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Protein

Glucose-6-phosphate isomerase A

Gene

pgiA

Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathway:iglycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase A (pgiA), Glucose-6-phosphate isomerase (GT94_02025), Glucose-6-phosphate isomerase (GT94_17655), Glucose-6-phosphate isomerase B (pgiB)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. Fructose-bisphosphate aldolase (fba)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei290 – 2901Proton donorBy similarity
Active sitei311 – 3111By similarity
Active sitei425 – 4251By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

SABIO-RKP13375.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase A (EC:5.3.1.9)
Short name:
GPI A
Alternative name(s):
Phosphoglucose isomerase A
Short name:
PGI-A
Phosphohexose isomerase A
Short name:
PHI-A
Gene namesi
Name:pgiA
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Glucose-6-phosphate isomerase APRO_0000180591Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP13375.
SMRiP13375. Positions 4-448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13375-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHIRFDYSK ALSFFGEHEL TYLRDAVKVA HHSLHEKTGV GNDFLGWLDL
60 70 80 90 100
PVNYDKEEFA RIQKAAAKIQ ADSDVLLVIG IGGSYLGARA AIEMLHHSFY
110 120 130 140 150
NALPKEKRNT PQIIFVGNNI SSTYMKEVMD LLEGKDFSIN VISKSGTTTE
160 170 180 190 200
PAIAFRIFRK LLEEKYGKEE ARKRIYATTD RARGALKTLA TAEGYETFII
210 220 230 240 250
PDDVGGRYSV LTAVGLLPIA VSGANIEEMM KGAAQAREDF SSSELEENAA
260 270 280 290 300
YQYAAIRNIL YNKGKTIELL INYEPALQYF AEWWKQLFGE SEGKDQKGIF
310 320 330 340 350
PASANFSTDL HSLGQYIQEG RRDLFETVLK VEKPRHDLVI EAEENDLDGL
360 370 380 390 400
NYLAGKTVDF VNTKAFEGTL LAHTDGGVPN LVITLPELNE YTFGYLVYFF
410 420 430 440
EKACAMSGYL LGVNPFDQPG VEAYKVNMFA LLGKPGYEEK KAELEKRLK
Length:449
Mass (Da):50,337
Last modified:January 1, 1990 - v1
Checksum:i89C1FA04A393DFDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16639 Genomic DNA. Translation: CAA34634.1.
PIRiS15936. NUBSSA.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16639 Genomic DNA. Translation: CAA34634.1.
PIRiS15936. NUBSSA.

3D structure databases

ProteinModelPortaliP13375.
SMRiP13375. Positions 4-448.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
SABIO-RKP13375.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete nucleotide sequences of two phosphoglucoisomerase isozymes from Bacillus stearothermophilus."
    Tao W., Wang L., Shen R., Sheng Z.
    Nucleic Acids Res. 17:10107-10108(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: T521.

Entry informationi

Entry nameiG6PIA_GEOSE
AccessioniPrimary (citable) accession number: P13375
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: January 7, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.