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P13419

- FTHS_CLOAC

UniProt

P13419 - FTHS_CLOAC

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs
Organism
Clostridium acidurici (Clostridium acidi-urici)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
OrganismiClostridium acidurici (Clostridium acidi-urici)
Taxonomic identifieri1556 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesGottschalkia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000199338Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP13419.
SMRiP13419. Positions 4-554.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13419-1 [UniParc]FASTAAdd to Basket

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MKTDIQIAQE AQMKHIKDVA ELIDIHEDDL ELYGKYKAKV SLDVLDQLKD    50
KPDGKLVLVT AINPTPAGEG KTTTNIGLSM GLNKLGKKTS TALREPSLGP 100
SFGVKGGAAG GGYAQVVPMA DINLHFTGDF HAITSAHSLL AALVDNHLHH 150
GNALRIDTNR IVWKRVVDMN DRALRKIVVG LGGKAQGITR EDGFDITVAS 200
EIMAILCLAN DREDLKERLG NMVVAYNVDG DAVRAKDLEA QGALTLILKD 250
AINPNIVQTL ENTPAFIHGG PFANIAHGCN SVLATKLALK TGDYAVTEAG 300
FGADLGAEKF FDIKCRYAGL NPDVAVIVAT VRALKMHGGV AKEDLGTENL 350
DALAKGMTNL ERHIENVAKF GVPSVVAINA FPTDTEAEKQ LVFDKCKEMG 400
VDVAISDVFA KGGDGGVELA QKVIDVCENK KSDFKVLYDV EESIPEKITK 450
IAKEIYRADK VNFSKAAKKQ IAELEKLGLD KLPICMAKTQ YSFSDDPALL 500
GAPEGFELTI RDLELAAGAG FIVALTGDIM RMPGLPKVPA ANRMDVLPNG 550
EIIGLF 556
Length:556
Mass (Da):59,589
Last modified:January 1, 1990 - v1
Checksum:i72D9D485863F0334
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21507 Genomic DNA. Translation: AAA53187.1.
PIRiA28185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21507 Genomic DNA. Translation: AAA53187.1 .
PIRi A28185.

3D structure databases

ProteinModelPortali P13419.
SMRi P13419. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the Clostridium acidiurici ('Clostridium acidi-urici') gene for 10-formyltetrahydrofolate synthetase shows extensive amino acid homology with the trifunctional enzyme C1-tetrahydrofolate synthase from Saccharomyces cerevisiae."
    Whitehead T.R., Rabinowitz J.C.
    J. Bacteriol. 170:3255-3261(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiFTHS_CLOAC
AccessioniPrimary (citable) accession number: P13419
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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