P13412 (TNNI2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Troponin I, fast skeletal muscle

Alternative name(s):
Troponin I, fast-twitch isoform

Gene names

Name:

Tnni2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	182 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Subunit structure	Binds to actin and tropomyosin.
Sequence similarities	Belongs to the troponin I family.

Ontologies

Keywords
Ligand	Actin-binding Calcium Metal-binding
Molecular function	Muscle protein
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara skeletal muscle contraction Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from electronic annotation. Source: Compara troponin complex Inferred from electronic annotation. Source: Compara
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 182	181	Troponin I, fast skeletal muscle		PRO_0000186144
Regions
	Calcium binding	105 – 116	12	By similarity
	Region	2 – 48	47	Involved in binding TNC
	Region	97 – 117	21	Involved in binding TNC and actin
Amino acid modifications
	Modified residue	2	1	N-acetylglycine By similarity
	Modified residue	12	1	Phosphothreonine By similarity
	Modified residue	118	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P13412 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: B09B6657CC85F73C	FASTA	182	21,358
	10 20 30 40 50 60 MGDEEKRNRA ITARRQHLKS VMLQIAATEL EKEESRRESE KENYLSEHCP PLHIPGSMSE 70 80 90 100 110 120 VQELCKQLHA KIDVAEEEKY DMEVKVQKSS KELEDMNQKL FDLRGKFKRP PLRRVRMSAD 130 140 150 160 170 180 AMLKALLGSK HKVCMDLRAN LKQVKKEDTE KERDLRDVGD WRKNIEEKSG MEGRKKMFES ES

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA clone and expression analysis of rodent fast and slow skeletal muscle troponin I mRNAs." Koppe R.I., Hallauer P.L., Karpati G., Hastings K.E.M. J. Biol. Chem. 264:14327-14333(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J04992 mRNA. Translation: AAA40485.1. AL603651 Genomic DNA. Translation: CAM23286.1. BC028515 mRNA. Translation: AAH28515.1.
IPI	IPI00223196.
PIR	A44786.
RefSeq	NP_033431.1. NM_009405.2.
UniGene	Mm.39469.
3D structure databases
ProteinModelPortal	P13412.
SMR	P13412. Positions 4-180.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000033422.
PTM databases
PhosphoSite	P13412.
2D gel databases
SWISS-2DPAGE	P13412.
Proteomic databases
PRIDE	P13412.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000105971; ENSMUSP00000101591; ENSMUSG00000031097. ENSMUST00000149529; ENSMUSP00000122733; ENSMUSG00000031097.
GeneID	21953.
KEGG	mmu:21953.
UCSC	uc009kna.1. mouse.
Organism-specific databases
CTD	7136.
MGI	MGI:105070. Tnni2.
Phylogenomic databases
eggNOG	NOG297734.
GeneTree	ENSGT00390000002746.
HOGENOM	HOG000293300.
HOVERGEN	HBG052737.
KO	K12043.
OrthoDB	EOG4001KH.
Gene expression databases
ArrayExpress	P13412.
Bgee	P13412.
CleanEx	MM_TNNI2.
Genevestigator	P13412.
GermOnline	ENSMUSG00000031097. Mus musculus.
Family and domain databases
InterPro	IPR001978. Troponin. [Graphical view]
Pfam	PF00992. Troponin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TNNI2. mouse.
NextBio	301624.
SOURCE	Search...

Entry information

Entry name

TNNI2_MOUSE

Accession

Primary (citable) accession number: P13412
Secondary accession number(s): A2A6J9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program