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P13375

- G6PIA_GEOSE

UniProt

P13375 - G6PIA_GEOSE

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Protein

Glucose-6-phosphate isomerase A

Gene
pgiA
Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei290 – 2901Proton donor By similarity
Active sitei311 – 3111 By similarity
Active sitei425 – 4251 By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

SABIO-RKP13375.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase A (EC:5.3.1.9)
Short name:
GPI A
Alternative name(s):
Phosphoglucose isomerase A
Short name:
PGI-A
Phosphohexose isomerase A
Short name:
PHI-A
Gene namesi
Name:pgiA
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Glucose-6-phosphate isomerase AUniRule annotationPRO_0000180591Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381Phosphothreonine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP13375.
SMRiP13375. Positions 4-448.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13375-1 [UniParc]FASTAAdd to Basket

« Hide

MTHIRFDYSK ALSFFGEHEL TYLRDAVKVA HHSLHEKTGV GNDFLGWLDL    50
PVNYDKEEFA RIQKAAAKIQ ADSDVLLVIG IGGSYLGARA AIEMLHHSFY 100
NALPKEKRNT PQIIFVGNNI SSTYMKEVMD LLEGKDFSIN VISKSGTTTE 150
PAIAFRIFRK LLEEKYGKEE ARKRIYATTD RARGALKTLA TAEGYETFII 200
PDDVGGRYSV LTAVGLLPIA VSGANIEEMM KGAAQAREDF SSSELEENAA 250
YQYAAIRNIL YNKGKTIELL INYEPALQYF AEWWKQLFGE SEGKDQKGIF 300
PASANFSTDL HSLGQYIQEG RRDLFETVLK VEKPRHDLVI EAEENDLDGL 350
NYLAGKTVDF VNTKAFEGTL LAHTDGGVPN LVITLPELNE YTFGYLVYFF 400
EKACAMSGYL LGVNPFDQPG VEAYKVNMFA LLGKPGYEEK KAELEKRLK 449
Length:449
Mass (Da):50,337
Last modified:January 1, 1990 - v1
Checksum:i89C1FA04A393DFDC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16639 Genomic DNA. Translation: CAA34634.1.
PIRiS15936. NUBSSA.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16639 Genomic DNA. Translation: CAA34634.1 .
PIRi S15936. NUBSSA.

3D structure databases

ProteinModelPortali P13375.
SMRi P13375. Positions 4-448.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
SABIO-RK P13375.

Family and domain databases

HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete nucleotide sequences of two phosphoglucoisomerase isozymes from Bacillus stearothermophilus."
    Tao W., Wang L., Shen R., Sheng Z.
    Nucleic Acids Res. 17:10107-10108(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: T521.

Entry informationi

Entry nameiG6PIA_GEOSE
AccessioniPrimary (citable) accession number: P13375
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: June 11, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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