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Protein

T-cell surface glycoprotein CD5

Gene

Cd5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a receptor in regulating T-cell proliferation.

GO - Molecular functioni

  1. scavenger receptor activity Source: InterPro

GO - Biological processi

  1. apoptotic signaling pathway Source: MGI
  2. T cell costimulation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD5
Alternative name(s):
Lymphocyte antigen 1
Short name:
Ly-1
Short name:
Lyt-1
CD_antigen: CD5
Gene namesi
Name:Cd5
Synonyms:Ly-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:88340. Cd5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 371347ExtracellularSequence AnalysisAdd
BLAST
Transmembranei372 – 40130HelicalSequence AnalysisAdd
BLAST
Topological domaini402 – 49493CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 494471T-cell surface glycoprotein CD5PRO_0000033223Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 85PROSITE-ProRule annotation
Disulfide bondi59 ↔ 125PROSITE-ProRule annotation
Disulfide bondi80 ↔ 132PROSITE-ProRule annotation
Disulfide bondi106 ↔ 116PROSITE-ProRule annotation
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi201 ↔ 267PROSITE-ProRule annotation
Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi244 ↔ 250PROSITE-ProRule annotation
Disulfide bondi285 ↔ 321PROSITE-ProRule annotation
Disulfide bondi301 ↔ 358PROSITE-ProRule annotation
Disulfide bondi316 ↔ 366PROSITE-ProRule annotation
Disulfide bondi341 ↔ 349PROSITE-ProRule annotation
Modified residuei438 – 4381PhosphoserineBy similarity
Modified residuei452 – 4521PhosphotyrosineBy similarity
Modified residuei459 – 4591PhosphoserineBy similarity
Modified residuei482 – 4821PhosphoserineBy similarity
Modified residuei484 – 4841PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP13379.
PRIDEiP13379.

PTM databases

PhosphoSiteiP13379.

Expressioni

Gene expression databases

BgeeiP13379.
CleanExiMM_CD5.
ExpressionAtlasiP13379. baseline and differential.
GenevestigatoriP13379.

Interactioni

Subunit structurei

Interacts with CD72/LYB-2. Interacts with PTPN6/SHP-1.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP13379.
SMRiP13379. Positions 31-134, 270-368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 133100SRCR 1PROSITE-ProRule annotationAdd
BLAST
Domaini159 – 268110SRCR 2PROSITE-ProRule annotationAdd
BLAST
Domaini276 – 36792SRCR 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 SRCR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG86650.
HOGENOMiHOG000111490.
HOVERGENiHBG005286.
InParanoidiP13379.
KOiK06455.
OMAiMSFHRNH.
OrthoDBiEOG7TF792.
PhylomeDBiP13379.
TreeFamiTF329295.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR003566. Tcell_CD5.
[Graphical view]
PfamiPF00530. SRCR. 2 hits.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
PR01409. TCELLCD5.
SMARTiSM00202. SR. 2 hits.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 2 hits.
PROSITEiPS50287. SRCR_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13379-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSHEVLLAA TYLLGTLAAF CLGQSGRGGL DIQVMLSGSN SKCQGQVEIQ
60 70 80 90 100
MENKWKTVCS SSWRLSQDHS KNAQQASAVC KQLRCGDPLA LGPFPSLNRP
110 120 130 140 150
QNQVFCQGSP WSISNCNNTS SQDQCLPLSL ICLEPQRTTP PPTTTPPTTV
160 170 180 190 200
PEPTAPPRLQ LVPGHEGLRC TGVVEFYNGS WGGTILYKAK DRPLGLGNLI
210 220 230 240 250
CKSLQCGSFL THLSGTEAAG TPAPAELRDP RPLPIRWEAP NGSCVSLQQC
260 270 280 290 300
FQKTTAQEGG QALTVICSDF QPKVQSRLVG GSSVCEGIAE VRQRSQWEAL
310 320 330 340 350
CDSSAARGRG RWEELCREQQ CGDLISFHTV DADKTSPGFL CAQEKLSQCY
360 370 380 390 400
HLQKKKHCNK RVFVTCQDPN PAGLAPGTVA SIILTLVLLV VLLAMCGPLV
410 420 430 440 450
YKKLVKKFRQ KKQRQWIGPT GVNQNMSFHR SHTATVRSQV ENPTASHVDN
460 470 480 490
EYSQPPRNSH LSAYPALEGA LHRSSTQPDN SSDSDYDLQV AQRL
Length:494
Mass (Da):53,849
Last modified:January 1, 1990 - v1
Checksum:i1EBBBBFE2488C162
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15177 mRNA. Translation: AAA39453.1.
U09204 Genomic DNA. Translation: AAC52187.1.
CCDSiCCDS29586.1.
PIRiA29079.
RefSeqiNP_031676.3. NM_007650.3.
UniGeneiMm.779.

Genome annotation databases

EnsembliENSMUST00000025571; ENSMUSP00000025571; ENSMUSG00000024669.
GeneIDi12507.
KEGGimmu:12507.
UCSCiuc008gqv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15177 mRNA. Translation: AAA39453.1.
U09204 Genomic DNA. Translation: AAC52187.1.
CCDSiCCDS29586.1.
PIRiA29079.
RefSeqiNP_031676.3. NM_007650.3.
UniGeneiMm.779.

3D structure databases

ProteinModelPortaliP13379.
SMRiP13379. Positions 31-134, 270-368.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP13379.

Proteomic databases

PaxDbiP13379.
PRIDEiP13379.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025571; ENSMUSP00000025571; ENSMUSG00000024669.
GeneIDi12507.
KEGGimmu:12507.
UCSCiuc008gqv.1. mouse.

Organism-specific databases

CTDi921.
MGIiMGI:88340. Cd5.

Phylogenomic databases

eggNOGiNOG86650.
HOGENOMiHOG000111490.
HOVERGENiHBG005286.
InParanoidiP13379.
KOiK06455.
OMAiMSFHRNH.
OrthoDBiEOG7TF792.
PhylomeDBiP13379.
TreeFamiTF329295.

Miscellaneous databases

NextBioi281478.
PROiP13379.
SOURCEiSearch...

Gene expression databases

BgeeiP13379.
CleanExiMM_CD5.
ExpressionAtlasiP13379. baseline and differential.
GenevestigatoriP13379.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR003566. Tcell_CD5.
[Graphical view]
PfamiPF00530. SRCR. 2 hits.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
PR01409. TCELLCD5.
SMARTiSM00202. SR. 2 hits.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 2 hits.
PROSITEiPS50287. SRCR_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of Ly-1, a membrane glycoprotein of mouse T lymphocytes and a subset of B cells: molecular homology to its human counterpart Leu-1/T1 (CD5)."
    Huang H.-J.S., Jones N.H., Strominger J.L., Herzenberg L.A.
    Proc. Natl. Acad. Sci. U.S.A. 84:204-208(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: T-cell.
  2. "Cloning of the murine CD5 promoter and its tissue-specific regulation."
    Weichert T.R., Schwartz R.C.
    J. Immunol. 154:4603-4612(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-17.
    Strain: NIH Swiss.
  3. "Negative regulation of B cell receptor-mediated signaling in B-1 cells through CD5 and Ly49 co-receptors via Lyn kinase activity."
    Ochi H., Watanabe T.
    Int. Immunol. 12:1417-1423(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY LYN, INTERACTION WITH PTPN6/SHP-1.

Entry informationi

Entry nameiCD5_MOUSE
AccessioniPrimary (citable) accession number: P13379
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: February 4, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.