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Protein

DNA-directed RNA polymerase, mitochondrial

Gene

RPO41

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei945By similarity1
Active sitei1014By similarity1
Active sitei1189By similarity1

GO - Molecular functioni

  • DNA binding Source: InterPro
  • DNA-directed 5'-3' RNA polymerase activity Source: SGD
  • DNA primase activity Source: SGD

GO - Biological processi

  • DNA replication, synthesis of RNA primer Source: SGD
  • mitochondrial genome maintenance Source: SGD
  • mitochondrial transcription Source: SGD

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription

Enzyme and pathway databases

BioCyciYEAST:G3O-30426-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase, mitochondrial (EC:2.7.7.6)
Gene namesi
Name:RPO41
Ordered Locus Names:YFL036W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFL036W
SGDiS000001858 RPO41

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000031078? – 1351DNA-directed RNA polymerase, mitochondrial
Transit peptidei1 – ?Mitochondrion

Proteomic databases

MaxQBiP13433
PaxDbiP13433
PRIDEiP13433

Interactioni

Protein-protein interaction databases

BioGridi31110, 272 interactors
DIPiDIP-2431N
IntActiP13433, 7 interactors
MINTiP13433
STRINGi4932.YFL036W

Structurei

3D structure databases

ProteinModelPortaliP13433
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000008060
HOGENOMiHOG000248537
InParanoidiP13433
KOiK10908
OMAiNHMGADH
OrthoDBiEOG092C0A5U

Family and domain databases

Gene3Di1.10.1320.10, 1 hit
1.10.287.260, 1 hit
InterProiView protein in InterPro
IPR024075 DNA-dir_RNA_pol_helix_hairp_sf
IPR002092 DNA-dir_Rpol_phage-type
IPR037159 RNA_POL_N_sf
IPR029262 RPOL_N
PANTHERiPTHR10102 PTHR10102, 1 hit
PfamiView protein in Pfam
PF00940 RNA_pol, 1 hit
PF14700 RPOL_N, 1 hit
SMARTiView protein in SMART
SM01311 RPOL_N, 1 hit
PROSITEiView protein in PROSITE
PS00900 RNA_POL_PHAGE_1, 1 hit
PS00489 RNA_POL_PHAGE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13433-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRPAYKSLV KTSLLQRRLI SSKGSKLFKP SPDSTSTILI SEDPLVTGSS
60 70 80 90 100
PTSSTTSGII SSNDFPLFNK NRKDAKSSIS YQWKNPSELE FDPFNKSHAS
110 120 130 140 150
AVTSMTRTRD VMQLWSLLEA CLQSNLMKRA FSILESLYLV PEHKQRFIED
160 170 180 190 200
YNMYLNSFSK NDPNFPILKM NEKLTNDLET SFKDVNYNDK TLAIMIHHAL
210 220 230 240 250
NFHSTTSSML LKPIISAYLK MSVNGIREIF SCLDILTISD LNILMNDLKV
260 270 280 290 300
ITPSQLPNSV RPILESLTLS PTPVNNIENE EGLNKVEAEN DSKLHKASNA
310 320 330 340 350
SSDSIKKPSL DPLREVSFHG STEVLSKDAE KLIAVDTIGM RVIRHTLLGL
360 370 380 390 400
SLTPEQKEQI SKFKFDANDN VLKMKPTKND DNNNSINFFE IYNSLPTLEE
410 420 430 440 450
KKAFESALNI FNQDRQKVLE NRATEAARER WKHDFEEAKA RGDISIEKNL
460 470 480 490 500
NVKLWKWYNE MLPLVKEEIN HCRSLLSEKL SDKKGLNKVD TNRLGYGPYL
510 520 530 540 550
TLIDPGKMCV ITILELLKLN STGGVIEGMR TARAVISVGK AIEMEFRSEQ
560 570 580 590 600
VLKSESQAFR DVNKKSPEFK KLVQNAKSVF RSSQIEQSKI LWPQSIRARI
610 620 630 640 650
GSVLISMLIQ VAKVSVQGVD PVTKAKVHGE APAFAHGYQY HNGSKLGVLK
660 670 680 690 700
IHKTLIRQLN GERLIASVQP QLLPMLVEPK PWVNWRSGGY HYTQSTLLRT
710 720 730 740 750
KDSPEQVAYL KAASDNGDID RVYDGLNVLG RTPWTVNRKV FDVVSQVWNK
760 770 780 790 800
GEGFLDIPGA QDEMVLPPAP PKNSDPSILR AWKLQVKTIA NKFSSDRSNR
810 820 830 840 850
CDTNYKLEIA RAFLGEKLYF PHNLDFRGRA YPLSPHFNHL GNDMSRGLLI
860 870 880 890 900
FWHGKKLGPS GLKWLKIHLS NLFGFDKLPL KDRVAFTESH LQDIKDSAEN
910 920 930 940 950
PLTGDRWWTT ADKPWQALAT CFELNEVMKM DNPEEFISHQ PVHQDGTCNG
960 970 980 990 1000
LQHYAALGGD VEGATQVNLV PSDKPQDVYA HVARLVQKRL EIAAEKGDEN
1010 1020 1030 1040 1050
AKILKDKITR KVVKQTVMTN VYGVTYVGAT FQIAKQLSPI FDDRKESLDF
1060 1070 1080 1090 1100
SKYLTKHVFS AIRELFHSAH LIQDWLGESA KRISKSIRLD VDEKSFKNGN
1110 1120 1130 1140 1150
KPDFMSSVIW TTPLGLPIVQ PYREESKKQV ETNLQTVFIS DPFAVNPVNA
1160 1170 1180 1190 1200
RRQKAGLPPN FIHSLDASHM LLSAAECGKQ GLDFASVHDS YWTHASDIDT
1210 1220 1230 1240 1250
MNVVLREQFI KLHEVDLVLR LKEEFDQRYK NYVKIGKLKR STDLAQKIIR
1260 1270 1280 1290 1300
IRKDLSRKLG RSTTLADEIY FEKKRQELLN SPLIEDRNVG EKMVTTVSLF
1310 1320 1330 1340 1350
EDITDLDALE LENGGDENSG MSVLLPLRLP EIPPKGDFDV TVLRNSQYFF

S
Length:1,351
Mass (Da):153,047
Last modified:October 5, 2010 - v2
Checksum:i70A055CB71DB223E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti485G → S in AAA35007 (PubMed:3308116).Curated1
Sequence conflicti900 – 901NP → KS in AAA35007 (PubMed:3308116).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17539 Genomic DNA Translation: AAA35007.1
D50617 Genomic DNA Translation: BAA09203.1
BK006940 Genomic DNA Translation: DAA12404.1
PIRiS56218
RefSeqiNP_116617.1, NM_001179930.1

Genome annotation databases

EnsemblFungiiBAA09203; BAA09203; BAA09203
YFL036W; YFL036W; YFL036W
GeneIDi850507
KEGGisce:YFL036W

Similar proteinsi

Entry informationi

Entry nameiRPOM_YEAST
AccessioniPrimary (citable) accession number: P13433
Secondary accession number(s): D6VTJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 5, 2010
Last modified: May 23, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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