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P13406 (FYN_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase Fyn

EC=2.7.10.2
Alternative name(s):
Proto-oncogene c-Fyn
p59-Fyn
Gene names
Name:fyn
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length537 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels By similarity. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by ntn1 by phosphorylating its receptor ddc. Ref.4

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Cofactor

Manganese.

Enzyme regulation

Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site.

Subunit structure

Associates through its SH3 domain, to the p85 subunit of phosphatidylinositol 3-kinase.

Developmental stage

Expressed in early tail-bud embryos at stage 20 in the brain region of the neural tube and at lower levels throughout the remaining length of the neural tube. Present at stage 32 in the forebrain, midbrain, the ventral half of the hindbrain and the spinal cord. Ref.3

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Contains 1 SH3 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 537536Tyrosine-protein kinase Fyn
PRO_0000088101

Regions

Domain82 – 14362SH3
Domain149 – 24698SH2
Domain271 – 524254Protein kinase
Nucleotide binding277 – 2859ATP By similarity

Sites

Active site3901Proton acceptor By similarity
Binding site2991ATP By similarity

Amino acid modifications

Modified residue121Phosphothreonine; by PKC By similarity
Modified residue4201Phosphotyrosine; by autocatalysis By similarity
Modified residue5311Phosphotyrosine By similarity
Lipidation21N-myristoyl glycine By similarity
Lipidation31S-palmitoyl cysteine By similarity
Lipidation61S-palmitoyl cysteine By similarity

Experimental info

Sequence conflict1021S → N in AAH43749. Ref.2
Sequence conflict2231T → A in AAH43749. Ref.2
Sequence conflict3761R → A in AAH43749. Ref.2
Sequence conflict4931I → N in AAH43749. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P13406 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 771E5799682A1326

FASTA53760,846
        10         20         30         40         50         60 
MGCVQCKDKE ATKLTDERDN SLTQSLGYRY GTDPTPQHYP SFTVTTIPNY NNFHATAGQG 

        70         80         90        100        110        120 
LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFQKGEKFQ ILNSSEGDWW 

       130        140        150        160        170        180 
EARSLTTGGT GYIPSNYVAP VDSIQAEEWY FGKLGRKDAE RQLLSFGNPR GTYLIRESET 

       190        200        210        220        230        240 
TKGAYSLSIR DWDDMKGDHV KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC 

       250        260        270        280        290        300 
RLVVPCHKGM PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT 

       310        320        330        340        350        360 
LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMSKGSL LDFLKDGEGR 

       370        380        390        400        410        420 
ALKLPNLVDM AAQVARGMAY IERMNYIHRD LRSANILVGN GLICKIADFG LARLIEDNEY 

       430        440        450        460        470        480 
TARQGAKFPI KWTAPEAALY GRFTIKSDVW SFGILLTELV TKGRVPYPGM NNREVLEQVE 

       490        500        510        520        530 
RGYRMPCPQD CPISLHELML NCWKKDPEER PTFEYLQGFL EDYFTATEPQ YQPGDNL 

« Hide

References

« Hide 'large scale' references
[1]"Structure and expression of fyn genes in Xenopus laevis."
Steele R.E., Deng J.C., Ghosn C.R., Fero J.B.
Oncogene 5:369-376(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.
[3]"Overexpression of Fyn tyrosine kinase causes abnormal development of primary sensory neurons in Xenopus laevis embryos."
Saito R., Fujita N., Nagata S.
Dev. Growth Differ. 43:229-238(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
[4]"Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance."
Meriane M., Tcherkezian J., Webber C.A., Danek E.I., Triki I., McFarlane S., Bloch-Gallego E., Lamarche-Vane N.
J. Cell Biol. 167:687-698(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X52188 Genomic DNA. Translation: CAA36435.1.
M27502 mRNA. Translation: AAA49719.1.
BC043749 mRNA. Translation: AAH43749.1.
PIRA43806.
RefSeqNP_001079077.1. NM_001085608.1.
NP_001080120.1. NM_001086651.1.
UniGeneXl.21919.
Xl.501.

3D structure databases

ProteinModelPortalP13406.
SMRP13406. Positions 84-537.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID373609.
379812.
KEGGxla:373609.
xla:379812.

Organism-specific databases

CTD2534.
XenbaseXB-GENE-6252893. fyn.

Phylogenomic databases

HOVERGENHBG008761.
KOK05703.

Enzyme and pathway databases

BRENDA2.7.10.2. 6726.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFYN_XENLA
AccessionPrimary (citable) accession number: P13406
Secondary accession number(s): Q7ZYK3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families