SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P13412

- TNNI2_MOUSE

UniProt

P13412 - TNNI2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Troponin I, fast skeletal muscle
Gene
Tnni2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi105 – 11612 By similarity
Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: Ensembl
  2. skeletal muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin I, fast skeletal muscle
Alternative name(s):
Troponin I, fast-twitch isoform
Gene namesi
Name:Tnni2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:105070. Tnni2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: Ensembl
  2. troponin complex Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 182181Troponin I, fast skeletal muscle
PRO_0000186144Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine By similarity
Modified residuei12 – 121Phosphothreonine By similarity
Modified residuei118 – 1181Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP13412.
PRIDEiP13412.

2D gel databases

SWISS-2DPAGEP13412.

PTM databases

PhosphoSiteiP13412.

Expressioni

Gene expression databases

BgeeiP13412.
CleanExiMM_TNNI2.
GenevestigatoriP13412.

Interactioni

Subunit structurei

Binds to actin and tropomyosin.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033422.

Structurei

3D structure databases

ProteinModelPortaliP13412.
SMRiP13412. Positions 4-180.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 4847Involved in binding TNC
Add
BLAST
Regioni97 – 11721Involved in binding TNC and actin
Add
BLAST

Sequence similaritiesi

Belongs to the troponin I family.

Phylogenomic databases

eggNOGiNOG297734.
GeneTreeiENSGT00390000002746.
HOGENOMiHOG000293300.
HOVERGENiHBG052737.
KOiK12043.
OrthoDBiEOG71G9WD.
PhylomeDBiP13412.
TreeFamiTF313374.

Family and domain databases

InterProiIPR001978. Troponin.
[Graphical view]
PfamiPF00992. Troponin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13412-1 [UniParc]FASTAAdd to Basket

« Hide

MGDEEKRNRA ITARRQHLKS VMLQIAATEL EKEESRRESE KENYLSEHCP    50
PLHIPGSMSE VQELCKQLHA KIDVAEEEKY DMEVKVQKSS KELEDMNQKL 100
FDLRGKFKRP PLRRVRMSAD AMLKALLGSK HKVCMDLRAN LKQVKKEDTE 150
KERDLRDVGD WRKNIEEKSG MEGRKKMFES ES 182
Length:182
Mass (Da):21,358
Last modified:January 23, 2007 - v2
Checksum:iB09B6657CC85F73C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04992 mRNA. Translation: AAA40485.1.
AL603651 Genomic DNA. Translation: CAM23286.1.
BC028515 mRNA. Translation: AAH28515.1.
CCDSiCCDS40192.1.
PIRiA44786.
RefSeqiNP_033431.1. NM_009405.2.
XP_006508602.1. XM_006508539.1.
UniGeneiMm.39469.

Genome annotation databases

EnsembliENSMUST00000105971; ENSMUSP00000101591; ENSMUSG00000031097.
ENSMUST00000149529; ENSMUSP00000122733; ENSMUSG00000031097.
GeneIDi21953.
KEGGimmu:21953.
UCSCiuc009kna.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04992 mRNA. Translation: AAA40485.1 .
AL603651 Genomic DNA. Translation: CAM23286.1 .
BC028515 mRNA. Translation: AAH28515.1 .
CCDSi CCDS40192.1.
PIRi A44786.
RefSeqi NP_033431.1. NM_009405.2.
XP_006508602.1. XM_006508539.1.
UniGenei Mm.39469.

3D structure databases

ProteinModelPortali P13412.
SMRi P13412. Positions 4-180.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000033422.

PTM databases

PhosphoSitei P13412.

2D gel databases

SWISS-2DPAGE P13412.

Proteomic databases

MaxQBi P13412.
PRIDEi P13412.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000105971 ; ENSMUSP00000101591 ; ENSMUSG00000031097 .
ENSMUST00000149529 ; ENSMUSP00000122733 ; ENSMUSG00000031097 .
GeneIDi 21953.
KEGGi mmu:21953.
UCSCi uc009kna.1. mouse.

Organism-specific databases

CTDi 7136.
MGIi MGI:105070. Tnni2.

Phylogenomic databases

eggNOGi NOG297734.
GeneTreei ENSGT00390000002746.
HOGENOMi HOG000293300.
HOVERGENi HBG052737.
KOi K12043.
OrthoDBi EOG71G9WD.
PhylomeDBi P13412.
TreeFami TF313374.

Miscellaneous databases

ChiTaRSi TNNI2. mouse.
NextBioi 301624.
PROi P13412.
SOURCEi Search...

Gene expression databases

Bgeei P13412.
CleanExi MM_TNNI2.
Genevestigatori P13412.

Family and domain databases

InterProi IPR001978. Troponin.
[Graphical view ]
Pfami PF00992. Troponin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA clone and expression analysis of rodent fast and slow skeletal muscle troponin I mRNAs."
    Koppe R.I., Hallauer P.L., Karpati G., Hastings K.E.M.
    J. Biol. Chem. 264:14327-14333(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiTNNI2_MOUSE
AccessioniPrimary (citable) accession number: P13412
Secondary accession number(s): A2A6J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi