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P13376

- G6PIB_GEOSE

UniProt

P13376 - G6PIB_GEOSE

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Protein

Glucose-6-phosphate isomerase B

Gene

pgiB

Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei285 – 2851Proton donorBy similarity
Active sitei306 – 3061By similarity
Active sitei420 – 4201By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

SABIO-RKP13376.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase B (EC:5.3.1.9)
Short name:
GPI B
Alternative name(s):
Phosphoglucose isomerase B
Short name:
PGI-B
Phosphohexose isomerase B
Short name:
PHI-B
Gene namesi
Name:pgiB
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Glucose-6-phosphate isomerase BPRO_0000180592Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

1
445
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 64Combined sources
Helixi8 – 103Combined sources
Turni11 – 133Combined sources
Helixi16 – 216Combined sources
Helixi23 – 3412Combined sources
Helixi41 – 433Combined sources
Turni45 – 484Combined sources
Helixi49 – 524Combined sources
Helixi55 – 7117Combined sources
Beta strandi73 – 786Combined sources
Helixi81 – 833Combined sources
Helixi85 – 9410Combined sources
Helixi99 – 1013Combined sources
Beta strandi102 – 1054Combined sources
Beta strandi107 – 1148Combined sources
Helixi117 – 12711Combined sources
Beta strandi132 – 1376Combined sources
Beta strandi139 – 1413Combined sources
Helixi144 – 16118Combined sources
Helixi163 – 1664Combined sources
Helixi167 – 1693Combined sources
Beta strandi170 – 1745Combined sources
Helixi180 – 1889Combined sources
Beta strandi191 – 1944Combined sources
Turni207 – 2104Combined sources
Helixi211 – 2177Combined sources
Helixi221 – 23515Combined sources
Helixi240 – 2423Combined sources
Helixi244 – 25714Combined sources
Beta strandi262 – 2698Combined sources
Helixi270 – 2723Combined sources
Helixi273 – 28715Combined sources
Beta strandi295 – 3006Combined sources
Helixi303 – 3064Combined sources
Helixi309 – 3146Combined sources
Beta strandi319 – 32810Combined sources
Turni346 – 3505Combined sources
Helixi353 – 37018Combined sources
Beta strandi375 – 3828Combined sources
Helixi385 – 40622Combined sources
Helixi416 – 42611Combined sources
Turni430 – 4323Combined sources
Helixi433 – 4419Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B0ZX-ray2.30A1-445[»]
1C7QX-ray2.30A1-445[»]
1C7RX-ray2.50A1-445[»]
2PGIX-ray2.30A1-445[»]
ProteinModelPortaliP13376.
SMRiP13376. Positions 2-443.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13376.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13376-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAISFDYSNA LPFMQENELD YLSEFVKAAH HMLHERKGPG SDFLGWVDWP
60 70 80 90 100
IRYDKNEFSR IKQAAERIRN HSDALVVIGI GGSYLGARAA IEALSHTFHN
110 120 130 140 150
QMNDTTQIYF AGQNISSTYI SHLLDVLEGK DLSINVISKS GTTTEPAIAF
160 170 180 190 200
RIFRDYMEKK YGKEEARKRI YVTTDRTKGA LKKLADQEGY ETFVIPDNIG
210 220 230 240 250
GRYSVLTAVG LLPIAVAGLN IDRMMEGAAS AYHKYNNPDL LTNESYQYAA
260 270 280 290 300
VRNILYRKGK AIELLVNYEP SLHYVSEWWK QLFGESEGKD QKGLFPASVD
310 320 330 340 350
FTTDLHSMGQ YVQEGRRNLI ETVLHVKKPQ IELTIQEDPE NIDGLNFLAG
360 370 380 390 400
KTLDEVNKKA FQGTLLAHVD GGVPNLIVEL DEMNEYTFGE MVYFFEKACG
410 420 430 440
ISGHLLGVNP FDQPGVEAYK KNMFALLGKP GFEDEKAALM KRLSK
Length:445
Mass (Da):50,141
Last modified:January 1, 1990 - v1
Checksum:i078AD337669D1AE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16640 Genomic DNA. Translation: CAA34635.1.
PIRiS06198. NUBSS.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16640 Genomic DNA. Translation: CAA34635.1 .
PIRi S06198. NUBSS.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1B0Z X-ray 2.30 A 1-445 [» ]
1C7Q X-ray 2.30 A 1-445 [» ]
1C7R X-ray 2.50 A 1-445 [» ]
2PGI X-ray 2.30 A 1-445 [» ]
ProteinModelPortali P13376.
SMRi P13376. Positions 2-443.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
SABIO-RK P13376.

Miscellaneous databases

EvolutionaryTracei P13376.

Family and domain databases

HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete nucleotide sequences of two phosphoglucoisomerase isozymes from Bacillus stearothermophilus."
    Tao W., Wang L., Shen R., Sheng Z.
    Nucleic Acids Res. 17:10107-10108(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: T521.
  2. "The crystal structure of a multifunctional protein: phosphoglucose isomerase/autocrine motility factor/neuroleukin."
    Sun Y.-J., Chou C.-C., Chen W.-S., Wu R.-T., Meng M., Hsiao C.-D.
    Proc. Natl. Acad. Sci. U.S.A. 96:5412-5417(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).

Entry informationi

Entry nameiG6PIB_GEOSE
AccessioniPrimary (citable) accession number: P13376
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 26, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3