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P13379 (CD5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-cell surface glycoprotein CD5
Alternative name(s):
Lymphocyte antigen 1
Short name=Ly-1
Short name=Lyt-1
CD_antigen=CD5
Gene names
Name:Cd5
Synonyms:Ly-1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as a receptor in regulating T-cell proliferation.

Subunit structure

Interacts with CD72/LYB-2. Interacts with PTPN6/SHP-1. Ref.3

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Post-translational modification

Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1. Ref.3

Sequence similarities

Contains 3 SRCR domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323
Chain24 – 494471T-cell surface glycoprotein CD5
PRO_0000033223

Regions

Topological domain25 – 371347Extracellular Potential
Transmembrane372 – 40130Helical; Potential
Topological domain402 – 49493Cytoplasmic Potential
Domain34 – 133100SRCR 1
Domain159 – 268110SRCR 2
Domain276 – 36792SRCR 3

Amino acid modifications

Modified residue4381Phosphoserine By similarity
Modified residue4521Phosphotyrosine By similarity
Modified residue4591Phosphoserine By similarity
Modified residue4821Phosphoserine By similarity
Modified residue4841Phosphoserine By similarity
Glycosylation1171N-linked (GlcNAc...) Potential
Glycosylation1181N-linked (GlcNAc...) Potential
Glycosylation1781N-linked (GlcNAc...) Potential
Glycosylation2411N-linked (GlcNAc...) Potential
Disulfide bond43 ↔ 85 By similarity
Disulfide bond59 ↔ 125 By similarity
Disulfide bond80 ↔ 132 By similarity
Disulfide bond106 ↔ 116 By similarity
Disulfide bond201 ↔ 267 By similarity
Disulfide bond244 ↔ 250 By similarity
Disulfide bond285 ↔ 321 By similarity
Disulfide bond301 ↔ 358 By similarity
Disulfide bond316 ↔ 366 By similarity
Disulfide bond341 ↔ 349 By similarity

Sequences

Sequence LengthMass (Da)Tools
P13379 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: 1EBBBBFE2488C162

FASTA49453,849
        10         20         30         40         50         60 
MDSHEVLLAA TYLLGTLAAF CLGQSGRGGL DIQVMLSGSN SKCQGQVEIQ MENKWKTVCS 

        70         80         90        100        110        120 
SSWRLSQDHS KNAQQASAVC KQLRCGDPLA LGPFPSLNRP QNQVFCQGSP WSISNCNNTS 

       130        140        150        160        170        180 
SQDQCLPLSL ICLEPQRTTP PPTTTPPTTV PEPTAPPRLQ LVPGHEGLRC TGVVEFYNGS 

       190        200        210        220        230        240 
WGGTILYKAK DRPLGLGNLI CKSLQCGSFL THLSGTEAAG TPAPAELRDP RPLPIRWEAP 

       250        260        270        280        290        300 
NGSCVSLQQC FQKTTAQEGG QALTVICSDF QPKVQSRLVG GSSVCEGIAE VRQRSQWEAL 

       310        320        330        340        350        360 
CDSSAARGRG RWEELCREQQ CGDLISFHTV DADKTSPGFL CAQEKLSQCY HLQKKKHCNK 

       370        380        390        400        410        420 
RVFVTCQDPN PAGLAPGTVA SIILTLVLLV VLLAMCGPLV YKKLVKKFRQ KKQRQWIGPT 

       430        440        450        460        470        480 
GVNQNMSFHR SHTATVRSQV ENPTASHVDN EYSQPPRNSH LSAYPALEGA LHRSSTQPDN 

       490 
SSDSDYDLQV AQRL 

« Hide

References

[1]"Molecular cloning of Ly-1, a membrane glycoprotein of mouse T lymphocytes and a subset of B cells: molecular homology to its human counterpart Leu-1/T1 (CD5)."
Huang H.-J.S., Jones N.H., Strominger J.L., Herzenberg L.A.
Proc. Natl. Acad. Sci. U.S.A. 84:204-208(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: T-cell.
[2]"Cloning of the murine CD5 promoter and its tissue-specific regulation."
Weichert T.R., Schwartz R.C.
J. Immunol. 154:4603-4612(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-17.
Strain: NIH Swiss.
[3]"Negative regulation of B cell receptor-mediated signaling in B-1 cells through CD5 and Ly49 co-receptors via Lyn kinase activity."
Ochi H., Watanabe T.
Int. Immunol. 12:1417-1423(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION BY LYN, INTERACTION WITH PTPN6/SHP-1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M15177 mRNA. Translation: AAA39453.1.
U09204 Genomic DNA. Translation: AAC52187.1.
CCDSCCDS29586.1.
PIRA29079.
RefSeqNP_031676.3. NM_007650.3.
UniGeneMm.779.

3D structure databases

ProteinModelPortalP13379.
SMRP13379. Positions 31-134, 270-368.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP13379.

Proteomic databases

PaxDbP13379.
PRIDEP13379.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025571; ENSMUSP00000025571; ENSMUSG00000024669.
GeneID12507.
KEGGmmu:12507.
UCSCuc008gqv.1. mouse.

Organism-specific databases

CTD921.
MGIMGI:88340. Cd5.

Phylogenomic databases

eggNOGNOG86650.
HOGENOMHOG000111490.
HOVERGENHBG005286.
InParanoidP13379.
KOK06455.
OMAMSFHRNH.
OrthoDBEOG7TF792.
PhylomeDBP13379.
TreeFamTF329295.

Gene expression databases

ArrayExpressP13379.
BgeeP13379.
CleanExMM_CD5.
GenevestigatorP13379.

Family and domain databases

Gene3D3.10.250.10. 1 hit.
InterProIPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR003566. Tcell_CD5.
[Graphical view]
PfamPF00530. SRCR. 2 hits.
[Graphical view]
PRINTSPR00258. SPERACTRCPTR.
PR01409. TCELLCD5.
SMARTSM00202. SR. 2 hits.
[Graphical view]
SUPFAMSSF56487. SSF56487. 2 hits.
PROSITEPS50287. SRCR_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio281478.
PROP13379.
SOURCESearch...

Entry information

Entry nameCD5_MOUSE
AccessionPrimary (citable) accession number: P13379
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot