Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P13379

- CD5_MOUSE

UniProt

P13379 - CD5_MOUSE

Protein

T-cell surface glycoprotein CD5

Gene

Cd5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May act as a receptor in regulating T-cell proliferation.

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. scavenger receptor activity Source: InterPro

    GO - Biological processi

    1. apoptotic signaling pathway Source: MGI
    2. T cell costimulation Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-cell surface glycoprotein CD5
    Alternative name(s):
    Lymphocyte antigen 1
    Short name:
    Ly-1
    Short name:
    Lyt-1
    CD_antigen: CD5
    Gene namesi
    Name:Cd5
    Synonyms:Ly-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:88340. Cd5.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Add
    BLAST
    Chaini24 – 494471T-cell surface glycoprotein CD5PRO_0000033223Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi43 ↔ 85PROSITE-ProRule annotation
    Disulfide bondi59 ↔ 125PROSITE-ProRule annotation
    Disulfide bondi80 ↔ 132PROSITE-ProRule annotation
    Disulfide bondi106 ↔ 116PROSITE-ProRule annotation
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi201 ↔ 267PROSITE-ProRule annotation
    Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi244 ↔ 250PROSITE-ProRule annotation
    Disulfide bondi285 ↔ 321PROSITE-ProRule annotation
    Disulfide bondi301 ↔ 358PROSITE-ProRule annotation
    Disulfide bondi316 ↔ 366PROSITE-ProRule annotation
    Disulfide bondi341 ↔ 349PROSITE-ProRule annotation
    Modified residuei438 – 4381PhosphoserineBy similarity
    Modified residuei452 – 4521PhosphotyrosineBy similarity
    Modified residuei459 – 4591PhosphoserineBy similarity
    Modified residuei482 – 4821PhosphoserineBy similarity
    Modified residuei484 – 4841PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP13379.
    PRIDEiP13379.

    PTM databases

    PhosphoSiteiP13379.

    Expressioni

    Gene expression databases

    ArrayExpressiP13379.
    BgeeiP13379.
    CleanExiMM_CD5.
    GenevestigatoriP13379.

    Interactioni

    Subunit structurei

    Interacts with CD72/LYB-2. Interacts with PTPN6/SHP-1.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliP13379.
    SMRiP13379. Positions 31-134, 270-368.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 371347ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini402 – 49493CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei372 – 40130HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 133100SRCR 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini159 – 268110SRCR 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini276 – 36792SRCR 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 3 SRCR domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG86650.
    HOGENOMiHOG000111490.
    HOVERGENiHBG005286.
    InParanoidiP13379.
    KOiK06455.
    OMAiMSFHRNH.
    OrthoDBiEOG7TF792.
    PhylomeDBiP13379.
    TreeFamiTF329295.

    Family and domain databases

    Gene3Di3.10.250.10. 1 hit.
    InterProiIPR001190. SRCR.
    IPR017448. SRCR-like_dom.
    IPR003566. Tcell_CD5.
    [Graphical view]
    PfamiPF00530. SRCR. 2 hits.
    [Graphical view]
    PRINTSiPR00258. SPERACTRCPTR.
    PR01409. TCELLCD5.
    SMARTiSM00202. SR. 2 hits.
    [Graphical view]
    SUPFAMiSSF56487. SSF56487. 2 hits.
    PROSITEiPS50287. SRCR_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P13379-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSHEVLLAA TYLLGTLAAF CLGQSGRGGL DIQVMLSGSN SKCQGQVEIQ    50
    MENKWKTVCS SSWRLSQDHS KNAQQASAVC KQLRCGDPLA LGPFPSLNRP 100
    QNQVFCQGSP WSISNCNNTS SQDQCLPLSL ICLEPQRTTP PPTTTPPTTV 150
    PEPTAPPRLQ LVPGHEGLRC TGVVEFYNGS WGGTILYKAK DRPLGLGNLI 200
    CKSLQCGSFL THLSGTEAAG TPAPAELRDP RPLPIRWEAP NGSCVSLQQC 250
    FQKTTAQEGG QALTVICSDF QPKVQSRLVG GSSVCEGIAE VRQRSQWEAL 300
    CDSSAARGRG RWEELCREQQ CGDLISFHTV DADKTSPGFL CAQEKLSQCY 350
    HLQKKKHCNK RVFVTCQDPN PAGLAPGTVA SIILTLVLLV VLLAMCGPLV 400
    YKKLVKKFRQ KKQRQWIGPT GVNQNMSFHR SHTATVRSQV ENPTASHVDN 450
    EYSQPPRNSH LSAYPALEGA LHRSSTQPDN SSDSDYDLQV AQRL 494
    Length:494
    Mass (Da):53,849
    Last modified:January 1, 1990 - v1
    Checksum:i1EBBBBFE2488C162
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M15177 mRNA. Translation: AAA39453.1.
    U09204 Genomic DNA. Translation: AAC52187.1.
    CCDSiCCDS29586.1.
    PIRiA29079.
    RefSeqiNP_031676.3. NM_007650.3.
    UniGeneiMm.779.

    Genome annotation databases

    EnsembliENSMUST00000025571; ENSMUSP00000025571; ENSMUSG00000024669.
    GeneIDi12507.
    KEGGimmu:12507.
    UCSCiuc008gqv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M15177 mRNA. Translation: AAA39453.1 .
    U09204 Genomic DNA. Translation: AAC52187.1 .
    CCDSi CCDS29586.1.
    PIRi A29079.
    RefSeqi NP_031676.3. NM_007650.3.
    UniGenei Mm.779.

    3D structure databases

    ProteinModelPortali P13379.
    SMRi P13379. Positions 31-134, 270-368.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P13379.

    Proteomic databases

    PaxDbi P13379.
    PRIDEi P13379.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025571 ; ENSMUSP00000025571 ; ENSMUSG00000024669 .
    GeneIDi 12507.
    KEGGi mmu:12507.
    UCSCi uc008gqv.1. mouse.

    Organism-specific databases

    CTDi 921.
    MGIi MGI:88340. Cd5.

    Phylogenomic databases

    eggNOGi NOG86650.
    HOGENOMi HOG000111490.
    HOVERGENi HBG005286.
    InParanoidi P13379.
    KOi K06455.
    OMAi MSFHRNH.
    OrthoDBi EOG7TF792.
    PhylomeDBi P13379.
    TreeFami TF329295.

    Miscellaneous databases

    NextBioi 281478.
    PROi P13379.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P13379.
    Bgeei P13379.
    CleanExi MM_CD5.
    Genevestigatori P13379.

    Family and domain databases

    Gene3Di 3.10.250.10. 1 hit.
    InterProi IPR001190. SRCR.
    IPR017448. SRCR-like_dom.
    IPR003566. Tcell_CD5.
    [Graphical view ]
    Pfami PF00530. SRCR. 2 hits.
    [Graphical view ]
    PRINTSi PR00258. SPERACTRCPTR.
    PR01409. TCELLCD5.
    SMARTi SM00202. SR. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56487. SSF56487. 2 hits.
    PROSITEi PS50287. SRCR_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of Ly-1, a membrane glycoprotein of mouse T lymphocytes and a subset of B cells: molecular homology to its human counterpart Leu-1/T1 (CD5)."
      Huang H.-J.S., Jones N.H., Strominger J.L., Herzenberg L.A.
      Proc. Natl. Acad. Sci. U.S.A. 84:204-208(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: T-cell.
    2. "Cloning of the murine CD5 promoter and its tissue-specific regulation."
      Weichert T.R., Schwartz R.C.
      J. Immunol. 154:4603-4612(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-17.
      Strain: NIH Swiss.
    3. "Negative regulation of B cell receptor-mediated signaling in B-1 cells through CD5 and Ly49 co-receptors via Lyn kinase activity."
      Ochi H., Watanabe T.
      Int. Immunol. 12:1417-1423(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY LYN, INTERACTION WITH PTPN6/SHP-1.

    Entry informationi

    Entry nameiCD5_MOUSE
    AccessioniPrimary (citable) accession number: P13379
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3