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P13375

- G6PIA_GEOSE

UniProt

P13375 - G6PIA_GEOSE

Protein

Glucose-6-phosphate isomerase A

Gene

pgiA

Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei290 – 2901Proton donorBy similarity
    Active sitei311 – 3111By similarity
    Active sitei425 – 4251By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    SABIO-RKP13375.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase A (EC:5.3.1.9)
    Short name:
    GPI A
    Alternative name(s):
    Phosphoglucose isomerase A
    Short name:
    PGI-A
    Phosphohexose isomerase A
    Short name:
    PHI-A
    Gene namesi
    Name:pgiA
    OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
    Taxonomic identifieri1422 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 449449Glucose-6-phosphate isomerase APRO_0000180591Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei38 – 381PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    3D structure databases

    ProteinModelPortaliP13375.
    SMRiP13375. Positions 4-448.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Family and domain databases

    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P13375-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTHIRFDYSK ALSFFGEHEL TYLRDAVKVA HHSLHEKTGV GNDFLGWLDL    50
    PVNYDKEEFA RIQKAAAKIQ ADSDVLLVIG IGGSYLGARA AIEMLHHSFY 100
    NALPKEKRNT PQIIFVGNNI SSTYMKEVMD LLEGKDFSIN VISKSGTTTE 150
    PAIAFRIFRK LLEEKYGKEE ARKRIYATTD RARGALKTLA TAEGYETFII 200
    PDDVGGRYSV LTAVGLLPIA VSGANIEEMM KGAAQAREDF SSSELEENAA 250
    YQYAAIRNIL YNKGKTIELL INYEPALQYF AEWWKQLFGE SEGKDQKGIF 300
    PASANFSTDL HSLGQYIQEG RRDLFETVLK VEKPRHDLVI EAEENDLDGL 350
    NYLAGKTVDF VNTKAFEGTL LAHTDGGVPN LVITLPELNE YTFGYLVYFF 400
    EKACAMSGYL LGVNPFDQPG VEAYKVNMFA LLGKPGYEEK KAELEKRLK 449
    Length:449
    Mass (Da):50,337
    Last modified:January 1, 1990 - v1
    Checksum:i89C1FA04A393DFDC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16639 Genomic DNA. Translation: CAA34634.1.
    PIRiS15936. NUBSSA.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16639 Genomic DNA. Translation: CAA34634.1 .
    PIRi S15936. NUBSSA.

    3D structure databases

    ProteinModelPortali P13375.
    SMRi P13375. Positions 4-448.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    SABIO-RK P13375.

    Family and domain databases

    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequences of two phosphoglucoisomerase isozymes from Bacillus stearothermophilus."
      Tao W., Wang L., Shen R., Sheng Z.
      Nucleic Acids Res. 17:10107-10108(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: T521.

    Entry informationi

    Entry nameiG6PIA_GEOSE
    AccessioniPrimary (citable) accession number: P13375
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3