SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P13379

- CD5_MOUSE

UniProt

P13379 - CD5_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

T-cell surface glycoprotein CD5

Gene
Cd5, Ly-1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May act as a receptor in regulating T-cell proliferation.

GO - Molecular functioni

  1. protein binding Source: MGI
  2. scavenger receptor activity Source: InterPro

GO - Biological processi

  1. apoptotic signaling pathway Source: MGI
  2. T cell costimulation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD5
Alternative name(s):
Lymphocyte antigen 1
Short name:
Ly-1
Short name:
Lyt-1
CD_antigen: CD5
Gene namesi
Name:Cd5
Synonyms:Ly-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:88340. Cd5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 371347Extracellular Reviewed predictionAdd
BLAST
Transmembranei372 – 40130Helical; Reviewed predictionAdd
BLAST
Topological domaini402 – 49493Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 494471T-cell surface glycoprotein CD5PRO_0000033223Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 85 By similarity
Disulfide bondi59 ↔ 125 By similarity
Disulfide bondi80 ↔ 132 By similarity
Disulfide bondi106 ↔ 116 By similarity
Glycosylationi117 – 1171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi118 – 1181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi178 – 1781N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi201 ↔ 267 By similarity
Glycosylationi241 – 2411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi244 ↔ 250 By similarity
Disulfide bondi285 ↔ 321 By similarity
Disulfide bondi301 ↔ 358 By similarity
Disulfide bondi316 ↔ 366 By similarity
Disulfide bondi341 ↔ 349 By similarity
Modified residuei438 – 4381Phosphoserine By similarity
Modified residuei452 – 4521Phosphotyrosine By similarity
Modified residuei459 – 4591Phosphoserine By similarity
Modified residuei482 – 4821Phosphoserine By similarity
Modified residuei484 – 4841Phosphoserine By similarity

Post-translational modificationi

Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP13379.
PRIDEiP13379.

PTM databases

PhosphoSiteiP13379.

Expressioni

Gene expression databases

ArrayExpressiP13379.
BgeeiP13379.
CleanExiMM_CD5.
GenevestigatoriP13379.

Interactioni

Subunit structurei

Interacts with CD72/LYB-2. Interacts with PTPN6/SHP-1.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP13379.
SMRiP13379. Positions 31-134, 270-368.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 133100SRCR 1Add
BLAST
Domaini159 – 268110SRCR 2Add
BLAST
Domaini276 – 36792SRCR 3Add
BLAST

Sequence similaritiesi

Contains 3 SRCR domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG86650.
HOGENOMiHOG000111490.
HOVERGENiHBG005286.
InParanoidiP13379.
KOiK06455.
OMAiMSFHRNH.
OrthoDBiEOG7TF792.
PhylomeDBiP13379.
TreeFamiTF329295.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR003566. Tcell_CD5.
[Graphical view]
PfamiPF00530. SRCR. 2 hits.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
PR01409. TCELLCD5.
SMARTiSM00202. SR. 2 hits.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 2 hits.
PROSITEiPS50287. SRCR_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13379-1 [UniParc]FASTAAdd to Basket

« Hide

MDSHEVLLAA TYLLGTLAAF CLGQSGRGGL DIQVMLSGSN SKCQGQVEIQ    50
MENKWKTVCS SSWRLSQDHS KNAQQASAVC KQLRCGDPLA LGPFPSLNRP 100
QNQVFCQGSP WSISNCNNTS SQDQCLPLSL ICLEPQRTTP PPTTTPPTTV 150
PEPTAPPRLQ LVPGHEGLRC TGVVEFYNGS WGGTILYKAK DRPLGLGNLI 200
CKSLQCGSFL THLSGTEAAG TPAPAELRDP RPLPIRWEAP NGSCVSLQQC 250
FQKTTAQEGG QALTVICSDF QPKVQSRLVG GSSVCEGIAE VRQRSQWEAL 300
CDSSAARGRG RWEELCREQQ CGDLISFHTV DADKTSPGFL CAQEKLSQCY 350
HLQKKKHCNK RVFVTCQDPN PAGLAPGTVA SIILTLVLLV VLLAMCGPLV 400
YKKLVKKFRQ KKQRQWIGPT GVNQNMSFHR SHTATVRSQV ENPTASHVDN 450
EYSQPPRNSH LSAYPALEGA LHRSSTQPDN SSDSDYDLQV AQRL 494
Length:494
Mass (Da):53,849
Last modified:January 1, 1990 - v1
Checksum:i1EBBBBFE2488C162
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M15177 mRNA. Translation: AAA39453.1.
U09204 Genomic DNA. Translation: AAC52187.1.
CCDSiCCDS29586.1.
PIRiA29079.
RefSeqiNP_031676.3. NM_007650.3.
UniGeneiMm.779.

Genome annotation databases

EnsembliENSMUST00000025571; ENSMUSP00000025571; ENSMUSG00000024669.
GeneIDi12507.
KEGGimmu:12507.
UCSCiuc008gqv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M15177 mRNA. Translation: AAA39453.1 .
U09204 Genomic DNA. Translation: AAC52187.1 .
CCDSi CCDS29586.1.
PIRi A29079.
RefSeqi NP_031676.3. NM_007650.3.
UniGenei Mm.779.

3D structure databases

ProteinModelPortali P13379.
SMRi P13379. Positions 31-134, 270-368.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P13379.

Proteomic databases

PaxDbi P13379.
PRIDEi P13379.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025571 ; ENSMUSP00000025571 ; ENSMUSG00000024669 .
GeneIDi 12507.
KEGGi mmu:12507.
UCSCi uc008gqv.1. mouse.

Organism-specific databases

CTDi 921.
MGIi MGI:88340. Cd5.

Phylogenomic databases

eggNOGi NOG86650.
HOGENOMi HOG000111490.
HOVERGENi HBG005286.
InParanoidi P13379.
KOi K06455.
OMAi MSFHRNH.
OrthoDBi EOG7TF792.
PhylomeDBi P13379.
TreeFami TF329295.

Miscellaneous databases

NextBioi 281478.
PROi P13379.
SOURCEi Search...

Gene expression databases

ArrayExpressi P13379.
Bgeei P13379.
CleanExi MM_CD5.
Genevestigatori P13379.

Family and domain databases

Gene3Di 3.10.250.10. 1 hit.
InterProi IPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR003566. Tcell_CD5.
[Graphical view ]
Pfami PF00530. SRCR. 2 hits.
[Graphical view ]
PRINTSi PR00258. SPERACTRCPTR.
PR01409. TCELLCD5.
SMARTi SM00202. SR. 2 hits.
[Graphical view ]
SUPFAMi SSF56487. SSF56487. 2 hits.
PROSITEi PS50287. SRCR_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of Ly-1, a membrane glycoprotein of mouse T lymphocytes and a subset of B cells: molecular homology to its human counterpart Leu-1/T1 (CD5)."
    Huang H.-J.S., Jones N.H., Strominger J.L., Herzenberg L.A.
    Proc. Natl. Acad. Sci. U.S.A. 84:204-208(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: T-cell.
  2. "Cloning of the murine CD5 promoter and its tissue-specific regulation."
    Weichert T.R., Schwartz R.C.
    J. Immunol. 154:4603-4612(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-17.
    Strain: NIH Swiss.
  3. "Negative regulation of B cell receptor-mediated signaling in B-1 cells through CD5 and Ly49 co-receptors via Lyn kinase activity."
    Ochi H., Watanabe T.
    Int. Immunol. 12:1417-1423(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY LYN, INTERACTION WITH PTPN6/SHP-1.

Entry informationi

Entry nameiCD5_MOUSE
AccessioniPrimary (citable) accession number: P13379
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi