P13375 (G6PIA_GEOSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase A
Short name=GPI A
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase A
Short name=PGI-A
Phosphohexose isomerase A
Short name=PHI-A

Gene names

Name:

pgiA

Organism

Geobacillus stearothermophilus (Bacillus stearothermophilus)

Taxonomic identifier

1422 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	449 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subunit structure	Homodimer.
Subcellular location	Cytoplasm HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 449	449	Glucose-6-phosphate isomerase A HAMAP MF_00473		PRO_0000180591
Sites
	Active site	290	1	Proton donor By similarity
	Active site	311	1	By similarity
	Active site	425	1	By similarity
Amino acid modifications
	Modified residue	38	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P13375 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: 89C1FA04A393DFDC	FASTA	449	50,337
	10 20 30 40 50 60 MTHIRFDYSK ALSFFGEHEL TYLRDAVKVA HHSLHEKTGV GNDFLGWLDL PVNYDKEEFA 70 80 90 100 110 120 RIQKAAAKIQ ADSDVLLVIG IGGSYLGARA AIEMLHHSFY NALPKEKRNT PQIIFVGNNI 130 140 150 160 170 180 SSTYMKEVMD LLEGKDFSIN VISKSGTTTE PAIAFRIFRK LLEEKYGKEE ARKRIYATTD 190 200 210 220 230 240 RARGALKTLA TAEGYETFII PDDVGGRYSV LTAVGLLPIA VSGANIEEMM KGAAQAREDF 250 260 270 280 290 300 SSSELEENAA YQYAAIRNIL YNKGKTIELL INYEPALQYF AEWWKQLFGE SEGKDQKGIF 310 320 330 340 350 360 PASANFSTDL HSLGQYIQEG RRDLFETVLK VEKPRHDLVI EAEENDLDGL NYLAGKTVDF 370 380 390 400 410 420 VNTKAFEGTL LAHTDGGVPN LVITLPELNE YTFGYLVYFF EKACAMSGYL LGVNPFDQPG 430 440 VEAYKVNMFA LLGKPGYEEK KAELEKRLK

References

[1]	"Complete nucleotide sequences of two phosphoglucoisomerase isozymes from Bacillus stearothermophilus." Tao W., Wang L., Shen R., Sheng Z. Nucleic Acids Res. 17:10107-10108(1989) [PubMed: 2532320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: T521.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X16639 Genomic DNA. Translation: CAA34634.1.
PIR	NUBSSA. S15936.
3D structure databases
ProteinModelPortal	P13375.
SMR	P13375. Positions 4-448.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PIA_GEOSE

Accession

Primary (citable) accession number: P13375

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	May 31, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program