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P13377

- G6PI_TRYBB

UniProt

P13377 - G6PI_TRYBB

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Protein
Glucose-6-phosphate isomerase, glycosomal
Gene
PGI
Organism
Trypanosoma brucei brucei
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei411 – 4111Proton donor By similarity
Active sitei442 – 4421 By similarity
Active sitei571 – 5711 By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-KW
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

SABIO-RKP13377.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase, glycosomal (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:PGI
OrganismiTrypanosoma brucei brucei
Taxonomic identifieri5702 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Subcellular locationi

Glycosome UniRule annotation

GO - Cellular componenti

  1. glycosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Glycosome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 607607Glucose-6-phosphate isomerase, glycosomalUniRule annotation
PRO_0000180548Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni49 – 524
Helixi54 – 6613
Helixi71 – 777
Helixi81 – 844
Beta strandi86 – 905
Beta strandi98 – 10710
Helixi110 – 12213
Helixi125 – 1339
Turni140 – 1434
Helixi148 – 1514
Beta strandi164 – 1663
Helixi167 – 18519
Beta strandi199 – 2035
Helixi206 – 2083
Helixi210 – 2189
Helixi220 – 2223
Beta strandi227 – 2326
Helixi237 – 24610
Helixi249 – 2513
Beta strandi252 – 2576
Beta strandi259 – 2613
Helixi264 – 28320
Helixi292 – 2954
Beta strandi296 – 3016
Helixi303 – 3097
Helixi313 – 3153
Beta strandi316 – 3183
Helixi325 – 3273
Helixi332 – 3343
Helixi335 – 3417
Helixi343 – 36220
Helixi365 – 3673
Helixi369 – 38214
Beta strandi388 – 3947
Helixi396 – 3983
Helixi401 – 41313
Beta strandi431 – 4333
Helixi439 – 4424
Helixi445 – 4506
Beta strandi451 – 4533
Beta strandi457 – 4648
Helixi472 – 48918
Helixi493 – 50210
Helixi508 – 5147
Turni515 – 5184
Beta strandi526 – 5338
Helixi536 – 55722
Helixi565 – 5673
Helixi568 – 57710
Helixi578 – 5803
Helixi592 – 60413

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AOLmodel-A157-562[»]
2O2CX-ray1.58A/B/C1-607[»]
2O2DX-ray1.90A/B/C1-607[»]
3CV0X-ray2.00B601-607[»]
ProteinModelPortaliP13377.
SMRiP13377. Positions 38-606.

Miscellaneous databases

EvolutionaryTraceiP13377.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi605 – 6073Microbody targeting signal Reviewed prediction

Sequence similaritiesi

Belongs to the GPI family.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13377-1 [UniParc]FASTAAdd to Basket

« Hide

MSSYLDDLRI DLAASPASGG SASIAVGSFN IPYEVTRRLK GVGADADTTL    50
TSCASWTQLQ KLYEQYGDEP IKKHFEADSE RGQRYSVKVS LGSKDENFLF 100
LDYSKSHIND EIKCALLRLA EERGIRQFVQ SVFRGERVNT TENRPVLHIA 150
LRNRSNRPIY VDGKDVMPAV NKVLDQMRSF SEKVRTGEWK GHTGKAIRHV 200
VNIGIGGSDL GPVMATEALK PFSQRDLSLH FVSNVDGTHI AEVLKSIDIE 250
ATLFIVASKT FTTQETITNA LSARRALLDY LRSRGIDEKG SVAKHFVALS 300
TNNQKVKEFG IDEENMFQFW DWVGGRYSMW SAIGLPIMIS IGYENFVELL 350
TGAHVIDEHF ANAPPEQNVP LLLALVGVWY INFFGAVTHA ILPYDQYLWR 400
LPAYLQQLDM ESNGKYVTRS GKTVSTLTGP IIFGEAGTNG QHAFYQLIHQ 450
GTNLIPCDFI GAIQSQNKIG DHHKIFMSNF FAQTEALMIG KSPSEVRREL 500
EAAGERSAEK INALLPHKTF IGGRPSNTLL IKSLTPRALG AIIAMYEHKV 550
LVQGAIWGID SYDQWGVELG KVLAKSILPQ LRPGMRVNNH DSSTNGLINM 600
FNELSHL 607
Length:607
Mass (Da):67,518
Last modified:January 1, 1990 - v1
Checksum:iAB237B7261CF2B74
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15540 Genomic DNA. Translation: CAA33547.1.
PIRiS06113. NUUTB.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15540 Genomic DNA. Translation: CAA33547.1 .
PIRi S06113. NUUTB.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2AOL model - A 157-562 [» ]
2O2C X-ray 1.58 A/B/C 1-607 [» ]
2O2D X-ray 1.90 A/B/C 1-607 [» ]
3CV0 X-ray 2.00 B 601-607 [» ]
ProteinModelPortali P13377.
SMRi P13377. Positions 38-606.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
SABIO-RK P13377.

Miscellaneous databases

EvolutionaryTracei P13377.

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Glucosephosphate isomerase from Trypanosoma brucei. Cloning and characterization of the gene and analysis of the enzyme."
    Marchand M., Kooystra U., Wierenga R.K., Lambeir A.-M., van Beeumen J., Opperdoes F.R., Michels P.A.M.
    Eur. J. Biochem. 184:455-464(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    Strain: 427.

Entry informationi

Entry nameiG6PI_TRYBB
AccessioniPrimary (citable) accession number: P13377
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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