By similarity
Modified residue1581N6-succinyllysine; alternate By similarity
Modified residue1711N6-acetyllysine; alternate By similarity
Modified residue1711N6-succinyllysine; alternate By similarity
Modified residue1911N6-acetyllysine; alternate By similarity
Modified residue1911N6-succinyllysine; alternate By similarity
Modified residue2091N6-acetyllysine; alternate By similarity
Modified residue2091N6-succinyllysine; alternate By similarity
Modified residue2111N6-succinyllysine By similarity
Modified residue2121N6-succinyllysine By similarity
Modified residue2141N6-succinyllysine By similarity
Modified residue2401N6-succinyllysine By similarity
Modified residue2411N6-acetyllysine By similarity
Modified residue2691N6-acetyllysine By similarity
Modified residue2701N6-acetyllysine By similarity
Modified residue3051N6-acetyllysine; alternate By similarity
Modified residue3051N6-succinyllysine; alternate By similarity
Modified residue3121N6-acetyllysine; alternate By similarity
Modified residue3121N6-succinyllysine; alternate By similarity
Modified residue3401N6-acetyllysine By similarity
Modified residue3751N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P13437 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: 8344FB7271C3E2E1

FASTA39741,871
        10         20         30         40         50         60 
MALLRGVFIV AAKRTPFGAY GGLLKDFTAT DLTEFAARAA LSAGKVPPET IDSVIVGNVM 

        70         80         90        100        110        120 
QSSSDAAYLA RHVGLRVGVP TETGALTLNR LCGSGFQSIV SGCQEICSKD AEVVLCGGTE 

       130        140        150        160        170        180 
SMSQSPYSVR NVRFGTKFGL DLKLEDTLWA GLTDQHVKLP MGMTAENLAA KYNISREDCD 

       190        200        210        220        230        240 
RYALQSQQRW KAANEAGYFN EEMAPIEVKT KKGKQTMQVD EHARPQTTLE QLQNLPPVFK 

       250        260        270        280        290        300 
KEGTVTAGNA SGMSDGAGVV IIASEDAVKK HNFTPLARVV GYFVSGCDPA IMGIGPVPAI 

       310        320        330        340        350        360 
TGALKKAGLS LKDMDLIDVN EAFAPQFLAV QKSLDLDPSK TNVSGGAIAL GHPLGGSGSR 

       370        380        390 
ITAHLVHELR RRGGKYAVGS ACIGGGQGIS LIIQNTA 

« Hide

References

[1]"cDNA-derived amino acid sequence of rat mitochondrial 3-oxoacyl-CoA thiolase with no transient presequence: structural relationship with peroxisomal isozyme."
Arakawa H., Takiguchi M., Amaya Y., Nagata S., Hayashi H., Mori M.
EMBO J. 6:1361-1366(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X05341 mRNA. Translation: CAA28952.1.
PIRXURT. A29452.
RefSeqNP_569117.1. NM_130433.1.
UniGeneRn.3786.

3D structure databases

ProteinModelPortalP13437.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP13437. 1 interaction.
STRING10116.ENSRNOP00000060140.

Proteomic databases

PaxDbP13437.
PRIDEP13437.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID170465.
KEGGrno:170465.

Organism-specific databases

CTD10449.
RGD620482. Acaa2.

Phylogenomic databases

eggNOGCOG0183.
HOGENOMHOG000012238.
HOVERGENHBG003112.
InParanoidP13437.
KOK07508.
PhylomeDBP13437.

Enzyme and pathway databases

SABIO-RKP13437.
UniPathwayUPA00199.

Gene expression databases

GenevestigatorP13437.

Family and domain databases

Gene3D3.40.47.10. 4 hits.
InterProIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PfamPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
TIGRFAMsTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio620987.
PROP13437.

Entry information

Entry nameTHIM_RAT
AccessionPrimary (citable) accession number: P13437
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: June 11, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways