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Protein

Troponin I, slow skeletal muscle

Gene

Tnni1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi106 – 11712By similarityAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of muscle contraction Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin I, slow skeletal muscle
Alternative name(s):
Troponin I, slow-twitch isoform
Gene namesi
Name:Tnni1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621765. Tnni1.

Subcellular locationi

GO - Cellular componenti

  1. troponin complex Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 187187Troponin I, slow skeletal musclePRO_0000186142Add
BLAST

Proteomic databases

PRIDEiP13413.

Expressioni

Gene expression databases

GenevestigatoriP13413.

Interactioni

Subunit structurei

Binds to actin and tropomyosin.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012096.

Structurei

3D structure databases

ProteinModelPortaliP13413.
SMRiP13413. Positions 5-129, 133-183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 4848Involved in binding TNCAdd
BLAST
Regioni97 – 11822Involved in binding TNC and actinAdd
BLAST

Sequence similaritiesi

Belongs to the troponin I family.Curated

Phylogenomic databases

eggNOGiNOG328514.
HOGENOMiHOG000293300.
HOVERGENiHBG052737.
InParanoidiP13413.
KOiK10371.
PhylomeDBiP13413.

Family and domain databases

InterProiIPR001978. Troponin.
[Graphical view]
PfamiPF00992. Troponin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13413-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPEVERKSKI TASRKLMLKS LMLAKAKECW EQEHEEREAE KVRYLSERIP
60 70 80 90 100
TLQTRGLSLS ALQDLCRELH AKVEVVDEER YDIEAKCLHN TREIKDLKLK
110 120 130 140 150
VLDLRGKFKR PPLRRVRVSA DAMLRALLGS KHKVSMDLRA NLKSVKKEDT
160 170 180
EKERPVEVGD WRKNVEAMSG MEGRKKMFDA AKSPTLQ
Length:187
Mass (Da):21,724
Last modified:January 23, 2007 - v2
Checksum:i69A62A39D0F471D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04993 mRNA. Translation: AAA42295.1.
PIRiB44786.
RefSeqiNP_058880.1. NM_017184.1.
UniGeneiRn.4035.

Genome annotation databases

GeneIDi29388.
KEGGirno:29388.
UCSCiRGD:621765. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04993 mRNA. Translation: AAA42295.1.
PIRiB44786.
RefSeqiNP_058880.1. NM_017184.1.
UniGeneiRn.4035.

3D structure databases

ProteinModelPortaliP13413.
SMRiP13413. Positions 5-129, 133-183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012096.

Proteomic databases

PRIDEiP13413.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29388.
KEGGirno:29388.
UCSCiRGD:621765. rat.

Organism-specific databases

CTDi7135.
RGDi621765. Tnni1.

Phylogenomic databases

eggNOGiNOG328514.
HOGENOMiHOG000293300.
HOVERGENiHBG052737.
InParanoidiP13413.
KOiK10371.
PhylomeDBiP13413.

Miscellaneous databases

NextBioi608995.
PROiP13413.

Gene expression databases

GenevestigatoriP13413.

Family and domain databases

InterProiIPR001978. Troponin.
[Graphical view]
PfamiPF00992. Troponin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA clone and expression analysis of rodent fast and slow skeletal muscle troponin I mRNAs."
    Koppe R.I., Hallauer P.L., Karpati G., Hastings K.E.M.
    J. Biol. Chem. 264:14327-14333(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Lubec G., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 147-152, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiTNNI1_RAT
AccessioniPrimary (citable) accession number: P13413
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.