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Protein

Epidermal growth factor receptor

Gene

EGFR

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:3260329). Known ligands include EGF and TGFA/TGF-alpha (PubMed:3260329). Ligand binding triggers receptor homo-and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (By similarity). May also activate the NF-kappa-B signaling cascade (By similarity).By similarity1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Enzyme regulationi

Endocytosis and inhibition of the activated EGFR by phosphatases constitute immediate regulatory mechanisms. Moreover, inducible feedback inhibitors may constitute alternative regulatory mechanisms for the EGFR signaling.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Receptor, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Epidermal growth factor receptor (EC:2.7.10.1)
Short name:
CER
Gene namesi
Name:EGFR
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 654ExtracellularSequence analysisAdd BLAST624
Transmembranei655 – 667HelicalSequence analysisAdd BLAST13
Topological domaini668 – ›703CytoplasmicSequence analysisAdd BLAST›36

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30By similarityAdd BLAST30
ChainiPRO_000001666731 – ›703Epidermal growth factor receptorAdd BLAST›673

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 64By similarity
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi164 ↔ 194By similarity
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi197 ↔ 206By similarity
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi201 ↔ 214By similarity
Disulfide bondi222 ↔ 230By similarity
Disulfide bondi226 ↔ 238By similarity
Disulfide bondi239 ↔ 247By similarity
Disulfide bondi243 ↔ 255By similarity
Disulfide bondi258 ↔ 267By similarity
Disulfide bondi271 ↔ 298By similarity
Disulfide bondi302 ↔ 314By similarity
Disulfide bondi318 ↔ 333By similarity
Disulfide bondi336 ↔ 340By similarity
Disulfide bondi344 ↔ 369By similarity
Glycosylationi359N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi420N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi477 ↔ 506By similarity
Disulfide bondi513 ↔ 522By similarity
Disulfide bondi517 ↔ 530By similarity
Disulfide bondi533 ↔ 542By similarity
Disulfide bondi546 ↔ 562By similarity
Disulfide bondi565 ↔ 581By similarity
Disulfide bondi569 ↔ 589By similarity
Glycosylationi573N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi578N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi592 ↔ 601By similarity
Disulfide bondi605 ↔ 627By similarity
Glycosylationi613N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi630 ↔ 638By similarity
Glycosylationi633N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi634 ↔ 646By similarity
Glycosylationi648N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei687PhosphothreonineBy similarity1
Modified residuei702PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated. Autophosphorylates.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP13387
PRIDEiP13387

PTM databases

iPTMnetiP13387

Expressioni

Gene expression databases

BgeeiENSGALG00000012363

Interactioni

Subunit structurei

Binding of the ligand triggers homo- and/or heterodimerization of the receptor triggering its autophosphorylation.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020165

Structurei

3D structure databases

ProteinModelPortaliP13387
SMRiP13387
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1025 Eukaryota
ENOG410XNSR LUCA
HOGENOMiHOG000230982
HOVERGENiHBG000490
InParanoidiP13387
KOiK04361
PhylomeDBiP13387

Family and domain databases

Gene3Di3.80.20.20, 2 hits
InterProiView protein in InterPro
IPR006211 Furin-like_Cys-rich_dom
IPR006212 Furin_repeat
IPR032778 GF_recep_IV
IPR009030 Growth_fac_rcpt_cys_sf
IPR000494 Rcpt_L-dom
IPR036941 Rcpt_L-dom_sf
PfamiView protein in Pfam
PF00757 Furin-like, 1 hit
PF14843 GF_recep_IV, 1 hit
PF01030 Recep_L_domain, 2 hits
SMARTiView protein in SMART
SM00261 FU, 5 hits
SUPFAMiSSF57184 SSF57184, 2 hits

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13387-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVRSPLSAS GPRGAAVLVL LLLGVALCSA VEEKKVCQGT NNKLTQLGHV
60 70 80 90 100
EDHFTSLQRM YNNCEVVLSN LEITYVEHNR DLTFLKTIQE VAGYVLIALN
110 120 130 140 150
MVDVIPLENL QIIRGNVLYD NSFALAVLSN YHMNKTQGLR ELPMKRLSEI
160 170 180 190 200
LNGGVKISNN PKLCNMDTVL WNDIIDTSRK PLTVLDFASN LSSCPKCHPN
210 220 230 240 250
CTEDHCWGAG EQNCQTLTKV ICAQQCSGRC RGKVPSDCCH NQCAAGCTGP
260 270 280 290 300
RESDCLACRK FRDDATCKDT CPPLVLYNPT TYQMDVNPEG KYSFGATCVR
310 320 330 340 350
ECPHNYVVTD HGSCVRSCNT DTYEVEENGV RKCKKCDGLC SKVCNGIGIG
360 370 380 390 400
ELKGILSINA TNIDSFKNCT KINGDVSILP VAFLGDAFTK TLPLDPKKLD
410 420 430 440 450
VFRTVKEISG FLLIQAWPDN ATDLYAFENL EIIRGRTKQH GQYSLAVVNL
460 470 480 490 500
KIQSLGLRSL KEISDGDIAI MKNKNLCYAD TMNWRSLFAT QSQKTKIIQN
510 520 530 540 550
RNKNDCTADR HVCDPLCSDV GCWGPGPFHC FSCRFFSRQK ECVKQCNILQ
560 570 580 590 600
GEPREFERDS KCLPCHSECL VQNSTAYNTT CSGPGPDHCM KCAHFIDGPH
610 620 630 640 650
CVKACPAGVL GENDTLVWKY ADANAVCQLC HPNCTRGCKG PGLEGCPNGS
660 670 680 690 700
KTPSIAAGVV GGLLCLVVVG LGIGLYLRRR HIVRKRTLRR LLQERELVEP

LTP
Length:703
Mass (Da):77,427
Last modified:January 1, 1990 - v1
Checksum:iAFF2DE11B735A690
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei7031

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20386 mRNA Translation: AAA48760.1
RefSeqiNP_990828.2, NM_205497.2
UniGeneiGga.35024

Genome annotation databases

GeneIDi396494
KEGGigga:396494

Similar proteinsi

Entry informationi

Entry nameiEGFR_CHICK
AccessioniPrimary (citable) accession number: P13387
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: April 25, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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