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Protein

Structural polyprotein

Gene
N/A
Organism
Cricket paralysis virus (isolate Teleogryllus commodus/Australia/CrPVVIC/1968) (CrPV)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Structural polyprotein: precursor of all the viral capsid proteins.
Capsid protein 1, together with capsid proteins 2 and 3, form an icosahedral capsid protecting the viral RNA genome. The icosahedral capsid has a pseudo-T=3 symmetry with a diameter of approximately 300 Angstroms, and is composed of 60 copies of each CP1, CP2, and CP3. CP1 is situated at the 12 fivefold axes, whereas CP2 and CP3 are located at the quasi-sixfold axes. All these proteins contain a beta-sheet structure called beta-barrel jelly roll.
Capsid protein 4 is a tstructural component of the icosahedral capsid protecting the genomic RNA. It may play an important role in capsid assembly.
Capsid protein 2, together with capsid proteins 1 and 3, form an icosahedral capsid protecting the viral RNA genome. The icosahedral capsid has a pseudo-T=3 symmetry with a diameter of approximately 300 Angstroms, and is composed of 60 copies of each CP1, CP2, and CP3. CP1 is situated at the 12 fivefold axes, whereas CP2 and CP3 are located at the quasi-sixfold axes. All these proteins contain a beta-sheet structure called beta-barrel jelly roll.
Capsid protein 3, together with capsid proteins 1 and 2, form an icosahedral capsid protecting the viral RNA genome. The icosahedral capsid has a pseudo-T=3 symmetry with a diameter of approximately 300 Angstroms, and is composed of 60 copies of each CP1, CP2, and CP3. CP1 is situated at the 12 fivefold axes, whereas CP2 and CP3 are located at the quasi-sixfold axes. All these proteins contain a beta-sheet structure called beta-barrel jelly roll.

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Structural polyprotein
Cleaved into the following 4 chains:
Alternative name(s):
CP1
Alternative name(s):
CP4
Alternative name(s):
CP2
Alternative name(s):
CP3
OrganismiCricket paralysis virus (isolate Teleogryllus commodus/Australia/CrPVVIC/1968) (CrPV)
Taxonomic identifieri928300 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stagePicornaviralesDicistroviridaeCripavirus
Virus hostiTeleogryllus oceanicus (black field cricket) [TaxID: 128161]
Proteomesi
  • UP000008590 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001238251 – 895Structural polyproteinAdd BLAST895
ChainiPRO_00003983681 – 283Capsid protein 1Add BLAST283
ChainiPRO_0000398369284 – 340Capsid protein 4Add BLAST57
ChainiPRO_0000398370341 – 635Capsid protein 2Add BLAST295
ChainiPRO_0000398371636 – 895Capsid protein 3Add BLAST260

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei283 – 284Cleavage2
Sitei340 – 341Cleavage2
Sitei635 – 636Cleavage2

Structurei

Secondary structure

1895
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi15 – 17Combined sources3
Beta strandi19 – 24Combined sources6
Beta strandi27 – 33Combined sources7
Beta strandi40 – 42Combined sources3
Helixi49 – 52Combined sources4
Turni53 – 56Combined sources4
Helixi64 – 67Combined sources4
Beta strandi72 – 80Combined sources9
Beta strandi88 – 94Combined sources7
Helixi96 – 99Combined sources4
Helixi102 – 108Combined sources7
Beta strandi111 – 125Combined sources15
Beta strandi131 – 140Combined sources10
Helixi142 – 144Combined sources3
Helixi146 – 153Combined sources8
Helixi156 – 160Combined sources5
Beta strandi162 – 168Combined sources7
Turni169 – 171Combined sources3
Beta strandi174 – 179Combined sources6
Beta strandi184 – 189Combined sources6
Turni190 – 193Combined sources4
Beta strandi198 – 209Combined sources12
Turni211 – 213Combined sources3
Beta strandi217 – 234Combined sources18
Helixi285 – 293Combined sources9
Helixi305 – 307Combined sources3
Beta strandi320 – 323Combined sources4
Helixi331 – 337Combined sources7
Beta strandi356 – 359Combined sources4
Beta strandi363 – 365Combined sources3
Turni384 – 387Combined sources4
Helixi396 – 400Combined sources5
Beta strandi404 – 412Combined sources9
Beta strandi420 – 425Combined sources6
Beta strandi431 – 437Combined sources7
Beta strandi440 – 444Combined sources5
Helixi446 – 451Combined sources6
Beta strandi455 – 459Combined sources5
Beta strandi461 – 468Combined sources8
Beta strandi473 – 483Combined sources11
Turni488 – 490Combined sources3
Beta strandi491 – 493Combined sources3
Helixi497 – 499Combined sources3
Beta strandi500 – 509Combined sources10
Beta strandi512 – 517Combined sources6
Beta strandi522 – 524Combined sources3
Helixi534 – 536Combined sources3
Turni542 – 545Combined sources4
Helixi546 – 548Combined sources3
Beta strandi552 – 564Combined sources13
Beta strandi570 – 580Combined sources11
Beta strandi593 – 597Combined sources5
Helixi603 – 617Combined sources15
Beta strandi637 – 639Combined sources3
Helixi645 – 648Combined sources4
Turni649 – 651Combined sources3
Helixi667 – 672Combined sources6
Helixi680 – 683Combined sources4
Beta strandi688 – 696Combined sources9
Beta strandi702 – 705Combined sources4
Beta strandi716 – 718Combined sources3
Helixi725 – 729Combined sources5
Helixi730 – 732Combined sources3
Beta strandi733 – 737Combined sources5
Beta strandi740 – 751Combined sources12
Beta strandi756 – 758Combined sources3
Beta strandi763 – 768Combined sources6
Beta strandi770 – 772Combined sources3
Helixi773 – 778Combined sources6
Beta strandi785 – 789Combined sources5
Beta strandi793 – 795Combined sources3
Beta strandi801 – 805Combined sources5
Helixi807 – 810Combined sources4
Beta strandi811 – 817Combined sources7
Beta strandi822 – 824Combined sources3
Beta strandi831 – 834Combined sources4
Helixi838 – 842Combined sources5
Beta strandi850 – 857Combined sources8
Turni861 – 863Combined sources3
Beta strandi864 – 874Combined sources11
Beta strandi879 – 883Combined sources5
Beta strandi889 – 891Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B35X-ray2.40A636-895[»]
B8-243[»]
C341-622[»]
D284-340[»]
ProteinModelPortaliP13418.
SMRiP13418.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13418.

Family & Domainsi

Sequence similaritiesi

Belongs to the picornaviruses polyprotein family.Curated

Family and domain databases

CDDicd00205. rhv_like. 2 hits.
Gene3Di2.60.120.20. 3 hits.
InterProiIPR014872. Dicistrovirus_capsid-polyPr_C.
IPR001676. Picornavirus_capsid.
IPR033703. Rhv-like.
IPR029053. Viral_coat.
IPR024343. VP4_dicistrovir.
[Graphical view]
PfamiPF08762. CRPV_capsid. 1 hit.
PF11492. Dicistro_VP4. 1 hit.
PF00073. Rhv. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13418-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ATFQDKQENS HIENEDKRLM SEQKEIVHFV SEGITPSTTA LPDIVNLSTN
60 70 80 90 100
YLDMTTREDR IHSIKDFLSG PIIIATNLWS SSDPVEKQLY TANFPEVLIS
110 120 130 140 150
NAMYQDKLKG FVGLRATLVV KVQVNSQPFQ QGRLMLQYIP YAQYMPNRVT
160 170 180 190 200
LINETLQGRS GCPTTDLELS VGTEVEMRIP YVSPHLYYNL ITGQGSFGSI
210 220 230 240 250
YVVVYSQLHD QVSGTGSIEY TVWAHLEDVD VQYPTGANIF TGNSPNYLSI
260 270 280 290 300
AERIATGDFT ETEMRKLWIH KTYLKRPARI YAQAAKELKQ LETNNSPSTA
310 320 330 340 350
LGQISEGLTT LSHIPVLGNI FSTPAWISAK AADLAKLFGF SKPTVQGKIG
360 370 380 390 400
ECKLRGQGRM ANFDGMDMSH KMALSSTNEI ETKEGLAGTS LDEMDLSRVL
410 420 430 440 450
SIPNYWDRFT WKTSDVTNTV LWDNYVSPFK VKPYSATITD RFRCTHMGYV
460 470 480 490 500
ANAFTYWRGS IVYTFKFVKT QYHSGRLRIS FIPYYYNTTI STGTPDVSRT
510 520 530 540 550
QKIVVDLRTS TEVSFTVPYI ASRPWLYCIR PESSWLSKDN KDGALMYNCV
560 570 580 590 600
SGIVRVEVLN QLVAAQNVFS EIDVICEVSG GPDLEFAGPT CPSYVPYAGD
610 620 630 640 650
LTLADTRKIE AERTQEYSNN EDNRITTQCS RIVAQVMGED QQIPRNEAQH
660 670 680 690 700
GVHPISIDTH RISNNWSPQA MCIGEKIVSI RQLIKRFGIF GDANTLQADG
710 720 730 740 750
SSFVVAPFTV TSPTKTLTST RNYTQFDYYY YLYAFWRGSM RIKMVAETQD
760 770 780 790 800
GTGTPRKKTN FTWFVRMFNS LQDSFNSLIS TSSSAVTTTV LPSGTINMGP
810 820 830 840 850
STQVIDPTVE GLIEVEVPYY NISHITPAVT IDDGTPSMED YLKGHSPPCL
860 870 880 890
LTFSPRDSIS ATNHHITASF MRAPGDDFSF MYLLEVPPLV NVARA
Length:895
Mass (Da):100,298
Last modified:October 11, 2004 - v2
Checksum:i92DA9084DDA850EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti445 – 447THM → HTH in AAA42889 (Ref. 2) Curated3
Sequence conflicti451A → T in AAA42889 (Ref. 2) Curated1
Sequence conflicti556V → T in AAA42889 (Ref. 2) Curated1
Sequence conflicti579S → N in AAA42889 (Ref. 2) Curated1
Sequence conflicti594 – 595YV → MY in AAA42889 (Ref. 2) Curated2
Sequence conflicti601L → D in AAA42889 (Ref. 2) Curated1
Sequence conflicti641 – 642QQ → HE in AAA42889 (Ref. 2) Curated2
Sequence conflicti648A → G in AAA42889 (Ref. 2) Curated1
Sequence conflicti678 – 683VSIRQL → IDSTT in AAA42889 (Ref. 2) Curated6
Sequence conflicti746A → V in AAA42889 (Ref. 2) Curated1
Sequence conflicti854 – 855SP → A in AAA42889 (Ref. 2) Curated2
Sequence conflicti861 – 895ATNHH…NVARA → TTHTRSYACAW in AAA42889 (Ref. 2) CuratedAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218039 Genomic RNA. Translation: AAF80999.1.
M21938 Genomic RNA. Translation: AAA42889.1.
PIRiS28374.
RefSeqiNP_647482.1. NC_003924.1.

Genome annotation databases

GeneIDi944542.
KEGGivg:944542.

Cross-referencesi

Web resourcesi

Virus Particle ExploreR db

Icosahedral capsid structure

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218039 Genomic RNA. Translation: AAF80999.1.
M21938 Genomic RNA. Translation: AAA42889.1.
PIRiS28374.
RefSeqiNP_647482.1. NC_003924.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B35X-ray2.40A636-895[»]
B8-243[»]
C341-622[»]
D284-340[»]
ProteinModelPortaliP13418.
SMRiP13418.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi944542.
KEGGivg:944542.

Miscellaneous databases

EvolutionaryTraceiP13418.

Family and domain databases

CDDicd00205. rhv_like. 2 hits.
Gene3Di2.60.120.20. 3 hits.
InterProiIPR014872. Dicistrovirus_capsid-polyPr_C.
IPR001676. Picornavirus_capsid.
IPR033703. Rhv-like.
IPR029053. Viral_coat.
IPR024343. VP4_dicistrovir.
[Graphical view]
PfamiPF08762. CRPV_capsid. 1 hit.
PF11492. Dicistro_VP4. 1 hit.
PF00073. Rhv. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPOLS_CRPVC
AccessioniPrimary (citable) accession number: P13418
Secondary accession number(s): Q9IJX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 11, 2004
Last modified: November 30, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Caution

Translation initiates on an Ala codon through an unusual Internal Ribosome Entry Site (IRES).Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.