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P13385

- TDGF1_HUMAN

UniProt

P13385 - TDGF1_HUMAN

Protein

Teratocarcinoma-derived growth factor 1

Gene

TDGF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.1 Publication

    GO - Molecular functioni

    1. growth factor activity Source: UniProtKB
    2. protein binding Source: HGNC
    3. receptor binding Source: UniProtKB

    GO - Biological processi

    1. activation of MAPK activity Source: UniProtKB
    2. anterior/posterior axis specification, embryo Source: UniProtKB
    3. BMP signaling pathway Source: Ensembl
    4. canonical Wnt signaling pathway Source: Ensembl
    5. cardiac muscle cell differentiation Source: Ensembl
    6. cell differentiation Source: UniProtKB
    7. cell migration involved in sprouting angiogenesis Source: UniProtKB
    8. cellular response to epidermal growth factor stimulus Source: UniProtKB
    9. cellular response to fibroblast growth factor stimulus Source: UniProtKB
    10. cellular response to hepatocyte growth factor stimulus Source: UniProtKB
    11. cellular response to interferon-gamma Source: UniProtKB
    12. cellular response to interleukin-6 Source: UniProtKB
    13. cellular response to tumor necrosis factor Source: UniProtKB
    14. embryo development Source: UniProtKB
    15. gastrulation Source: Ensembl
    16. heart development Source: UniProtKB
    17. in utero embryonic development Source: Ensembl
    18. mammary gland development Source: UniProtKB
    19. morphogenesis of a branching structure Source: UniProtKB
    20. negative regulation of apoptotic process Source: UniProtKB
    21. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    22. peptidyl-serine phosphorylation Source: UniProtKB
    23. positive regulation of cell-matrix adhesion Source: Ensembl
    24. positive regulation of cell migration Source: UniProtKB
    25. positive regulation of cell proliferation Source: UniProtKB
    26. positive regulation of endothelial cell migration Source: UniProtKB
    27. positive regulation of fibroblast proliferation Source: Ensembl
    28. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
    29. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    30. regulation of signal transduction Source: UniProtKB
    31. vasculogenesis Source: Ensembl

    Keywords - Molecular functioni

    Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_111057. Signaling by NODAL.
    REACT_111059. Regulation of signaling by NODAL.
    REACT_200759. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Teratocarcinoma-derived growth factor 1
    Alternative name(s):
    Cripto-1 growth factor
    Short name:
    CRGF
    Epidermal growth factor-like cripto protein CR1
    Gene namesi
    Name:TDGF1
    Synonyms:CRIPTO
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:11701. TDGF1.

    Subcellular locationi

    Cell membrane 1 Publication; Lipid-anchorGPI-anchor 1 Publication

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. apical plasma membrane Source: UniProtKB
    3. cell surface Source: UniProtKB
    4. extracellular space Source: UniProtKB
    5. extrinsic component of plasma membrane Source: UniProtKB
    6. Golgi apparatus Source: Ensembl
    7. membrane raft Source: UniProtKB
    8. nucleus Source: Ensembl
    9. perinuclear region of cytoplasm Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi188 – 1881Y → YVVVVV: Alters the localization and decreases the biological activity. 1 Publication

    Organism-specific databases

    MIMi187395. gene+phenotype.
    Orphaneti93925. Alobar holoprosencephaly.
    93924. Lobar holoprosencephaly.
    280200. Microform holoprosencephaly.
    93926. Midline interhemispheric variant of holoprosencephaly.
    220386. Semilobar holoprosencephaly.
    280195. Septopreoptic holoprosencephaly.
    PharmGKBiPA36420.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 30301 PublicationAdd
    BLAST
    Chaini31 – 150120Teratocarcinoma-derived growth factor 1PRO_0000007503Add
    BLAST
    Propeptidei151 – 18838Removed in mature formPRO_0000395410Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi82 ↔ 89PROSITE-ProRule annotation
    Disulfide bondi83 ↔ 95PROSITE-ProRule annotation
    Disulfide bondi97 ↔ 106PROSITE-ProRule annotation
    Disulfide bondi115 ↔ 1331 PublicationPROSITE-ProRule annotation
    Disulfide bondi128 ↔ 1491 PublicationPROSITE-ProRule annotation
    Disulfide bondi131 ↔ 1401 PublicationPROSITE-ProRule annotation
    Lipidationi150 – 1501GPI-anchor amidated aspartate1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiP13385.
    PRIDEiP13385.

    Expressioni

    Tissue specificityi

    Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.1 Publication

    Gene expression databases

    ArrayExpressiP13385.
    BgeeiP13385.
    CleanExiHS_TDGF1.
    GenevestigatoriP13385.

    Interactioni

    Subunit structurei

    Interacts with the activin type-1 receptor ACVR1B.1 Publication

    Protein-protein interaction databases

    BioGridi112856. 9 interactions.
    IntActiP13385. 9 interactions.
    MINTiMINT-1386411.
    STRINGi9606.ENSP00000296145.

    Structurei

    3D structure databases

    ProteinModelPortaliP13385.
    SMRiP13385. Positions 82-107, 112-150.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini78 – 10730EGF-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 EGF-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Signal

    Phylogenomic databases

    eggNOGiNOG320031.
    HOGENOMiHOG000145523.
    HOVERGENiHBG054705.
    InParanoidiP13385.
    OMAiMDCRKMA.
    OrthoDBiEOG76X61G.
    PhylomeDBiP13385.
    TreeFamiTF333187.

    Family and domain databases

    InterProiIPR017047. Cripto_growth_factor.
    IPR019011. Cryptic/Cripto_CFC-dom.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    [Graphical view]
    PfamiPF09443. CFC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036301. Cripto_growth_factor. 1 hit.
    SMARTiSM00181. EGF. 1 hit.
    [Graphical view]
    PROSITEiPS00022. EGF_1. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P13385-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDCRKMARFS YSVIWIMAIS KVFELGLVAG LGHQEFARPS RGYLAFRDDS    50
    IWPQEEPAIR PRSSQRVPPM GIQHSKELNR TCCLNGGTCM LGSFCACPPS 100
    FYGRNCEHDV RKENCGSVPH DTWLPKKCSL CKCWHGQLRC FPQAFLPGCD 150
    GLVMDEHLVA SRTPELPPSA RTTTFMLVGI CLSIQSYY 188
    Length:188
    Mass (Da):21,169
    Last modified:January 1, 1990 - v1
    Checksum:iAEE8727D0F27D886
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti22 – 221V → A.2 Publications
    Corresponds to variant rs11130097 [ dbSNP | Ensembl ].
    VAR_024262
    Natural varianti43 – 431Y → D.
    Corresponds to variant rs2293025 [ dbSNP | Ensembl ].
    VAR_021903
    Natural varianti111 – 1111R → G.
    Corresponds to variant rs34501971 [ dbSNP | Ensembl ].
    VAR_048975

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14253 mRNA. Translation: CAA32467.1.
    M96955 Genomic DNA. Translation: AAA61134.1.
    AC104304 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW64773.1.
    BC022393 mRNA. Translation: AAH22393.1.
    BC067844 mRNA. Translation: AAH67844.1.
    CCDSiCCDS2742.1.
    PIRiB39787. A30362.
    RefSeqiNP_001167607.1. NM_001174136.1.
    NP_003203.1. NM_003212.3.
    UniGeneiHs.385870.

    Genome annotation databases

    EnsembliENST00000296145; ENSP00000296145; ENSG00000241186.
    GeneIDi6997.
    KEGGihsa:6997.
    UCSCiuc003cpv.3. human.

    Polymorphism databases

    DMDMi117473.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14253 mRNA. Translation: CAA32467.1 .
    M96955 Genomic DNA. Translation: AAA61134.1 .
    AC104304 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW64773.1 .
    BC022393 mRNA. Translation: AAH22393.1 .
    BC067844 mRNA. Translation: AAH67844.1 .
    CCDSi CCDS2742.1.
    PIRi B39787. A30362.
    RefSeqi NP_001167607.1. NM_001174136.1.
    NP_003203.1. NM_003212.3.
    UniGenei Hs.385870.

    3D structure databases

    ProteinModelPortali P13385.
    SMRi P13385. Positions 82-107, 112-150.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112856. 9 interactions.
    IntActi P13385. 9 interactions.
    MINTi MINT-1386411.
    STRINGi 9606.ENSP00000296145.

    Polymorphism databases

    DMDMi 117473.

    Proteomic databases

    PaxDbi P13385.
    PRIDEi P13385.

    Protocols and materials databases

    DNASUi 6997.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296145 ; ENSP00000296145 ; ENSG00000241186 .
    GeneIDi 6997.
    KEGGi hsa:6997.
    UCSCi uc003cpv.3. human.

    Organism-specific databases

    CTDi 6997.
    GeneCardsi GC03P046616.
    HGNCi HGNC:11701. TDGF1.
    MIMi 187395. gene+phenotype.
    neXtProti NX_P13385.
    Orphaneti 93925. Alobar holoprosencephaly.
    93924. Lobar holoprosencephaly.
    280200. Microform holoprosencephaly.
    93926. Midline interhemispheric variant of holoprosencephaly.
    220386. Semilobar holoprosencephaly.
    280195. Septopreoptic holoprosencephaly.
    PharmGKBi PA36420.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG320031.
    HOGENOMi HOG000145523.
    HOVERGENi HBG054705.
    InParanoidi P13385.
    OMAi MDCRKMA.
    OrthoDBi EOG76X61G.
    PhylomeDBi P13385.
    TreeFami TF333187.

    Enzyme and pathway databases

    Reactomei REACT_111057. Signaling by NODAL.
    REACT_111059. Regulation of signaling by NODAL.
    REACT_200759. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.

    Miscellaneous databases

    ChiTaRSi TDGF1. human.
    GeneWikii Teratocarcinoma-derived_growth_factor_1.
    GenomeRNAii 6997.
    NextBioi 27331.
    PROi P13385.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P13385.
    Bgeei P13385.
    CleanExi HS_TDGF1.
    Genevestigatori P13385.

    Family and domain databases

    InterProi IPR017047. Cripto_growth_factor.
    IPR019011. Cryptic/Cripto_CFC-dom.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    [Graphical view ]
    Pfami PF09443. CFC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036301. Cripto_growth_factor. 1 hit.
    SMARTi SM00181. EGF. 1 hit.
    [Graphical view ]
    PROSITEi PS00022. EGF_1. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells."
      Ciccodicola A., Dono R., Obici S., Zollo M., Persico M.G.
      EMBO J. 8:1987-1991(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Isolation and characterization of the CRIPTO autosomal gene and its X-linked related sequence."
      Dono R., Montuori N., Rocchi M., de Ponti-Zilli L., Ciccodicola A., Persico M.G.
      Am. J. Hum. Genet. 49:555-565(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-22.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-22.
      Tissue: Brain and Kidney.
    6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 31-45.
    7. "Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells."
      Bianco C., Adkins H.B., Wechselberger C., Seno M., Normanno N., De Luca A., Sun Y., Khan N., Kenney N., Ebert A., Williams K.P., Sanicola M., Salomon D.S.
      Mol. Cell. Biol. 22:2586-2597(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ACVR1B, FUNCTION.
    8. Cited for: DISULFIDE BONDS.
    9. "Characterization of the glycosylphosphatidylinositol-anchor signal sequence of human Cryptic with a hydrophilic extension."
      Watanabe K., Nagaoka T., Strizzi L., Mancino M., Gonzales M., Bianco C., Salomon D.S.
      Biochim. Biophys. Acta 1778:2671-2681(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, GPI-ANCHOR AT ASP-150, MUTAGENESIS OF TYR-188.
    10. Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiTDGF1_HUMAN
    AccessioniPrimary (citable) accession number: P13385
    Secondary accession number(s): Q8TCC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3