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P13375 (G6PIA_GEOSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase A

Short name=GPI A
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase A
Short name=PGI-A
Phosphohexose isomerase A
Short name=PHI-A
Gene names
Name:pgiA
OrganismGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifier1422 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subunit structure

Homodimer.

Subcellular location

Cytoplasm HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   PTMPhosphoprotein
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 449449Glucose-6-phosphate isomerase A HAMAP-Rule MF_00473
PRO_0000180591

Sites

Active site2901Proton donor By similarity
Active site3111 By similarity
Active site4251 By similarity

Amino acid modifications

Modified residue381Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
P13375 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: 89C1FA04A393DFDC

FASTA44950,337
        10         20         30         40         50         60 
MTHIRFDYSK ALSFFGEHEL TYLRDAVKVA HHSLHEKTGV GNDFLGWLDL PVNYDKEEFA 

        70         80         90        100        110        120 
RIQKAAAKIQ ADSDVLLVIG IGGSYLGARA AIEMLHHSFY NALPKEKRNT PQIIFVGNNI 

       130        140        150        160        170        180 
SSTYMKEVMD LLEGKDFSIN VISKSGTTTE PAIAFRIFRK LLEEKYGKEE ARKRIYATTD 

       190        200        210        220        230        240 
RARGALKTLA TAEGYETFII PDDVGGRYSV LTAVGLLPIA VSGANIEEMM KGAAQAREDF 

       250        260        270        280        290        300 
SSSELEENAA YQYAAIRNIL YNKGKTIELL INYEPALQYF AEWWKQLFGE SEGKDQKGIF 

       310        320        330        340        350        360 
PASANFSTDL HSLGQYIQEG RRDLFETVLK VEKPRHDLVI EAEENDLDGL NYLAGKTVDF 

       370        380        390        400        410        420 
VNTKAFEGTL LAHTDGGVPN LVITLPELNE YTFGYLVYFF EKACAMSGYL LGVNPFDQPG 

       430        440 
VEAYKVNMFA LLGKPGYEEK KAELEKRLK 

« Hide

References

[1]"Complete nucleotide sequences of two phosphoglucoisomerase isozymes from Bacillus stearothermophilus."
Tao W., Wang L., Shen R., Sheng Z.
Nucleic Acids Res. 17:10107-10108(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: T521.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X16639 Genomic DNA. Translation: CAA34634.1.
PIRNUBSSA. S15936.

3D structure databases

ProteinModelPortalP13375.
SMRP13375. Positions 4-448.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKP13375.
UniPathwayUPA00109; UER00181.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PIA_GEOSE
AccessionPrimary (citable) accession number: P13375
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: June 11, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways