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P13376

- G6PIB_GEOSE

UniProt

P13376 - G6PIB_GEOSE

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Protein

Glucose-6-phosphate isomerase B

Gene
pgiB
Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei285 – 2851Proton donor By similarity
Active sitei306 – 3061 By similarity
Active sitei420 – 4201 By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

SABIO-RKP13376.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase B (EC:5.3.1.9)
Short name:
GPI B
Alternative name(s):
Phosphoglucose isomerase B
Short name:
PGI-B
Phosphohexose isomerase B
Short name:
PHI-B
Gene namesi
Name:pgiB
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Glucose-6-phosphate isomerase BUniRule annotationPRO_0000180592Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

1
445
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 64
Helixi8 – 103
Turni11 – 133
Helixi16 – 216
Helixi23 – 3412
Helixi41 – 433
Turni45 – 484
Helixi49 – 524
Helixi55 – 7117
Beta strandi73 – 786
Helixi81 – 833
Helixi85 – 9410
Helixi99 – 1013
Beta strandi102 – 1054
Beta strandi107 – 1148
Helixi117 – 12711
Beta strandi132 – 1376
Beta strandi139 – 1413
Helixi144 – 16118
Helixi163 – 1664
Helixi167 – 1693
Beta strandi170 – 1745
Helixi180 – 1889
Beta strandi191 – 1944
Turni207 – 2104
Helixi211 – 2177
Helixi221 – 23515
Helixi240 – 2423
Helixi244 – 25714
Beta strandi262 – 2698
Helixi270 – 2723
Helixi273 – 28715
Beta strandi295 – 3006
Helixi303 – 3064
Helixi309 – 3146
Beta strandi319 – 32810
Turni346 – 3505
Helixi353 – 37018
Beta strandi375 – 3828
Helixi385 – 40622
Helixi416 – 42611
Turni430 – 4323
Helixi433 – 4419

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B0ZX-ray2.30A1-445[»]
1C7QX-ray2.30A1-445[»]
1C7RX-ray2.50A1-445[»]
2PGIX-ray2.30A1-445[»]
ProteinModelPortaliP13376.
SMRiP13376. Positions 2-443.

Miscellaneous databases

EvolutionaryTraceiP13376.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13376-1 [UniParc]FASTAAdd to Basket

« Hide

MAISFDYSNA LPFMQENELD YLSEFVKAAH HMLHERKGPG SDFLGWVDWP    50
IRYDKNEFSR IKQAAERIRN HSDALVVIGI GGSYLGARAA IEALSHTFHN 100
QMNDTTQIYF AGQNISSTYI SHLLDVLEGK DLSINVISKS GTTTEPAIAF 150
RIFRDYMEKK YGKEEARKRI YVTTDRTKGA LKKLADQEGY ETFVIPDNIG 200
GRYSVLTAVG LLPIAVAGLN IDRMMEGAAS AYHKYNNPDL LTNESYQYAA 250
VRNILYRKGK AIELLVNYEP SLHYVSEWWK QLFGESEGKD QKGLFPASVD 300
FTTDLHSMGQ YVQEGRRNLI ETVLHVKKPQ IELTIQEDPE NIDGLNFLAG 350
KTLDEVNKKA FQGTLLAHVD GGVPNLIVEL DEMNEYTFGE MVYFFEKACG 400
ISGHLLGVNP FDQPGVEAYK KNMFALLGKP GFEDEKAALM KRLSK 445
Length:445
Mass (Da):50,141
Last modified:January 1, 1990 - v1
Checksum:i078AD337669D1AE1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16640 Genomic DNA. Translation: CAA34635.1.
PIRiS06198. NUBSS.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16640 Genomic DNA. Translation: CAA34635.1 .
PIRi S06198. NUBSS.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1B0Z X-ray 2.30 A 1-445 [» ]
1C7Q X-ray 2.30 A 1-445 [» ]
1C7R X-ray 2.50 A 1-445 [» ]
2PGI X-ray 2.30 A 1-445 [» ]
ProteinModelPortali P13376.
SMRi P13376. Positions 2-443.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
SABIO-RK P13376.

Miscellaneous databases

EvolutionaryTracei P13376.

Family and domain databases

HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete nucleotide sequences of two phosphoglucoisomerase isozymes from Bacillus stearothermophilus."
    Tao W., Wang L., Shen R., Sheng Z.
    Nucleic Acids Res. 17:10107-10108(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: T521.
  2. "The crystal structure of a multifunctional protein: phosphoglucose isomerase/autocrine motility factor/neuroleukin."
    Sun Y.-J., Chou C.-C., Chen W.-S., Wu R.-T., Meng M., Hsiao C.-D.
    Proc. Natl. Acad. Sci. U.S.A. 96:5412-5417(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).

Entry informationi

Entry nameiG6PIB_GEOSE
AccessioniPrimary (citable) accession number: P13376
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: June 11, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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