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P13376

- G6PIB_GEOSE

UniProt

P13376 - G6PIB_GEOSE

Protein

Glucose-6-phosphate isomerase B

Gene

pgiB

Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei285 – 2851Proton donorBy similarity
    Active sitei306 – 3061By similarity
    Active sitei420 – 4201By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    SABIO-RKP13376.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase B (EC:5.3.1.9)
    Short name:
    GPI B
    Alternative name(s):
    Phosphoglucose isomerase B
    Short name:
    PGI-B
    Phosphohexose isomerase B
    Short name:
    PHI-B
    Gene namesi
    Name:pgiB
    OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
    Taxonomic identifieri1422 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Glucose-6-phosphate isomerase BPRO_0000180592Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    Secondary structure

    1
    445
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 64
    Helixi8 – 103
    Turni11 – 133
    Helixi16 – 216
    Helixi23 – 3412
    Helixi41 – 433
    Turni45 – 484
    Helixi49 – 524
    Helixi55 – 7117
    Beta strandi73 – 786
    Helixi81 – 833
    Helixi85 – 9410
    Helixi99 – 1013
    Beta strandi102 – 1054
    Beta strandi107 – 1148
    Helixi117 – 12711
    Beta strandi132 – 1376
    Beta strandi139 – 1413
    Helixi144 – 16118
    Helixi163 – 1664
    Helixi167 – 1693
    Beta strandi170 – 1745
    Helixi180 – 1889
    Beta strandi191 – 1944
    Turni207 – 2104
    Helixi211 – 2177
    Helixi221 – 23515
    Helixi240 – 2423
    Helixi244 – 25714
    Beta strandi262 – 2698
    Helixi270 – 2723
    Helixi273 – 28715
    Beta strandi295 – 3006
    Helixi303 – 3064
    Helixi309 – 3146
    Beta strandi319 – 32810
    Turni346 – 3505
    Helixi353 – 37018
    Beta strandi375 – 3828
    Helixi385 – 40622
    Helixi416 – 42611
    Turni430 – 4323
    Helixi433 – 4419

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1B0ZX-ray2.30A1-445[»]
    1C7QX-ray2.30A1-445[»]
    1C7RX-ray2.50A1-445[»]
    2PGIX-ray2.30A1-445[»]
    ProteinModelPortaliP13376.
    SMRiP13376. Positions 2-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP13376.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Family and domain databases

    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P13376-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAISFDYSNA LPFMQENELD YLSEFVKAAH HMLHERKGPG SDFLGWVDWP    50
    IRYDKNEFSR IKQAAERIRN HSDALVVIGI GGSYLGARAA IEALSHTFHN 100
    QMNDTTQIYF AGQNISSTYI SHLLDVLEGK DLSINVISKS GTTTEPAIAF 150
    RIFRDYMEKK YGKEEARKRI YVTTDRTKGA LKKLADQEGY ETFVIPDNIG 200
    GRYSVLTAVG LLPIAVAGLN IDRMMEGAAS AYHKYNNPDL LTNESYQYAA 250
    VRNILYRKGK AIELLVNYEP SLHYVSEWWK QLFGESEGKD QKGLFPASVD 300
    FTTDLHSMGQ YVQEGRRNLI ETVLHVKKPQ IELTIQEDPE NIDGLNFLAG 350
    KTLDEVNKKA FQGTLLAHVD GGVPNLIVEL DEMNEYTFGE MVYFFEKACG 400
    ISGHLLGVNP FDQPGVEAYK KNMFALLGKP GFEDEKAALM KRLSK 445
    Length:445
    Mass (Da):50,141
    Last modified:January 1, 1990 - v1
    Checksum:i078AD337669D1AE1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16640 Genomic DNA. Translation: CAA34635.1.
    PIRiS06198. NUBSS.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16640 Genomic DNA. Translation: CAA34635.1 .
    PIRi S06198. NUBSS.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1B0Z X-ray 2.30 A 1-445 [» ]
    1C7Q X-ray 2.30 A 1-445 [» ]
    1C7R X-ray 2.50 A 1-445 [» ]
    2PGI X-ray 2.30 A 1-445 [» ]
    ProteinModelPortali P13376.
    SMRi P13376. Positions 2-443.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    SABIO-RK P13376.

    Miscellaneous databases

    EvolutionaryTracei P13376.

    Family and domain databases

    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequences of two phosphoglucoisomerase isozymes from Bacillus stearothermophilus."
      Tao W., Wang L., Shen R., Sheng Z.
      Nucleic Acids Res. 17:10107-10108(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: T521.
    2. "The crystal structure of a multifunctional protein: phosphoglucose isomerase/autocrine motility factor/neuroleukin."
      Sun Y.-J., Chou C.-C., Chen W.-S., Wu R.-T., Meng M., Hsiao C.-D.
      Proc. Natl. Acad. Sci. U.S.A. 96:5412-5417(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).

    Entry informationi

    Entry nameiG6PIB_GEOSE
    AccessioniPrimary (citable) accession number: P13376
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3