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Protein

Troponin I, fast skeletal muscle

Gene

Tnni2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi105 – 11612By similarityAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. troponin T binding Source: MGI

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: MGI
  2. regulation of muscle contraction Source: Ensembl
  3. skeletal muscle contraction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_324616. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin I, fast skeletal muscle
Alternative name(s):
Troponin I, fast-twitch isoform
Gene namesi
Name:Tnni2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:105070. Tnni2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
  2. troponin complex Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 182181Troponin I, fast skeletal musclePRO_0000186144Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycineBy similarity
Modified residuei12 – 121PhosphothreonineBy similarity
Modified residuei118 – 1181PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP13412.
PRIDEiP13412.

2D gel databases

SWISS-2DPAGEP13412.

PTM databases

PhosphoSiteiP13412.

Expressioni

Gene expression databases

BgeeiP13412.
CleanExiMM_TNNI2.
ExpressionAtlasiP13412. baseline and differential.
GenevestigatoriP13412.

Interactioni

Subunit structurei

Binds to actin and tropomyosin.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033422.

Structurei

3D structure databases

ProteinModelPortaliP13412.
SMRiP13412. Positions 4-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 4847Involved in binding TNCAdd
BLAST
Regioni97 – 11721Involved in binding TNC and actinAdd
BLAST

Sequence similaritiesi

Belongs to the troponin I family.Curated

Phylogenomic databases

eggNOGiNOG297734.
GeneTreeiENSGT00390000002746.
HOGENOMiHOG000293300.
HOVERGENiHBG052737.
InParanoidiP13412.
KOiK12043.
OrthoDBiEOG71G9WD.
PhylomeDBiP13412.
TreeFamiTF313374.

Family and domain databases

InterProiIPR001978. Troponin.
[Graphical view]
PfamiPF00992. Troponin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDEEKRNRA ITARRQHLKS VMLQIAATEL EKEESRRESE KENYLSEHCP
60 70 80 90 100
PLHIPGSMSE VQELCKQLHA KIDVAEEEKY DMEVKVQKSS KELEDMNQKL
110 120 130 140 150
FDLRGKFKRP PLRRVRMSAD AMLKALLGSK HKVCMDLRAN LKQVKKEDTE
160 170 180
KERDLRDVGD WRKNIEEKSG MEGRKKMFES ES
Length:182
Mass (Da):21,358
Last modified:January 22, 2007 - v2
Checksum:iB09B6657CC85F73C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04992 mRNA. Translation: AAA40485.1.
AL603651 Genomic DNA. Translation: CAM23286.1.
BC028515 mRNA. Translation: AAH28515.1.
CCDSiCCDS40192.1.
PIRiA44786.
RefSeqiNP_033431.1. NM_009405.2.
XP_006508602.1. XM_006508539.2.
UniGeneiMm.39469.

Genome annotation databases

EnsembliENSMUST00000105971; ENSMUSP00000101591; ENSMUSG00000031097.
ENSMUST00000149529; ENSMUSP00000122733; ENSMUSG00000031097.
GeneIDi21953.
KEGGimmu:21953.
UCSCiuc009kna.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04992 mRNA. Translation: AAA40485.1.
AL603651 Genomic DNA. Translation: CAM23286.1.
BC028515 mRNA. Translation: AAH28515.1.
CCDSiCCDS40192.1.
PIRiA44786.
RefSeqiNP_033431.1. NM_009405.2.
XP_006508602.1. XM_006508539.2.
UniGeneiMm.39469.

3D structure databases

ProteinModelPortaliP13412.
SMRiP13412. Positions 4-180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033422.

PTM databases

PhosphoSiteiP13412.

2D gel databases

SWISS-2DPAGEP13412.

Proteomic databases

MaxQBiP13412.
PRIDEiP13412.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105971; ENSMUSP00000101591; ENSMUSG00000031097.
ENSMUST00000149529; ENSMUSP00000122733; ENSMUSG00000031097.
GeneIDi21953.
KEGGimmu:21953.
UCSCiuc009kna.1. mouse.

Organism-specific databases

CTDi7136.
MGIiMGI:105070. Tnni2.

Phylogenomic databases

eggNOGiNOG297734.
GeneTreeiENSGT00390000002746.
HOGENOMiHOG000293300.
HOVERGENiHBG052737.
InParanoidiP13412.
KOiK12043.
OrthoDBiEOG71G9WD.
PhylomeDBiP13412.
TreeFamiTF313374.

Enzyme and pathway databases

ReactomeiREACT_324616. Striated Muscle Contraction.

Miscellaneous databases

NextBioi301624.
PROiP13412.
SOURCEiSearch...

Gene expression databases

BgeeiP13412.
CleanExiMM_TNNI2.
ExpressionAtlasiP13412. baseline and differential.
GenevestigatoriP13412.

Family and domain databases

InterProiIPR001978. Troponin.
[Graphical view]
PfamiPF00992. Troponin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA clone and expression analysis of rodent fast and slow skeletal muscle troponin I mRNAs."
    Koppe R.I., Hallauer P.L., Karpati G., Hastings K.E.M.
    J. Biol. Chem. 264:14327-14333(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiTNNI2_MOUSE
AccessioniPrimary (citable) accession number: P13412
Secondary accession number(s): A2A6J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 31, 1989
Last sequence update: January 22, 2007
Last modified: March 31, 2015
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.