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Protein

Teratocarcinoma-derived growth factor 1

Gene

TDGF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.1 Publication

GO - Molecular functioni

  • growth factor activity Source: UniProtKB
  • receptor binding Source: UniProtKB

GO - Biological processi

  • activation of MAPK activity Source: UniProtKB
  • anterior/posterior axis specification, embryo Source: UniProtKB
  • cell differentiation Source: UniProtKB
  • cell migration involved in sprouting angiogenesis Source: UniProtKB
  • cellular response to epidermal growth factor stimulus Source: UniProtKB
  • cellular response to fibroblast growth factor stimulus Source: UniProtKB
  • cellular response to hepatocyte growth factor stimulus Source: UniProtKB
  • cellular response to interferon-gamma Source: UniProtKB
  • cellular response to interleukin-6 Source: UniProtKB
  • cellular response to tumor necrosis factor Source: UniProtKB
  • embryo development Source: UniProtKB
  • heart development Source: UniProtKB
  • mammary gland development Source: UniProtKB
  • morphogenesis of a branching structure Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • peptidyl-serine phosphorylation Source: UniProtKB
  • positive regulation of cell migration Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of endothelial cell migration Source: UniProtKB
  • positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
  • regulation of signal transduction Source: UniProtKB
  • somatic stem cell population maintenance Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-HSA-1181150. Signaling by NODAL.
R-HSA-1433617. Regulation of signaling by NODAL.
R-HSA-2892247. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.
SIGNORiP13385.

Names & Taxonomyi

Protein namesi
Recommended name:
Teratocarcinoma-derived growth factor 1
Alternative name(s):
Cripto-1 growth factor
Short name:
CRGF
Epidermal growth factor-like cripto protein CR1
Gene namesi
Name:TDGF1
Synonyms:CRIPTO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:11701. TDGF1.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • apical plasma membrane Source: UniProtKB
  • cell surface Source: UniProtKB
  • extracellular space Source: UniProtKB
  • extrinsic component of plasma membrane Source: UniProtKB
  • membrane raft Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi188Y → YVVVVV: Alters the localization and decreases the biological activity. 1 Publication1

Organism-specific databases

DisGeNETi6997.
MalaCardsiTDGF1.
MIMi187395. gene+phenotype.
OpenTargetsiENSG00000241186.
Orphaneti93925. Alobar holoprosencephaly.
93924. Lobar holoprosencephaly.
280200. Microform holoprosencephaly.
93926. Midline interhemispheric variant of holoprosencephaly.
220386. Semilobar holoprosencephaly.
280195. Septopreoptic holoprosencephaly.
PharmGKBiPA36420.

Polymorphism and mutation databases

BioMutaiTDGF1.
DMDMi117473.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 301 PublicationAdd BLAST30
ChainiPRO_000000750331 – 150Teratocarcinoma-derived growth factor 1Add BLAST120
PropeptideiPRO_0000395410151 – 188Removed in mature formAdd BLAST38

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi82 ↔ 89PROSITE-ProRule annotation
Disulfide bondi83 ↔ 95PROSITE-ProRule annotation
Disulfide bondi97 ↔ 106PROSITE-ProRule annotation
Disulfide bondi115 ↔ 133PROSITE-ProRule annotation1 Publication
Disulfide bondi128 ↔ 149PROSITE-ProRule annotation1 Publication
Disulfide bondi131 ↔ 140PROSITE-ProRule annotation1 Publication
Lipidationi150GPI-anchor amidated aspartate1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiP13385.
PaxDbiP13385.
PeptideAtlasiP13385.
PRIDEiP13385.

Expressioni

Tissue specificityi

Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.1 Publication

Gene expression databases

BgeeiENSG00000241186.
CleanExiHS_TDGF1.
ExpressionAtlasiP13385. baseline and differential.
GenevisibleiP13385. HS.

Interactioni

Subunit structurei

Interacts with the activin type-1 receptor ACVR1B.1 Publication

GO - Molecular functioni

  • growth factor activity Source: UniProtKB
  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112856. 31 interactors.
IntActiP13385. 9 interactors.
MINTiMINT-1386411.
STRINGi9606.ENSP00000296145.

Structurei

3D structure databases

ProteinModelPortaliP13385.
SMRiP13385.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 107EGF-likePROSITE-ProRule annotationAdd BLAST30

Sequence similaritiesi

Contains 1 EGF-like domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
GeneTreeiENSGT00530000063804.
HOGENOMiHOG000145523.
HOVERGENiHBG054705.
InParanoidiP13385.
OMAiNCEHDVR.
OrthoDBiEOG091G0RA4.
PhylomeDBiP13385.
TreeFamiTF333187.

Family and domain databases

InterProiIPR017047. Cripto_growth_factor.
IPR019011. Cryptic/Cripto_CFC-dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
[Graphical view]
PANTHERiPTHR14949:SF26. PTHR14949:SF26. 1 hit.
PfamiPF09443. CFC. 1 hit.
[Graphical view]
PIRSFiPIRSF036301. Cripto_growth_factor. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13385-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCRKMARFS YSVIWIMAIS KVFELGLVAG LGHQEFARPS RGYLAFRDDS
60 70 80 90 100
IWPQEEPAIR PRSSQRVPPM GIQHSKELNR TCCLNGGTCM LGSFCACPPS
110 120 130 140 150
FYGRNCEHDV RKENCGSVPH DTWLPKKCSL CKCWHGQLRC FPQAFLPGCD
160 170 180
GLVMDEHLVA SRTPELPPSA RTTTFMLVGI CLSIQSYY
Length:188
Mass (Da):21,169
Last modified:January 1, 1990 - v1
Checksum:iAEE8727D0F27D886
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02426222V → A.2 PublicationsCorresponds to variant rs11130097dbSNPEnsembl.1
Natural variantiVAR_02190343Y → D.Corresponds to variant rs2293025dbSNPEnsembl.1
Natural variantiVAR_048975111R → G.Corresponds to variant rs34501971dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14253 mRNA. Translation: CAA32467.1.
M96955 Genomic DNA. Translation: AAA61134.1.
AC104304 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64773.1.
BC022393 mRNA. Translation: AAH22393.1.
BC067844 mRNA. Translation: AAH67844.1.
CCDSiCCDS2742.1.
PIRiB39787. A30362.
RefSeqiNP_001167607.1. NM_001174136.1.
NP_003203.1. NM_003212.3.
UniGeneiHs.385870.

Genome annotation databases

EnsembliENST00000296145; ENSP00000296145; ENSG00000241186.
GeneIDi6997.
KEGGihsa:6997.
UCSCiuc003cpv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14253 mRNA. Translation: CAA32467.1.
M96955 Genomic DNA. Translation: AAA61134.1.
AC104304 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64773.1.
BC022393 mRNA. Translation: AAH22393.1.
BC067844 mRNA. Translation: AAH67844.1.
CCDSiCCDS2742.1.
PIRiB39787. A30362.
RefSeqiNP_001167607.1. NM_001174136.1.
NP_003203.1. NM_003212.3.
UniGeneiHs.385870.

3D structure databases

ProteinModelPortaliP13385.
SMRiP13385.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112856. 31 interactors.
IntActiP13385. 9 interactors.
MINTiMINT-1386411.
STRINGi9606.ENSP00000296145.

Polymorphism and mutation databases

BioMutaiTDGF1.
DMDMi117473.

Proteomic databases

EPDiP13385.
PaxDbiP13385.
PeptideAtlasiP13385.
PRIDEiP13385.

Protocols and materials databases

DNASUi6997.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296145; ENSP00000296145; ENSG00000241186.
GeneIDi6997.
KEGGihsa:6997.
UCSCiuc003cpv.4. human.

Organism-specific databases

CTDi6997.
DisGeNETi6997.
GeneCardsiTDGF1.
HGNCiHGNC:11701. TDGF1.
MalaCardsiTDGF1.
MIMi187395. gene+phenotype.
neXtProtiNX_P13385.
OpenTargetsiENSG00000241186.
Orphaneti93925. Alobar holoprosencephaly.
93924. Lobar holoprosencephaly.
280200. Microform holoprosencephaly.
93926. Midline interhemispheric variant of holoprosencephaly.
220386. Semilobar holoprosencephaly.
280195. Septopreoptic holoprosencephaly.
PharmGKBiPA36420.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
GeneTreeiENSGT00530000063804.
HOGENOMiHOG000145523.
HOVERGENiHBG054705.
InParanoidiP13385.
OMAiNCEHDVR.
OrthoDBiEOG091G0RA4.
PhylomeDBiP13385.
TreeFamiTF333187.

Enzyme and pathway databases

ReactomeiR-HSA-1181150. Signaling by NODAL.
R-HSA-1433617. Regulation of signaling by NODAL.
R-HSA-2892247. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.
SIGNORiP13385.

Miscellaneous databases

ChiTaRSiTDGF1. human.
GeneWikiiTeratocarcinoma-derived_growth_factor_1.
GenomeRNAii6997.
PROiP13385.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000241186.
CleanExiHS_TDGF1.
ExpressionAtlasiP13385. baseline and differential.
GenevisibleiP13385. HS.

Family and domain databases

InterProiIPR017047. Cripto_growth_factor.
IPR019011. Cryptic/Cripto_CFC-dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
[Graphical view]
PANTHERiPTHR14949:SF26. PTHR14949:SF26. 1 hit.
PfamiPF09443. CFC. 1 hit.
[Graphical view]
PIRSFiPIRSF036301. Cripto_growth_factor. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTDGF1_HUMAN
AccessioniPrimary (citable) accession number: P13385
Secondary accession number(s): Q8TCC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 2, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.