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P13412 (TNNI2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Troponin I, fast skeletal muscle
Alternative name(s):
Troponin I, fast-twitch isoform
Gene names
Name:Tnni2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length182 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Subunit structure

Binds to actin and tropomyosin.

Sequence similarities

Belongs to the troponin I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 182181Troponin I, fast skeletal muscle
PRO_0000186144

Regions

Calcium binding105 – 11612 By similarity
Region2 – 4847Involved in binding TNC
Region97 – 11721Involved in binding TNC and actin

Amino acid modifications

Modified residue21N-acetylglycine By similarity
Modified residue121Phosphothreonine By similarity
Modified residue1181Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P13412 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: B09B6657CC85F73C

FASTA18221,358
        10         20         30         40         50         60 
MGDEEKRNRA ITARRQHLKS VMLQIAATEL EKEESRRESE KENYLSEHCP PLHIPGSMSE 

        70         80         90        100        110        120 
VQELCKQLHA KIDVAEEEKY DMEVKVQKSS KELEDMNQKL FDLRGKFKRP PLRRVRMSAD 

       130        140        150        160        170        180 
AMLKALLGSK HKVCMDLRAN LKQVKKEDTE KERDLRDVGD WRKNIEEKSG MEGRKKMFES 


ES 

« Hide

References

« Hide 'large scale' references
[1]"cDNA clone and expression analysis of rodent fast and slow skeletal muscle troponin I mRNAs."
Koppe R.I., Hallauer P.L., Karpati G., Hastings K.E.M.
J. Biol. Chem. 264:14327-14333(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J04992 mRNA. Translation: AAA40485.1.
AL603651 Genomic DNA. Translation: CAM23286.1.
BC028515 mRNA. Translation: AAH28515.1.
PIRA44786.
RefSeqNP_033431.1. NM_009405.2.
XP_006508602.1. XM_006508539.1.
UniGeneMm.39469.

3D structure databases

ProteinModelPortalP13412.
SMRP13412. Positions 4-180.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000033422.

PTM databases

PhosphoSiteP13412.

2D gel databases

SWISS-2DPAGEP13412.

Proteomic databases

PRIDEP13412.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000105971; ENSMUSP00000101591; ENSMUSG00000031097.
ENSMUST00000149529; ENSMUSP00000122733; ENSMUSG00000031097.
GeneID21953.
KEGGmmu:21953.
UCSCuc009kna.1. mouse.

Organism-specific databases

CTD7136.
MGIMGI:105070. Tnni2.

Phylogenomic databases

eggNOGNOG297734.
GeneTreeENSGT00390000002746.
HOGENOMHOG000293300.
HOVERGENHBG052737.
KOK12043.
OrthoDBEOG71G9WD.
PhylomeDBP13412.
TreeFamTF313374.

Gene expression databases

BgeeP13412.
CleanExMM_TNNI2.
GenevestigatorP13412.

Family and domain databases

InterProIPR001978. Troponin.
[Graphical view]
PfamPF00992. Troponin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTNNI2. mouse.
NextBio301624.
PROP13412.
SOURCESearch...

Entry information

Entry nameTNNI2_MOUSE
AccessionPrimary (citable) accession number: P13412
Secondary accession number(s): A2A6J9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot