Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Insulin-like growth factor-binding protein 2

Gene

IGFBP2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Growth regulation

Keywords - Ligandi

Growth factor binding

Protein family/group databases

MEROPSiI31.953.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 2
Short name:
IBP-2
Short name:
IGF-binding protein 2
Short name:
IGFBP-2
Gene namesi
Name:IGFBP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 33331 PublicationAdd
BLAST
Chaini34 – 317284Insulin-like growth factor-binding protein 2PRO_0000014369Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi219 ↔ 253PROSITE-ProRule annotation
Disulfide bondi264 ↔ 275PROSITE-ProRule annotation
Disulfide bondi277 ↔ 298PROSITE-ProRule annotation

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP13384.

Interactioni

Subunit structurei

Binds IGF2 more than IGF1.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP13384.
SMRiP13384. Positions 37-125, 212-317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 12692IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini216 – 29883Thyroglobulin type-1PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi293 – 2953Cell attachment siteSequence analysis

Domaini

The C-terminus is required for IGF-binding and growth inhibition.By similarity

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP13384.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_.
IPR012210. IGFBP-2.
IPR000867. IGFBP-like.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01978. IGFBPFAMILY2.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13384-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPRLGGPAL LLLPPLLLLL LLGAGGGDCG ARAEVLFRCP PCTPESLAAC
60 70 80 90 100
KPPPGAAAGP AGDARVPCEL VREPGCGCCS VCARLEGERC GVYTPRCGQG
110 120 130 140 150
LRCYPNPGSE LPLRALVHGE GTCEKHGDAE YSASPEQVAD NGEEHSEGGL
160 170 180 190 200
VENHVDGNVN LMGGGGGAGR KPLKSGMKEL AVFREKVTEQ HRQMGKGGKH
210 220 230 240 250
HLGLEEPKKL RPPPARTPCQ QELDQVLERI STMRLPDERG PLEHLYSLHI
260 270 280 290 300
PNCDKHGLYN LKQCKMSLNG QRGECWCVNP NTGKLIQGAP TIRGDPECHL
310
FYNEQQGARG VHTQRMQ
Length:317
Mass (Da):34,015
Last modified:November 23, 2004 - v2
Checksum:i2B552BC61CA7E9CD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 332RA → AS (PubMed:1697752).Curated
Sequence conflicti46 – 461S → C AA sequence (PubMed:2450535).Curated
Sequence conflicti60 – 612PA → AP (PubMed:1697752).Curated
Sequence conflicti82 – 821C → F AA sequence (PubMed:2450535).Curated
Sequence conflicti114 – 1141R → H (PubMed:1697752).Curated
Sequence conflicti128 – 1281D → S (PubMed:1697752).Curated
Sequence conflicti134 – 1341S → T (PubMed:1697752).Curated
Sequence conflicti313 – 3131T → N (PubMed:1697752).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074854 mRNA. Translation: AAD04862.1.
PIRiA60967.
RefSeqiNP_776980.1. NM_174555.1.
UniGeneiBt.149.

Genome annotation databases

GeneIDi282260.
KEGGibta:282260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074854 mRNA. Translation: AAD04862.1.
PIRiA60967.
RefSeqiNP_776980.1. NM_174555.1.
UniGeneiBt.149.

3D structure databases

ProteinModelPortaliP13384.
SMRiP13384. Positions 37-125, 212-317.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI31.953.

Proteomic databases

PRIDEiP13384.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282260.
KEGGibta:282260.

Organism-specific databases

CTDi3485.

Phylogenomic databases

HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP13384.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_.
IPR012210. IGFBP-2.
IPR000867. IGFBP-like.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01978. IGFBPFAMILY2.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIBP2_BOVIN
AccessioniPrimary (citable) accession number: P13384
Secondary accession number(s): O97599
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.