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P13387

- EGFR_CHICK

UniProt

P13387 - EGFR_CHICK

Protein

Epidermal growth factor receptor

Gene

EGFR

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade.

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Enzyme regulationi

    Endocytosis and inhibition of the activated EGFR by phosphatases constitute immediate regulatory mechanisms. Moreover, inducible feedback inhibitors may constitute alternative regulatory mechanisms for the EGFR signaling.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein tyrosine kinase activity Source: UniProtKB
    3. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular response to epidermal growth factor stimulus Source: UniProtKB
    2. epidermal growth factor receptor signaling pathway Source: UniProtKB
    3. learning or memory Source: UniProtKB
    4. peptidyl-tyrosine phosphorylation Source: GOC

    Keywords - Molecular functioni

    Kinase, Receptor, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_189756. PLCG1 events in ERBB2 signaling.
    REACT_189763. Signaling by ERBB2.
    REACT_194392. GRB2 events in ERBB2 signaling.
    REACT_194394. Signaling by ERBB4.
    REACT_194410. SHC1 events in ERBB2 signaling.
    REACT_196285. EGFR Transactivation by Gastrin.
    REACT_196849. PI3K events in ERBB2 signaling.
    REACT_197116. Signaling by constitutively active EGFR.
    REACT_198076. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_216353. EGFR downregulation.
    REACT_217737. GAB1 signalosome.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Epidermal growth factor receptor (EC:2.7.10.1)
    Short name:
    CER
    Gene namesi
    Name:EGFR
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity. Golgi apparatus membrane By similarity; Single-pass type I membrane protein By similarity. Nucleus membrane By similarity; Single-pass type I membrane protein By similarity. Endosome. Endosome membrane. Nucleus By similarity
    Note: In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER. Endocytosed upon activation by ligand By similarity.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. endosome membrane Source: UniProtKB-SubCell
    3. Golgi membrane Source: UniProtKB-SubCell
    4. integral component of membrane Source: UniProtKB-KW
    5. nuclear membrane Source: UniProtKB-SubCell
    6. nucleus Source: UniProtKB
    7. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Add
    BLAST
    Chaini31 – ›703›673Epidermal growth factor receptorPRO_0000016667Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi197 ↔ 206By similarity
    Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi201 ↔ 214By similarity
    Disulfide bondi222 ↔ 230By similarity
    Disulfide bondi226 ↔ 238By similarity
    Disulfide bondi239 ↔ 247By similarity
    Disulfide bondi243 ↔ 255By similarity
    Disulfide bondi258 ↔ 267By similarity
    Disulfide bondi271 ↔ 298By similarity
    Disulfide bondi302 ↔ 314By similarity
    Disulfide bondi318 ↔ 333By similarity
    Disulfide bondi336 ↔ 340By similarity
    Glycosylationi359 – 3591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi420 – 4201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi513 ↔ 522By similarity
    Disulfide bondi517 ↔ 530By similarity
    Disulfide bondi533 ↔ 542By similarity
    Disulfide bondi546 ↔ 562By similarity
    Disulfide bondi565 ↔ 581By similarity
    Disulfide bondi569 ↔ 589By similarity
    Glycosylationi573 – 5731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi578 – 5781N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi592 ↔ 601By similarity
    Disulfide bondi605 ↔ 627By similarity
    Glycosylationi613 – 6131N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi630 ↔ 638By similarity
    Glycosylationi633 – 6331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi634 ↔ 646By similarity
    Glycosylationi648 – 6481N-linked (GlcNAc...)Sequence Analysis
    Modified residuei687 – 6871PhosphothreonineBy similarity
    Modified residuei702 – 7021PhosphothreonineBy similarity

    Post-translational modificationi

    Phosphorylated. Autophosphorylates By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP13387.

    Interactioni

    Subunit structurei

    Binding of the ligand triggers homo- and/or heterodimerization of the receptor triggering its autophosphorylation.By similarity

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000020165.

    Structurei

    3D structure databases

    ProteinModelPortaliP13387.
    SMRiP13387. Positions 31-530, 678-703.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 654624ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini668 – ›703›36CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei655 – 66713HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000230982.
    HOVERGENiHBG000490.
    KOiK04361.
    PhylomeDBiP13387.

    Family and domain databases

    Gene3Di3.80.20.20. 2 hits.
    InterProiIPR000494. EGF_rcpt_L.
    IPR006211. Furin-like_Cys-rich_dom.
    IPR006212. Furin_repeat.
    IPR009030. Growth_fac_rcpt_N_dom.
    [Graphical view]
    PfamiPF00757. Furin-like. 1 hit.
    PF01030. Recep_L_domain. 2 hits.
    [Graphical view]
    SMARTiSM00261. FU. 5 hits.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 2 hits.

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P13387-1 [UniParc]FASTAAdd to Basket

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    MGVRSPLSAS GPRGAAVLVL LLLGVALCSA VEEKKVCQGT NNKLTQLGHV    50
    EDHFTSLQRM YNNCEVVLSN LEITYVEHNR DLTFLKTIQE VAGYVLIALN 100
    MVDVIPLENL QIIRGNVLYD NSFALAVLSN YHMNKTQGLR ELPMKRLSEI 150
    LNGGVKISNN PKLCNMDTVL WNDIIDTSRK PLTVLDFASN LSSCPKCHPN 200
    CTEDHCWGAG EQNCQTLTKV ICAQQCSGRC RGKVPSDCCH NQCAAGCTGP 250
    RESDCLACRK FRDDATCKDT CPPLVLYNPT TYQMDVNPEG KYSFGATCVR 300
    ECPHNYVVTD HGSCVRSCNT DTYEVEENGV RKCKKCDGLC SKVCNGIGIG 350
    ELKGILSINA TNIDSFKNCT KINGDVSILP VAFLGDAFTK TLPLDPKKLD 400
    VFRTVKEISG FLLIQAWPDN ATDLYAFENL EIIRGRTKQH GQYSLAVVNL 450
    KIQSLGLRSL KEISDGDIAI MKNKNLCYAD TMNWRSLFAT QSQKTKIIQN 500
    RNKNDCTADR HVCDPLCSDV GCWGPGPFHC FSCRFFSRQK ECVKQCNILQ 550
    GEPREFERDS KCLPCHSECL VQNSTAYNTT CSGPGPDHCM KCAHFIDGPH 600
    CVKACPAGVL GENDTLVWKY ADANAVCQLC HPNCTRGCKG PGLEGCPNGS 650
    KTPSIAAGVV GGLLCLVVVG LGIGLYLRRR HIVRKRTLRR LLQERELVEP 700
    LTP 703
    Length:703
    Mass (Da):77,427
    Last modified:January 1, 1990 - v1
    Checksum:iAFF2DE11B735A690
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei703 – 7031

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M20386 mRNA. Translation: AAA48760.1.
    RefSeqiNP_990828.2. NM_205497.2.
    UniGeneiGga.35024.

    Genome annotation databases

    GeneIDi396494.
    KEGGigga:396494.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M20386 mRNA. Translation: AAA48760.1 .
    RefSeqi NP_990828.2. NM_205497.2.
    UniGenei Gga.35024.

    3D structure databases

    ProteinModelPortali P13387.
    SMRi P13387. Positions 31-530, 678-703.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000020165.

    Proteomic databases

    PaxDbi P13387.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396494.
    KEGGi gga:396494.

    Organism-specific databases

    CTDi 1956.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000230982.
    HOVERGENi HBG000490.
    KOi K04361.
    PhylomeDBi P13387.

    Enzyme and pathway databases

    Reactomei REACT_189756. PLCG1 events in ERBB2 signaling.
    REACT_189763. Signaling by ERBB2.
    REACT_194392. GRB2 events in ERBB2 signaling.
    REACT_194394. Signaling by ERBB4.
    REACT_194410. SHC1 events in ERBB2 signaling.
    REACT_196285. EGFR Transactivation by Gastrin.
    REACT_196849. PI3K events in ERBB2 signaling.
    REACT_197116. Signaling by constitutively active EGFR.
    REACT_198076. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_216353. EGFR downregulation.
    REACT_217737. GAB1 signalosome.

    Miscellaneous databases

    NextBioi 20816533.

    Family and domain databases

    Gene3Di 3.80.20.20. 2 hits.
    InterProi IPR000494. EGF_rcpt_L.
    IPR006211. Furin-like_Cys-rich_dom.
    IPR006212. Furin_repeat.
    IPR009030. Growth_fac_rcpt_N_dom.
    [Graphical view ]
    Pfami PF00757. Furin-like. 1 hit.
    PF01030. Recep_L_domain. 2 hits.
    [Graphical view ]
    SMARTi SM00261. FU. 5 hits.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha."
      Lax I., Johnson A., Howk R., Sap J., Bellot F., Winkler M., Ullrich A., Vennstrom B., Schlessinger J., Givol D.
      Mol. Cell. Biol. 8:1970-1978(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiEGFR_CHICK
    AccessioniPrimary (citable) accession number: P13387
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3