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Reviewed, UniProtKB/Swiss-Prot P13369 (CSF1R_FELCA)

Last modified June 16, 2009. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Macrophage colony-stimulating factor 1 receptor
      Short name=CSF-1-R
    EC=2.7.10.1
Alternative name(s):
    Fms proto-oncogene
    c-fms
    CD_antigen=CD115
Gene names
Name: CSF1R
Synonyms: FMS
OrganismFelis silvestris catus (Cat)
Taxonomic identifier9685 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis

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Protein attributes

Sequence length980 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Protein tyrosine-kinase transmembrane receptor for CSF1 and IL34 By similarity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure

Interacts with INPPL1/SHIP2 and THOC5 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.

Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 protein kinase domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 980961Macrophage colony-stimulating factor 1 receptor
PRO_0000016764

Regions

Topological domain20 – 509490Extracellular Potential
Transmembrane510 – 53526 Potential
Topological domain536 – 980445Cytoplasmic Potential
Domain21 – 10080Ig-like C2-type 1
Domain107 – 19791Ig-like C2-type 2
Domain202 – 29796Ig-like C2-type 3
Domain299 – 39799Ig-like C2-type 4
Domain400 – 499100Ig-like C2-type 5
Domain579 – 908330Protein kinase
Nucleotide binding585 – 5939ATP By similarity

Sites

Active site7761Proton acceptor By similarity
Binding site6131ATP By similarity

Amino acid modifications

Modified residue5521Phosphoserine By similarity
Modified residue5531Phosphotyrosine By similarity
Modified residue5591Phosphothreonine By similarity
Modified residue5641Phosphothreonine By similarity
Modified residue6961Phosphotyrosine; by autocatalysis By similarity
Modified residue7051Phosphotyrosine; by autocatalysis By similarity
Modified residue7131Phosphoserine By similarity
Modified residue8071Phosphotyrosine; by autocatalysis By similarity
Glycosylation451N-linked (GlcNAc...) Potential
Glycosylation731N-linked (GlcNAc...) Potential
Glycosylation941N-linked (GlcNAc...) Potential
Glycosylation1531N-linked (GlcNAc...) Potential
Glycosylation2751N-linked (GlcNAc...) Potential
Glycosylation2861N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential
Glycosylation3351N-linked (GlcNAc...) Potential
Glycosylation4101N-linked (GlcNAc...) Potential
Glycosylation4771N-linked (GlcNAc...) Potential
Glycosylation4901N-linked (GlcNAc...) Potential
Disulfide bond42 ↔ 84 Potential
Disulfide bond127 ↔ 177 Potential
Disulfide bond224 ↔ 278 Potential
Disulfide bond417 ↔ 482 Potential

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Sequences

Sequence LengthMass (Da)Tools
P13369-1 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: 4E5CF661E97CFCFF

FASTA980108,507
        10         20         30         40         50         60 
MGPRALLVLL VATAWHAQGV PVIQPSGPEL VVEPGTTVTL RCVGNGSVEW DGPISPHWNL 

        70         80         90        100        110        120 
DLDPPSSILT TNNATFQNTG TYHCTEPGNP QGGNATIHLY VKDPARPWKV LAQEVTVLEG 

       130        140        150        160        170        180 
QDALLPCLLT DPALEAGVSL VRVRGRPVLR QTNYSFSPWH GFTIHKAKFI ENHVYQCSAR 

       190        200        210        220        230        240 
VDGRTVTSMG IWLKVQKDIS GPATLTLEPA ELVRIQGEAA QIVCSASNID VNFDVSLRHG 

       250        260        270        280        290        300 
DTKLTISQQS DFHDNRYQKV LTLNLDHVSF QDAGNYSCTA TNAWGNHSAS MVFRVVESAY 

       310        320        330        340        350        360 
LNLTSEQSLL QEVTVGEKVD LQVKVEAYPG LESFNWTYLG PFSDYQDKLD FVTIKDTYRY 

       370        380        390        400        410        420 
TSTLSLPRLK RSEAGRYSFL ARNAGGQNAL TFELTLRYPP EVRVTMTLIN GSDTLLCEAS 

       430        440        450        460        470        480 
GYPQPSVTWV QCRSHTDRCD ESAGLVLEDS HSEVLSQVPF HEVIVHSLLA IGTLEHNRTY 

       490        500        510        520        530        540 
ECRAFNSVGN SSQTFWPISI GAHTQLPDEL LFTPVLLTCM SIMALLLLLL LLLLYKYKQK 

       550        560        570        580        590        600 
PKYQVRWKII ESYEGNSYTF IDPTQLPYNE KWEFPRNNLQ FGKTLGAGAF GKVVEATAFG 

       610        620        630        640        650        660 
LGKEDAVLKV AVKMLKSTAH ADEKEALMSE LKIMSHLGQH ENIVNLLGAC THGGPVLVIT 

       670        680        690        700        710        720 
EYCCYGDLLN FLRRQAEAML GPSLSVGQDP EAGAGYKNIH LEKKYVRRDS DFSSQGVDTY 

       730        740        750        760        770        780 
VEMRPVSTSS SNDSFSEEDL GKEDGRPLEL RDLLHFSSQV AQGMAFLASK NCIHRDVAAR 

       790        800        810        820        830        840 
NVLLTSGRVA KIGDFGLARD IMNDSNYIVK GNARLPVKWM APESIFDCVY TVQSDVWSYG 

       850        860        870        880        890        900 
ILLWEIFSLG LNPYPGILVN SKFYKLVKDG YQMAQPAFAP KNIYSIMQAC WALEPTRRPT 

       910        920        930        940        950        960 
FQQICSLLQK QAQEDRRVPN YTNLPSSSSS SSSSSSSCRT GSGGGSSSEP EEESSSEHLA 

       970        980 
CCEQGDIAQP LLQPNNYQFC

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References

[1]"Activation of the feline c-fms proto-oncogene: multiple alterations are required to generate a fully transformed phenotype."
Woolford J., McAuliffe A., Rohrschneider L.R.
Cell 55:965-977(1988) [PubMed: 2849512] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

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Cross-references

Sequence databases

J03149 mRNA. Translation: AAA30811.1.
PIRTVCTMD. A31636.
RefSeqNP_001009231.1.

3D structure databases

HSSPHSSP built from PDB template 1FGK based on UniProtKB P11362.
SMRP13369. Positions 544-917.
ModBaseSearch...

Genome annotation databases

GeneID493706.

Phylogenomic databases

HOVERGENP13369.

Family and domain databases

InterProIPR013151. Ig.
IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR001824. Recept_tyr_kinase-III_CS.
IPR001245. Tyr_pkinase.
IPR008266. Tyr_pkinase_AS.
IPR016243. TyrPK_CSF1-R.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 3 hits.
PfamPF00047. ig. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PIRSFPIRSF000615. TyrPK_CSF1-R. 1 hit.
ProDomPD000001. Prot_kinase. 2 hits.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCSF1R_FELCA
AccessionPrimary (citable) accession number: P13369
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: June 16, 2009
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents