Reviewed, UniProtKB/Swiss-Prot P13389 (NEU1_SHEEP)

Names and origin

Protein names

Recommended name:
    Oxytocin-neurophysin 1
      Short name=OT-NPI
Cleaved into the following 2 chains:
    1- Recommended name:
            Oxytocin
        Alternative name(s):
            Ocytocin
    2- Recommended name:
            Neurophysin 1

Gene names

Name:

OXT

Organism

Ovis aries (Sheep)

Taxonomic identifier

9940 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Neurophysin 1 specifically binds oxytocin. Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.
Sequence similarities	Belongs to the vasopressin/oxytocin family.

Ontologies

Keywords
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues
Technical term	Direct protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 19	19
	Peptide	20 – 28	9	Oxytocin
	Chain	32 – 125	94	Neurophysin 1
Amino acid modifications
	Modified residue	28	1	Glycine amide
	Disulfide bond	20 ↔ 25
	Disulfide bond	41 ↔ 85		By similarity
	Disulfide bond	44 ↔ 58		By similarity
	Disulfide bond	52 ↔ 75		By similarity
	Disulfide bond	59 ↔ 65		By similarity
	Disulfide bond	92 ↔ 104		By similarity
	Disulfide bond	98 ↔ 116		By similarity
	Disulfide bond	105 ↔ 110		By similarity
Experimental info
	Sequence conflict	48	1	G → A in CAA34184 and CAA34186. Ref.1
	Sequence conflict	110	1	C → S in CAA34184 and CAA34186. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P13389-1 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: 3B4C05141422E432	FASTA	125	12,635
	10 20 30 40 50 60 MAGSSLACCL LGLLALTSAC YIQNCPLGGK RAVLDLDVRT CLPCGPGGKG RCFGPSICCG 70 80 90 100 110 120 DELGCFVGTA EALRCREENY LPSPCQSGQK PCGSGGRCAA AGICCSPDGC HADPACDPEA AFSQH

References

[1]	"Nucleotide sequence of a full length cDNA clone encoding the oxytocin-neurophysin I precursor isolated from the ovine corpus luteum." Jones D.S.C., Flint A.P.F. Nucleic Acids Res. 17:7990-7990(1989) [PubMed: 2798140] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Corpus luteum.
[2]	"Structure and ovarian expression of the oxytocin gene in sheep." Ivell R., Hunt N., Abend N., Brackman B., Nollmeyer D., Lamsa J.C., McCracken J.A. Reprod. Fertil. Dev. 2:703-711(1990) [PubMed: 2095591] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Ovary.
[3]	"Purification and structure of sheep oxytocin and vasopressin." Acher R., Chauvet J., Lenci M.T. C.R. Hebd. Seances Acad. Sci., D, Sci. Nat. 248:1435-1438(1959) Cited for: PROTEIN SEQUENCE OF 20-28.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X16052 mRNA. Translation: CAA34184.1. X16052 mRNA. Translation: CAA34185.1. Sequence problems. X16052 mRNA. Translation: CAA34186.1. Different initiation. X55131 Genomic DNA. Translation: CAA38924.1.
PIR	NFSH1. S06086.
UniGene	Oar.444
3D structure databases
SMR	P13389. Positions 32-123.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P13389.
Family and domain databases
InterPro	IPR000981. Neurhyp_horm. IPR016321. Nonapeptide_hormone_prcur. [Graphical view]
Gene3D	G3DSA:2.60.9.10. Neurhyp_horm. 1 hit.
Pfam	PF00220. Hormone_4. 1 hit. PF00184. Hormone_5. 1 hit. [Graphical view]
PIRSF	PIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTS	PR00831. NEUROPHYSIN.
ProDom	PD001676. Neurhyp_horm. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00003. NH. 1 hit. [Graphical view]
PROSITE	PS00264. NEUROHYPOPHYS_HORM. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
LinkHub	P13389.
ProtoNet	Search...

Entry information

Entry name

NEU1_SHEEP

Accession

Primary (citable) accession number: P13389
Secondary accession number(s): P01188

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	February 1, 1996
Last modified:	July 22, 2008
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)