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P13413

- TNNI1_RAT

UniProt

P13413 - TNNI1_RAT

Protein

Troponin I, slow skeletal muscle

Gene

Tnni1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi106 – 11712By similarityAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of muscle contraction Source: RGD

    Keywords - Molecular functioni

    Muscle protein

    Keywords - Ligandi

    Actin-binding, Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Troponin I, slow skeletal muscle
    Alternative name(s):
    Troponin I, slow-twitch isoform
    Gene namesi
    Name:Tnni1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621765. Tnni1.

    Subcellular locationi

    GO - Cellular componenti

    1. troponin complex Source: RGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 187187Troponin I, slow skeletal musclePRO_0000186142Add
    BLAST

    Proteomic databases

    PRIDEiP13413.

    Expressioni

    Gene expression databases

    GenevestigatoriP13413.

    Interactioni

    Subunit structurei

    Binds to actin and tropomyosin.

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000012096.

    Structurei

    3D structure databases

    ProteinModelPortaliP13413.
    SMRiP13413. Positions 5-129, 133-183.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 4848Involved in binding TNCAdd
    BLAST
    Regioni97 – 11822Involved in binding TNC and actinAdd
    BLAST

    Sequence similaritiesi

    Belongs to the troponin I family.Curated

    Phylogenomic databases

    eggNOGiNOG328514.
    HOGENOMiHOG000293300.
    HOVERGENiHBG052737.
    InParanoidiP13413.
    KOiK10371.
    PhylomeDBiP13413.

    Family and domain databases

    InterProiIPR001978. Troponin.
    [Graphical view]
    PfamiPF00992. Troponin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P13413-1 [UniParc]FASTAAdd to Basket

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    MPEVERKSKI TASRKLMLKS LMLAKAKECW EQEHEEREAE KVRYLSERIP    50
    TLQTRGLSLS ALQDLCRELH AKVEVVDEER YDIEAKCLHN TREIKDLKLK 100
    VLDLRGKFKR PPLRRVRVSA DAMLRALLGS KHKVSMDLRA NLKSVKKEDT 150
    EKERPVEVGD WRKNVEAMSG MEGRKKMFDA AKSPTLQ 187
    Length:187
    Mass (Da):21,724
    Last modified:January 23, 2007 - v2
    Checksum:i69A62A39D0F471D4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04993 mRNA. Translation: AAA42295.1.
    PIRiB44786.
    RefSeqiNP_058880.1. NM_017184.1.
    UniGeneiRn.4035.

    Genome annotation databases

    GeneIDi29388.
    KEGGirno:29388.
    UCSCiRGD:621765. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04993 mRNA. Translation: AAA42295.1 .
    PIRi B44786.
    RefSeqi NP_058880.1. NM_017184.1.
    UniGenei Rn.4035.

    3D structure databases

    ProteinModelPortali P13413.
    SMRi P13413. Positions 5-129, 133-183.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000012096.

    Proteomic databases

    PRIDEi P13413.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29388.
    KEGGi rno:29388.
    UCSCi RGD:621765. rat.

    Organism-specific databases

    CTDi 7135.
    RGDi 621765. Tnni1.

    Phylogenomic databases

    eggNOGi NOG328514.
    HOGENOMi HOG000293300.
    HOVERGENi HBG052737.
    InParanoidi P13413.
    KOi K10371.
    PhylomeDBi P13413.

    Miscellaneous databases

    NextBioi 608995.
    PROi P13413.

    Gene expression databases

    Genevestigatori P13413.

    Family and domain databases

    InterProi IPR001978. Troponin.
    [Graphical view ]
    Pfami PF00992. Troponin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA clone and expression analysis of rodent fast and slow skeletal muscle troponin I mRNAs."
      Koppe R.I., Hallauer P.L., Karpati G., Hastings K.E.M.
      J. Biol. Chem. 264:14327-14333(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Lubec G., Kang S.U.
      Submitted (JUL-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 147-152, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiTNNI1_RAT
    AccessioniPrimary (citable) accession number: P13413
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3