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P13412

- TNNI2_MOUSE

UniProt

P13412 - TNNI2_MOUSE

Protein

Troponin I, fast skeletal muscle

Gene

Tnni2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi105 – 11612By similarityAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. positive regulation of transcription, DNA-templated Source: Ensembl
    2. skeletal muscle contraction Source: Ensembl

    Keywords - Molecular functioni

    Muscle protein

    Keywords - Ligandi

    Actin-binding, Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Troponin I, fast skeletal muscle
    Alternative name(s):
    Troponin I, fast-twitch isoform
    Gene namesi
    Name:Tnni2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:105070. Tnni2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: Ensembl
    2. troponin complex Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 182181Troponin I, fast skeletal musclePRO_0000186144Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylglycineBy similarity
    Modified residuei12 – 121PhosphothreonineBy similarity
    Modified residuei118 – 1181PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP13412.
    PRIDEiP13412.

    2D gel databases

    SWISS-2DPAGEP13412.

    PTM databases

    PhosphoSiteiP13412.

    Expressioni

    Gene expression databases

    BgeeiP13412.
    CleanExiMM_TNNI2.
    GenevestigatoriP13412.

    Interactioni

    Subunit structurei

    Binds to actin and tropomyosin.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000033422.

    Structurei

    3D structure databases

    ProteinModelPortaliP13412.
    SMRiP13412. Positions 4-180.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 4847Involved in binding TNCAdd
    BLAST
    Regioni97 – 11721Involved in binding TNC and actinAdd
    BLAST

    Sequence similaritiesi

    Belongs to the troponin I family.Curated

    Phylogenomic databases

    eggNOGiNOG297734.
    GeneTreeiENSGT00390000002746.
    HOGENOMiHOG000293300.
    HOVERGENiHBG052737.
    KOiK12043.
    OrthoDBiEOG71G9WD.
    PhylomeDBiP13412.
    TreeFamiTF313374.

    Family and domain databases

    InterProiIPR001978. Troponin.
    [Graphical view]
    PfamiPF00992. Troponin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P13412-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDEEKRNRA ITARRQHLKS VMLQIAATEL EKEESRRESE KENYLSEHCP    50
    PLHIPGSMSE VQELCKQLHA KIDVAEEEKY DMEVKVQKSS KELEDMNQKL 100
    FDLRGKFKRP PLRRVRMSAD AMLKALLGSK HKVCMDLRAN LKQVKKEDTE 150
    KERDLRDVGD WRKNIEEKSG MEGRKKMFES ES 182
    Length:182
    Mass (Da):21,358
    Last modified:January 23, 2007 - v2
    Checksum:iB09B6657CC85F73C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04992 mRNA. Translation: AAA40485.1.
    AL603651 Genomic DNA. Translation: CAM23286.1.
    BC028515 mRNA. Translation: AAH28515.1.
    CCDSiCCDS40192.1.
    PIRiA44786.
    RefSeqiNP_033431.1. NM_009405.2.
    XP_006508602.1. XM_006508539.1.
    UniGeneiMm.39469.

    Genome annotation databases

    EnsembliENSMUST00000105971; ENSMUSP00000101591; ENSMUSG00000031097.
    ENSMUST00000149529; ENSMUSP00000122733; ENSMUSG00000031097.
    GeneIDi21953.
    KEGGimmu:21953.
    UCSCiuc009kna.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04992 mRNA. Translation: AAA40485.1 .
    AL603651 Genomic DNA. Translation: CAM23286.1 .
    BC028515 mRNA. Translation: AAH28515.1 .
    CCDSi CCDS40192.1.
    PIRi A44786.
    RefSeqi NP_033431.1. NM_009405.2.
    XP_006508602.1. XM_006508539.1.
    UniGenei Mm.39469.

    3D structure databases

    ProteinModelPortali P13412.
    SMRi P13412. Positions 4-180.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000033422.

    PTM databases

    PhosphoSitei P13412.

    2D gel databases

    SWISS-2DPAGE P13412.

    Proteomic databases

    MaxQBi P13412.
    PRIDEi P13412.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000105971 ; ENSMUSP00000101591 ; ENSMUSG00000031097 .
    ENSMUST00000149529 ; ENSMUSP00000122733 ; ENSMUSG00000031097 .
    GeneIDi 21953.
    KEGGi mmu:21953.
    UCSCi uc009kna.1. mouse.

    Organism-specific databases

    CTDi 7136.
    MGIi MGI:105070. Tnni2.

    Phylogenomic databases

    eggNOGi NOG297734.
    GeneTreei ENSGT00390000002746.
    HOGENOMi HOG000293300.
    HOVERGENi HBG052737.
    KOi K12043.
    OrthoDBi EOG71G9WD.
    PhylomeDBi P13412.
    TreeFami TF313374.

    Miscellaneous databases

    ChiTaRSi TNNI2. mouse.
    NextBioi 301624.
    PROi P13412.
    SOURCEi Search...

    Gene expression databases

    Bgeei P13412.
    CleanExi MM_TNNI2.
    Genevestigatori P13412.

    Family and domain databases

    InterProi IPR001978. Troponin.
    [Graphical view ]
    Pfami PF00992. Troponin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA clone and expression analysis of rodent fast and slow skeletal muscle troponin I mRNAs."
      Koppe R.I., Hallauer P.L., Karpati G., Hastings K.E.M.
      J. Biol. Chem. 264:14327-14333(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiTNNI2_MOUSE
    AccessioniPrimary (citable) accession number: P13412
    Secondary accession number(s): A2A6J9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3