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P13385

- TDGF1_HUMAN

UniProt

P13385 - TDGF1_HUMAN

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Protein

Teratocarcinoma-derived growth factor 1

Gene
TDGF1, CRIPTO
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.1 Publication

GO - Molecular functioni

  1. growth factor activity Source: UniProtKB
  2. protein binding Source: HGNC
  3. receptor binding Source: UniProtKB

GO - Biological processi

  1. activation of MAPK activity Source: UniProtKB
  2. anterior/posterior axis specification, embryo Source: UniProtKB
  3. BMP signaling pathway Source: Ensembl
  4. canonical Wnt signaling pathway Source: Ensembl
  5. cardiac muscle cell differentiation Source: Ensembl
  6. cell differentiation Source: UniProtKB
  7. cell migration involved in sprouting angiogenesis Source: UniProtKB
  8. cellular response to epidermal growth factor stimulus Source: UniProtKB
  9. cellular response to fibroblast growth factor stimulus Source: UniProtKB
  10. cellular response to hepatocyte growth factor stimulus Source: UniProtKB
  11. cellular response to interferon-gamma Source: UniProtKB
  12. cellular response to interleukin-6 Source: UniProtKB
  13. cellular response to tumor necrosis factor Source: UniProtKB
  14. embryo development Source: UniProtKB
  15. gastrulation Source: Ensembl
  16. heart development Source: UniProtKB
  17. in utero embryonic development Source: Ensembl
  18. mammary gland development Source: UniProtKB
  19. morphogenesis of a branching structure Source: UniProtKB
  20. negative regulation of apoptotic process Source: UniProtKB
  21. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  22. peptidyl-serine phosphorylation Source: UniProtKB
  23. positive regulation of cell-matrix adhesion Source: Ensembl
  24. positive regulation of cell migration Source: UniProtKB
  25. positive regulation of cell proliferation Source: UniProtKB
  26. positive regulation of endothelial cell migration Source: UniProtKB
  27. positive regulation of fibroblast proliferation Source: Ensembl
  28. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
  29. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  30. regulation of signal transduction Source: UniProtKB
  31. vasculogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_111057. Signaling by NODAL.
REACT_111059. Regulation of signaling by NODAL.
REACT_200759. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.

Names & Taxonomyi

Protein namesi
Recommended name:
Teratocarcinoma-derived growth factor 1
Alternative name(s):
Cripto-1 growth factor
Short name:
CRGF
Epidermal growth factor-like cripto protein CR1
Gene namesi
Name:TDGF1
Synonyms:CRIPTO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:11701. TDGF1.

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor 1 Publication

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. apical plasma membrane Source: UniProtKB
  3. cell surface Source: UniProtKB
  4. extracellular space Source: UniProtKB
  5. extrinsic component of plasma membrane Source: UniProtKB
  6. Golgi apparatus Source: Ensembl
  7. membrane raft Source: UniProtKB
  8. nucleus Source: Ensembl
  9. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi188 – 1881Y → YVVVVV: Alters the localization and decreases the biological activity. 1 Publication

Organism-specific databases

MIMi187395. gene+phenotype.
Orphaneti93925. Alobar holoprosencephaly.
93924. Lobar holoprosencephaly.
280200. Microform holoprosencephaly.
93926. Midline interhemispheric variant of holoprosencephaly.
220386. Semilobar holoprosencephaly.
280195. Septopreoptic holoprosencephaly.
PharmGKBiPA36420.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 30301 PublicationAdd
BLAST
Chaini31 – 150120Teratocarcinoma-derived growth factor 1PRO_0000007503Add
BLAST
Propeptidei151 – 18838Removed in mature formPRO_0000395410Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi79 – 791N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi82 ↔ 89 By similarity
Disulfide bondi83 ↔ 95 By similarity
Disulfide bondi97 ↔ 106 By similarity
Disulfide bondi115 ↔ 1331 Publication
Disulfide bondi128 ↔ 1491 Publication
Disulfide bondi131 ↔ 1401 Publication
Lipidationi150 – 1501GPI-anchor amidated aspartate1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP13385.
PRIDEiP13385.

Expressioni

Tissue specificityi

Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.1 Publication

Gene expression databases

ArrayExpressiP13385.
BgeeiP13385.
CleanExiHS_TDGF1.
GenevestigatoriP13385.

Interactioni

Subunit structurei

Interacts with the activin type-1 receptor ACVR1B.1 Publication

Protein-protein interaction databases

BioGridi112856. 9 interactions.
IntActiP13385. 9 interactions.
MINTiMINT-1386411.
STRINGi9606.ENSP00000296145.

Structurei

3D structure databases

ProteinModelPortaliP13385.
SMRiP13385. Positions 82-107, 112-150.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini78 – 10730EGF-likeAdd
BLAST

Sequence similaritiesi

Contains 1 EGF-like domain.

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiNOG320031.
HOGENOMiHOG000145523.
HOVERGENiHBG054705.
InParanoidiP13385.
OMAiMDCRKMA.
OrthoDBiEOG76X61G.
PhylomeDBiP13385.
TreeFamiTF333187.

Family and domain databases

InterProiIPR017047. Cripto_growth_factor.
IPR019011. Cryptic/Cripto_CFC-dom.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
[Graphical view]
PfamiPF09443. CFC. 1 hit.
[Graphical view]
PIRSFiPIRSF036301. Cripto_growth_factor. 1 hit.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13385-1 [UniParc]FASTAAdd to Basket

« Hide

MDCRKMARFS YSVIWIMAIS KVFELGLVAG LGHQEFARPS RGYLAFRDDS    50
IWPQEEPAIR PRSSQRVPPM GIQHSKELNR TCCLNGGTCM LGSFCACPPS 100
FYGRNCEHDV RKENCGSVPH DTWLPKKCSL CKCWHGQLRC FPQAFLPGCD 150
GLVMDEHLVA SRTPELPPSA RTTTFMLVGI CLSIQSYY 188
Length:188
Mass (Da):21,169
Last modified:January 1, 1990 - v1
Checksum:iAEE8727D0F27D886
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti22 – 221V → A.2 Publications
Corresponds to variant rs11130097 [ dbSNP | Ensembl ].
VAR_024262
Natural varianti43 – 431Y → D.
Corresponds to variant rs2293025 [ dbSNP | Ensembl ].
VAR_021903
Natural varianti111 – 1111R → G.
Corresponds to variant rs34501971 [ dbSNP | Ensembl ].
VAR_048975

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14253 mRNA. Translation: CAA32467.1.
M96955 Genomic DNA. Translation: AAA61134.1.
AC104304 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64773.1.
BC022393 mRNA. Translation: AAH22393.1.
BC067844 mRNA. Translation: AAH67844.1.
CCDSiCCDS2742.1.
PIRiB39787. A30362.
RefSeqiNP_001167607.1. NM_001174136.1.
NP_003203.1. NM_003212.3.
UniGeneiHs.385870.

Genome annotation databases

EnsembliENST00000296145; ENSP00000296145; ENSG00000241186.
GeneIDi6997.
KEGGihsa:6997.
UCSCiuc003cpv.3. human.

Polymorphism databases

DMDMi117473.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14253 mRNA. Translation: CAA32467.1 .
M96955 Genomic DNA. Translation: AAA61134.1 .
AC104304 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64773.1 .
BC022393 mRNA. Translation: AAH22393.1 .
BC067844 mRNA. Translation: AAH67844.1 .
CCDSi CCDS2742.1.
PIRi B39787. A30362.
RefSeqi NP_001167607.1. NM_001174136.1.
NP_003203.1. NM_003212.3.
UniGenei Hs.385870.

3D structure databases

ProteinModelPortali P13385.
SMRi P13385. Positions 82-107, 112-150.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112856. 9 interactions.
IntActi P13385. 9 interactions.
MINTi MINT-1386411.
STRINGi 9606.ENSP00000296145.

Polymorphism databases

DMDMi 117473.

Proteomic databases

PaxDbi P13385.
PRIDEi P13385.

Protocols and materials databases

DNASUi 6997.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296145 ; ENSP00000296145 ; ENSG00000241186 .
GeneIDi 6997.
KEGGi hsa:6997.
UCSCi uc003cpv.3. human.

Organism-specific databases

CTDi 6997.
GeneCardsi GC03P046616.
HGNCi HGNC:11701. TDGF1.
MIMi 187395. gene+phenotype.
neXtProti NX_P13385.
Orphaneti 93925. Alobar holoprosencephaly.
93924. Lobar holoprosencephaly.
280200. Microform holoprosencephaly.
93926. Midline interhemispheric variant of holoprosencephaly.
220386. Semilobar holoprosencephaly.
280195. Septopreoptic holoprosencephaly.
PharmGKBi PA36420.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG320031.
HOGENOMi HOG000145523.
HOVERGENi HBG054705.
InParanoidi P13385.
OMAi MDCRKMA.
OrthoDBi EOG76X61G.
PhylomeDBi P13385.
TreeFami TF333187.

Enzyme and pathway databases

Reactomei REACT_111057. Signaling by NODAL.
REACT_111059. Regulation of signaling by NODAL.
REACT_200759. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.

Miscellaneous databases

ChiTaRSi TDGF1. human.
GeneWikii Teratocarcinoma-derived_growth_factor_1.
GenomeRNAii 6997.
NextBioi 27331.
PROi P13385.
SOURCEi Search...

Gene expression databases

ArrayExpressi P13385.
Bgeei P13385.
CleanExi HS_TDGF1.
Genevestigatori P13385.

Family and domain databases

InterProi IPR017047. Cripto_growth_factor.
IPR019011. Cryptic/Cripto_CFC-dom.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
[Graphical view ]
Pfami PF09443. CFC. 1 hit.
[Graphical view ]
PIRSFi PIRSF036301. Cripto_growth_factor. 1 hit.
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
PROSITEi PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells."
    Ciccodicola A., Dono R., Obici S., Zollo M., Persico M.G.
    EMBO J. 8:1987-1991(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation and characterization of the CRIPTO autosomal gene and its X-linked related sequence."
    Dono R., Montuori N., Rocchi M., de Ponti-Zilli L., Ciccodicola A., Persico M.G.
    Am. J. Hum. Genet. 49:555-565(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-22.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-22.
    Tissue: Brain and Kidney.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 31-45.
  7. "Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells."
    Bianco C., Adkins H.B., Wechselberger C., Seno M., Normanno N., De Luca A., Sun Y., Khan N., Kenney N., Ebert A., Williams K.P., Sanicola M., Salomon D.S.
    Mol. Cell. Biol. 22:2586-2597(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ACVR1B, FUNCTION.
  8. Cited for: DISULFIDE BONDS.
  9. "Characterization of the glycosylphosphatidylinositol-anchor signal sequence of human Cryptic with a hydrophilic extension."
    Watanabe K., Nagaoka T., Strizzi L., Mancino M., Gonzales M., Bianco C., Salomon D.S.
    Biochim. Biophys. Acta 1778:2671-2681(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, GPI-ANCHOR AT ASP-150, MUTAGENESIS OF TYR-188.
  10. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiTDGF1_HUMAN
AccessioniPrimary (citable) accession number: P13385
Secondary accession number(s): Q8TCC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: September 3, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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