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Protein

Troponin I, fast skeletal muscle

Gene

Tnni2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi105 – 116By similarityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-390522. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin I, fast skeletal muscle
Alternative name(s):
Troponin I, fast-twitch isoform
Gene namesi
Name:Tnni2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:105070. Tnni2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001861442 – 182Troponin I, fast skeletal muscleAdd BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineBy similarity1
Modified residuei12PhosphothreonineBy similarity1
Modified residuei118PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP13412.
PaxDbiP13412.
PRIDEiP13412.

2D gel databases

SWISS-2DPAGEP13412.

PTM databases

iPTMnetiP13412.
PhosphoSitePlusiP13412.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031097.
CleanExiMM_TNNI2.
ExpressionAtlasiP13412. baseline and differential.
GenevisibleiP13412. MM.

Interactioni

Subunit structurei

Binds to actin and tropomyosin.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101591.

Structurei

3D structure databases

ProteinModelPortaliP13412.
SMRiP13412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 48Involved in binding TNCAdd BLAST47
Regioni97 – 117Involved in binding TNC and actinAdd BLAST21

Sequence similaritiesi

Belongs to the troponin I family.Curated

Phylogenomic databases

eggNOGiKOG3977. Eukaryota.
ENOG410Y9IX. LUCA.
GeneTreeiENSGT00390000002746.
HOGENOMiHOG000293300.
HOVERGENiHBG052737.
InParanoidiP13412.
KOiK12043.
PhylomeDBiP13412.
TreeFamiTF313374.

Family and domain databases

InterProiIPR001978. Troponin.
[Graphical view]
PfamiPF00992. Troponin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDEEKRNRA ITARRQHLKS VMLQIAATEL EKEESRRESE KENYLSEHCP
60 70 80 90 100
PLHIPGSMSE VQELCKQLHA KIDVAEEEKY DMEVKVQKSS KELEDMNQKL
110 120 130 140 150
FDLRGKFKRP PLRRVRMSAD AMLKALLGSK HKVCMDLRAN LKQVKKEDTE
160 170 180
KERDLRDVGD WRKNIEEKSG MEGRKKMFES ES
Length:182
Mass (Da):21,358
Last modified:January 23, 2007 - v2
Checksum:iB09B6657CC85F73C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04992 mRNA. Translation: AAA40485.1.
AL603651 Genomic DNA. Translation: CAM23286.1.
BC028515 mRNA. Translation: AAH28515.1.
CCDSiCCDS40192.1.
PIRiA44786.
RefSeqiNP_033431.1. NM_009405.2.
XP_006508602.1. XM_006508539.3.
UniGeneiMm.39469.

Genome annotation databases

EnsembliENSMUST00000105971; ENSMUSP00000101591; ENSMUSG00000031097.
ENSMUST00000149529; ENSMUSP00000122733; ENSMUSG00000031097.
GeneIDi21953.
KEGGimmu:21953.
UCSCiuc033jdj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04992 mRNA. Translation: AAA40485.1.
AL603651 Genomic DNA. Translation: CAM23286.1.
BC028515 mRNA. Translation: AAH28515.1.
CCDSiCCDS40192.1.
PIRiA44786.
RefSeqiNP_033431.1. NM_009405.2.
XP_006508602.1. XM_006508539.3.
UniGeneiMm.39469.

3D structure databases

ProteinModelPortaliP13412.
SMRiP13412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101591.

PTM databases

iPTMnetiP13412.
PhosphoSitePlusiP13412.

2D gel databases

SWISS-2DPAGEP13412.

Proteomic databases

MaxQBiP13412.
PaxDbiP13412.
PRIDEiP13412.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105971; ENSMUSP00000101591; ENSMUSG00000031097.
ENSMUST00000149529; ENSMUSP00000122733; ENSMUSG00000031097.
GeneIDi21953.
KEGGimmu:21953.
UCSCiuc033jdj.1. mouse.

Organism-specific databases

CTDi7136.
MGIiMGI:105070. Tnni2.

Phylogenomic databases

eggNOGiKOG3977. Eukaryota.
ENOG410Y9IX. LUCA.
GeneTreeiENSGT00390000002746.
HOGENOMiHOG000293300.
HOVERGENiHBG052737.
InParanoidiP13412.
KOiK12043.
PhylomeDBiP13412.
TreeFamiTF313374.

Enzyme and pathway databases

ReactomeiR-MMU-390522. Striated Muscle Contraction.

Miscellaneous databases

PROiP13412.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031097.
CleanExiMM_TNNI2.
ExpressionAtlasiP13412. baseline and differential.
GenevisibleiP13412. MM.

Family and domain databases

InterProiIPR001978. Troponin.
[Graphical view]
PfamiPF00992. Troponin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNNI2_MOUSE
AccessioniPrimary (citable) accession number: P13412
Secondary accession number(s): A2A6J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.