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P13387

- EGFR_CHICK

UniProt

P13387 - EGFR_CHICK

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Protein
Epidermal growth factor receptor
Gene
EGFR
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme regulationi

Endocytosis and inhibition of the activated EGFR by phosphatases constitute immediate regulatory mechanisms. Moreover, inducible feedback inhibitors may constitute alternative regulatory mechanisms for the EGFR signaling.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein tyrosine kinase activity Source: UniProtKB
  3. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellular response to epidermal growth factor stimulus Source: UniProtKB
  2. epidermal growth factor receptor signaling pathway Source: UniProtKB
  3. learning or memory Source: UniProtKB
  4. peptidyl-tyrosine phosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_189756. PLCG1 events in ERBB2 signaling.
REACT_189763. Signaling by ERBB2.
REACT_194392. GRB2 events in ERBB2 signaling.
REACT_194394. Signaling by ERBB4.
REACT_194410. SHC1 events in ERBB2 signaling.
REACT_196285. EGFR Transactivation by Gastrin.
REACT_196849. PI3K events in ERBB2 signaling.
REACT_197116. Signaling by constitutively active EGFR.
REACT_198076. Constitutive PI3K/AKT Signaling in Cancer.
REACT_216353. EGFR downregulation.
REACT_217737. GAB1 signalosome.

Names & Taxonomyi

Protein namesi
Recommended name:
Epidermal growth factor receptor (EC:2.7.10.1)
Short name:
CER
Gene namesi
Name:EGFR
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity. Golgi apparatus membrane; Single-pass type I membrane protein By similarity. Nucleus membrane; Single-pass type I membrane protein By similarity. Endosome. Endosome membrane. Nucleus By similarity
Note: In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER. Endocytosed upon activation by ligand By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 654624Extracellular Reviewed prediction
Add
BLAST
Transmembranei655 – 66713Helical; Reviewed prediction
Add
BLAST
Topological domaini668 – ›703›36Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. endosome membrane Source: UniProtKB-SubCell
  4. integral component of membrane Source: UniProtKB-KW
  5. nuclear membrane Source: UniProtKB-SubCell
  6. nucleus Source: UniProtKB
  7. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030
Add
BLAST
Chaini31 – ›703›673Epidermal growth factor receptor
PRO_0000016667Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi134 – 1341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi190 – 1901N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi197 ↔ 206 By similarity
Glycosylationi200 – 2001N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi201 ↔ 214 By similarity
Disulfide bondi222 ↔ 230 By similarity
Disulfide bondi226 ↔ 238 By similarity
Disulfide bondi239 ↔ 247 By similarity
Disulfide bondi243 ↔ 255 By similarity
Disulfide bondi258 ↔ 267 By similarity
Disulfide bondi271 ↔ 298 By similarity
Disulfide bondi302 ↔ 314 By similarity
Disulfide bondi318 ↔ 333 By similarity
Disulfide bondi336 ↔ 340 By similarity
Glycosylationi359 – 3591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi368 – 3681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi420 – 4201N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi513 ↔ 522 By similarity
Disulfide bondi517 ↔ 530 By similarity
Disulfide bondi533 ↔ 542 By similarity
Disulfide bondi546 ↔ 562 By similarity
Disulfide bondi565 ↔ 581 By similarity
Disulfide bondi569 ↔ 589 By similarity
Glycosylationi573 – 5731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi578 – 5781N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi592 ↔ 601 By similarity
Disulfide bondi605 ↔ 627 By similarity
Glycosylationi613 – 6131N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi630 ↔ 638 By similarity
Glycosylationi633 – 6331N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi634 ↔ 646 By similarity
Glycosylationi648 – 6481N-linked (GlcNAc...) Reviewed prediction
Modified residuei687 – 6871Phosphothreonine By similarity
Modified residuei702 – 7021Phosphothreonine By similarity

Post-translational modificationi

Phosphorylated. Autophosphorylates By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP13387.

Interactioni

Subunit structurei

Binding of the ligand triggers homo- and/or heterodimerization of the receptor triggering its autophosphorylation By similarity.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020165.

Structurei

3D structure databases

ProteinModelPortaliP13387.
SMRiP13387. Positions 31-530, 678-703.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000230982.
HOVERGENiHBG000490.
KOiK04361.
PhylomeDBiP13387.

Family and domain databases

Gene3Di3.80.20.20. 2 hits.
InterProiIPR000494. EGF_rcpt_L.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
SMARTiSM00261. FU. 5 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13387-1 [UniParc]FASTAAdd to Basket

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MGVRSPLSAS GPRGAAVLVL LLLGVALCSA VEEKKVCQGT NNKLTQLGHV    50
EDHFTSLQRM YNNCEVVLSN LEITYVEHNR DLTFLKTIQE VAGYVLIALN 100
MVDVIPLENL QIIRGNVLYD NSFALAVLSN YHMNKTQGLR ELPMKRLSEI 150
LNGGVKISNN PKLCNMDTVL WNDIIDTSRK PLTVLDFASN LSSCPKCHPN 200
CTEDHCWGAG EQNCQTLTKV ICAQQCSGRC RGKVPSDCCH NQCAAGCTGP 250
RESDCLACRK FRDDATCKDT CPPLVLYNPT TYQMDVNPEG KYSFGATCVR 300
ECPHNYVVTD HGSCVRSCNT DTYEVEENGV RKCKKCDGLC SKVCNGIGIG 350
ELKGILSINA TNIDSFKNCT KINGDVSILP VAFLGDAFTK TLPLDPKKLD 400
VFRTVKEISG FLLIQAWPDN ATDLYAFENL EIIRGRTKQH GQYSLAVVNL 450
KIQSLGLRSL KEISDGDIAI MKNKNLCYAD TMNWRSLFAT QSQKTKIIQN 500
RNKNDCTADR HVCDPLCSDV GCWGPGPFHC FSCRFFSRQK ECVKQCNILQ 550
GEPREFERDS KCLPCHSECL VQNSTAYNTT CSGPGPDHCM KCAHFIDGPH 600
CVKACPAGVL GENDTLVWKY ADANAVCQLC HPNCTRGCKG PGLEGCPNGS 650
KTPSIAAGVV GGLLCLVVVG LGIGLYLRRR HIVRKRTLRR LLQERELVEP 700
LTP 703
Length:703
Mass (Da):77,427
Last modified:January 1, 1990 - v1
Checksum:iAFF2DE11B735A690
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei703 – 7031

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M20386 mRNA. Translation: AAA48760.1.
RefSeqiNP_990828.2. NM_205497.2.
UniGeneiGga.35024.

Genome annotation databases

GeneIDi396494.
KEGGigga:396494.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M20386 mRNA. Translation: AAA48760.1 .
RefSeqi NP_990828.2. NM_205497.2.
UniGenei Gga.35024.

3D structure databases

ProteinModelPortali P13387.
SMRi P13387. Positions 31-530, 678-703.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000020165.

Proteomic databases

PaxDbi P13387.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396494.
KEGGi gga:396494.

Organism-specific databases

CTDi 1956.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000230982.
HOVERGENi HBG000490.
KOi K04361.
PhylomeDBi P13387.

Enzyme and pathway databases

Reactomei REACT_189756. PLCG1 events in ERBB2 signaling.
REACT_189763. Signaling by ERBB2.
REACT_194392. GRB2 events in ERBB2 signaling.
REACT_194394. Signaling by ERBB4.
REACT_194410. SHC1 events in ERBB2 signaling.
REACT_196285. EGFR Transactivation by Gastrin.
REACT_196849. PI3K events in ERBB2 signaling.
REACT_197116. Signaling by constitutively active EGFR.
REACT_198076. Constitutive PI3K/AKT Signaling in Cancer.
REACT_216353. EGFR downregulation.
REACT_217737. GAB1 signalosome.

Miscellaneous databases

NextBioi 20816533.

Family and domain databases

Gene3Di 3.80.20.20. 2 hits.
InterProi IPR000494. EGF_rcpt_L.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view ]
Pfami PF00757. Furin-like. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view ]
SMARTi SM00261. FU. 5 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha."
    Lax I., Johnson A., Howk R., Sap J., Bellot F., Winkler M., Ullrich A., Vennstrom B., Schlessinger J., Givol D.
    Mol. Cell. Biol. 8:1970-1978(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiEGFR_CHICK
AccessioniPrimary (citable) accession number: P13387
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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