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P13419 (FTHS_CLOAC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
OrganismClostridium acidurici (Clostridium acidi-urici)
Taxonomic identifier1556 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199338

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P13419 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: 72D9D485863F0334

FASTA55659,589
        10         20         30         40         50         60 
MKTDIQIAQE AQMKHIKDVA ELIDIHEDDL ELYGKYKAKV SLDVLDQLKD KPDGKLVLVT 

        70         80         90        100        110        120 
AINPTPAGEG KTTTNIGLSM GLNKLGKKTS TALREPSLGP SFGVKGGAAG GGYAQVVPMA 

       130        140        150        160        170        180 
DINLHFTGDF HAITSAHSLL AALVDNHLHH GNALRIDTNR IVWKRVVDMN DRALRKIVVG 

       190        200        210        220        230        240 
LGGKAQGITR EDGFDITVAS EIMAILCLAN DREDLKERLG NMVVAYNVDG DAVRAKDLEA 

       250        260        270        280        290        300 
QGALTLILKD AINPNIVQTL ENTPAFIHGG PFANIAHGCN SVLATKLALK TGDYAVTEAG 

       310        320        330        340        350        360 
FGADLGAEKF FDIKCRYAGL NPDVAVIVAT VRALKMHGGV AKEDLGTENL DALAKGMTNL 

       370        380        390        400        410        420 
ERHIENVAKF GVPSVVAINA FPTDTEAEKQ LVFDKCKEMG VDVAISDVFA KGGDGGVELA 

       430        440        450        460        470        480 
QKVIDVCENK KSDFKVLYDV EESIPEKITK IAKEIYRADK VNFSKAAKKQ IAELEKLGLD 

       490        500        510        520        530        540 
KLPICMAKTQ YSFSDDPALL GAPEGFELTI RDLELAAGAG FIVALTGDIM RMPGLPKVPA 

       550 
ANRMDVLPNG EIIGLF 

« Hide

References

[1]"Nucleotide sequence of the Clostridium acidiurici ('Clostridium acidi-urici') gene for 10-formyltetrahydrofolate synthetase shows extensive amino acid homology with the trifunctional enzyme C1-tetrahydrofolate synthase from Saccharomyces cerevisiae."
Whitehead T.R., Rabinowitz J.C.
J. Bacteriol. 170:3255-3261(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M21507 Genomic DNA. Translation: AAA53187.1.
PIRA28185.

3D structure databases

ProteinModelPortalP13419.
SMRP13419. Positions 4-554.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_CLOAC
AccessionPrimary (citable) accession number: P13419
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways