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P13377

- G6PI_TRYBB

UniProt

P13377 - G6PI_TRYBB

Protein

Glucose-6-phosphate isomerase, glycosomal

Gene

PGI

Organism
Trypanosoma brucei brucei
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei411 – 4111Proton donorBy similarity
    Active sitei442 – 4421By similarity
    Active sitei571 – 5711By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-KW
    2. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    SABIO-RKP13377.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase, glycosomal (EC:5.3.1.9)
    Short name:
    GPI
    Alternative name(s):
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphohexose isomerase
    Short name:
    PHI
    Gene namesi
    Name:PGI
    OrganismiTrypanosoma brucei brucei
    Taxonomic identifieri5702 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

    Subcellular locationi

    GO - Cellular componenti

    1. glycosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Glycosome, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 607607Glucose-6-phosphate isomerase, glycosomalPRO_0000180548Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    Secondary structure

    1
    607
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni49 – 524
    Helixi54 – 6613
    Helixi71 – 777
    Helixi81 – 844
    Beta strandi86 – 905
    Beta strandi98 – 10710
    Helixi110 – 12213
    Helixi125 – 1339
    Turni140 – 1434
    Helixi148 – 1514
    Beta strandi164 – 1663
    Helixi167 – 18519
    Beta strandi199 – 2035
    Helixi206 – 2083
    Helixi210 – 2189
    Helixi220 – 2223
    Beta strandi227 – 2326
    Helixi237 – 24610
    Helixi249 – 2513
    Beta strandi252 – 2576
    Beta strandi259 – 2613
    Helixi264 – 28320
    Helixi292 – 2954
    Beta strandi296 – 3016
    Helixi303 – 3097
    Helixi313 – 3153
    Beta strandi316 – 3183
    Helixi325 – 3273
    Helixi332 – 3343
    Helixi335 – 3417
    Helixi343 – 36220
    Helixi365 – 3673
    Helixi369 – 38214
    Beta strandi388 – 3947
    Helixi396 – 3983
    Helixi401 – 41313
    Beta strandi431 – 4333
    Helixi439 – 4424
    Helixi445 – 4506
    Beta strandi451 – 4533
    Beta strandi457 – 4648
    Helixi472 – 48918
    Helixi493 – 50210
    Helixi508 – 5147
    Turni515 – 5184
    Beta strandi526 – 5338
    Helixi536 – 55722
    Helixi565 – 5673
    Helixi568 – 57710
    Helixi578 – 5803
    Helixi592 – 60413

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2AOLmodel-A157-562[»]
    2O2CX-ray1.58A/B/C1-607[»]
    2O2DX-ray1.90A/B/C1-607[»]
    3CV0X-ray2.00B601-607[»]
    ProteinModelPortaliP13377.
    SMRiP13377. Positions 38-606.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP13377.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi605 – 6073Microbody targeting signalSequence Analysis

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P13377-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSYLDDLRI DLAASPASGG SASIAVGSFN IPYEVTRRLK GVGADADTTL    50
    TSCASWTQLQ KLYEQYGDEP IKKHFEADSE RGQRYSVKVS LGSKDENFLF 100
    LDYSKSHIND EIKCALLRLA EERGIRQFVQ SVFRGERVNT TENRPVLHIA 150
    LRNRSNRPIY VDGKDVMPAV NKVLDQMRSF SEKVRTGEWK GHTGKAIRHV 200
    VNIGIGGSDL GPVMATEALK PFSQRDLSLH FVSNVDGTHI AEVLKSIDIE 250
    ATLFIVASKT FTTQETITNA LSARRALLDY LRSRGIDEKG SVAKHFVALS 300
    TNNQKVKEFG IDEENMFQFW DWVGGRYSMW SAIGLPIMIS IGYENFVELL 350
    TGAHVIDEHF ANAPPEQNVP LLLALVGVWY INFFGAVTHA ILPYDQYLWR 400
    LPAYLQQLDM ESNGKYVTRS GKTVSTLTGP IIFGEAGTNG QHAFYQLIHQ 450
    GTNLIPCDFI GAIQSQNKIG DHHKIFMSNF FAQTEALMIG KSPSEVRREL 500
    EAAGERSAEK INALLPHKTF IGGRPSNTLL IKSLTPRALG AIIAMYEHKV 550
    LVQGAIWGID SYDQWGVELG KVLAKSILPQ LRPGMRVNNH DSSTNGLINM 600
    FNELSHL 607
    Length:607
    Mass (Da):67,518
    Last modified:January 1, 1990 - v1
    Checksum:iAB237B7261CF2B74
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15540 Genomic DNA. Translation: CAA33547.1.
    PIRiS06113. NUUTB.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15540 Genomic DNA. Translation: CAA33547.1 .
    PIRi S06113. NUUTB.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2AOL model - A 157-562 [» ]
    2O2C X-ray 1.58 A/B/C 1-607 [» ]
    2O2D X-ray 1.90 A/B/C 1-607 [» ]
    3CV0 X-ray 2.00 B 601-607 [» ]
    ProteinModelPortali P13377.
    SMRi P13377. Positions 38-606.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    SABIO-RK P13377.

    Miscellaneous databases

    EvolutionaryTracei P13377.

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Glucosephosphate isomerase from Trypanosoma brucei. Cloning and characterization of the gene and analysis of the enzyme."
      Marchand M., Kooystra U., Wierenga R.K., Lambeir A.-M., van Beeumen J., Opperdoes F.R., Michels P.A.M.
      Eur. J. Biochem. 184:455-464(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
      Strain: 427.

    Entry informationi

    Entry nameiG6PI_TRYBB
    AccessioniPrimary (citable) accession number: P13377
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3