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P13413 (TNNI1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Troponin I, slow skeletal muscle
Alternative name(s):
Troponin I, slow-twitch isoform
Gene names
Name:Tnni1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length187 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Subunit structure

Binds to actin and tropomyosin.

Sequence similarities

Belongs to the troponin I family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 187187Troponin I, slow skeletal muscle
PRO_0000186142

Regions

Calcium binding106 – 11712 By similarity
Region1 – 4848Involved in binding TNC
Region97 – 11822Involved in binding TNC and actin

Sequences

Sequence LengthMass (Da)Tools
P13413 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 69A62A39D0F471D4

FASTA18721,724
        10         20         30         40         50         60 
MPEVERKSKI TASRKLMLKS LMLAKAKECW EQEHEEREAE KVRYLSERIP TLQTRGLSLS 

        70         80         90        100        110        120 
ALQDLCRELH AKVEVVDEER YDIEAKCLHN TREIKDLKLK VLDLRGKFKR PPLRRVRVSA 

       130        140        150        160        170        180 
DAMLRALLGS KHKVSMDLRA NLKSVKKEDT EKERPVEVGD WRKNVEAMSG MEGRKKMFDA 


AKSPTLQ 

« Hide

References

[1]"cDNA clone and expression analysis of rodent fast and slow skeletal muscle troponin I mRNAs."
Koppe R.I., Hallauer P.L., Karpati G., Hastings K.E.M.
J. Biol. Chem. 264:14327-14333(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Lubec G., Kang S.U.
Submitted (JUL-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 147-152, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J04993 mRNA. Translation: AAA42295.1.
PIRB44786.
RefSeqNP_058880.1. NM_017184.1.
UniGeneRn.4035.

3D structure databases

ProteinModelPortalP13413.
SMRP13413. Positions 5-129, 133-183.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000012096.

Proteomic databases

PRIDEP13413.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID29388.
KEGGrno:29388.
UCSCRGD:621765. rat.

Organism-specific databases

CTD7135.
RGD621765. Tnni1.

Phylogenomic databases

eggNOGNOG328514.
HOGENOMHOG000293300.
HOVERGENHBG052737.
InParanoidP13413.
KOK10371.
PhylomeDBP13413.

Gene expression databases

GenevestigatorP13413.

Family and domain databases

InterProIPR001978. Troponin.
[Graphical view]
PfamPF00992. Troponin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio608995.
PROP13413.

Entry information

Entry nameTNNI1_RAT
AccessionPrimary (citable) accession number: P13413
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families